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Thread: Nucynta (Tapentadol)

  1. #1
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    Default Nucynta (Tapentadol)

    so has anyone got their hands on this stuff yet? I read an account from someone who has back pain who recently got it prescribed at 75mg every 4-6 hours. they said that it made their heart pound really hard and they felt "wired." I always wondered if tapentadols norepinephrine effects would make it sort of an opioid-stimulant combo (like lefetamine but no where as good). I would also like to know how the euphoric and pain killing effects of tapentadol compare to something like morphine, methadone, or oxycodone.
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    Default Re: Nucynta (Tapentadol)

    Sounds like some pretty wicked shit from what I read on wiki. Think I might just have to head back down to Broward county to see if I can get a "doctored" MRI and some New Nucynta.
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    Default Re: Nucynta (Tapentadol)

    by the way, levorphanol is another opioid which has SNRI properties too, I didn't know that till tonight, only knew about it also effecting NMDA.
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    Default Re: Nucynta (Tapentadol)

    From what you described it reminds me of the sensation I experienced when I got high on Ultram for the only two days I ever did the stuff. It definitely made my heart beat faster and had a stimulant effect and an odd opiate effect.
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    Default Re: Nucynta (Tapentadol)

    Tapentadol sounds like it might be not-very-potent but lacking a ceiling effect ... which means it's weak, but ya can get high as fuck on it. That's the impression I got from the scheduling decision, at least. It's interesting (the molecule) ... so damn simple for an opioid.
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    Default Re: Nucynta (Tapentadol)

    Tapentadol is on my itemized list bill from getting my wisdom teeth removal, the surgeon got really pissed at me when it took 3x the dose of fentanyl to put me out, and i remember waking up and complaining that the fent had worn off so he gave me an IM of Tapentadol, to which i responded "NO NOT TRAMADOL"....the Versed gets to me....i digress...

    antinociceptive

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    Default Re: Nucynta (Tapentadol)

    are you serious? that is bizarre because last night I was looking into the very issue of injectable tapentadol. I couldn't find any information about any IM or IV tapentadol products being approved or used in the US. all I could find is that the IR pills are out in the US as of June 23. right now Johnson and Johnson is studying extended release tapentadol and plans to submit a New Drug Application for it sometime this year. they have studied tapentadol injections but it never was submitted or approved. how did it work for you? did you receive the injection as part of a clinical study/trial? truly bizarre, let us know!
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    Default Re: Nucynta (Tapentadol)

    thats VERY bizarre, mind you i had just woken up from a Versed coma and asked for more pain relief and he had said "im giving you Tapentadol" and i heard "i bet you junkies love tramadol" and i said NO TRAM lol... no but im fairly certain it was Tapentadol, im searching for my itemized bill atm....maybe this surgeon has a clinical study going on in his office....which doesnt make sense seeing how he didnt ask (or care) about my pain for that matter...

    antinociceptive

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    Default Re: Nucynta (Tapentadol)

    Aren't they supposed to ask if you're willing to participate in a clinical study? You know,explain what's happening and seek permission.
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    Default Re: Nucynta (Tapentadol)

    They had local wisdom tooth took studies and would give you tapentadol, but by the time my tooth swelled up and needed to be removed - the study was closed.

    I'm thinking about trying some, but I'm already one really strong meds - I just can't find a dosing calculator...
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    Default Re: Nucynta (Tapentadol)

    I tryed the shit before and i dont get all the hype...i tryed 4 50 mgs and snorted one last week.If you guys get ur hands on it DO NOT SNORT IT.it hurts so bad and drip is nasty.But i honestly do not like it it makes you shake because of bunepenphrine it releases and you dont really nod that well at all and people compare to all kinds of drugs like ibuprofen,oxys,morphine and those are a wide range of drugs and there not like any of em if anything i think there like tramadol but maybe less potent if thats possible lol

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    Default Re: Nucynta (Tapentadol)

    what do you mean because of buprenorphine it releases? its a full mu agonist and isn't at all related to buprenorphine. it should feel somewhat like tramadol, because its an analog of it, but much more potent. its obviously got to be stronger than tramadol its CII whereas tramadol isn't even controlled. maybe it made you shakey because of its NRI properties.
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    Default Re: Nucynta (Tapentadol)

    dosent that mean it realeaes norepinephrin? which means it releases adreniline thats what i heard and thought.look it up on wikipedia i dint get norepinenephrin from nowhere
    and i no it works on the mu opioid receptor...idk how to type that lil u lol but i hate it and its not really that much stronger then tramadol nobody really nos why its scheduled 2. and my bad forr the typeing im on fent and its like 3 in morn here

