Do you get any Oxymorphone when you IV Oxycodone?

[NY Hippie]

I read somewhere here that when you take oxycodone, your body converts some of that (I think it was 5%) into oxymorphone. However, I was wondering if this still happens when you IV the drug, and if not, are there any other routes of administration other then oral that would still give you the oxymorphone?

The reason I ask, is because I went through my Opana script a little too fast, and now I'm going to have to make due with oxycodone. But right now my body is longing for that oxymorphone and I don't want to miss out on that conversion by IVing the oxycodone if that's the case.

[jersey_emt]

Approximately 10% of oxycodone is metabolized into oxymorphone. This happens in the liver and happens with all routes of administration.

This 10% number can vary greatly from person to person however; 10% is the average.

[NY Hippie]

Thanks so much Jersey_emt. And thanks for helping keep lives safe if you are indeed an emergency medical technician.

[NY Hippie]

Hmm, I can't seem to edit my post. Just a clarification, I wasn't suggesting that you were posing as an emergency medical technician or anything like that, I just wasn't sure if maybe the "emt" in your name stod for something else.

[pharmacoKinetic]

Yes, you will get metabolites of the parent drug, Oxycodone, via IV push bolus, oral, rectal, other routes.

Although, specifying the amount of oxymorphone an individual will end up with gets a bit sticky.

Since IV will dump the dosage directly into the blood stream, the drug will travel through the central compartment (blood stream) and then into peripheral compartment (tissues); along the way it will hit the targets.

As mentioned, liver is the primary organ for metabolism, therefore, IV push avoids first pass metabolism initially, thereby enabling the drug to hit the target (opiate receptors) more rapidly than any other route of administration.

When the drug has moved through circulation, the remainer will eventually make its way back to liver and get cut up (the organs have the ultimate agenda to excrete the foreign substance it encounters), how much makes it back to liver after an alternate route aside from oral, is often time dose dependent for numerous drugs.

Oral administration clearly has a longer onset and more barriers to overcome prior to drug interaction with the target.

For example, one eats an Oxycontin 40mg, it swallowed, enters the stomach where liberation and dissolution begins, contents of the stomach are released into the small intestine where absorption will occur to a high degree. The wall of the gut is highly vascularized (lots of blood vessels), the drug traverses the gut wall, enters the portal vein, in turn enters liver.

Some Oxycontin is lost in the gut, it will be excreted via kidney.

CYP450 is a large family of metabolizing enzymes that primarily exist to a large extent in the liver. However, some CYP450 are in the gut wall and the kidney, thus, metabolism cut up the drug during its travels.

As far as the exact percent of the oxymorphone metabolite, indeed it will vary between individuals; the numbers are aggregated from clinical trials data.

Each individual has a certain amount of CYP450 expression, along with the sub-families 34A, 2D6, 2C19, 1A2, etc. Thus, there are genetic factors that cause this variation.

SNPs (snips) Single Nucleotide Polymorphisms exist (without jumping too much deeper into molecular genetics) and it is these variations in SNPs that give rise to differing rates of metabolism among individuals.

There are extensive metabolizers (EM) that cut drugs up so fast, that by the time drug enters circulation, they are at a sub-therapeutic level; hence one is faced with therapeutic failure.

There are poor metabolizers (PM) that barley cut up any of the drug, thus, a large amount of drug is released to circulation, more than anticipated, leading to more severe side-effects and possible toxicity.

Furthermore, many "metabolizer" classes have been defined; but I hope you have picked up the idea.

This holds true for most classes of medications, along with the opiate family.

[Thanat0s]

i dont think
using oxy codone as a prodrug
for oxymorph
is very realistic


hey OP!
psht!
you got opana...


whatta you worry for?



merri holidai NY HIPPIE!

[NY Hippie]

Originally Posted by Thanat0s

i dont think
using oxy codone as a prodrug
for oxymorph
is very realistic


hey OP!
psht!
you got opana...


whatta you worry for?



merri holidai NY HIPPIE!

No, I don't have Opana right now, that's the problem. I've been really depressed since losing my girlfriend of two and a half years, and I was stupid and only thinking about the present and not the future, and I went through my Opana script too fast. Now I have two weeks to go without any Opana.

[hero 1]

Originally Posted by Thanat0s

you got opana...


whatta you worry for?



merri holidai NY HIPPIE!

oppana sucks 10 mg pills for 8 bucks a peice at the pharm got em from the doc a couple time would rather have a 90 cent k4 dilly

[Import]

Off topic, but the longer you cover up the break-up with with drugs, the longer you're gonna be dealing with it (probably). If I was you, I'd go back to yer normal drug usage and move on by dating or maybe therapy.
On topic, call the po-po and tell em someone swiped your backpack containing. Meds outta yer car. They'll come over jot some notes, and give you a case number. Call doctor, tell what hapend and provide case number. Pick up yer new script of opana.

[Morgulon]

Originally Posted by Import

Off topic, but the longer you cover up the break-up with with drugs, the longer you're gonna be dealing with it (probably). If I was you, I'd go back to yer normal drug usage and move on by dating or maybe therapy.
On topic, call the po-po and tell em someone swiped your backpack containing. Meds outta yer car. They'll come over jot some notes, and give you a case number. Call doctor, tell what hapend and provide case number. Pick up yer new script of opana.

This A more advanced version of what I do, which is basically to make up some story for my doctor. The last time I did it (I do it about once a year), I made up a story about slipping and all my dillies falling in the sink and melting. He smiled, laughed, and gave me another 90 dillie 4s

As for your question... well, I find that IV oxy feels almost exactly the same as oral, sans the added strength and wonderful rush, of course. Anecdotal experiences tells me IV converts it as well, although probably less. Real evidence, on the other hand, I have none of.

[Restharrow]

Originally Posted by Import

On topic, call the po-po and tell em someone swiped your backpack containing. Meds outta yer car. They'll come over jot some notes, and give you a case number. Call doctor, tell what hapend and provide case number. Pick up yer new script of opana.

IMO this could backfire and cause problems with the doctor. If I take my meds too fast, I would rather tough it out for 2 weeks than take a chance of screwing up my relationship with a doctor who is scripting me both Oxycodone and Opana.

Everyone has a different opinion on these type situations, but I am a chicken and always err on the side of NOT screwing up my doctor relationships.

Will

[Thanat0s]

i heard somewhere
that the oxymorph yer body makes
accumulates
in the lungs
and a chest xray
is the bestr way
to find
that pesky oxymnorphone...

well swim herd it from a frriend...
who isnt me...

btw.

[jersey_emt]

Originally Posted by Thanat0s

i heard somewhere
that the oxymorph yer body makes
accumulates
in the lungs
and a chest xray
is the bestr way
to find
that pesky oxymnorphone...

well swim herd it from a frriend...
who isnt me...

btw.

Don't believe junkie rumors.