Advertise on Opiophile
+ Reply to Thread
Results 1 to 30 of 30

Thread: Home Fentanyl Synthesis

  1. #1
    Occasionally Opiated Samcastic is an unknown quantity at this point Samcastic's Avatar
    Join Date
    Dec 2005
    Location
    The Valley, California.
    Posts
    13

    Default Home Fentanyl Synthesis

    SWIM ran across this, searched the forums here for it, didn't see it, so he's posting it here for anyone who is savvy enough...


    Drone's home-made fentanyl analog!

    Yep, drone has doen what was thought impossible, and
    will now divulge what is thought unmentionable,
    because DRONE #342 is DRONE #342, and can do that!

    Folks, have you ever had a hankering for a big, juicy
    ounce or two of synthetic heroin, but just thought it
    impossible to allocate the necessary chemicals? Well,
    your friend drone has taken out the guesswork and
    managed to develope a synthetic route to a chemical
    1000 or so stronger than conventional smack.
    Impossible, you say? NAY, my dear worker bees.

    Here's the general overview of fentanyl synthesis.
    4-piperidone is reacted with a trimethyliodo
    (quaternary) salt of a phenethylamine (or any number
    of aromatic ethylamines), to produce an
    N-arylethylpiperidone (you can use the quaternary salt
    of the piperidone with the primary substituted
    arylethytlamine, if you like, too.) Anyways, this is
    reacted with aniline, and reduced with NaBH4, and then
    reacted with propionic anhydride to produce the
    fentanyl freebase.

    It turns out:

    *adding an ethyl carbon bridge to the piperidine ring
    will not reduce potency.

    *adding an extra methyl to the phenethyl substituent
    to make a phenylisopropyl makes for a strong,
    long-lasting compound.

    *adding a hydroxy to the alpha-carbon of the pehethyl
    side chain -- as seen in ephedrine -- will also
    increase potency.

    *as I said in a previous post, propionic anhydride can
    be made at home (this is the most closely watched
    chemical on the DEA's list, but this watching was
    rendered obsolete by YoursTruly not too long ago.)

    The Fentanyl Suite, in d(l)-major; Movement 1

    (the curtain rises, our anti-hero is found quietly
    sauntering through the woods, foraging for
    precursors.)

    Taking this into account, Atropine is extracted from
    nightshade. It is hydrolyzed to form tropine. Tropine
    is oxidized to form tropinone. Tropinone is then
    exhaustively methylated with iodomethane.

    Second Movement

    Dexatrim is bought in a fiendish quantity. The PPA is
    extracted and isolated as its free base. This is
    combined with tropinone, to form
    N-(1-hydroxy-1-phenyl)isopropyl tropinone.

    (intermezzeo)

    Third Movement

    Aniline is combined with the aforementioned
    freshly-made tropinone, and reduced with NaBH4.

    Fourth Movement
    (Allegro)

    Propionic anhydride is made from a propionate salt
    like calcium propionate by adding bromine or even
    chlorine. Alternatively, propionate esters are
    hydrolyzed, the acid component isolated, and combined
    with acetic anhydride and allowed to reflux, with the
    product being fractionally distilled.

    (crescendo)

    The propionic anhydride is added to our soon-to-be
    fentanyl analog compound, and allowed to react (I
    think around 50 C). The product is flash
    chromatographed, combined with citric acid (or any
    acid of your choice), and allowed to dry.

    The material is cut with hundreds of times its mass of
    mannitol.

    Viola! China white has just been made out of
    Nightshade, diet tablets, aniline, and food
    preservatives. It's all there in the literature. Ref's
    available upon request.

    Are we having fun yet?

    -drone #342

  2. #2
    Opiophorum Member Mokelly is an unknown quantity at this point Mokelly's Avatar
    Join Date
    Dec 2005
    Location
    NY
    Posts
    252

    Default Re: Home Fentanyl Synthesis

    someone do this now! (Bogumil?) and send product to me for quality assurance testing.....
    All of the above is false.

