Potentiators...

[SafeHaven]

I read somewhere that grapefruit juice potentiates certain opiates. anyone know the reason for this? also, does it matter whether its ruby grapefruit or white grapefruit? any feedback would be appreciated...

[Paregoric Kid]

it inhibits the intestinal cytochrome P-450 3A4 system (specifically CYP3A4-mediated drug metabolism) which is responsible for the first-pass metabolism of many drugs.
white grapefruit is more potent

[jacky]

lots of other things potentiate opiates. antideppressants are notorious. the obvious shit like alcohol and benzo,s ( seems like most OD,s are associated with these, I know mine was.) cats claw herb, and a host of other herbs most likely......memantine, TAGAMET. I think the word potentiate sometimes should really be lengthen, some compounds keep the opiates in your body longer....which can be a good tool for the user.

[Paregoric Kid]

memantine is a partial NMDA antagonist which could lower your tolerance but I think dextromethorphan might work better. Memantine is not available in the US at this time. It is in stage 3 trials for Alzheimer’s disease. US approval may come within the next 2 years. Memantine is now approved in the European Union for the treatment of Alzheimer’s. It has been marketed in Germany since 1978 for the treatment of dementia and other cognitive disorders. It comes in 10mg tablets. One or two tablets/day are sufficient to prevent opiate/amphetamine tolerance, overactivity of the NMDA receptor and consequent free radical stress inside the neuron. The most expensive option though.
benzos add to it but I get really bad memory loss if I use to big a dose. when I first started using opiates/opioids I was on prozac, then effexor, I got more fucked up than I ever did back then but I think it is a case of tolerance than antidepressants potentiating. there was a period after prozac and before effexor and it still worked great for me, so I don't think it made all that much of a difference, but definitly some. alcohol is never good to me, when I drink more than a few beers or a few shots I end up getting really sick, last time I drank a lot with opiates I threw up blood the next morning.
immodium can potentiate but you could get really constipated as a result.
diphenhydramine and other antihistamines are great for potentiating in my expierience
tagamet works too, just like grapefruit juice it inhibits CYP2D6

[doctor diesel]

Does anyone know if ranitidine works as a potentiator, and also lansoprazole? Tagamet tabs used to be widely available here in the UK, but they've vanished over the past couple of years - can't think why. I take daily lansoprazole (zoton) for G.E.R.D. (reflux) and I can get ranitidine over the counter.

Thanks,

Diesel

[replicant76]

do these potentiators work with all opiates or just heroin?

[jacky]

I think you need to consider each opiate on its own, some opioids have quite different chemical structures, some drugs work to potentiate by stopping enyme destruction of opiates, some potentiate the ability of binding inhibition perhaps, or complement opiates by creating added somniferic effects. I have read that Uncaria (cats claw) stops the destruction of methadone and thus potentiates that drug, but perhaps this might work with other opiates, in my experience I THINK that it does. perhaps cats claw also stops the enzyme destruction of endogenous opiates as well, which may have an added effect for helping with rheumatic pain? doing interent searches/consulting a doctor, reading books is a good idea when considering trying to augment the effects of opiates in these ways.

[Endorph]

cat's claw eh? hmm, haven't heard of that one.. is it an herb? think i should give it a whirl jacky?

[jacky]

consult your local DR......I take mine in the standardized 4% extract, as the raw herb contains more like.3% alkaloids....this cats claw herb and kratom actually have some familiar chemistry, it would be interesting if cats claw would also effect kratom as well? I dont endorse anyone do anything on a whim, herbs can have serious side effects, cats claw may affect a person on opioids in a NEGATIVE way as well, that is why in the literature there are warnings about consuming cats claw with methadone or buprenorphine.

[replicant76]

Originally Posted by jacky

cats claw would also effect kratom as well? I dont endorse anyone do anything on a whim, herbs can have serious side effects, cats claw may affect a person on opioids in a NEGATIVE way as well, that is why in the literature there are warnings about consuming cats claw with methadone or buprenorphine.

jacky , do u know something we dont about cat's claw and kratom? if so, please share.

[Perspect]

Is it really worth it messing around with the pH-balance in the stomach by supplying baking soda and such? I can only imagine it would induce major nausea. Otherwise, how much should one take, a tablespoon or so in half a glass of water I've heard been recommended?

