Best Abusable Benzos acording to Science.

[DCBA]

Whilst all benzodiazepines have abuse potential, certain characteristics increase their potential for abuse. A short elimination half-life, high potency and a rapid onset of action are characteristics which increase the abuse potential of benzodiazepines.

The following table provides the elimination half-life, relevant potency to other benzodiazepines, speed of onset of action and duration of behavioural effects

Drug Name______Onset of action______Duration of action (h)**___________Half-Life (h) [metabolite]_______Dose***
Alprazolam_________Fast______________ 3-5___________________________ 6-12 hours__________________0.5 mg
Chlordiazepoxide____Intermediate_______???________ ____________________ 5-30 hours [36-200 hours]_____25 mg
Clonazepam________Intermediate_______ 10-12_________________________ 18-50 hours_________________0.5 mg
Clorazepate________Intermediate_______ ???___________________________ [36-100 hours]______________15 mg
Diazepam__________Fast______________ 4-6____________________________ 20-100 hours [36-200]_______10 mg
Estazolam__________Slow_____________ 6-8____________________________ 10-24 h____________________1-2 mg
Flunitrazepam_______Fast______________6-8____________________________ 18-26 hours [36-200 hours]____1 mg
Flurazepam_________Fast______________7-10___________________________ [40-250 hours]_______________15-30 mg
Lorazepam _________Fast______________4-6____________________________ 10-20 hours__________________1 mg
Midazolam_________ Ultra-fast__________0.5-1__________________________ 3 hours [1.8-6 hours]__________5 mg
Oxazepam_________ Slow_____________???____________________________ 4-15 hours___________________30 mg
Prazepam__________Slow_____________???____________ ________________ 36-200 hours_________________20 mg
Quazepam_________Slow______________6______________ _______________ 39-120 hours_________________20 mg
Temazepam________Intermediate_______5-6____________________________ 8-22 hours__________________20 mg
Triazolam__________Fast______________0.5-1___________________________ 2 hours____________________0.25 mg

And benzos effects don't last allways according to the half-life when one is tolerant to them as you can see, the duration of action is for tolerant people.

[RifRaf]

Nice list, I've seen some like this but not as thorough. Personally my favortie benzo, from those that I have had, would be the Clonazepam mainly because it is water soluble (of course, after a little work!) and has a fairly long lasting effect. I don't touch benzos as much as I used to so a good dose of 6-8mg's IV'd is always fantastic, not something I recommend to anyone due to (1) the lactose, mag. stearate, microcrystaline cellulose, and corn starch, and (2) the "proper" way of preperation is a bit trickier than simply letting it dissolve in cold water.

My second favorite is Diazepam because of that long half-life, as shown on your graph above. I always take these orally and would trade a nut for a box full of ampoules.

And last up is my script for Mogadon (nitrazepam) which is a total knock out benzo even in low doses (I get 30 5mg pills a month and take anywhere from 10-25mg's depending on situation. This may not be a good dose for a person who has low tolerance to Benzo's). These I take orally as well.


P.S. I have always wanted to know if there is a term used for (the very unsafe) mixing of benzos and opiates in the same rig and IV'ing it (i.e. speedball for uppers and opiates)?

Love your blog DCBA.

[DCBA]

The factor that makes benzos more abusable is:

1th - Being Fast Acting, taking little time to reach peak state.

2th - The smaller the half-life, the better! Because with longer half-life the drugs acumulate in your body just like methadone does, so that increases your tolerance and decrease your high.

3th - Potency of the molecule. The greater the potenty by weitght of the substance the greater the affinity for the receptors, and the greater the affinity for the receptor the greater the effect is on them.

4th - Duration. This is differente than half-life. Alltought the effects may continue more than the duration mostly due to lack of tolerance. Generally the duration has little do with the half-life. Don't know why but it happens in tolerant people.

5h - The effect you are after: As most of us note there are different effects/kinds of benzos,To me the "the drunk ones are ": temazepam; nitrazepam; midazolam; flunitrazepam;etc.. The "i feel so sedated without a care.." ones: diazepam; alprazolam; bromazepam; lorazepam; oxazepam;etc. The "sleep inductors": brotizolam; flurazepam;estazolam;etc. And the "feel so light headed but am totally fucked up" ones:triazolam; zolpidem;etc..