  3. #3
    Never Looked Back exitwound is an unknown quantity at this point exitwound's Avatar
    Join Date
    Dec 2005
    Location
    Shoot yourself in the balls and then electrocute yourself. That's how I always feel!!!
    Posts
    1,229

    Default Re: Home Fentanyl Synthesis

    dang! Somehow I doubt that anyone with the resources and equipment would risk such a ghetto synth.....but hell, if it works, it works!
    "I hate to advocate drugs, alcohol, violence, or insanity to anyone, but they've always worked for me." - The Good Doctor, Hunter S. Thompson

  4. #4
    OpioNoMo caesee is an unknown quantity at this point caesee's Avatar
    Join Date
    Feb 2006
    Location
    california
    Posts
    369

    Default Re: Home Fentanyl Synthesis

    ok, guess I just flush the kilo of o I was going to use o make h, and go with this..lol

  5. #5
    Never Looked Back exitwound is an unknown quantity at this point exitwound's Avatar
    Join Date
    Dec 2005
    Location
    Shoot yourself in the balls and then electrocute yourself. That's how I always feel!!!
    Posts
    1,229

    Default Re: Home Fentanyl Synthesis

    LMAO! Yeah, who needs opium when you have ghetto fentanyl made from deadly nightshade! LOL
    "I hate to advocate drugs, alcohol, violence, or insanity to anyone, but they've always worked for me." - The Good Doctor, Hunter S. Thompson

  6. #6
    New Opiophile tophatgr is an unknown quantity at this point
    Join Date
    Sep 2006
    Posts
    1

    Default Re: Home Fentanyl Synthesis

    Hey Guys...I am new, and aced Chem 1 in college, IQ 191 and have a several engineering degrees.
    Think I can systhesize some FA?
    I want to develop a detailed procedure for this, step by freaking tiny step, listing every piece of equipment and labwear, how and where to get all the precusors (nightshade, dexatrim, sodium propionate).
    All Who Participate Will Be Compensated! We will share the wealth.
    This is a SERIOUS PROPOSAL....REMEMBER THAT THIS IS FOR THE DEVELOPMENT OF THE PROCEDURE ONLY AND IS NOT INTENDED TO BE ACTUALLY USED...

    Let us start with complete, detailed lab procedure steps for the following modules:
    1)
    PPA(Phenylpropanolamine) free base extraction from Dexatrim tablets. This procdeure needs detailing.
    2) Extraction and purification of Atropine from Nightshade ==>hydrolyzation==>oxydation==>methylation (iodomethane)==>tropinone (or can atropine be bought? Sched IV drug - so I don't think so...) the plant is only found in a few areas of the USA, can it be bought at nurseries? This procdeure needs detailing.
    3) Pro
    pionic anhydride synthesis: Calcium propionate + Br ==> Propionic anhydride This procdeure needs detailing.
    4) Obtaining Aniline: Is it a monitored chemical? I don't think so as it is used in dye production.
    What specific type of aniline is required for this process?
    5) Aniline + tropinone, then reduced with NaBH4. This procdeure needs detailing.
    6) Details of the flash chromatographing operation used to separate the product. What is the citric acid used for? Recomendations on the type and brand of unit are needed.


    __________________________________________________ ______________

    Taking this into account, Atropine is extracted from
    nightshade. It is hydrolyzed to form tropine. Tropine
    is oxidized to form tropinone. Tropinone is then
    exhaustively methylated with iodomethane.


    Drone's home-made fentanyl analog!

    Yep, drone has doen what was thought impossible, and
    will now divulge what is thought unmentionable,
    because DRONE #342 is DRONE #342, and can do that!

    Folks, have you ever had a hankering for a big, juicy
    ounce or two of synthetic heroin, but just thought it
    impossible to allocate the necessary chemicals? Well,
    your friend drone has taken out the guesswork and
    managed to develope a synthetic route to a chemical
    1000 or so stronger than conventional smack.
    Impossible, you say? NAY, my dear worker bees.

    Here's the general overview of fentanyl synthesis.
    4-piperidone is reacted with a trimethyliodo
    (quaternary) salt of a phenethylamine (or any number
    of aromatic ethylamines), to produce an
    N-arylethylpiperidone (you can use the quaternary salt
    of the piperidone with the primary substituted
    arylethytlamine, if you like, too.) Anyways, this is
    reacted with aniline, and reduced with NaBH4, and then
    reacted with propionic anhydride to produce the
    fentanyl freebase.

    It turns out:

    *adding an ethyl carbon bridge to the piperidine ring
    will not reduce potency.