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    Default Re: Nucynta (Tapentadol)

    Quote Originally Posted by KoDeInaaaae View Post
    dosent that mean it realeaes norepinephrin? which means it releases adreniline thats what i heard and thought.look it up on wikipedia i dint get norepinenephrin from nowhere
    and i no it works on the mu opioid receptor...idk how to type that lil u lol but i hate it and its not really that much stronger then tramadol nobody really nos why its scheduled 2. and my bad forr the typeing im on fent and its like 3 in morn here
    You can't combine the spelling of 2 words (Buprenorphine and Norepinephrine) into one and expect *Not* to confuse people.

    Bunepenphrine... Hmmm...

    I don't know about everybody else but I'm going to completely disregard your experience reports here as nonsense. Be careful with the Fent dude!

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    Default Re: Nucynta (Tapentadol)

    I really want to get the chance to try this.
    Its pretty exciting seeing as how its the first new opioid drug in a long time.

    I would imagine it would have some properties similar to tramadol (antideprassanct potential, stimulating) seeing how it's structure is similar; only It sounds like its ALOT stronger as a Mu agonist; which is good - because tramadol has VERY weak binding affinity which lowers its 'enjoyability potential'

    Anyhow - I really cant wait to try it

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    Default Re: Nucynta (Tapentadol)

    Quote Originally Posted by lespaulpower View Post
    I really want to get the chance to try this.
    Its pretty exciting seeing as how its the first new opioid drug in a long time.

    I would imagine it would have some properties similar to tramadol (antideprassanct potential, stimulating) seeing how it's structure is similar; only It sounds like its ALOT stronger as a Mu agonist; which is good - because tramadol has VERY weak binding affinity which lowers its 'enjoyability potential'

    Anyhow - I really cant wait to try it

    Me too. I actually enjoy tramadol if I have enough of it and my tolerance isn't too high. I'd take it over codeine or propoxyphene any day.

    With that being said, I hope I get to try Tapentadol some time.

    Is it Schedule II??? That sucks...

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    Default Re: Nucynta (Tapentadol)

    dont disregard it bro i was really really tired..i ment norepinephrin which has stimulint like properties right? maybe thats why it made me shake?

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    Default Re: Nucynta (Tapentadol)

    Quote Originally Posted by KoDeInaaaae View Post
    dont disregard it bro i was really really tired..i ment norepinephrin which has stimulint like properties right? maybe thats why it made me shake?
    Right... Norepinephrine is stronger then epinephrine. (OK, I made this up, don't know what the difference is)That shit will definately make you shake. It makes me fuckin manic sometimes...

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    Default Re: Nucynta (Tapentadol)

    so has anyone else tried this new opiod yet?

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    Default Re: Nucynta (Tapentadol)

    Quote Originally Posted by Papa Verine View Post
    Right... Norepinephrine is stronger then epinephrine. (OK, I made this up, don't know what the difference is)That shit will definately make you shake. It makes me fuckin manic sometimes...
    Epinephrine is another word for adrenaline, and this is a Hormone secreted by glands on our kidneys. Norepinephrine aka Noradrenaline is a neurotransmitter used by our neurons to communicate and also release a similar signal when compared to epinephrine. Chemically they are almost exactly the same and produce similar effects although when you get a burst of adrenaline it is more likely the hormone..... adrenaline.
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    Default Re: Nucynta (Tapentadol)

    i met a guy at where i work who was selling these little orange pills as 100mg ocs for ten each. i figured that was a lie, but looked up the pill imprint and it was 100mg nucynta. i was interested enough to buy it so i talked him down to 7.50 because most of the web sites about nucyntas analgesic potential is about 15 mg of oxycodone per 100mg of tapentadol and fifty cents a mg isn't too terrible for oc in my area.

    it was alright, not much of a buzz but i was in the middle of an opana binge. but if i was sick or desparate i'd definately consider buying it again. i didn't really notice it was paticularly stimulating, but i find all opiates sedating either way. oh well. good luck to everyone who tries this, maybe they will get more from it than i did

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    Default Re: Nucynta (Tapentadol)

    how many mg did you end up taking?
    doses required for euphoria from tapentadol are higher than the analgesic dose. so you really can't compare the equivalent analgesic dose of oxycodone to tapentadol if you are expecting to get high.
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    Default Re: Nucynta (Tapentadol)

    Quote Originally Posted by lib.sOCialist View Post
    Tapentadol is on my itemized list bill from getting my wisdom teeth removal, the surgeon got really pissed at me when it took 3x the dose of fentanyl to put me out, and i remember waking up and complaining that the fent had worn off so he gave me an IM of Tapentadol, to which i responded "NO NOT TRAMADOL"....the Versed gets to me....i digress...

