I think i'm gonna try Akuamma seed

[Indy]

So it's 10$ from phyto, and i think that coupon code still works, so i figure it's worth a shot. It seems too good to be true though, according to what i've read the dose for a non-opioid tolerant person is like 250 mg, and an ounce is 10 bucks. It definitely has pure opioid activity, but there's a couple things i'm concerned about:

the primary action of akkuamine and whatever the other active alkaloid in akuamma seed is through metabolism to a full agonist. unmetabolized, the primary alkaloid (whose exact name escapes me right now, but its something-akkuamine i think) is actually an ANTagonist. BUT it's metabolized in the body to a full agonist, thereby inducing analgesia, constipation, and all the other opioid effects we know and love. The question is: IS there a limit to how much the body can metabolize at once a la codeine, and if so, is this limit high enough that an opioid tolerant person such as myself would be able to take a large amount and get the agonist effect. moreover, if this IS a problem, does the antagonist have a higher binding affinity for the opioid receptors than most other opioids? meaning, does it block other opioids, or even worse, would it rip them from your receptors?

I'm willing to bet that it won't be a problem, so i'm finally gonna pay up and try this out. I'm not around as much anymore though so i might not be able to check back in for a while.

To be honest, i'm surprised akkuamine hasn't been talked about more.

http://en.wikipedia.org/wiki/Akuammine

[clinton]

has anyone on here tried this?
id like to read 1st hand experiences......

[Ad Nauseam]

So it's 10$ from phyto, and i think that coupon code still works, so i figure it's worth a shot. It seems too good to be true though, according to what i've read the dose for a non-opioid tolerant person is like 250 mg, and an ounce is 10 bucks. It definitely has pure opioid activity, but there's a couple things i'm concerned about:

the primary action of akkuamine and whatever the other active alkaloid in akuamma seed is through metabolism to a full agonist. unmetabolized, the primary alkaloid (whose exact name escapes me right now, but its something-akkuamine i think) is actually an ANTagonist. BUT it's metabolized in the body to a full agonist, thereby inducing analgesia, constipation, and all the other opioid effects we know and love. The question is: IS there a limit to how much the body can metabolize at once a la codeine, and if so, is this limit high enough that an opioid tolerant person such as myself would be able to take a large amount and get the agonist effect. moreover, if this IS a problem, does the antagonist have a higher binding affinity for the opioid receptors than most other opioids? meaning, does it block other opioids, or even worse, would it rip them from your receptors?

I'm willing to bet that it won't be a problem, so i'm finally gonna pay up and try this out. I'm not around as much anymore though so i might not be able to check back in for a while.

To be honest, i'm surprised akkuamine hasn't been talked about more.

http://en.wikipedia.org/wiki/Akuammine

I'm shocked that I've never heard of it. Not a lot of information on the plant on the web. The only thing that I could offer is that on the wiki page it says that it is closely related to the kratom alkaloids. We all know that kratom won't out you into WD's and I don't think there is any reason to assume that this would put you into precipated WD's.

I really don't think you have to worry about anything. The only way to find out if your bosy will metabolize enough of it is to give it a shot. I think :P.

[Synack]

Extracts of the seeds of Picralima nitida (fam. Apocynaceae) have been reported to have opioid analgesic activity. In this investigation, isolated tissue bioassays and radioligand binding assays have been used to determine the opioid activity of five alkaloids--akuammidine, akuammine, akuammicine, akuammigine and pseudoakuammigine--extracted from the seeds of P. nitida. Akuammidine showed a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 microM at mu-, delta- and kappa-opioid binding sites, respectively. The agonist actions of akuammidine in the mouse-isolated vas deferens were antagonised by naloxone and the mu-opioid receptor selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) confirming an action at mu-opioid receptors. In contrast, akuammine also showed highest affinity for mu-opioid binding sites (Ki 0.5 microM) but was an antagonist at mu-opioid receptors with a pK(B) of 5.7 against the selective mu-opioid receptor agonist [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO). Akuammicine has the highest affinity for kappa-opioid binding sites (Ki 0.2 microM) and was a full agonist at kappa-opioid receptors in the guinea pig ileum preparation but a partial kappa-opioid receptor agonist in the vasa deferentia of the mouse and the rabbit. Akuammigine and pseudoakuammigine showed little or no efficacy in the opioid bioassays. None of the alkaloids had significant activity for opioid receptor-like binding sites (ORL1-binding sites) with Ki values >> 10 microM. These data show that some alkaloids extracted from the medicinal plant P. nitida possess varying degrees of agonist and antagonist activity at opioid receptors but possess neither high affinity nor selectivity for mu-, delta- or kappa-opioid receptors or the ORL1-receptor.

