hodgkinsine

[savethedogs]

Natural opiate of the tryptamine class found in Psychotria colorata, acts as a mu-opiate receptor agonist and NMDA antagonist, similar to methadone. Also has antibacterial, antifungal, and antiviral effects.

I haven't been able to find much information, aside from a wikipedia article ( http://en.wikipedia.org/wiki/Hodgkinsine ), but it does look promising.

Look at the structure of this alkaloid, it's insane! I am searching for a place to order some bulk leaves or bark, whatever has the highest concentration of alkaloids. If I find a vendor, I'll post it here.

[Fran]

Genus Psychotria was already known to contain psychedelic tryptamines like N,N-DMT ...These rubiaceae seems to be more interesting than I thought ...

[jacky]

there are around 3-4 other psychotria species besides p. colorata that are rumored to have opioid and/or nmda antagonist activity.

recently there is a bit of a rumor that some company is going to start selling a 30% alkaloidal extract of psychotria colorata.

I would like to know where they sourced this one, as I have a contact in brazil that can and does ship me nearly anything that I want from the jungles/plains of that country, but he for nearly two years has had no luck finding even small voucher specimens of this species.
he looked into some of the schultes information on this plant of course, and noted that his particular area was listed as a source for the plant....but that book is decades old, and he found no people claiming to know of the plant in their area any longer.

since I learned of these plants, I have thought about the potential that using natural mu agonists coupled with the possibly potential effects of using a natural nmda antagonist active herb might help keep a cap on the tolerance response.

these bushes can produce some abundant leaf material over time most likely, if they are similiar to psychotria viridis, they are not too hard to grow most likely either.

hopefully if commercial extracts are going to be produced, the raw leaf and live plants and seeds might follow.

someone, let the damn cat out of the bag.
these plants has been in the literature for too long, they need to be in our greenhouses!

[savethedogs]

there are around 3-4 other psychotria species besides p. colorata that are rumored to have opioid and/or nmda antagonist activity.

recently there is a bit of a rumor that some company is going to start selling a 30% alkaloidal extract of psychotria colorata.

I would like to know where they sourced this one, as I have a contact in brazil that can and does ship me nearly anything that I want from the jungles/plains of that country, but he for nearly two years has had no luck finding even small voucher specimens of this species.
he looked into some of the schultes information on this plant of course, and noted that his particular area was listed as a source for the plant....but that book is decades old, and he found no people claiming to know of the plant in their area any longer.

since I learned of these plants, I have thought about the potential that using natural mu agonists coupled with the possibly potential effects of using a natural nmda antagonist active herb might help keep a cap on the tolerance response.

these bushes can produce some abundant leaf material over time most likely, if they are similiar to psychotria viridis, they are not too hard to grow most likely either.

hopefully if commercial extracts are going to be produced, the raw leaf and live plants and seeds might follow.

someone, let the damn cat out of the bag.
these plants has been in the literature for too long, they need to be in our greenhouses!

Here, here!

[Raisin]

Actually, it's "hear, hear" as in "now hear this" or closer yet "hear ye, hear ye"

[SHELLEY]

there are like, 3 words in this entire thread that i understand...

[Badly Drawn Girl]

there are like, 3 words in this entire thread that i understand...

Your post was the only thing complete thought I understood...

[Paregoric Kid]

does anyone know a source for seeds? this looks really interesting.

[Papa Verine]

does anyone know a source for seeds? this looks really interesting.

It doesn't sound like it.

But I hope one pops up soon.

[Paregoric Kid]

so has anyone tried this yet or grown it or found a good source for this stuff yet? I mean I'm not asking for someone to say WHERE they found it but I'd just like to know if it was ever made available.
if not, does anyone know if Psychotria lyciiflora or Calycodendron milnei is any easier to find? both of those contain hodgkinsine.
there is also Psychotria brachypoda which sounds very interesting. any info on that would be appreciated.