[COLONELWAYNE]

The grapefruit juice thing worked fantastic for me !!! At first I thought "bullshit" but then again, what did I have to lose? a $1.59 for a pint of juice I could just pour out if I didn't like? Anyway I had "nasally induced" an oc 40 an hour or so earlier and thought the ride was all but over and was kinda thirsty.Went into a quickstop,happened to see a pint of "DOLE" ruby red grapefruit juice and remembered reading here about the effects of this stuff with opiates.Gulped down 16 ozs.as fast as I could and 10-15 minutes later if that long I had another rush going that was stronger than the original!!!and it lasted 30 maybe 45 minutes before I noticed it tapering off! So go figure! Maybe just a freak one time thing for it to be that intense but I'll definitely gamble on the splurge again! Made a believer out of me! Kratom is what I can't get to produce results.Any suggestions anyone? How much should it usually take for a 180lb man? And does anyone know if there has been any extensive research done as far as long term effects on the "liver"? with this stuff.I know the last I tried in brew form and it wasn't a very large amount made me feel kind of sickly the next day and gave me a headache which is something I never have!I noticed I kind of felt tender and swelled in the general area around my liver.Maybe it's just a coincedence or maybe I was kind of paranoid because I remembered reading this article years ago about some kid who brewed the wrong kind of mushrooms in his tea and died a few months later waiting on a"liver transplant" as a result.Don't want a rush to the cemetary, I just want a rush!

[replicant76]

Originally Posted by COLONELWAYNE

The grapefruit juice thing worked fantastic for me !!! At first I thought "bullshit" but then again, what did I have to lose? a $1.59 for a pint of juice I could just pour out if I didn't like? Anyway I had "nasally induced" an oc 40 an hour or so earlier and thought the ride was all but over and was kinda thirsty.Went into a quickstop,happened to see a pint of "DOLE" ruby red grapefruit juice and remembered reading here about the effects of this stuff with opiates.Gulped down 16 ozs.as fast as I could and 10-15 minutes later if that long I had another rush going that was stronger than the original!!!and it lasted 30 maybe 45 minutes before I noticed it tapering off! So go figure! Maybe just a freak one time thing for it to be that intense but I'll definitely gamble on the splurge again! Made a believer out of me! Kratom is what I can't get to produce results.Any suggestions anyone? How much should it usually take for a 180lb man? And does anyone know if there has been any extensive research done as far as long term effects on the "liver"? with this stuff.I know the last I tried in brew form and it wasn't a very large amount made me feel kind of sickly the next day and gave me a headache which is something I never have!I noticed I kind of felt tender and swelled in the general area around my liver.Maybe it's just a coincedence or maybe I was kind of paranoid because I remembered reading this article years ago about some kid who brewed the wrong kind of mushrooms in his tea and died a few months later waiting on a"liver transplant" as a result.Don't want a rush to the cemetary, I just want a rush!

well i weigh about 230 and i use 6-8 grams regular leaf everyday with the erowid recipe. but i will give u my exact recipe:
6-8 grams regular strength powdered kratom in a mason jar
fill it just above the kratom with 110 proof vodka
nuke for 15 secs. by then the alcohol kinda soaked into the kratom
fill with the vodka again just above (just enough to wet it) the kratom
nuke for 10 secs, strain it into a coffee cup using a tea strainer
put the kratom back into the mason jar add 1 tsp chamomile and 1.5 tsp kava
put 80-90 ml of water in the jar
nuke for 45 secs then let it sit in the micro for about 5 mins to steep (may not be necessary)
nuke for 10 more secs
strain into same coffee cup as the alcohol extraction (keep the kratom, can be water extracted 1 more time later)
pour about 12 oz grapefruit juice in a glass, add the kratom extraction
drink up (iff u added enough juice u should just barely taste the kratom)
about 20 mins l8tr u will have a good nod going

[replicant76]

Originally Posted by jacky

I think you need to consider each opiate on its own, some opioids have quite different chemical structures, some drugs work to potentiate by stopping enyme destruction of opiates, some potentiate the ability of binding inhibition perhaps, or complement opiates by creating added somniferic effects. I have read that Uncaria (cats claw) stops the destruction of methadone and thus potentiates that drug, but perhaps this might work with other opiates, in my experience I THINK that it does. perhaps cats claw also stops the enzyme destruction of endogenous opiates as well, which may have an added effect for helping with rheumatic pain? doing interent searches/consulting a doctor, reading books is a good idea when considering trying to augment the effects of opiates in these ways.

does anyone have any idea what cats claw has to do with kratom?

[COLONELWAYNE]

Much obliged rep 76,next time I run out of the other,I'll definitely give your formula a try! Thanks again and I'll let you know how it worked for me. Later C.W.