Let us know how it goes... and do me a small favor when your done with the seeds, plant one or two and see if they grow...

[jacky]

when I consumed this seed I tried 20 grams my first time.

after that experience I wouldve tried for at least twice that amount.

but the seed is so intolerably bitter I couldnt do it the 2nd time.

now I have some alkaloid material sitting around for the future, this was prepared by a chemist freind.
t. pachysiphon leaf and possibly rootbark contains similiar/same compounds, but far less prevelant compared to the nitida seed.

expect stimulation effects, dizziness.
I experienced a skin allergy reaction, a bump formed on my forehead, it was itchy and red.
soon a spongy hard bump flattened out, and remained under my skin for almost 9 days.

I was opiate dependent at the time, this was around 4-5 years ago.

I think the alkaloids have potential, but possibly more potential if isolated and seperated.

if I was going to consume the seeds, I would take a measure of 30% lemon or lime juice to 70% water...
then heat the seeds in this mixture, possibly at a low boil.
extract twice using this method, and then let the extract evaporate water content at a low 110 degree in a few glass pans in the oven...
this method generally reduces the extraneous material by 90%, or at least 30%....

a more competent chemist might defat this mixture and perform additional isolation, but I dont know which alkaloids might be preferable, and I dont know which alkaloids would be soluable in what solvents.

consider the reason that this medicine might be used is that the area of consumption is very poor, and there is little money for standard opiate painkillers..
I think this seed has shown some anti malarial ability, so it has uses other than as a pain killer.
in conjunction with some compounds found in the mitragyna species range, this seed might provide decent protection against malaria.

one chemist I know suggested that he felt iboga like stimulation when consuming the alkaloid extract, I would say that it was a low grade comparison, in that he didnt complain of the stimulation, but rather that it was similiar, but not equal to iboga alkaloid stimulation, and with no assumption that by taking more p. nitida alkaloids would any iboga like psychedelic effects present themselves.

very interesting plant, though I would like to see some more ethnobotanical facts on this subject.

[jacky]

Pseudo-akuammigine seems to be the stronger compound...

also, 250 milligrams of akkuammine is probably what the pharmacists are using, not 250 milligrams of picralima nitida seed,
and I havnt been able to find any relevant alkaloid profiles of this plant.
there might only be 250 milligrams of akkuamine present in a pound of picralima seed for all we know.

250 milligrams of just the seed probably wont do anything for you.

I tried to gag down 40 grams of seed material the 2nd time I consumed this material, but it was so intolerably horrible I couldnt do it.
I think my recipe for making a resin extract, and then stuffing that in gel caps is the way to go, unless you have access to the 70% alkaloid extract.

the stimulation I did feel was mild, slightly enjoyable, there was some transient nausea that was traveling with the dizziness thoughout the night, and I probably found sleep around 5.45 in the morning, so we are talking mild stimulation.

this seed is avialable by the ton, and the prices are not too expensive, the seed is a prolific source of these alkaloids, so the right chemist could potentially harvest a good amount of isolated compounds to sell on the reference compound market.
if prices could be kept down, I think more people might pay attention to the potential of this plant as a dietary supplement some day.
but only with standardization and processing could this seed stand a chance in the human consumption market.

[Opiyum]

Years ago I ordered some poppy seeds from phyto (i think) and for whatever reason along with the order was a small zip lock with a few grams of these seeds. I didn't know shit about them and didn't really know what to do with them. We ended up just making a god awful tea out of it.
It was truly awful and I, having the worst gag reflex in the world, gave up after a few sips. My roommate then chocked down what was left which was pretty much all of it.
It was hard to tell what if any effect it had on him since he wasn't an "opio" in any sense and was a big drinker and it was hard to see through the alcohol. I remember him being up later that night. He didn't pass out as easily as he normally would.

He also sent me 10-15 Yopo seeds. We dried these in the oven and ground them into a fine powder. At the time I was avoiding Hallucinagens at all costs and pussed out but my other non-alchy roommate then began snorting the huge piles of powder.
A mild trip in his words and from what I saw. Im sure we did some stuff wrong and didn't have enough.