 |
|
|
|
|
|||||||
| Notices |
| Morphine Topics concerning Morphine should be posted here in this forum. Since this is a little harder to come by, anything morphine related can be posted here until additional forums are necessary. |
 |
|
|
Thread Tools | Display Modes |
08-10-2006, 12:28 PM
|
#1 |
|
Opiophorum Member
 
Join Date: Jun 2006
Posts: 288
|
morphine bioavailability
simple question here:
Is morphine more bioavailable sublingually opposed to orally, just wondering if shoving the used cottons under my tounge is better than just eatin em. thanks -SDP-
__________________
I opened-up a yogurt, underneath the lid it said, "Please try again." because they were having a contest that I was unaware of, I thought maybe I opened the yogurt wrong. ...Or maybe Yoplait was trying to inspire me... "Come on Mitchell, don't give up!" An inspirational message from your friends at Yoplait, fruit on the bottom, hope on top. - Mitch Hedberg
 |
|
|
|
08-10-2006, 12:46 PM
|
#2 |
|
Opiophile
Join Date: Jun 2006
Location: MD
Posts: 857
|
Re: morphine bioavailability
are you asking if it is MORE available subL?? or if it is at all?
__________________
 "PROLLY" is NOT a word!
|
|
|
|
|
08-10-2006, 12:57 PM
|
#3 |
|
Opiophile
Join Date: Jun 2006
Location: MD
Posts: 857
|
Re: morphine bioavailability
I meant to answer and got distracted...
In terms of time to max serum concentration, oral morph is lightly faster (this has been argued about for years though!). Bioavailability is around 9% sl and 23% po. In order for a drug to be effective sl, it has to be potent, non-ionized at the pH of saliva, and lipophillic. Morphine is not the most potent opiate, is ionized at the pH of your mouth and it not very lipophillic at all. It is actually one of the least lipophillic, so no it doesn't work very well sl. Most people agree that the fact that it works at all is due to it being swallowed while the person is attempting to keep it under the tounge.
__________________
"PROLLY" is NOT a word!
|
|
|
|
|
08-14-2006, 02:08 PM
|
#4 |
|
Never Looked Back
 
Join Date: Apr 2006
Location: Indy
Posts: 1,013
|
Re: morphine bioavailability
Wow... I didn't know that about morphine. Cool info there.
|
|
|
|
|
08-14-2006, 07:12 PM
|
#5 | |
|
Junky
Join Date: Feb 2006
Location: California
Posts: 441
|
Re: morphine bioavailability
Quote:
__________________
"There are even circumstances where poisons are useful to men;with mandrake doctors give us sleep; with opium they lull violent pain." St. Basil the Great Hierarch (329-379AD) in his 5th Homily "The Germination of the Earth" "The feeling opiophiles wish to attain is freedom.......a freedom from pain...psychological or physical. Opiates are a way for us to experience life in its fullest."----The Prize Fighter Inferno 
|
|
|
|
|
|
| Bookmarks |
| Thread Tools | |
| Display Modes | |
|
|
Similar Threads
|
||||
| Thread | Thread Starter | Forum | Replies | Last Post |
| morphine | verodo | Morphine | 3 | 08-07-2006 10:04 AM |
| Benzo Recipe... Potentiation Through Higher Bioavailability | chemboy7 | Sedatives and Hypnotics | 1 | 07-06-2006 09:45 PM |
| morphine | opiapleez | Morphine | 10 | 05-13-2006 01:36 AM |
| getting off of morphine | shootingstar | Morphine | 6 | 04-02-2006 11:32 PM |
| Morphine, where? | kramorph | Morphine | 1 | 03-24-2006 10:33 PM |
Linear Mode
