Opiophile.org - Pharmaceuticals http://forum.opiophile.org/ Topics concerning opiate-based pharmaceuticals should be posted here. General questions unrelated to specific pharmaceuticals should be posted in the main forum. Pain Management questions should be posted in the Pain Management Forum. en Fri, 03 Sep 2010 06:02:10 GMT vBulletin 120 http://forum.opiophile.org/images/gnome/misc/rss.jpg Opiophile.org - Pharmaceuticals http://forum.opiophile.org/ <![CDATA[Big Pharma: Sickening Greed & Corruption]]> http://forum.opiophile.org/showthread.php?t=31453&goto=newpost Fri, 20 Aug 2010 12:35:21 GMT I've been doing a lot of reading lately (cannot sleep) plus I saw an interesting documentary and I've compiled a bunch of facts that will probably turn your stomach. Don't say I didn't offer a disclaimer.

Pharmaceutical companies pick a targeted disorder to treat from the DSM.
  • In Phase I they test it on animals.
  • In Phase II they test out dosing and try to figure out the safest maximum dosage.
  • In Phase III they do real pill vs. placebo.
  • Phase III trials only have to last 4-6 weeks. You would think they'd want to commit to longer but mind you, their bottom line demands getting the product into the pipeline ASAP.
  • Data is skewed in several ways: people who say they feel better from the placebo are selectively dropped. They can't say zero people did better but the real numbers have been proven to be distorted in many cases.
  • They can do as many studies as they want. They only have to submit two to the FDA. So, logically it's in their interest to choose the two that statistically make their drug look the most effective.
  • They find ways to get rid of people that have a lot of adverse reactions by deeming them non-compliant.
  • Example of manipulation: In one study with Zyprexa 2/3 of 2,500 people experienced major side effects; in a study with just 800 it was less than 1/4 so naturally they used that one.
  • In a study done on Prozac only 3% of the people who first enrolled completed it!

A TV documentary brought the Paxil 329 study up so I did a little digging.
http://psychcentral.com/blog/archive...xil-study-329/
  • Homicidal ideation was classified as "showing hostility."
  • Suidical Ideation was referred to as "emotional inability."
  • They extolled the virtues of prescribing it for children.
  • In a study of 93 children 11 out out of 93 had very serious side effects; 6 were even hospitalized.
  • A 2008 lawsuit exposed the lies that were told and that indication was removed by the FDA; Glaxo Smith Klein (GSK) settled out of court for $82.5 million.
  • Psychiatrists that participate are most often hand-picked by these companies.
  • Some of them have clear conflicts of interest as in owning stock in the company.

Lets move on to Phase IV: These medications are tried on the population at large and then data is reported back.
  • Some medications have taken as many as SEVEN YEARS to manifest symptoms.
  • Indications often change; Zoloft was approved in '91 for depression; since then they've added a whole bunch of other indications.
Did you know that it costs about 2.3 CENTS to manufacture 100 Xanax?
Then those Xanax can retail for over a dollar each; talk about mark-up!
  • The CEOs of the top 10 pharmaceutical companies average an $18 million annual salary.
  • The FDA is apparently out to lunch on many issues and easily manipulated.

I just found so many of these facts too outrageous NOT to share with you guys. Along with so many American industries have many lobbyists. I am surprised by these facts yet I'm not... ]]> Pharmaceuticals limitless_euphoria http://forum.opiophile.org/showthread.php?t=31453 Comprehensive Bioavailability Thread (For Oral Users) http://forum.opiophile.org/showthread.php?t=31426&goto=newpost Thu, 19 Aug 2010 01:08:05 GMT I've put together this little guide; based off the actual numbers in the product literature which is based from studies. It's been a while since my last genuine contribution to this site; I put this together in my free time and figured it would be of value to someone, even if only the belonephobes who haven't taken the plunge to IV use. ENJOY
__________________________________________________ _________________________

MORPHINE SULFATE ORAL (40 %) Based off product information for ORAMORPH
15mg: 6mg b/a
30mg: 12mg b/a
60mg: 24mg b/a
100mg: 40mg b/a

For an effect of 60 milligrams, a dose of 150 milligrams morphine must be taken orally.
__________________________________________________ __________________________

Hydromorphone Oral (25 %) Based off product information for ETHEX hydromorphone tablets
2mg: 0.5-0.75mg b/a
4mg: 1-1.5mg b/a
8mg: 2-3mg b/a
16mg: 4-6mg b/a

For an effect of 8 milligrams of hydromorphone, a total oral dose of 32 milligrams must be administered. 8 milligrams of hydromorphone crossing the BBB into the central compartment will produce a similar effect to 48 milligrams of morphine in the CNS (fully bioavailable).
In other words, a total oral dose of 32 milligrams hydromorphone will be comparable to 120 milligrams of morphine taken orally.
So according to the literature; hydromorphone is approximately 6 times stronger than morphine parenterally and 4 times stronger orally (due to it's oral bioavailability being lower than that of morphine)
__________________________________________________ ___________________________

Oxycodone IR Oral (90 %) Based off product information for ROXICODONE
5mg: 4.5mg b/a
10mg: 9mg b/a
15mg: 13.5mg b/a
30mg: 27mg b/a

Pretty straightforward. Generally, 30 milligrams of oxycodone taken orally, assures that 27 milligrams will make it to the central nervous system. In other words, 30 milligrams taken orally will produce an effect equivalent to 27 milligrams IV. Obviously, IV use carries little benefit over oral use, unless it's the rush you seek.
Also remember: When injected intravenously or intramuscularly, oxycodone is only 60 to 70 percent (figure 65%) as potent as parentarel (injected) morphine. Say you decide to inject 30 milligrams of oxycodone (a blue 'roxicodone' tablet); this will produce a similar effect to a 20 milligram shot of morphine sufate.