6th - Personal Preferenced! We are not the same, but the above factors make benzos more abusable in tests..
NOTE: The table above is not the best abusable benzos according to Science, its only a table so you can read what makes the best abusable, and why...


ANSWER TO QUESTION:
Yes its very, very, very unsafe to mix benzos with opiates in the same shoot! Its very dangerous even orally but much more IVed. But still, tolerance to benzos grows as fast if not faster than tolerance to opiates. And like opiate tolerance it can be HUGE, like people take up to 2 to 3 grams (documentated) of morphine per day (200x to 300x the normal IV dose) there are people who take hundreds of mgs of diazepam or other benzos. I used to take 750mgs or more of diazepam per day (75x the normal dose). Its all about tolerance, but even with tolerance it can be DANGEROUS AS HELL!

[chopstix]

Originally Posted by DCBA

Whilst all benzodiazepines have abuse potential, certain characteristics increase their potential for abuse. A short elimination half-life, high potency and a rapid onset of action are characteristics which increase the abuse potential of benzodiazepines.

The following table provides the elimination half-life, relevant potency to other benzodiazepines, speed of onset of action and duration of behavioural effects

And benzos effects don't last allways according to the half-life when one is tolerant to them as you can see, the duration of action is for tolerant people.

Duration of action and half-life are un-related - I take Valium daily and it's the metabolites that contribute to the long half life, it's not like I'm loaded for 200hrs after I dose; "duration of action" is the field more appropriate for these assertions.

Nice list, although I've seen probably 15 others like it, but I disagree that valium has a fast onset, and I'll hazard a guess that a lot of people will disagree with bits and pieces, as everyone metabolizes differently and especially when talking psychoactive depressants among opiate addicts, whatever else is floating around in the blood today is gonna have a huge affect..

I don't often notice clonazepam (klonopin) listed with a realistic DOA (pun slightly intended) - I used to love that shit cos it lasted so long..

I'd recommend posting your sources when compiling lists like this.

Originally Posted by RifRaf

Nice list, I've seen some like this but not as thorough. Personally my favortie benzo, from those that I have had, would be the Clonazepam mainly because it is water soluble (of course, after a little work!) and has a fairly long lasting effect. I don't touch benzos as much as I used to so a good dose of 6-8mg's IV'd is always fantastic, not something I recommend to anyone due to (1) the lactose, mag. stearate, microcrystaline cellulose, and corn starch, and (2) the "proper" way of preperation is a bit trickier than simply letting it dissolve in cold water.

Clonazepam IS NOT water soluble, <1mg/ml solubility in water (http://www.drugbank.ca/drugs/DB01068). Please don't spread this kind of disinformation on the board, we get a lot of young, inexperienced needle freaks who read something once, don't bother researching and shooting up dumb shit. VERY few benzos are water soluble. *Please* make damn sure you post accurate information when it comes to solubility because I guarantee you 20 kids are sitting there trying to figure out if they should shoot the milky mess they just made in the spoon, probably fucking cooking the shit to see it that'll help

Please don't do that, unless you can back it up with something besides a step-by-step recipe in someone's kitchen (ie, not a lab) and some real sources.

[RifRaf]

Clonazepam is "almost insoluble" with water, true. There is a process to make it water soluble after using other specific solutions, and a few cleaning procedures which is why I said "the "proper" way of preperation is a bit trickier than simply letting it dissolve in cold water" and I was pretty specific when saying that IV'ing this is "not something I recommend to anyone."

Sorry, sometimes I realize that I only have first hand experience doing some of these things and that doesn't matter much here on the internet, I know. But when I get above 1,000 posts apparently I will receive my bachelor's degree in Pharmaceutical Science and Chemistry?

[DCBA]

Could it be that "allmost unsoluble" in water could be enought to IV a normal dose of clonazepam, because its small dose.

Clonazepam is a very potent drug, 1mg to 2 mgs.... Like i said its a very small dose..

Considering one persorn is doing 1mg pill in a 1ml syringe.
1mg in 1ml of water is like 1:1000 dilution. So 1mg of clonazepam in 1000mg of water can still be declared "almost soluble".

So it can work, i never tried..

I dont know that its soluble, but if you find the solubility in water of clonazepam you should have your answer.
What i'm saying is that when one thinks a substance is almost unsolube is not so simple saying because of that it will not work IV/nasal.
One needs to check the concentration needed and seing if one can fit a normal dose there... In the case of clonazepam (because of its high potency) it may very well be the case.

