SWIM ran across this, searched the forums here for it, didn't see it, so he's posting it here for anyone who is savvy enough...
Drone's home-made fentanyl analog!
Yep, drone has doen what was thought impossible, and
will now divulge what is thought unmentionable,
because DRONE #342 is DRONE #342, and can do that!
Folks, have you ever had a hankering for a big, juicy
ounce or two of synthetic heroin, but just thought it
impossible to allocate the necessary chemicals? Well,
your friend drone has taken out the guesswork and
managed to develope a synthetic route to a chemical
1000 or so stronger than conventional smack.
Impossible, you say? NAY, my dear worker bees.
Here's the general overview of fentanyl synthesis.
4-piperidone is reacted with a trimethyliodo
(quaternary) salt of a phenethylamine (or any number
of aromatic ethylamines), to produce an
N-arylethylpiperidone (you can use the quaternary salt
of the piperidone with the primary substituted
arylethytlamine, if you like, too.) Anyways, this is
reacted with aniline, and reduced with NaBH4, and then
reacted with propionic anhydride to produce the
It turns out:
*adding an ethyl carbon bridge to the piperidine ring
will not reduce potency.
*adding an extra methyl to the phenethyl substituent
to make a phenylisopropyl makes for a strong,
*adding a hydroxy to the alpha-carbon of the pehethyl
side chain -- as seen in ephedrine -- will also
*as I said in a previous post, propionic anhydride can
be made at home (this is the most closely watched
chemical on the DEA's list, but this watching was
rendered obsolete by YoursTruly not too long ago.)
The Fentanyl Suite, in d(l)-major; Movement 1
(the curtain rises, our anti-hero is found quietly
sauntering through the woods, foraging for
Taking this into account, Atropine is extracted from
nightshade. It is hydrolyzed to form tropine. Tropine
is oxidized to form tropinone. Tropinone is then
exhaustively methylated with iodomethane.
Dexatrim is bought in a fiendish quantity. The PPA is
extracted and isolated as its free base. This is
combined with tropinone, to form
Aniline is combined with the aforementioned
freshly-made tropinone, and reduced with NaBH4.
Propionic anhydride is made from a propionate salt
like calcium propionate by adding bromine or even
chlorine. Alternatively, propionate esters are
hydrolyzed, the acid component isolated, and combined
with acetic anhydride and allowed to reflux, with the
product being fractionally distilled.
The propionic anhydride is added to our soon-to-be
fentanyl analog compound, and allowed to react (I
think around 50 C). The product is flash
chromatographed, combined with citric acid (or any
acid of your choice), and allowed to dry.
The material is cut with hundreds of times its mass of
Viola! China white has just been made out of
Nightshade, diet tablets, aniline, and food
preservatives. It's all there in the literature. Ref's
available upon request.
Are we having fun yet?