    *adding an extra methyl to the phenethyl substituent
    to make a phenylisopropyl makes for a strong,
    long-lasting compound.

    *adding a hydroxy to the alpha-carbon of the pehethyl
    side chain -- as seen in ephedrine -- will also
    increase potency.

    *as I said in a previous post, propionic anhydride can
    be made at home (this is the most closely watched
    chemical on the DEA's list, but this watching was
    rendered obsolete by YoursTruly not too long ago.)

    The Fentanyl Suite, in d(l)-major; Movement 1

    (the curtain rises, our anti-hero is found quietly
    sauntering through the woods, foraging for
    precursors.)

    Taking this into account, Atropine is extracted from
    nightshade. It is hydrolyzed to form tropine. Tropine
    is oxidized to form tropinone. Tropinone is then
    exhaustively methylated with iodomethane.

    Second Movement

    Dexatrim is bought in a fiendish quantity. The PPA is
    extracted and isolated as its free base. This is
    combined with tropinone, to form
    N-(1-hydroxy-1-phenyl)isopropyl tropinone.

    (intermezzeo)

    Third Movement

    Aniline is combined with the aforementioned
    freshly-made tropinone, and reduced with NaBH4.

    Fourth Movement
    (Allegro)

    Propionic anhydride is made from a propionate salt
    like calcium propionate by adding bromine or even
    chlorine. Alternatively, propionate esters are
    hydrolyzed, the acid component isolated, and combined
    with acetic anhydride and allowed to reflux, with the
    product being fractionally distilled.

    (crescendo)

    The propionic anhydride is added to our soon-to-be
    fentanyl analog compound, and allowed to react (I
    think around 50 C). The product is flash
    chromatographed, combined with citric acid (or any
    acid of your choice), and allowed to dry.

    The material is cut with hundreds of times its mass of
    mannitol.

    Viola! China white has just been made out of
    Nightshade, diet tablets, aniline, and food
    preservatives. It's all there in the literature. Ref's
    available upon request.

    Are we having fun yet?

    -drone #342[/quote]

  7. #7
    Jr. Opiophile trainwrecker is a jewel in the rough trainwrecker is a jewel in the rough trainwrecker is a jewel in the rough trainwrecker is a jewel in the rough trainwrecker is a jewel in the rough trainwrecker is a jewel in the rough trainwrecker is a jewel in the rough trainwrecker's Avatar
    Join Date
    Sep 2006
    Location
    in the Aether
    Posts
    559

    Default Re: Home Fentanyl Synthesis

    Well, I know Bitter sweet night shade grows all over here (Pacific North West) I would be willing to collect a bunch and make it available to anyone who pays for shipping.

  8. #8
    New Opiophile EndRun is an unknown quantity at this point EndRun's Avatar
    Join Date
    Aug 2006
    Location
    CO
    Posts
    7

    Default Re: Home Fentanyl Synthesis

    Quote Originally Posted by tophatgr View Post
    (or can atropine be bought? Sched IV drug - so I don't think so...)
    I thought atropine was in immodium? Or is that only in the prescription version (lomotil, me thinks?) If it's in immodium, I assume it'd be much easier to get from here than to pull from nighshade. But then, my chem degree came free with a bundle of smack, so what do I know?
    "Even the weariest river winds somewhere safe to sea"

  9. #9
    Opiophile superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman's Avatar
    Join Date
    Jun 2005
    Location
    Western Canada
    Posts
    853

    Default Re: Home Fentanyl Synthesis

    "All Who Participate Will Be Compensated! We will share the wealth.
    This is a SERIOUS PROPOSAL...."

    first of all, to propose something like this makes you sound like a cop. to say you're a chemist, and a genius, and looking for people to help you make fentanyl...... now that's just stupid.

    besides these points, you're on the wrong forum for this kind of shit. it's not secure, it's not chemistry oriented, and it's not going to be much help (unless you're looking for some suckers to throw in jail)

  10. #10
    Departed Opiophile chemboy7 has disabled reputation chemboy7's Avatar
    Join Date
    Apr 2006
    Location
    Inebria
    Posts
    4,866

    Default Re: Home Fentanyl Synthesis

    Yeah, superman's right that kinda sounds like there would be an exchange of an illegal substance and this is strictly forbidden. There's alittle chemistry talk around here, not too much though; this is a forum that get's into sythesis alot more/indepth (although they seem to be down at the moment)

    https://www.synthetikal.com/

    I'm not too sure that Atropine is a controlled substance either, in the medication Lomotil it is schedualed but that is due to the Diphenoxylate not the Atropine. The Atropine is in there to prevent abuse and thus the low schedual (or high I guess); I bet that Diphenoxylate by itself would be a much lower schedual. I know of at least one chemical supply house that currently advertises Atropine HCL in it's cateloge... whether or not they have it in stock is another matter though, if you had your email addy up I could send it along but I won't post it publically and you don't have PM ability yet.

