Tolerance Question

[wheatpenny]

I'm a chronic pain patient, so my meds come from my doc. I had been on vicoden for 9 months or so (10mg/day) and it was giving me trouble so I was switched to liquid roxicodone. Problem with that is wears off in 2 hours, max. So I've been off the vicoden for 3 weeks or so, and I'm picking up a refill of that tomorow. Will my tolerance for the vicoden be lower then it was, or will my use of the roxicodone in the interim keep my overall opiate tolerance up? Ideally, I can swap between the two every few weeks to keep my tolerance lower, or do I have the science wrong? It's oxycodone vs hydrocodone, right?

Thanks.

[Ickyuck]

I think your tolerence will be up. Thats my general two cent answer.

[More Feen]

How much of the roxicodone have you been taking?

I assume you're dosing every 2 hours, or so.

If the level of pain relief is similar--and you're not taking more than needed for pain relief, you should be okay. Your tolerance might be a little higher.

If you don't mind discusing what problems you had with vicodin, that could help. I found that hydrocodone was a little too powerful when I took it, and changed to T3s. My doctor was shocked when I asked this: "You want to use a weaker opioid analgesic?? Sure !!"

All opiates / opioids should have cross-tolerances, now freak drugs like buprenorphine kind mess things up, but that's a story for another thread.

Hope your pain is minimized!

M F

[GOLD N DIEMONDS]

Yes- would agree with the above knowledge ones
tolerance with be about the same or a bit higher.
more info on liquid roxicodone, would be need-
Not really sure if possible, but you may want to skip a few days
before starting with the vics again, may help tolerance drop just abit
also, personal believe that switching between the two drug groups
say every 3-4 days, helps keep both more effect at lower tolerance
good luck, curious as to how it will work out for thee
please update

[wheatpenny]

I've been taking 10mg roxi per day, NOT every 2 hours- don't want to mess up my doctors orders. I take meds at bedtime so I get quality sleep.
I had weight loss surgery a few years ago and cannot tolerate NSAIDS OR tylenol anymore. The vicoden tends to make me vomit profusely- hence the roxi with no tylenol as a liquid. I wouldn't even mind just codeine alone, maybe I should ask my doc for that? I just cannot keep the tyloneol or NSAIDS down. Thats mean no ibuprofin, no acetominaphen, etc.

[GOLD N DIEMONDS]

Originally Posted by wheatpenny

I've been taking 10mg roxi per day, NOT every 2 hours- don't want to mess up my doctors orders. I take meds at bedtime so I get quality sleep.
I had weight loss surgery a few years ago and cannot tolerate NSAIDS OR tylenol anymore. The vicoden tends to make me vomit profusely- hence the roxi with no tylenol as a liquid. I wouldn't even mind just codeine alone, maybe I should ask my doc for that? I just cannot keep the tyloneol or NSAIDS down. Thats mean no ibuprofin, no acetominaphen, etc.

HEY PERFECT TIMING!
Have your heard of a 'CWE' - cold water extraction
It is a very simple procedure you can do with the Vics
That will remove almost all the APAP-(tylonel) from the Vics
leaving behind mostly pure HYDROCODONE

so you can get great pain relief without any STOMACH ISSUES from the vicodone
Can use search engine here, though maybe to many results
let us know if you know of this
That would be Idea, don't you need to see Doctor every time for the hard copy of Roxis

[Ickyuck]

Originally Posted by wheatpenny

I've been taking 10mg roxi per day, NOT every 2 hours- don't want to mess up my doctors orders..

Than what are you doing on opiophile??

[Thanat0s]

Originally Posted by Ickyuck

Than what are you doing on opiophile??

you sound like my dad...

[pdxninja]

after my tonsils and also after jaw surgery i had liquid oxy.

that stuff has zero legs let me tell you. 2 hours seems about right for how often you have to dose for relief. although with my jaw surgery i the mixture i had included vistiril which gave it some legs. although i dont know if doctors will prescribe just for opiate potentiation. or do they actually rx it for opiate related stuff?

if you werent taking it for that long i doubt you will have too much trouble. especially if you were taking just the dr reccomended dose. maybe it will be up a tad.

let us know how you feel though

[Thebane]

If it's just tylenol that's the problem maybe ask your doc for vicoprofen (sp.?) I'm pretty sure that's hydrocodone and ibuprofen. But if you have a problem with all NSAIDs I think you're out of luck unless you can find a compounding pharmacy and convince your doc to write for hydro alone (which is Schedule 2 instead of 3 I think).

[wheatpenny]

Ugh- tolerance isn't drastically changed either way, but the APAP makes me puke my guts out. I'm going CWE, I can't spend the whole day next to the toilet.

[More Feen]

Yeah, that sucks about the APAP & the other crap they throw into Vikes. A CWE is a good step.

If you take 10 vikes a day, but not every two hours: I get: 24hours / 10 vikes = 2.4 hours between doses, unless you're taking 2 vikes every 4.8 hours, etc... (I'm just being a jerk--don't answer).

I think the problem with pure codeine, or hydro (without the APAP or Profen or ASA) is that such a preparation goes from schedule III to schedule II.

I don't know about the pure oxycodone one person posted, if its anything like codeine, it will be C-II, unless mixed with something like APAP to make it C-III. How does that work?

You shouldn't have to do a CWE (do not tell your doctor that you are altering your medication, unless they are really, really cool). Your doctor should Rx you something that will not make you sick.

If they are cool, then you can tell him that the CWE prep did NOT make you sick, indicating that the APAP is responsible for this vomiting.

M F

[Underdose]

Originally Posted by More Feen

I think the problem with pure codeine, or hydro (without the APAP or Profen or ASA) is that such a preparation goes from schedule III to schedule II.

I don't know about the pure oxycodone one person posted, if its anything like codeine, it will be C-II, unless mixed with something like APAP to make it C-III. How does that work?

You shouldn't have to do a CWE (do not tell your doctor that you are altering your medication, unless they are really, really cool). Your doctor should Rx you something that will not make you sick.

If they are cool, then you can tell him that the CWE prep did NOT make you sick, indicating that the APAP is responsible for this vomiting.

M F

that is alot of apap. ive been taking vikes n percs since the dr gave em to me last week, and ive been cwe'ing. 10 grams ofapap/day would be bad.

putting apap in with oxy is percocet, still sched 2...doesn't change it as its a stronger opiate.

[More Feen]

Thanks Under-D,

I have never dealt with Oxycodone in any way, so I don't know much about it.

Of course, were I less lazy, I could have Gugeled the shite.

'Preciate the info!

M F

[jersey_emt]

The maximum recommended daily dosage (spread out over a 24-hour period) of APAP is 4000 mg. But even that number is too high -- the FDA is currently investigating whether to decrease the recommended maximum. I have a pretty strong feeling that they will drop it to 3000 mg or 2500 mg.

But all of that means nothing if you can't tolerate APAP. Like other have mentioned, you have a few options:

1. Continue with the liquid oxycodone or switch to single entity IR oxycodone tablets.
2. Switch from Vicodin to Vicoprofen.
3. Switch from Vicodin to custom compounded single entity IR hydrocodone.

#2 would be CIII just like Vicodin, but #1 or #3 is CII.

I would just tell your doctor the truth. Tell him that the Vicodin was making you nauseous, but the liquid oxycodone is not. And that the liquid oxycodone works well, just not long enough.

Good luck.