IV Oxymorphone tolerance solution - bupe

[Synack]

As some of you know I was shooting large 30+ (up to 65mg) of oxymorphone (opana IR) in the past. After a recent lope run, I couldn't feel any rush from that or large doses of dilaudid.

I tried a 10mg shot the other day, same issue - tolerance prevented any rush.

I have a little bit of bupe without nalaxone (subutex) given to me recently. I added a few tiny tiny crumbs to only 5mg oxymorphone powder expecting nothing.

Good news, I was so wrong.... 5mg oxym with a bit of bupe gave me what oxymorphone IV used to - a nice rush... I wasn't in withdrawal nor have I touched lope in 5 days either as I was taking 10-30mg oxymorphone intranasally for the past three days, and on the first day - I took a total of 6mg of bupe had some 40mg long PWD from lope then felt okay after I woke up (still benzo'd out) and still felt like shit for the night until the next morning.

just something awesome I thought I'd mention.. I guessed this would work with narcan but couldn't test it. I had tested this yesterday with intranasal oxym/bupe with no difference.

[ka11ink]

What made you give this a try?

[Billy the kid]

What the fuck? Was your logic the ULDN (ultra low dose naltrexone) theory?

[Synack]

What the fuck? Was your logic the ULDN (ultra low dose naltrexone) theory?

bupe affinity is only slightly higher than oxym (if I remember right) - so yeah, it was similar logic to ULDN

you guys all think I'm an idiot because this could have sent me into PWD but I think I'm a genius

edit: I was worried about PWD if I had aded too much - which i'm sure would have happened since I had some opana IR's for the past 3 days. - thankfully, it didn't...

I'm still buzzin'.

just a guess but the dose was probably around .005ug - .0005ug

[Billy the kid]

I don't think you're an idiot. I think you are a brave mofo.

[Thanat0s]

...i find that at low enough doses the bupe is actually the best potentiator there is,
simply because it cannot be displaced.

...as long as you do little enough bupe to have plenty of receptor available for other opiates those other opiates will slam the remaining receptors...

max receptor light up, max high...

good on ya, synack!

[normus420]

So my question is will bupe + nalaxone (suboxone) work the same way too? I dont want to try it because I dont want to waste my subs. I understand its just a couple crumbs but I need them for when I dont have anything. Im guessing it will going on what you guys have said and this should potentiate any opiate not just oxymorph rite?

[Thanat0s]

dunno if id recommend any try it unless tolerant and comfortable enough...
doesnt take much bupe or esp bupe/nalox to be too much.

if u dont have to do this, dont.

[doctor diesel]

I don't understand this. Could somebody try to explain to me in fairly simple terms what the interaction is between the bitsy bupe and A.N. Opie?
I hear what Than said above but I still don't really comprehend.
Pity the fool.


Doc

[Billy the kid]

I don't understand this. Could somebody try to explain to me in fairly simple terms what the interaction is between the bitsy bupe and A.N. Opie?
I hear what Than said above but I still don't really comprehend.
Pity the fool.


Doc

It is very similar to ULDN (Ultra low dose naltrexone). In ULDN therapy very low doses (microgram range) of naltrexone are used to potentiate opiates and reverse tolerance. When naltrexone is used at very minute doses the mu receptor (the one that makes you feel good) is not touched by the naltrexone but some of the other not so important receptors are. So what happens when you actually use a full agonist opiate is that more of that opiate is able to bind to the mu receptor since the naltrexone is filling the sites on the other receptors.

The same can happen with bupe and as Thanato0's said it is even more effective since bupe's binding affinity is so much higher than naltrexone thus making it even harder for the full agonist to displace the bupe at the "not so important" receptors so that the full agonist can go straight to the mu receptor and not have to bother with binding to the others since the bupe or naltrexone is filling that spot.

I hope that helps. I tried to keep it simple.

[limitless_euphoria]

...i find that at low enough doses the bupe is actually the best potentiator there is,
simply because it cannot be displaced.
...as long as you do little enough bupe to have plenty of receptor available for other opiates those other opiates will slam the remaining receptors...
max receptor light up, max high...
good on ya, synack!

Yeah, I mean shit, I had taken 1 mg of bupe around 7 am on a Sunday morning and around 7 pm I took 10 mg of oxycodone (that's right, two perk 5s) and I got a little buzz. I mean it was nothing like having not doing opies for weeks and months then doing it but... wow, what a difference only a little bupe makes. The problem I've found is once you go below 1 mg of powder, it's almost like you're better off railing it or shooting it because even sprinkling it directly under your tongue doesn't seem to do shit.