__________________________________________________ ____________________________

Oxymorphone Oral (10 %) Based off product information for OPANA (IR Version)
5mg: 0.5mg b/a
10mg: 1mg b/a
15mg: 1.5mg b/a
20mg: 2mg b/a
30mg: 3mg b/a
40mg: 4mg b/a

50mg: 5mg b/a
100mg: 10mg b/a

For users planning to consume oxymorphone orally, an entire 50 milligram dose is generally required for an effect of 5 milligrams: Note that 5 milligrams of oxymorphone (fully bioavailable) is approximately equivalent to 40 milligrams of morphine (fully bioavailable). In other words; A 50 milligram dose of oxymorphone taken orally, will be approximately equivalent to an oral morphine dose of 100 milligrams.
User should take into consideration the fact that a completely equivalent dose of oxymorphone may not be equivalent in subjective effects (euphoria, high, etc) to the equivalent dose of morphine sulfate. As we all know; euphoria, high, and overall kick does not coincide with equianalgesia . Every opioid has it's own individually unique properties in terms of 'glow'. ]]> Pharmaceuticals lespaulpower http://forum.opiophile.org/showthread.php?t=31426 <![CDATA[Been 'cleanish' for 6 weeks....Chipping?]]> http://forum.opiophile.org/showthread.php?t=31412&goto=newpost Wed, 18 Aug 2010 07:05:02 GMT OK, so I've been clean for about 6 weeks now, I got high for a couple days after 1 month, got 10 30s from a buddy, got wasted, didn't get anymore. I think I did pretty good. Was high as shit off 45 mg, that wouldn't even get me well a few weeks ago.

Here's the million dollar question: Is it ok to chip? EVER? How many folks here have successfully kicked, then are able to chip without getting another habit?

I don't think in 10 years I've really tried to make a good sober run like I am now...I really do want to stay clean for the most part, and it really hasn't been hard. I haven't even tried to get high, I live in the hood and have met people with anything I need (coke, dope, pills) and haven't even tried that route- didn't even get their #s when they told me to call them- that took some willpower.

So I REALLY don't wanna fuck this run up, but damn, I do like getting high. I'm a junky after all...

Has anyone been able to do this successfully? If I get a bunch of no's I'll just keep it cool, but if it IS possible I wanna get high once in a while. I'm going to SF for vacation next week and we're staying next to the TL even.... ]]> Pharmaceuticals Underdose http://forum.opiophile.org/showthread.php?t=31412 Illegal to hold onto pain meds after discard date? http://forum.opiophile.org/showthread.php?t=31290&goto=newpost Sun, 08 Aug 2010 04:54:59 GMT Hi all,
This might seem like a silly question but is it illegal to keep your pain meds past the "discard after" date? When I travel with my meds I always put a few in an old bottle, some bottles are over a year old (and expired). A friend told me it was illegal to possess controlled medication after they should have been thrown out - if you are no longer prescribed the drug. Sounds strange to me but I guess it could make sense if you no longer were prescribed the medication. If it weren't against the law you could reuse the prescription bottle for Vicodin you were given for getting your wisdom teeth pulled for years and years to avoid breaking the law while possessing the drug.
Does anyone know for sure? Now I am curious :p I searched everywhere and didn't find anything.
Thanks!!! ]]> Pharmaceuticals alleycat http://forum.opiophile.org/showthread.php?t=31290 What is the difference between an agonist and an antagonist? http://forum.opiophile.org/showthread.php?t=31274&goto=newpost Sat, 07 Aug 2010 07:11:51 GMT I've read the definition of an agonist and an antagonist but don't quite understand the difference between the two. So can some one give me a better definition of the two. Maybe more in laymen's terms?
Thanks everyone! ]]> Pharmaceuticals krinkov http://forum.opiophile.org/showthread.php?t=31274 Philips Pill Dispensing Machine for Home Use http://forum.opiophile.org/showthread.php?t=31251&goto=newpost Thu, 05 Aug 2010 22:47:19 GMT http://www.managemypills.com/content/

Check it out... this is what I was talking about in a thread I started ions ago. I was thinking of a sort of "time-lock" pill dispenser so that those of us who fiend through our benzos and/or opiates too quickly could have a machine do the daily rationing vs. burdening a family member (that will most likely end up annoyed).

I couldn't find exactly if this thing has a way to time-lock it or secure it (let's say if someone's in your house they can't just open it and see what goodies are inside INCLUDING YOU IF YOU WANT) so that you only get how many ever pills your supposed to get at whatever time. If there were a key or an override code you could give it to a trusted friend or family member who stays off the premises or is GOOD at hiding shit.

Has anyone seen one of these suckers? I saw this on TV so I googled it and there ya go...

P.S. I'm sure it's quite pricy and yes BML, as this is an afterthought, they'd have to make it out of steel! Even then there are burning bars! ]]> Pharmaceuticals limitless_euphoria http://forum.opiophile.org/showthread.php?t=31251