I know theres a sticky, but I think some of you need to be more educated on Bupe:

[Tylercwxzy]

Also would like to add other peoples experiences on bupe to this thread to compile information about how everyone reacts on it and how well it works for them day to day.
Buprenorphine is a semi-synthetic opioid in the oripavine/thebaine family of opiates (They tend to be more stimulating than the opiates more similar to morphine (Hydromorphone, Codeine, heroin, etc.) in low doses >4mg a day bupe does act very similar to a full agonist, thats why its prescribed for pain in such low doses. Such as the 35ug/hr patch, up to 75ug actually and the .3, .4mg Temgesic tablets/Buprenex. Partial agonist at the mu opiate receptor, antagonist at the k, and partial to full like its metabolite at the delta receptor. For opiate mait. it comes in two different types Suboxone (Bupe and naloxone) and subutex which they have a generic for(just bupe). Remember though it is 25x stronger than morphine so it can be useful for pain especially when combined with cannabis or otc pain relievers.



This gets a bit complicated, but I’ll do my best. A couple background issues; buprenorphine has a ‘ceiling’ to its effect, meaning that beyond a certain dose, increases in dose do not cause greater opioid effect. That is the mechanism for how buprenorphine blocks cravings.
If the blood level of buprenorphine is ABOVE that ceiling, the opioid receptors are maximally, 100% stimulated. If the person takes more buprenorphine, and the blood level increases, the opioid receptors don’t feel the increase, as they cannot be stimulated more than 100%. But more importantly: when the person takes less, and the blood level of buprenorphine goes DOWN, the receptors also sense nothing– as long as the level stays above the ‘ceiling’ level.Below that ceiling level, the opioid effect from buprenorphine varies directly with dose—just as with oxycodone, hydrocodone, heroin, etc. Medications that have effects that increase with dose are called ‘agonists’. Buprenorphine is a ‘partial agonist;’ it acts like an agonist up to point, the ceiling effect, beyond which increases in blood level have no greater effect.


The ceiling effect is normally reached around 32mg give or take, even at 8mg the agonist effects seem to just flat out and start's to block itself. If you take subs to stay clean and deal with daily pain, I recommend staying in the 2-5mg range for optimal pain relief and to stay well. I notice that bupe doesn't help as much with the pain in higher doses, mostly lower ones.


Metabolites, main one is norbuprenorphine but there's a few other minor ones. It is thought that norbup plays a decent role in the effects you get from taking sub. norbups pharmacology is a μ-opioid, δ-opioid, and nociceptin receptor full agonist, as well as a κ-opioid receptor partial agonist. The half life of this drug is anywhere from 20-60/65 hours max. Most people metabolize it within 24-35 hours, I myself have to dose more than once a day and by the next morning when I need to dose the early w/d signs kick in.



I know alot of people bitch about buprenorphine, that it wont hold them over and is just a nasty drug that will ruin your opiate receptors and liver but just presenting the facts is all I can do. Buprenorphine can be a wonderful drug, especially since the availability compared to methadone. Out of 1-10, bupe's agonist effects are a 6.9 or almost 70% agonist activity which is higher than pentazocine and people tend to like that more. Even with the 70% only being activated for alot of us, that little extra kick you get from it is just enough to get you by day to day. Shit I wish could get scripted methadone instead, if I had the option of choice which opiate I would want to be on for Mait. theres no way in hell i'd stay on bupe. I would probably switch to oral oxycodone/morphine(time release of course) or even hydrocodone. I wouldn't mind maintaining on hydro as long as its pure and maybe a 6 hour time release. Hell methadone would be on my list to since I went to the clinic for 2 years basically and it always held me over for 24hours.