One of our nurse members here used to say she'd start off the mornings with 0.5 mg of bupe (she was on full agonist narcotics) and we all thought she was nuts but she swore up and down it potentiated her experience. If there's ONE THING drug addicts don't lie about it's weather they actually got high off of doing something. At least most of the ones I've met, I cannot speak for all of them.

I remember another time where I had taken half a sub at night (4 mg) back in like 2006. I forget why. But the next day I hurt myself (I was dealing with an exposed outlet) and I got ZAPPED! Mrs. LE made me go to the hospital and I'll never forget she goes "I'll give you something really strong... that's got to hurt!"

Her idea of something strong was 20 vike 5/500s. I almost laughed but thankfully didn't. I got home, took only like two or three of them and I was bombed! Now for me to get bombed on two or three vikes... you're talking years and years and years ago!

I think the theory of ultra low-dose bupe (UDLB) being similar to ULDN holds up under this analogy.

[doctor diesel]

Thanks Billy, I think I understood that.
So, what about UDLB possibly being the explanation for the subs/trams combo working so well? (Although I admit I first discovered this when I was on 6mg subs, which I guess you wouldn't call ultra-low dose).
Anybody?


Doc

[Billy the kid]

Thanks Billy, I think I understood that.
So, what about UDLB possibly being the explanation for the subs/trams combo working so well? (Although I admit I first discovered this when I was on 6mg subs, which I guess you wouldn't call ultra-low dose).
Anybody?


Doc

Personally I think the sub tram combo getting you high is a mixture of 3 things. First, the bupe probably has some type of ULDN MOA that contributes. Second, the non opioid effects of tramadol probably contribute as well (NE and seretonin). Thirdly, tramadol definitely seems to not have complete cross tolerance.

Interestingly enough when I was attending my pain clinic I had tried using doses of OC around 1100 mg (not taken as prescribed) while on the methadone but even that didn't get me buzzed. The amazing thing is that 4 or 5 tramadols would though. It was a mix of the stimulant and opiate effects which is why I think tramadol effects some receptor sites that are not commonly triggered by standard opioids. Maybe some mu subtype receptors?

[doctor diesel]

What's the relevance of tramadol seeming to not have complete cross tolerance?


Doc

[Synack]

did it again with about 6.5mg and the same (if not a bit more) bupe. At first, it burned - my skin, I started shaking, got sick to my stomach thinking 'oh SHIT' this lasted for about 5 seconds post shot - I immediately began to pray to the God of PWD begining him for forgivinesss, then all of a sudden it stops and I'm covered with the warm blanket feeling we all love so much. - 'cept it feels like the blanket it too small and isn't covering my feet...normally with a full agonist shot I'd get warn hand and warm feed in 40 degree weather.

This is something I'd like for others to confirm or deny for me.

Since that was my very last bit of precious oxym until the FEDEX truck arrives with my semi-full refill. All I've got is 2mg of bupe without naloxone - and 8mg with naloxone on the way. I figured since I've IV'd my last 3 doses the half-life should be much shoulder, so if I benzo out tonight, I can began my induction tomorrow.

to much bupe?

[Synack]

So my question is will bupe + nalaxone (suboxone) work the same way too? I dont want to try it because I dont want to waste my subs. I understand its just a couple crumbs but I need them for when I dont have anything. Im guessing it will going on what you guys have said and this should potentiate any opiate not just oxymorph rite?

In theory, yes - I haven't tested it yet.

[Thanat0s]

to much bupe?

not necc too much for induction purposes,
but after a couple initial doses of over 2mg
you should be able to taper to 1/.5mg 1 or 2 xs a day no problem...

[Aces N 8s]

Since that was my very last bit of precious oxym until the FEDEX truck arrives with my semi-full refill. All I've got is 2mg of bupe without naloxone - and 8mg with naloxone on the way. I figured since I've IV'd my last 3 doses the half-life should be much shoulder, so if I benzo out tonight, I can began my induction tomorrow.

to much bupe?

To my knowledge, ROA does not affect half life. the reason that ROA will affect the length of the effects you experience has to do with peak plasma concentration and how that alows your body to process it. For instance if you eat your drug then your body doesnt even begin to metabolize the last bit of it until well after it has began the mtabolize the first part that was absorbed. but once it is in your system it will all be metabolized at the same rate.