Most effective MAOI as a potentiator

[Doublewire]

I wasn't sure whether to put this here or in the potentiators section, but SWIM has been able to acquire some mescaline. The dose is somewhat small I think (125mg) and I'm considering how rare an opportunity this is and how I probably won't be able to do it again for quite a long time. Aldous Huxley claims to have taken four tenths of a gram, which makes my dose slightly less than a third of his. I know everyone's different, but I suspect 125mg will be fairly threshold.

I know monoamine oxidase inhibitors can potentiate many psychedelics including phenethylamines like mescaline. I'm wondering what you all think is the most effective OTC MAOI. Do people even purchase MAOIs for the purpose of potentiation? I figure they must...

[chopstix]

I didn't know that worked with Mescaline. I'd guess Syrian Rue (Peganum Harmala) would be fine, it's enough Harmine to trip on it alone..

Plz report back!! 125mg isn't much but who knows.. I have yet to *really* get off on mescaline, but I had a heavy body load once (I think morning benzos killed the visuals)..

What color is it?

[TheTalkingAsshole]

125mg of mescaline should be nearly impossible to notice, mentally

as for combining it with an MAOI to increase effects, just be ridiculously careful with dosing the MAOI
i cant give you a dose, but try getting some passiflora incarnata extract(Passion Flower)
although it is weaker than both caapi and syrian rue, its a lot more safer too

be safe and enjoy the trip(assuming you get more mesc)
(assuming it is mescaline)

[chopstix]

Bah, do your homework on rue, you should be fine..

I tried passionflower with DMT and it did fuck all..

I've heard a couple times 50-100mg can make for a happy-lollipop day =) - worth a shot..

[Woody Bear]

400 mg maybe enough mescaline to trip on, but when I tried amount of cactus alkaloids it wasn't. 600 mg is a good dose that first time users would be able to handle, for a really strong trip 800 mg - 1000 mg is better.

If you don't take enough mescaline to actually trip, then you'll get all the negative side-effects, but not get any of the good effects to make it worth doing. I'd expect that 125 mg mescaline would just give a minor bit of nausea and speediness, but that's about it.

That is if it's actually mescaline you were given. A lot of research drugs are sold as "mescaline" and plenty of them are fully active at a 125 mg dose. So if the person selling it to you told you that it was one dose, then take it as it is, but if it does make you trip, then you'll know that it's not mescaline, because mescaline takes at least more then twice as much to trip from.

If you do have a RC, then it's best to avoid mixing it with an MAOI.

[chopstix]

Erowid Mescaline Dosage Page: http://www.erowid.org/chemicals/mesc...ine_dose.shtml

Last time I took it, I ate just over 50g known good, dried skins (where the highest alkaloid concentration tends to be), I tripped but no visuals, felt a lot like a light acid trip..

Want moar..

[Doublewire]

I know Syrian Rue as sort of the most famous herbal MAOI--do they really sell that stuff in nutrition stores and is it really worth having an experience with it on its own? Most curious.

SWIM asked about the source, thinking it might be synthetic (is mescaline even feasible to synthesize?), and was told it was extracted from the peruvian torch cactus. I didn't consider that it might be an RC but the source seems reliable enough. Don't think I'll be able to resist attempting an MAOI mix, though, if what you're saying is true and the dose is too small for any true effects. Mescaline is just too rare.

On the dose calculator for psilocybin mushrooms on the shroomery, if you check the MAOI box it halves the suggested dose. I always sort of assumed it would double the potency for that reason, though I realize it's just an estimate. It might potentiate differently with phenethylamines rather than tryptamines too.

as for combining it with an MAOI to increase effects, just be ridiculously careful with dosing the MAOI

Are MAOIs that dangerous/dose sensitive? This makes me a little more nervous about it...

[Agathos]

I know Syrian Rue as sort of the most famous herbal MAOI--do they really sell that stuff in nutrition stores and is it really worth having an experience with it on its own? Most curious.

I haven't seen Peganum Harmala being sold in nutritional shops. It's peddled commonly in Iranian markets as Aspand, but you can find it easily from online botanical supply stores.

Are MAOIs that dangerous/dose sensitive? This makes me a little more nervous about it...

There are some horror stories out there about bad combinations with improper dosage. Stick with reversible MAOI's and you shouldn't have many problems.



