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Old 11-26-2009, 04:23 PM   #1
Tylercwxzy
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Question Buprenorphines effects at higher and lower doses

I always thought, as I'm sure others do that the higher dose of bupe causes more antagonist effect than the lower doses do. But I was looking around on the web after plugging an entire sub instead of my usual half (So 4mgs instead of 2 due to bio.) and getting a warm glow and found this:
Abstract
Buprenorphine is a mixed opioid agonist/antagonist analgesic. This study was designed to determine the role of opioid receptor subtypes, especially κ3, in buprenorphine-induced analgesia in mice. Buprenorphine, when injected systemically, revealed a potent analgesic effect by tailflick assay, with a biphasic dose–response curve, which was reversed by naloxone. The presence of analgesic cross-tolerance between buprenorphine and naloxone benzoylhydrazone (NalBzoH) and morphine indicated a role for κ3 and μ receptor subtype in buprenorphine analgesia. Additional studies with selective opioid antagonists indicated κ1 mechanisms of action. We did not detect any involvement of the δ receptor subtype. Low doses of buprenorphine antagonized morphine analgesia, while high doses of buprenorphine coadministered with morphine elicited increasing analgesia in a dose-dependent manner. These findings suggest that buprenorphine elicits analgesia through an interaction with κ3 receptors and to a lesser extent with κ1 as well as its activity as partial μ receptor agonist.

So are they saying the higher doses actually increased the morphines ability at killing pain, not really saying it increased euphoria but from the sounds of it, you would think the bupe would take over and just kick all them morphine out of your system. But co-administering both? Strange news to me. I was wondering if anyone else has more information about buprenorphines affects at high doses and if its more of an antagonist or agonist compared to low doses such as between 0.3mg-2mg ?

OH! by the way, happy thanksgiving everyone.
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Last edited by Tylercwxzy; 11-26-2009 at 04:32 PM.. Reason: Thanksgiving!
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