Opioid-like activity of Psychotria brachypoda

M B Leal and E Elisabetsky*

Strong opioid-like analgesic activity has been detected in alkaloids from Psychotria colorata (Willd ex R. & S.) Muell. Arg., used by Amazonian caboclos of Brazil as a pain killer. The present work was undertaken to study Psychotria brachypoda (Muell. Arg.) Britton in regard to the presence of alkaloids and potential analgesic activity. The leaf ethanol extract is rich in alkaloids and was evaluated for analgesia (mouse tail-flick), effects on body temperature and acute toxicity. In the tail-flick test the extract was active in a dose-effect pattern (i.p. 350 mg/kg comparable to 6 mg/kg of morphine) and the activity was reversed by naloxone. The body temperature decreased significantly. Sedation, blepharoptosis, but not loss of righting reflex were observed in acute toxicity test. These results show that the ethanol extract of P. brachypoda is rich in alkaloids with opioid-like analgesic activity. These data indicate the pertinence of isolating these alkaloids and further characterizing their pharmacological profile. Psychotria alkaloids can be regarded as potential templates for new analgesic compounds.

[Schwip]

Edit:Oops. Misread the specie name. Thought for sure I had a source, but wrong plant

[Paregoric Kid]

also if anyone knows anything about Psychotria umbellata or a source for seeds please post. this is another Psychotria that has opioid activity and I believe also produces hodgkinsine as well as NMDA antagonists.
another thing is that Psychotria brachypoda is also known as Palicourea brachypoda.

[Paregoric Kid]

apparently there are a few opioids related to hodgkinsine, this class of phyto-opioids are known as Pyrrolidinoindolines. Psychotria oleoides and Psychotria lyciiflora contain hodgkinsine as well as meso-chimonanthine, Nb-desmethyl-meso-chimonanthine, and calycosidine. calycosidine is also found in Psychotria rostrata as well as other Psychotria species. the chimonanthine monourethanes are said to have a much stronger binding affinity than hodgkinsine and meso-chimonanthine. chemonanthine and related alkaloids can also be found in Idiospermum australiense.
also wanted to add that hodgkinsine and possibly other opioid pyrrolidinoindolines can also be found in Hodgkinsonia frutescens, Hodgkinsonia ovatiflora, and Calycodendron milnei.

Synthesis and antinociceptive activity of chimonanthines and pyrrolidinoindoline-Type alkaloids
Abstract

Hodgkinsine, a trimeric pyrrolidinoindoline type alkaloid, present as a major constituent of Psychotria spp. (Rubiaceae), has shown to produce dose-dependent, naloxone reversible, analgesic effect in thermal models of nociception and in the capsaicin-induced pain. SAR studies have been initiated by synthesizing the three diastereomeric dimers (chimonanthines) (11–13) which were evaluated in vitro and in vivo along with the synthetic intermediates. Strong binding affinities for μ opioid receptors were found for (−)- and (+)-chimonanthine monourethanes (9 and 10), whereas (−)-, (+)- and (meso)-chimonanthine (11–13) and hodgkinsine displayed low affinity. In vivo data have shown that only (+)-chimonanthine (12) and calycosidine resemble the analgesic profile found for hodgkinsine.


Graphical Abstract

(+)-, (−)-, (meso)-chimonanthine and the pyrrolidinoindoline-type intermediates from the synthetic pathway were tested in in vitro, in vivo models of analgesia, and compared to the active natural compound hodgkinsine, a trimeric pyrrolidinoindoline alkaloid isolated from Psychotria colorata (Rubiaceae).

Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora.

The chemical study of two Rubiaceae from New Caledonia, Psychotria lyciiflora and Psychotria oleoides, led to the isolation of several pyrrolidinoindoline alkaloids. Two dimers, the known meso-chimonanthine (9) and the new Nb-desmethyl-meso-chimonanthine (5), and a known trimer, hodgkinsine (1), have been isolated from P. lyciiflora. Hodgkinsine (1), quadrigemine C (2), isopsychotridine B (3), psychotridine (4), and three new alkaloids, quadrigemine I (6), oleoidine (7), and caledonine (8), have been isolated from P. oleoides. Structural assignments of the compounds were based on mass spectra analysis and 2D NMR experiments. A tentative stereochemical determination is made from 2D NMR experiments, circular dichroism study and chemical correlations. Some of these compounds are functional antagonists of somatostatine (SRIH).