    And this is the second time in a week that someone has dropped their IQ on us... that's just weird.

    --The Sock Puppet Pervert--


  11. #11
    Never Looked Back devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice devilsdrug is just really nice
    Join Date
    Nov 2005
    Location
    or.
    Posts
    2,732

    Default Re: Home Fentanyl Synthesis

    yea 191 no less shit that is signifigant what % does that fall in yikes

  12. #12
    Junky RobOC is an unknown quantity at this point
    Join Date
    Jun 2006
    Location
    San Diego, California
    Posts
    302

    Default Re: Home Fentanyl Synthesis

    Oh yea! Well my IQ is so high all I have to do is think about fent and WHAMO, it exists. Who needs ghetto synthesis when your a super genius with psychokinetic powers?
    You say you're down on your luck.
    Hey baby it's long, long way up.
    Hold back now, hold back your fears.
    You say you're really down and out.
    And you feel like there's no way out now.
    Let go now, let go of your tears.
    -"Angels Wings" by Social Distortion. Fuckin' Mike Ness,

  13. #13
    Never Looked Back antony will become famous soon enough antony will become famous soon enough antony will become famous soon enough antony will become famous soon enough antony's Avatar
    Join Date
    Jan 2006
    Location
    chicago
    Posts
    1,085

    Default Re: Home Fentanyl Synthesis

    I wanna know when we had to start posting our IQs.
    <img src=http://www.iicbarcellona.esteri.it/IIC_Barcellona/Templates/..%5C..%5CIICManager%5CUpload%5CIMG%5C%5CBarcellona%5Ctrinacria.jpg border=0 alt= />

  14. #14
    Honorary Charter Member nick has disabled reputation nick's Avatar
    Join Date
    Aug 2006
    Location
    Perdition's flame
    Posts
    19,885

    Default Re: Home Fentanyl Synthesis

    Peeps have already started posting their IQ's.So when it feels right go for it Antony.

  15. #15
    Never Looked Back antony will become famous soon enough antony will become famous soon enough antony will become famous soon enough antony will become famous soon enough antony's Avatar
    Join Date
    Jan 2006
    Location
    chicago
    Posts
    1,085

    Default Re: Home Fentanyl Synthesis

    thanks, nick. I'll retake the test when I'm finished writing up my American Scientific Journal article on how I recently discovered and produced dark matter.
    <img src=http://www.iicbarcellona.esteri.it/IIC_Barcellona/Templates/..%5C..%5CIICManager%5CUpload%5CIMG%5C%5CBarcellona%5Ctrinacria.jpg border=0 alt= />

  16. #16
    Opiophorum Member northernstar is an unknown quantity at this point northernstar's Avatar
    Join Date
    Apr 2006
    Location
    usa
    Posts
    140

    Default Re: Home Fentanyl Synthesis

    the atropine is easy to get.....the dexatrim now.....thats hard,
    but ChRIST theres a million steps......i remeber some parkinsons breakthrough occured becuse some jackass was only 10 degrees off on a snthetic fentanyl recipie.. it made some brain-mushifying compound form in the batch, and then a bunch of junkies were zombies within a week. really helped scientists understand how parkinsons fucks the brain up tho...those 20 junkies are still getting poked and proded ......

