Pregnenolone prevents development of tolerance?

[Morfiend]

Article abstract:

The effect of neurosteroids on the development of morphine tolerance and dependence was examined in mice. Development of tolerance to the antinociceptive effect of morphine sulfate (10 mg/kg, twice daily for 9 days) was measured in the tail-flick test and dependence was assessed from naloxone (2 mg/kg)-precipitated withdrawal jumps on day 10 of testing. Concomitant chronic administration of neurosteroids, allopregnanolone (0.5 mg/kg), pregnenolone sulfate (2 and 5 mg/kg) or dehydroepiandrosterone sulfate (2 and 5 mg/kg), followed by morphine (10 mg/kg) prevented the development of tolerance to the antinociceptive effect of morphine and suppressed the naloxone-precipitated withdrawal jumps. In contrast, dehydroepiandrosterone acetate (5 mg/kg) failed to modulate the morphine tolerance and dependence. The inhibitory effect was also seen upon concomitant administration of a neurosteroid precursor, progesterone (1–10 mg/kg), and a mitochondrial diazepam binding inhibitor receptor agonist, 4′-chlordiazepam (0.25–1 mg/kg), while an adrenocorticosteroid, hydrocortisone (1 and 10 mg/kg), failed to do so. However, acute treatment with these neurosteroids was not associated with any decrease in withdrawal jumping behavior in morphine-dependent mice. Neurosteroids themselves, at doses employed in the study, did not exert any effects on antinociception. These results support a role for neurosteroids in the development of tolerance to and dependence on morphine and suggest the potential utility of specific neuroactive steroids in its treatment.

What is it? --> the wiki

Where can I buy it? --> Amazon.com link

Haven't tested this myself.

[DCBA]

if you werent a member i would think of and add.

[hydro chris]

just what you need more estrogen

[ryan]

I am suspicious since the referenced article is from 1997 and haven't really heard anything about this..
I don't think I would ever try this..I am more interested in http://en.wikipedia.org/wiki/J-113,397 -- that's something I would actually try.

[HandMeSomeOpiates]

Yeah reminds me of an article I read on here a while back "Blowfish organs treat opiate addiction" or something like that. Haven't heard anything since. Either the stuff works and not many people know about it, or it was released by "The Onion" lol

[Shadowsblaze]

Fuck I could only find a J-113-396 anybody got a 1 I could add.

[Morfiend]

well it (Pregnenolone) increases neurogenesis (creation of neurons) in the hippocampus (deals with memory, in the limbic system, also marijuana has been shown to disable this part of the brain). So if it gives you more neurons in the limbic system it would seem this could be either wonderful for recovery during withdrawal, or terrible/wonderful in creating a greater dependence on opiates while taking them (wonderful in the sense that they would maybe give you a better high)... I can't rationalize the results of the above study...

any thoughts? I am not a doctor or biology student of any kind.