I'd take any full agonist over bupe just has to be medium to high potency. For now the best option and easiest choice for me is sub. I could go back on the methadone if I wanted to, which is tempting but dealing with the whole clinic thing and going in everyday isn't convenient for me. When I get my regular license in the next week or 2 and can drive my truck I might consider going back since I could drive myself, the subs are pretty damn easy to get though and I get basically 2 months worth per visit it's just not quite the same as a full agonist though no matter what you do. There feels like somethings missing after you take it. Like you start to feel those familiar opiate effects for 10mins when you dose then it just disappears as suddenly as it came and your body isn't fully satisfied.
(sorry for going off topic, back to bupe info):
My dose range is anywhere from 1.5-6mg depending on the kinda day i'm having. As I mentioned above I have to redose atleast once during the day or I start to w/d after around 25hour mark. I have a fast metabolism though so its different for everyone.

List of Interactions:

Benzodiazapines
Opiates
Anti-histamines
Stimulants
Marijuana(couldn't call it a psychedelic)
NMDA antagonist/anaesthetics
Possibly SSRIs and anti-psychotics
Feel free to shout out more interactions if you find them, i'll keep adding to it.

Also would like to add other peoples experiences on bupe to this thread to compile information about how everyone reacts on it and how well it works for them day to day.

[zoomer]

Understand completely...nice read

[Tylercwxzy]

I tried to make a more simplified version of the web articles and the sticky, thanks man.

[No Looking Back]

I love my bupe. After playing around on it for 3.5 years I've finally figured out exactly what works for me. I've jumped off it to my DOC and then back on to bupe several times. I've mastered the transition. What works best for me is 1mg snorted around 9:30am at work and then another 1mg snorted around 7pm at home. At these low doses it actually does give me a decent buzz. Nothing near a full agonist, but I can definitely feel it. And since it keeps me on the straight and narrow with no side effects I feel no reason to stop using.

[Tylercwxzy]

No I know what you mean, in the 1-3mg range theres something there for sure. Sometimes if I add gabapentin and dxm its almost indistinguishable from a full agonist, just the other day I was nodding out from 3mg taken over the course of 12 hours (half in the morning half in the evening) and got a nice opiate stone.

[kdog]

I take about 4-8 mgs/day tex right now, depending on how I feel. I say that because sometimes that extra 4 mgs later in the day gives me a little boost, if you will. But to add to your thread, I usually dose my sub about 20 mins after ingesting any kind of benzo. I'm pretty tolerant to clonazepam at the moment, I do only take about 1mg/day average, but maybe once a week or two I will take about 5mgs clonazepam then my bupe dose and it's just pure bliss for me. Also, I highly take to other benzo's, such as temazepam or xanax, meaning I can take maybe 60mgs of temazepam or a few mgs of xanax and I get that benzo high even though I'm somewhat tolerant to clonazepam, and then the tex top off REALLY sets me off.

Don't get me wrong, I am gradually trying to get my benzo use down to a recreational type usage, I know the dangers of tolerance.

[Matt]

Buprenorphine has become my second-in-line, next to BTH. But it is out of necessity and not recreational use, it is to lower me gently back to the ground when I decide to quit using. I had the Suboxone working a little too well for me during the early months of this year, so I would always go on Sub for a week or two and then back to black for another week or so before returning to Sub with little to no pain, but the more you use bupe the less it works. In the last couple of years that I've been using Suboxone when not using heroin, I've been up and down the spectrum of buprenorphine efficacy. From only needing 2mg at induction to using 16mg. Sub can be a very tricky organism.

On this recent Sub detox, I did about 6mg over the course of four hours after beginning induction. I try my hardest to wait 24 hours before starting so that it can go as smooth as possible, but I always break at 18-20 hours. The last few Sub detoxes, days 1 and 2 were spent still pretty much in physical withdrawal but the mental anxiety was removed which made it tolerable, and the physical symptoms were alleviated a bit but not much. Still had to sweat it out and have my skin wanting to push itself off from goosebumping so hard. On day 2 of this and the last detox I did a shot of dope to help me sleep and stop sweating and was able to carry on with my Suboxone dose perfectly fine the next day. First four days are generally 2mg every 12 hours, and then 2mg every 24. I usually stop at day 6-7. Have yet to go beyond that point without running into heroin again.

[Tylercwxzy]

This is perfect guys, just what the thread needed. Personal first hand accounts