    This is really cool, and there must be a way to make homeade opiates...but this recipie lacks details, and way to many steps....without yeild...and from my experince atropine s a fragile chemical that breaks down easy. the final yeild must be like .02% lol

  17. #17
    Departed Opiophile chemboy7 has disabled reputation chemboy7's Avatar
    Join Date
    Apr 2006
    Location
    Inebria
    Posts
    4,866

    Default Re: Home Fentanyl Synthesis

    Quote Originally Posted by northernstar View Post
    the atropine is easy to get.....the dexatrim now.....thats hard,
    but ChRIST theres a million steps......i remeber some parkinsons breakthrough occured becuse some jackass was only 10 degrees off on a snthetic fentanyl recipie.. it made some brain-mushifying compound form in the batch, and then a bunch of junkies were zombies within a week. really helped scientists understand how parkinsons fucks the brain up tho...those 20 junkies are still getting poked and proded ......

    This is really cool, and there must be a way to make homeade opiates...but this recipie lacks details, and way to many steps....without yeild...and from my experince atropine s a fragile chemical that breaks down easy. the final yeild must be like .02% lol
    It was the Meperidine analoge MPPP that was the goal of the synthesis in question, it ended up being tainted with MPTP; which is the compound that caused the instant Parkinson's-like symptoms and subsequently all the ruckus.

    --The Sock Puppet Pervert--


  18. #18
    Never Looked Back Hammilton is fresh on the scene. Hammilton is fresh on the scene. Hammilton's Avatar
    Join Date
    Jun 2006
    Location
    Iwo Jima
    Posts
    1,041

    Default Re: Home Fentanyl Synthesis

    Actually Diphenoxylate is C2. It's pretty enjoyable stuff. It's a cogener of meperidine I believe.
    your mileage may vary.

  19. #19
    Opiophorum Member northernstar is an unknown quantity at this point northernstar's Avatar
    Join Date
    Apr 2006
    Location
    usa
    Posts
    140

    Default Re: Home Fentanyl Synthesis

    [quote=chemboy7;43117]It was the Meperidine analoge MPPP that was the goal of the synthesis in question, it ended up being tainted with MPTP; which is the compound that caused the instant Parkinson's-like symptoms and subsequently all the ruckus.[/quote}


    ahh, thanks chemboy!
    the important thing i remembered was that it all happened becuse of a 10 degree screwup in the cooking....home ghetto synth can have tempatures all over the place from lack of real lab equipment. it seems dogey to me, yet doable too in a way becuse atropine is gettable..in almost any quantity one would want...

  20. #20
    Occasionally Opiated john_doe is an unknown quantity at this point john_doe's Avatar
    Join Date
    Aug 2006
    Location
    Soviet Canuckistan
    Posts
    66

    Default Re: Home Fentanyl Synthesis

    In one of the recipes above it says to acquire DEXATRIM tablets. But they took those off the market so good luck finding that unless you live in Brazil or some crazy country like that. Nothing against brazil but you guys are crazy! Fentanyl synth is going to be more and more common in the future. People in America are going to start learning it and doing it. I think it's already begun. In mexico they could make this shit and pump it into the U.S and canada easily and it's very cheap to make and a good high very strong. but along with this comes unexperienced chemists and they will probably not dilute it right or cut it right and end up killing alot of people. people dont know how to handle fentanyl either they always asusme it's just good white heroin and shoot it up and they end up in a coma. I heard of a group of users in the U.S who were shooting up and they found them all dead in a circle. I think it was 8 people but i may be wrong. Apparently they all died from a fentanyl overdose. Not plain Fentanyl i think it was alpha methyl or methyl fentanyl i'm not sure of the name.

  21. #21
    Occasionally Opiated bonkers is an unknown quantity at this point bonkers's Avatar
    Join Date
    Mar 2006
    Location
    Ohio, USA
    Posts
    41

    Default Re: Home Fentanyl Synthesis

    Damn, why's chemistry gotta be so damn complicated? I just want some fent, I'm not trying to win a Nobel prize for science. Jeez...

  22. #22
    Honorary Charter Member nick has disabled reputation nick's Avatar
    Join Date
    Aug 2006
    Location
    Perdition's flame
    Posts
    19,885

    Default Re: Home Fentanyl Synthesis

    Wasn't that guy trying to make fent in Calafornia when he turned people into statues?