Harmala alkaloids (found in B. caapi, P. harmala, N. rustica, P. incarnata, and others) are what we call reversible MAO-A inhibiting agents (RIMA's) which means they temporarily inhibit your MAO-A enzymes from performing catabolic processes. The diet restrictions are generally those for irreversible MAO-A inhibitors, as those are permanent binders to the enzymes and thus much more dangerous in terms of diet control. Potential risks for MAOI/Tyramine interactions are hypertensive crisis, serotonin syndrome, and in some cases seizure, and fatalities.

MAO-A Inhibition - primarily effects serotonin, epinephrine, and norepinephrine
MAO-B Inhibition - primarily effects dopamine, and phenethylamine
Selective Inhibition - If one MAO site is effected primarily
Non-Selective Inhibition - If both MAO sites are effected equally

It should be noted however, that P. harmala contains Vasicinone, Vasicine and Deoxyvasicine which show no MAOI activity and are known uterotonic, oxytocic, and abortifacients. So far as we know, B. caapi does not contain these alkaloids and could be preferable by some compared to the former for this reason.

[Benz]

Erowid Mescaline Dosage Page: http://www.erowid.org/chemicals/mesc...ine_dose.shtml

Last time I took it, I ate just over 50g known good, dried skins (where the highest alkaloid concentration tends to be), I tripped but no visuals, felt a lot like a light acid trip..

Want moar..

I took mescaline once many years ago when I was thirteen. I remember having to consume quite a lot of plant material & the trip wasn't a patch on acid. I was expecting a lot due to all the hype & notoriety I suppose.

As others have said, it could be a RC. I'd be very wary of mixing MAOIs with anything. Be careful.

[chemboy7]

I'm actually kinda jealous (well, almost at 125mg anyways). Mescaline is one of the very few psychs I'll still mess with now-a-days; that or any of the DOX series. I gotta ask though, are you an addict? If yeah I'd be leery about using any MAOIs. To be safe stay away from Opiates for a couple days after you dose. Cut down on your cheese eating too (actually lots of dietary restrictions I can't remember now). That being said, I'd go with Rue. I know about 10 years ago buying pure Harmala alkaloids online was a breeze too, wouldn't know now (I stay away).

Good luck and have fun. I'd choose good Mescaline over LSD any day of the week.

edit - Seems they are still readily available. Figured they would be. Don't look for RC vendors, go with chemical supply houses. The only hang-up is a lot of them list things in their inventory that they actually don't have on hand... they just put it up because if they get an order big enough they will synth it for you. Don't know that that is the case, but it certainly was with Loperamide a few years back with the site I like.

[Doublewire]

SWIM wound up with 250mg because his friend left town and didn't take the 125 he paid for. SWIM still has the stuff around, and is waiting for the right time to take it. Will probably not use any MAOIs; SWIM tends to be sensitive to things anyway, and is hoping 250mg will produce a worthy experience.

SWIM is also fairly certain the stuff is legit.

And no, I am not an addict. I don't think so, anyway. By 'they', chem, do you mean mescaline? According to the vendor, the stuff SWIM has was extracted from the peruvian torch cactus, not synthesized.

[chemboy7]

SWIM wound up with 250mg because his friend left town and didn't take the 125 he paid for. SWIM still has the stuff around, and is waiting for the right time to take it. Will probably not use any MAOIs; SWIM tends to be sensitive to things anyway, and is hoping 250mg will produce a worthy experience.

SWIM is also fairly certain the stuff is legit.

And no, I am not an addict. I don't think so, anyway. By 'they', chem, do you mean mescaline? According to the vendor, the stuff SWIM has was extracted from the peruvian torch cactus, not synthesized.

I was speaking of the Harmala alkaloids, not Mescaline. I found two chemical supply houses that I have used in the past that still offer them. I would bet dollars to doughnuts that they have a minimum order they don't tell you about though. See my last post about Loperamide HCl. They have minimum orders on a lot of the more rare chems they offer and I'm fairly sure (not positive) it would be that way with these. They don't tell you that either. I ordered a couple grams of lope and waited a few weeks with no response or package before I asked for a refund. Why? Because not many people order such things... it's a custom synth they offer (even though they offer per gram pricing). I suspect over 5g would do them solid... that's speculation though.

At least 2-3 days between dosing on any MAOI before Opis though... OK? Look up dietary restrictions too, I'm not exactly fresh on the matter.

[Doublewire]

Good to know. Thanks.

[Chipper]

Perhaps avoid anything but tiny doses with Monoamineoxidase inhibitors and Phenethylamines.

Of course I've done it with amphet. and I don't recommend it, But, get the dose right and it makes for a potent tonic ... now that I think about it, it could even be lethal. OTC ? No idea.

I took Parnate, if I recall correctly. It's scheduled.