EDIT:
You even got the solubility in water, sorry, i didn't see it first. Its <1mg/ml, its still the minimum oral dose of clonazepam >0.250mg , the "normal" oral doses are from 0.25mg to 2mgs, so <1mg/ml is very doable IVing.. specially cause IVing the drugs are almost always more potent.
like i said one needs to see how much one can fit in there in the case of this potent substances when they are almost unsoluble.

Originally Posted by chopstix

Clonazepam IS NOT water soluble, <1mg/ml solubility in water (http://www.drugbank.ca/drugs/DB01068).

[chopstix]

Post count has jack shit to do with chemistry knowledge, ESPECIALLY here.

No offense, but I don't believe that you modified the molecule through some complex means to make it water soluble. If you wanna post the recipe, I'm sure a few of us would be happy to read it though..

It's like saying you can make meat loaf out of spaghetti-ohs if you reflux the vowels in hexane at a steady 200 degrees celsius for two hours. As long as you when you re-crystallize a sample in methanol for testing purposes, the crystals don't form an unmistakable BULLSHIT, you should be good for dinner..



























Man, I miss Mayo..

[DCBA]

Originally Posted by chopstix

No offense, but I don't believe that you modified the molecule through some complex means to make it water soluble. If you wanna post the recipe, I'm sure a few of us would be happy to read it though..

I think you are correct!
Its just that you haven't looked at the solubility right!
But hey look at the solubility you said it gots, <1mg per 1mg! Normal pills are sold in 0.25 to 2mgs, so <1mg is still an efective dose of clonazepam.
So it dissolves enought clonazepam in water to feel it IVed.

[RifRaf]

If you wanna post the recipe, I'm sure a few of us would be happy to read it though..

For the sake of example I will be using 4mg Klonopin's. Take 4mg's of Klonopin and place them in 3ml's of very cold water along with 1ml ethanol (all ethanol is denatured with something else, so using Everclear is fine) let this set over night and when you wake up it should have seperated into 3 or 4 different layers. Strain the clear liquid at the top of the vial/canister/mason jar, along with the milky coloring (whatever color the pill was, green, blue, etc.) into a sink making sure not to let the white solution (which will be sitting at the bottom) poor out, and it probably won't because it will be fairly thick still. The white will be milky so using another container, this time smaller, put roughly ~.2ml ethanol and 1ml cold water and shake, then once again let sit, but this time only for an hour or two until the solution looks like it did before. Straining this is the hard part because the white solution will not be milky anymore but you want to try and get as much ethanol out as you can (the water dilutes it so it doesn't burn even if there is some left over), you will probably waste a little bit of the Clonazepam but that comes with the territory. Whatever is left, which should be a pale white liquid and not milky can be filtered through a wheel-filter and then placed into your rigs (4mg's usually takes up almost two full 1cc rigs).

Waste of time? Yea, probably for most, although it is a good high in my opinion. Waste of drugs? Yes, you will, without a doubt, lose some in the process. This is how I was taught and it has worked for me, plus you asked. I usually do it in larger doses (~ 10mg's) instead of having to do this process repeatedly but this takes a lot more water, vials and ethanol as you can imagine.

P.S. Disclaimer: injecting alcohol is dumb, injecting pills is dumb, don't do this as I said before.

[squareone]

I don't see euphoria any where on that list.

[chopstix]

Originally Posted by DCBA

I think you are correct!
Its just that you haven't looked at the solubility right!
But hey look at the solubility you said it gots, <1mg per 1mg! Normal pills are sold in 0.25 to 2mgs, so <1mg is still an efective dose of clonazepam.
So it dissolves enought clonazepam in water to feel it IVed.

I looked at the solubility just fine and checked multiple sources, <1mg per ML of water (not mg) - less than 1 mg per rigfull of fucking water, for a benzo shot that probably comes on about like.... Nothing. If you find that ratio acceptable/worth it, then go hard bro. I'd just assume chew my pills and save my veins for something worth it.

