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Thread: Zantac and oxycodone

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    Occasionally Opiated jackflash is an unknown quantity at this point
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    Default Zantac and oxycodone

    SWIM has used ranitidine (Zantac) as a potentiator that gave him a stronger and longer ride.
    I have found that Zantac is most effective against the CYP4502D6 enzyme that metabolizes oxycodone. This isn't true for all opiates,but works really well for oxy. I hope this helps someone.:cool:

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    Default Re: Zantac and oxycodone

    Cimetidine (sp?) works much better for me and my methadone. Interesting that ranitidine works so well for you though. Perhaps more experimentation with combining the two is in order for me.
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    Default Re: Zantac and oxycodone

    I have a script for Ranitidine but haven't experimented with it as a potentiator. Mainly because (as Import pointed out) I thought Cimetidine was the one needed.

    I will try out the Ranitidine and report back on the results.. I'm currently on MMT at 55mgs though so not sure if this is ideal for that sorta of thing.

    Import, do you take Cimetidine to boost methadose or do you take the pills? When do you take the Cimetidine? 45 mins - 1 hr prior to dosing done seems to be the ideal time to me but was curious how you did it.. What about the Ranitidine Jackflash? What's your suggestion on when to take it?
    Last edited by Opie I. T.; 08-04-2010 at 09:05 PM.
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    Default Re: Zantac and oxycodone

    Cimetidine is the one for methadone - my neurologists and doctors told me that ranitidine does little/nothing for the methadone pathway, which is also what i thought from reading the pathways. I don't know about oxy though.
    I take mine about 45mins before dosing, orally. In pill form. It just seems to make the dose last a llitte longer.
    Last edited by OpiateQueen; 08-04-2010 at 10:06 PM.
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    Default Re: Zantac and oxycodone

    Quote Originally Posted by Opie I. T. View Post
    I have a script for Ranitidine but haven't experimented with it as a potentiator. Mainly because (as Import pointed out) I thought Cimetidine was the one needed.

    I will try out the Ranitidine and report back on the results.. I'm currently on MMT at 55mgs though so not sure if this is ideal for that sorta of thing.

    Import, do you take Cimetidine to boost methadose or do you take the pills? When do you take the Cimetidine? 45 mins - 1 hr prior to dosing done seems to be the ideal time to me but was curious how you did it.. What about the Ranitidine Jackflash? What's your suggestion on when to take it?
    I use 400 mgs. ranitidine 45 to 60 minutes before the oxycodone and it has allowed me to cut back my doses in half and increases duration. Ranitidine is best used against the CYP4502D6 enzyme that metabolizes oxycodone. Cimetidine works better for various other opiates but doesn't block the metabolizing of oxycodone as well. I am only talking about oxycodone with ranitidine and not other opiates. Good luck.

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    Default Re: Zantac and oxycodone

    150mg Ten to fifteen mins before dosing increased the power of oxycodone by 10-15 % nice little extension on the buzz to.

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    Default Re: Zantac and oxycodone

    400 milli's of ranitidine??? Correct me if I'm wrong but don't those come in 10-20mg doses??? How many pills do you take at a time to pre-load???

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    Default Re: Zantac and oxycodone

    ^ pretty sure he means 400mg of OC

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    Default Re: Zantac and oxycodone

    ^ Highly doubt he is taking 400mg oxy... Zantac is avail. in 300-400mg as an RX only.


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    Default Re: Zantac and oxycodone

    Quote Originally Posted by Hydrophoria View Post
    400 milli's of ranitidine??? Correct me if I'm wrong but don't those come in 10-20mg doses??? How many pills do you take at a time to pre-load???

    You are wrong. Ranitidine is the generic of Zantac; which comes in both 75mg and 150mg OTC and in both 150mg and 300mg by prescription.

    You are thinking of Pepcid which comes in both 10mg and 20mg OTC and in both 20mg ans 40mg by prescription. The generic is Famotidine.


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    Default Re: Zantac and oxycodone

    Thanx for sharing this cool little trick with everyone.

  12. #12
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    Default Re: Zantac and oxycodone

    ^^+1

    took 150mg brand name, and felt like taking 10-15mg valium on top, very cool!
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