  23. #23
    Jr. Opiophile jab will become famous soon enough jab will become famous soon enough jab will become famous soon enough jab's Avatar
    Join Date
    Jan 2006
    Location
    FLA
    Posts
    519

    Default Re: Home Fentanyl Synthesis

    Quote Originally Posted by nick View Post
    Wasn't that guy trying to make fent in Calafornia when he turned people into statues?
    No.. From Page 1, of this thread, entry #17

    Quote Originally Posted by chemboy7 View Post
    It was the Meperidine analoge MPPP that was the goal of the synthesis in question, it ended up being tainted with MPTP; which is the compound that caused the instant Parkinson's-like symptoms and subsequently all the ruckus.
    ..jab

  24. #24
    Opiophile superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman's Avatar
    Join Date
    Jun 2005
    Location
    Western Canada
    Posts
    853

    Default Re: Home Fentanyl Synthesis

    "In one of the recipes above it says to acquire DEXATRIM tablets. "
    that's odd... isn't dexatrim just dextroamphetamine?the only usefull thing someone would make with this is methamphetamine but it's not even worth the effort.

  25. #25
    Occasionally Opiated BorisB is an unknown quantity at this point BorisB's Avatar
    Join Date
    Sep 2006
    Location
    Wisconsin
    Posts
    14

    Default Re: Home Fentanyl Synthesis

    Yeah, Dexatrim is an odd thing to ask for as a precursor... also it's really an odd social habit to post your IQ and your college grades.

    Maybe I'm odd too, but I'm taking Organic Chem right now for the fun of it. I'm interested in this idea, but it doesn't seem to be a "home" thing.

    You're talking about fractional distillation. I think that's inherently not a "home" process. If we had fractional distillers everywhere, LSD would be just easy as pie too and I'd be stealing everyone's San Pedro's to get the mescaline out of em.

    Also, we're talking about working with phenethylamines - which are basically semi-scheduled right now. It's retarted. But dexatrim isn't going to be got and any sort of ephedrine/pseudoephedrine is sold in small amounts; it's very regulated.

    I wish it were possible, but it would probably be a much easier thing to become an amateur botanist rather than an amateur chemist - grow one's own poppies and harvest opium and then make heroin.

    Like it was mentioned: the %yield will probably be tiny for us amateur chemists without access to professional lab equipment and pure precursors. Also, there is no detailed info on reactions (I doubt these all work out fine at Room Temp in unfettered aqueous sol'n) and no good info on extraction. In the end, you might end up with a mess of white gook of which 1% is some random-ass fentanyl analogue and the other 99% is SodiumBromatoic acid or whatever.

    I just don't know about drone #342, but I wish it were good enough to be true. I think it's easier to be a social-engineer than a chemical-engineer and go doctor-shopping. However much I love chem, I'm still only going to stick to the easiest of reactions for now.

  26. #26
    Opiophorum Member northernstar is an unknown quantity at this point northernstar's Avatar
    Join Date
    Apr 2006
    Location
    usa
    Posts
    140

    Default Re: Home Fentanyl Synthesis

    Quote Originally Posted by BorisB View Post
    Yeah, Dexatrim is an odd thing to ask for as a precursor... also it's really an odd social habit to post your IQ and your college grades.

    Maybe I'm odd too, but I'm taking Organic Chem right now for the fun of it. I'm interested in this idea, but it doesn't seem to be a "home" thing.

    You're talking about fractional distillation. I think that's inherently not a "home" process. If we had fractional distillers everywhere, LSD would be just easy as pie too and I'd be stealing everyone's San Pedro's to get the mescaline out of em.

    Also, we're talking about working with phenethylamines - which are basically semi-scheduled right now. It's retarted. But dexatrim isn't going to be got and any sort of ephedrine/pseudoephedrine is sold in small amounts; it's very regulated.

    I wish it were possible, but it would probably be a much easier thing to become an amateur botanist rather than an amateur chemist - grow one's own poppies and harvest opium and then make heroin.

    Like it was mentioned: the %yield will probably be tiny for us amateur chemists without access to professional lab equipment and pure precursors. Also, there is no detailed info on reactions (I doubt these all work out fine at Room Temp in unfettered aqueous sol'n) and no good info on extraction. In the end, you might end up with a mess of white gook of which 1% is some random-ass fentanyl analogue and the other 99% is SodiumBromatoic acid or whatever.

    I just don't know about drone #342, but I wish it were good enough to be true. I think it's easier to be a social-engineer than a chemical-engineer and go doctor-shopping. However much I love chem, I'm still only going to stick to the easiest of reactions for now.