Originally Posted by RifRaf

For the sake of example I will be using 4mg Klonopin's. Take 4mg's of Klonopin and place them in 3ml's of very cold water along with 1ml ethanol (all ethanol is denatured with something else, so using Everclear is fine) let this set over night and when you wake up it should have seperated into 3 or 4 different layers. Strain the clear liquid at the top of the vial/canister/mason jar, along with the milky coloring (whatever color the pill was, green, blue, etc.) into a sink making sure not to let the white solution (which will be sitting at the bottom) poor out, and it probably won't because it will be fairly thick still. The white will be milky so using another container, this time smaller, put roughly ~.2ml ethanol and 1ml cold water and shake, then once again let sit, but this time only for an hour or two until the solution looks like it did before. Straining this is the hard part because the white solution will not be milky anymore but you want to try and get as much ethanol out as you can (the water dilutes it so it doesn't burn even if there is some left over), you will probably waste a little bit of the Clonazepam but that comes with the territory. Whatever is left, which should be a pale white liquid and not milky can be filtered through a wheel-filter and then placed into your rigs (4mg's usually takes up almost two full 1cc rigs).

Waste of time? Yea, probably for most, although it is a good high in my opinion. Waste of drugs? Yes, you will, without a doubt, lose some in the process. This is how I was taught and it has worked for me, plus you asked. I usually do it in larger doses (~ 10mg's) instead of having to do this process repeatedly but this takes a lot more water, vials and ethanol as you can imagine.

P.S. Disclaimer: injecting alcohol is dumb, injecting pills is dumb, don't do this as I said before.

So what you're doing is dissolving pills in water, then removing the active compound (and whatever else is soluble in ethanol) out of the water solution, the re-vaping back into water, where the kpin will fall out of solution, because..... it's not (technically it's *very* slightly soluble in water) soluble in water.

Using alcohol as an intermediary isn't gonna change the properties of the molecule (and fwiw, all ethanol is not denatured). Yeah, it's more soluble in alcohol than it is in water, but the statement that needed correction was "soluble in water," which it's really not.

Not trying to start shit with you, trying to keep the FACTS separate from the BS. Hopefully you can appreciate the difference..

Just chew the damn pills and save the needle fixation for shit that's worth putting in a rig.

[God_Albino]

Temazzi's are the ultimate unfightable sleep coma drug, 20x more than ambien (though small amounts work great w opiates), DCBA you are ass-backwards man, but diff'rnt strokes, diffrent metabolism.

Xanax is undeniably the most euphoric for me, but used even on a semi-regular basis, those effects go away very fast.

Kpins were my fav long-standing for quite awhile, because the relief from constant anxiety produces euphoria, plus they last a long time, go with anything, etc.

Lorazepam is a tricky fucker; it's got a darker vibe, and if i feel euphoria it's deeep in my insides, def more depressing long-term.

Halcion put me to sleep half the time, and the other half it was pretty lightt and euphoric, for a benzo.

Valium just blows, doesn't make me sleepy, euphoric, quell panic; just creates a schizo chatter in my brain and then i talk in my sleep like the russians drugged me for info

Versed was nice, but it was with fent and iv'd... wish i could go to bed everynight with that rush

[chopstix]

Temazepam was what got me addicted to benzos. One week, 30mg and half a bottle of wine was enough to put me out, the next week, I was taking handfulls (100mg+), going into Wd in the AM, and going downhill quick. My $400 "specialist" ignored my research, spent half the appt on his cell phone, and sent me home with an armload of temazepam. Asshole, last time I went there.

Xanaz is most "fun" for me, makes me happy, I like Ativan and usually have it around, and it seems to work pretty well for tapering down from other GABA receptor abuse, Valium and Kpin are great potentiators, but to me: there's little recreational value with benzos, and addiction is a major bitch. I like them cos they help me nod and sleep, and I rarely nod on dope.. Aside from that, meh, and certainly a waste trying to shoot them imo..

[Synack]

Originally Posted by chopstix

Man, I miss Mayo..

Mayo & Robo... I miss 'em both.

[AnitaFix]

what about stuff like liquid Valium for injection?

just wondering how it remains susp. in liquid; see, my friend had a lil. dipsensor
kept it in the fridge & injected the solution a few times..

not very recreational IHO, too large of a dose & he was out cold
IV benzos all you feel is your bp drop & start going faint vision
swarmed with creepy-crawly spiders out the periphery until
they cover entire rabge & thats the last thing you see..

i recall a funny thing how i was very sleepy & tired
wanting desperatley to get high(vowed no opiates that nite)
so i decided to do these strong ass benzos this girl gave me
(1st ever benzo experience):

" ok im gona wait for these bastards to kick in before i even consider passing out"