Diphenoxylate

[The Paregoric Man]

Ah yes my favorite little misfit opioid, such a weird little drug. Structurally related to methadone and pethedine and yet the closest thing I can subjectively compare it to is buprenorphine. And even then its not an exact fit, but it has the same odd partial agonist feeling if you catch my drift. Very energetic drug, no analgesia at all but tons of opiate motivation and energy. If you want a nod you probably won't find it.

If you doubt its power take a gander at these, can anyone find full versions of these articles?

http://www3.interscience.wiley.com/j...TRY=1&SRETRY=0
http://www.ncbi.nlm.nih.gov/pubmed/6640222

<
Br J Psychiatry. 1983 Nov;143:513-4.
Short-course diphenoxylate hydrochloride for treatment of methadone withdrawal symptoms.

Ives TJ, Stults CC.
The authors conducted a preliminary trial of a 5-day course of diphenoxylate in the treatment of out-patients with methadone withdrawal symptoms. Diphenoxylate provided substantial relief from detoxification symptoms with no drug-associated adverse effects.>

<
The Use of Diphenoxylate Hydrochloride (Lomotil) in the Management of the Minor Withdrawal Syndrome during Methadone Detoxification: A Clinical Report

Marc H. Kleinman, M.S. 1 Dan Arnon, M.D. 1 1 Division of Alcoholism and Drug Dependence, Department of Psychiatry, Downstate Medical Center, State University of New York, Brooklyn, N.T. 11203, U.S.A.

Copyright 1977 Society for the Study of Addiction to Alcohol and Other Drugs

ABSTRACT


Diphenoxylate Hydrochloride (Lomotil) was effective in alleviating the minor withdrawal symptoms that accompanies complete methadone detoxification. None of the subjects developed a tolerance to Lomotil nor did they experience withdrawal symptoms or craving when Lomotil was discontinued. This report indicates that the elimination of this minor withdrawal syndrome facilitates complete methadone detoxification.>

I'm honestly interested in the no tolerance or withdrawal mention, it is claimed this is a mu agonist. But it doesn't really feel like one, and yet it does have opiate effects. Weird.

[Larkin]

I read tons of good stuff about this shit because i had quite a few of them. I ate a handful of ~20 pills, NOTHING. Tried sniffing them, NOTHING. I read about the atropine before i got the bright idea to fix em. so thank god for that mess.

I got them when i was in the tail end of kicking (the physical part anyway). Boredom, restlessness and other things such as desperation to get away from being sober had me eating whatever pills i could find. These did nothing for me, the actually didn't even shut the old brown eye.

right around this time i had completely tapered off of bupe for about 2-3 weeks. I was still getting chills, body temp cant regulate, restless but tired, etc... but i found a peice of paper with some sub powder on it, not much at all. I would guess .5mg at most, i sniffed that and i was feeling much better than i had felt in a while. right after i sniffed it i had a few drinks (dunno if it matters but i would say so). I was very relaxed, comfortable, and i would go as far as to say i got a nod, but i did lay in bed with my eyes closed for about 2 hours, yet still kind of awake. I think bupe is way more potent

I think this drug especially is one of those that effects everyone totally differently, but i got nothing. I get kind of a glow from lope sometimes though, weird.

[Indy]

I made a similar topic about a year ago (6 months? hell I don't know it's oooooold) and yes, I agree, it is a very nice opioid actually. I wish they'd put it in schedule III so they could use it as a painkiller because it's actually very effective.

Also it's schedule V when mixed with atropine (pretty much the only preparation available in the US IIRC), so in some states you can actually buy it from the pharmacy like you can with codeine. Not that any pharmacist will ever sell it to you, but it's nice to dream, right?

Lomotil used to be a backup for me, and eventually i started looking forward to when it was long enough that i could get some more out of my doctor. I had to take 30 of them at once with a semi-decent tolerance, though, and at that dose you feel the atropine a little bit. I've heard of people taking over 100 without too many negative effects from the atropine (not that i would recommend it), since atropine is so inactive orally.

So yeah, I'm not surprised that 20 didn't do anything, if you have a tolerance you have to take a LOT, but if you take enough, it IS an opioid and will get you a buzz/high. One thing that's convenient for the opiophile is that the atropine wears off right around when the diphenoxylate kicks in. It's a very long-acting, speedy opiate that i thought was fairly euphoric, adjusted for dose and tolerance. Not TOO speedy, though.

[Billy the kid]

After my first little habit I had been clean for about 2 months and came across about 10 of these. I took them all and got a great glow and that restless, itchy sleep. I liked it so much that the next day I was back to the races with dope. They wouldnt do anything for me now but good memories...

[Indy]

The thing about atropine is that it makes it unpleasant for a couple hours, but it doesn't spoil the high much because it takes a couple hours for it to kick in anyway. And unless you're taking 200+ it's not going to pose any SERIOUS threat to you because of how little atropine there is and how inactive it is orally. I really wish i knew what the bioavailability of diphenoxylate was, because the fact that they put in an abuse deterrent that is SPECIFICALLY to deter IV use makes me think it might be way more powerful IV'd.

Anyways, I've always wondered if this stuff shows up on standard drug tests? I'm guessing that it does since it's related to demerol and that shows up (doesn't it?) as an opiate.