    I know this is off topic and for that I apologize -- BUT, how the hell did you get fent for wisdom tooth extraction? Fuck, I didn't even get nitrous during the surgery and they did two root canals and my wisdom teeth in one sitting. And here's the best part: for post-surgery pain, I got 20 5/500 Lortabs after convincing the dumbass dentist that T3's are a joke. I hate that motherfucker.

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    Default Re: Nucynta (Tapentadol)

    paregoric kid- i took 300mgs. i remember reading you are only supposed to have 400mgs in a day but that maybe wrong. I think that's what is medically recomended and i don't know if it would be safe to take more. i know there is a difference between tapentadols analgesics effects(or affects? my grammar sucks) but it was the only way i could try to find some value for how much the pill was worth. but, the reason why i used it's pain relieving properties as my indicator for what the pill was worth is because i am usually looking for pain relief first and a high second

    I liked it, tramadol makes me deathly nauseated but i can't throw up at all. i'd almost rather be sick than have to deal with tramadol but tapentadol didn't have that affect at all. i dunno, it's a tragedy this wasn't a scheduled differently. it would have been a great option for those that need something stronger than hydrocodone but weaker than oxycodone. oh well, no one likes the dea anyway.

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    Default Re: Nucynta (Tapentadol)

    there a couple reasons why the level of analgesia produced is not equal to the euphoria. one reason is because part of its analgesic properties come from its action as a norepinephrine reuptake inhibitor.

    it appears 700mg is the max dose when used to treat pain. I have read that there isn't a ceiling effect with this drug. although you may come to a point where the norepinephrine effects make it unpleasant. I would love to try tapentadol with something like clonidine that would cancel out the norepinephrine effects.

    I wouldn't doubt that in a few years as more patients with chronic pain use this to treat pain every day for years that we will see people getting prescribed even larger doses, possibly even with low dose clonidine.
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    Default Re: Nucynta (Tapentadol)

    Tapentadol is interesting. I agree that the NRI component can cause unpleasant side-effects at higher doses and is probably the main factor as to why they set the dosing limit, despite it also being a full agonist.

    With respect to opioids, full agonists do not have a max daily dose; as it is patient specific.

    Dosing for full agonists do not have the ceiling effect that partial agonists exhibit.

    The main limiting factor for full agonist opioid therapy is dose dependent on the individual.

    Those who are opioid tolerant clearly have a need to take larger doses of drug compared to those without such tolerance for relief.

    Drugs (including the opiate family) inherently have side-effect profiles and this is key for opioid tolerant patients.

    For example, theoretically, one could use 1000mg of Oxycodone for chronic pain if they have a high tolerance; however, it is the side-effects that cause problems, such as respiratory depression, issues with clearance (hepatic and renal function), and volume distribution (edema is an example); but again, it is patient specific.

    Using population pharmacokinetic data, which correlates variability in drug concentrations among people that are the target population recieving clinically relevant doses for the drug of interest. This helps establish dosing regimen guidelines

    In short, for full agonists, there is no ceiling dosage; one is merely limited by side-effects in which they cannot tolerate (this differs in eveyone).

  27. #27
    Opiophorum Member Spaazkaz has a spectacular aura about Spaazkaz has a spectacular aura about Spaazkaz has a spectacular aura about Spaazkaz has a spectacular aura about Spaazkaz has a spectacular aura about Spaazkaz has a spectacular aura about Spaazkaz's Avatar
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    Default Re: Nucynta (Tapentadol)

    might tapentadol synergize well with buprenorphine like tramadol, or should it be avoided because it is a full agonist?

  28. #28
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    Default Re: Nucynta (Tapentadol)

    really? a 2 year old thread? recently members from long ago are coming back and bring back old threads.....why is that?

    EDIT: also, I doubt bupe and tapentadol would be worth combing. usually a waste to combine full ags w/ bupe

    maybe you should have started a new thread?
    I loved when Bush came out and said, 'We are losing the war against drugs." ....You know what that implies? There's a war being fought, and the people on drugs are winning it!!" ~Bill Hicks




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