    I agree with you about this being a "dodgy" recipie, but about the fractional diastillation....its used in the refineing of oil, and in principle seems simple....altho prob misleading. What do they use in a O-chem lab to do this? Could someone build a fractional still at home.....diffrent chemicals sublimate at different tempatures, and are collected at different points in the colum, lowest to highest i belive.....

  27. #27
    Opiophile superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman is a jewel in the rough superman's Avatar
    Join Date
    Jun 2005
    Location
    Western Canada
    Posts
    853

    Default Re: Home Fentanyl Synthesis

    fractional distillation at home is definately do-able, even more so if you're willing to using google to find out how to do it. the only roadblock is the effort required to know how to build the apparatus, which in some cases is very simple, and in other quite the opposite.

    there are countless drugs that can be made at home, but i suggest anyone wanting to be a clandestine chemist learn to use search engines and find a strictly chem forum for support. if you want help with extractions and other basic things, you should be able to get the advice here (unless you didn't use the search engine first).

  28. #28
    Occasionally Opiated surreal is an unknown quantity at this point
    Join Date
    Oct 2006
    Location
    Interzone / Black Forrest
    Posts
    52

    Default Re: Home Fentanyl Synthesis

    Hey all,

    new here, just wanted to add my 2 cents to this as it's one of my favourit themes

    Dexatrim is, as far as i know only required as a source for Phenylpropanolamin, which is, banned now almost everywhere in "the western world". Don't know about the rest.

    Also i remember that drone's synth wasn't to be without controversy, regarding the details and the practical doability - at least it should be pretty impossible to perform without real good theoretical and practical chemical background.
    But there should be other ways if one is stearleggy enough.

    - none the less drone was a real genius - his name shall be praised in eternity

  29. #29
    Occasionally Opiated chemchem is an unknown quantity at this point
    Join Date
    Dec 2007
    Posts
    35

    Default Re: Home Fentanyl Synthesis

    my understanding is that tropine is taking place of the piperidone, and PPA replaces phenethyl-Br.

    Now, my question is if anyone knows why it must be a quaternary salt?

    I'm thinking of methylating piperidone and then reacting it with phenethylamine?

    I'll have to look into it more but this could be a feasible idea to get NPP.

    Edit: I'm having a real hard time seeing this reaction. He said either one can be the quaternary salt and react with the other, but how does this reaction occur and what is the side product?
    Last edited by chemchem; 11-04-2008 at 06:14 PM.

  30. #30
    robojunkie
    Guest

    Default Re: Home Fentanyl Synthesis

    As someone who actually knows what I am talking about, drone 342 is likely full of feces, and this would be best used to grow poppies, not synth fent. Very derivative procedure written by a creative guy with some knowledge of the structures, but one could only react the atropinonen with the exhaustively methylated (what he called the trimethy iodo salt of alpha whatever phenethylamine) quat amine salt of PEA/PPA/amp. And by the way, doing it a more creative way one can use amp to make AMF. This procedure may be actually doable in theory but not the way he says.

    I call self serving trollish bullshit on drone 342. The queen (or king) bee probably sacrificed his ass after that post...

    Oh yeah, a quarternary amine is positively charged so its a goood leaving group. The secondary amine of tropinone then attacks with its "lone pair" at the alpha methyl and kicks the trimethyamino group the fuck out. Since the once tropinone has a hydrogen that is easily lost, the reaction is irreversible, as alkly groups (from the trimethyl iodo salt) aren't easily exchanged the same way.

    For all of you guys who really want to know this stuff the best place to look is the college bookstore and pick up Ege or McMurry or Streetweiser Organic chem texts, then maybe March or another Advanced Organic text. Then you can figure out all thewhys and hows as well as nail the bullshit as it steams.

+ Reply to Thread

Similar Threads

  1. For you naughty opi pill snorters home made saline sol.
    By JoyDivision in forum Incidentals/Induction
    Replies: 18
    Last Post: 10-12-2006, 05:58 AM
  2. 4-DMAP Heroin Synthesis Method
    By insomnolent in forum Heroin
    Replies: 1
    Last Post: 02-07-2006, 02:39 PM
  3. Synthesis of Fentanyl
    By calox in forum Duragesic (Fentanyl)
    Replies: 0
    Last Post: 05-07-2005, 07:50 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts