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		<title>Opiophile.org - Buprenorphine</title>
		<link>http://forum.opiophile.org/</link>
		<description>Topics concerning buprenorphine (subutex, suboxone, buprenex, temgesic) should be posted here.  Please use the appropriate sub-forums for posting about supply and online resources for bup.</description>
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			<title>Opiophile.org - Buprenorphine</title>
			<link>http://forum.opiophile.org/</link>
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		<item>
			<title>suboxone s new form</title>
			<link>http://forum.opiophile.org/showthread.php?t=31637&amp;goto=newpost</link>
			<pubDate>Thu, 02 Sep 2010 05:57:35 GMT</pubDate>
			<description>WASHINGTON -- The FDA has approved a new sublingual film formulation of the opioid dependence treatment combination buprenorphrine/naloxone (Suboxone). 
 
The new formulation will be released in the same 2 mg buprenorphrine/0.5 mg naloxone and 8 mg...</description>
			<content:encoded><![CDATA[<div>WASHINGTON -- The FDA has approved a new sublingual film formulation of the opioid dependence treatment combination buprenorphrine/naloxone (Suboxone).<br />
<br />
The new formulation will be released in the same 2 mg buprenorphrine/0.5 mg naloxone and 8 mg buprenorphrine/2 mg naloxone doses as the drug's sublingual tablet form.<br />
<br />
&quot;During clinical tests, Suboxone sublingual film was shown to be faster dissolving than Suboxone sublingual tablets,&quot; Shaun Thaxter, president of manufacturer Reckitt Benckiser Pharmaceuticals, said in a prepared statement.<br />
<br />
Drug approval included a risk evaluation and mitigation strategy program, which requires the company to monitor patients to determine whether potential treatment benefits outweigh potential risks, especially with accidental overdose, misuse, and abuse of the film, the brief said.<br />
<br />
The drug can be abused in ways similar to other opioids. Healthcare professionals should monitor patients for proper use, the company said in the statement.<br />
<br />
Buprenorphrine reduces patient opioid cravings and withdrawal symptoms, and also blocks the effects of other opioids. Naloxone triggers withdrawal symptoms in patients who crush and inject the drug, but has limited bioavailability when taken sublingually, and should cause no adverse events.<br />
<br />
Chronic use of the drug may result in physical dependence and a sudden or rapid decrease in dose may result in withdrawal symptoms, though the symptoms are milder and more delayed than those occurring with full opioid agonists, the brief said.<br />
<br />
Patients taking the film, particularly if injected or through other improper means and with central nervous system depressants, may experience life-threatening respiratory depression or death. Healthcare professionals should consider a reduced dose of the central nervous system depressant, the combination, or both when prescribing buprenophrine/naloxone, the statement said.<br />
<br />
Pediatric patients taking the drug may have severe, potentially fatal respiratory depression.<br />
<br />
Those taking the film should have liver function monitored before and during drug treatment.<br />
<br />
Patients who take the drug prior to use or abuse of other full agonists, such as heroin or oxycodone, may experience withdrawal symptoms due to interactions with the drug's naloxone.<br />
<br />
Healthcare professionals should only prescribe pregnant or nursing patients the drug combination if potential gain outweighs potential risk, due to possible neonatal withdrawal symptoms associated with the drug, according to the manufacturer.<br />
<br />
The drug is contraindicated in patients hypersensitive to buprenophrine or naloxone.<br />
<br />
Adverse events associated with the film include numb mouth, sore tongue, mouth redness, headache, nausea, vomiting, sweating, constipation, insomnia, pain, swelling of limbs, attention disturbance, palpitations, blurred vision, cytolytic hepatitis, jaundice, and anaphylactic shock.</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>clinton</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31637</guid>
		</item>
		<item>
			<title>(Suboxone) Whinging yankees, ORT and double dosing in Oz</title>
			<link>http://forum.opiophile.org/showthread.php?t=31624&amp;goto=newpost</link>
			<pubDate>Wed, 01 Sep 2010 02:01:06 GMT</pubDate>
			<description>You yankees (no dis intended) are very lucky you even have the option of titrating your dose at home! 
Here in the land of Oz that is impossible, as a patient on ORT, it is a  daily trip to the local pharmacy and a $5 dispensing fee, no matter wat ...</description>
			<content:encoded><![CDATA[<div>You yankees (no dis intended) are very lucky you even have the option of titrating your dose at home!<br />
Here in the land of Oz that is impossible, as a patient on ORT, it is a  daily trip to the local pharmacy and a $5 dispensing fee, no matter wat  dose, each and everyday...this includes haing tabs crushed (tho not  always) and having to wait 5-10mins after dosing before pharmacist will  let u leave. <br />
Well only another month wait before I can even apply to for 1 take-away dose!<br />
<br />
And you guys think ya got it tuff with you $150 scripts? Im paying  $140AUD a month and cant even leave the pharmacy with my medicine!<br />
END RANT<br />
<br />
Of course there is method to this madness, stopping diversion, stopping most any chance of an agonist high ect.<br />
....but of course some users will still 'spit back' for IV use. Abscess's, Candida infections ewwwwww<br />
<br />
ANYWAY...<br />
<br />
Now luckily for me on my 1month checkup visit, my GP psychiatry was so  very satisfied wit my progress she has given me the option of receiving  on request to the pharmacist a 2xdose (every 2nd day pick up if wanted)  GOD SEND!<br />
<br />
Curious for others opinions on this efficiacy of this double dosing method? <br />
<br />
My first 2xdose was yesterday (24mg). I def did notice a more 'kick ass' increase in  qualatative effects not just quantity.<br />
<br />
But any idea how this may affect my tolerance when going back to single dosing??<br />
Of course I dont want to be 2xdosing every 2nd day! but it is nice to  have the 2xdose option there for that lil bit more 'relief', especially  instead of having to swallow my dose for 2-3 daze or hoping that the  pharmacist doesnt crush my pills to help me titrate my dose.<br />
<br />
Back on topic while I think this double dose thing could work for me  from what Ive read (less is more) there is probably a lower dose range  where I could get similiar effects to my current dose and double dosing  regime..?<br />
BUT HOW THE FUCK DO I FIND THAT OUT!?</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>retrogradeamnesia</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31624</guid>
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			<title><![CDATA[Low-dose buprenorphine: I'm a believer!]]></title>
			<link>http://forum.opiophile.org/showthread.php?t=31620&amp;goto=newpost</link>
			<pubDate>Tue, 31 Aug 2010 21:59:07 GMT</pubDate>
			<description><![CDATA[As a follow-up thread, I thought I'd keep you posted on my dosing reduction plan with bupe. Friday morning was the last time I took 16 mg of sub. Saturday I took 2 mg, Sunday I think I took either 4 or 6 mg, yesterday I took 2 mg in the morning and...]]></description>
			<content:encoded><![CDATA[<div>As a follow-up thread, I thought I'd keep you posted on my dosing reduction plan with bupe. Friday morning was the last time I took 16 mg of sub. Saturday I took 2 mg, Sunday I think I took either 4 or 6 mg, yesterday I took 2 mg in the morning and 2 mg after work. This morning, as a treat, in addition to taking 2 mg I smoked a &quot;water pipe&quot; of &quot;tobacco.&quot; Dude, I was so fucking blasted between the two I almost started having a panic attack!<br />
<br />
When I showed up at work, my face was all warm, I felt great, chatty, less depressed. I didn't even smoke good stuff, just regular and I stayed buzzed for at least 2-3 hours. That buprenorphine is a different animal in lower doses.<br />
<br />
The only thing is, when I got home from work the yawning and the opio-jonsing started. So, I took another 2 mg. It hasn't kicked in but my world as I know it has been changed. I will no longer ever allow myself to take a dosage of more than 2 mg at a time. Even if I keep it at 2 mg BID every 12h I would be able to hoard my buprenorphine pills like mothafuckas. You never know, what if I become unemployed or uninsured?<br />
<br />
I was figuring the 2 mg thing was only holding me at first due to the residual bupe in my system. Now, given how bombed I got this morning, I'm starting to see what you low-dosers are talking about.<br />
<br />
It's almost like a full-agonist... not quite... but LESS really is MORE. You guys have been saying this for so long I'm kicking myself in the ASS for not trying to listen sooner.<br />
<br />
The weirdest part: I didn't even have to do this slow, arduous taper. Here it is a few days later and I'm cool with what I've got.<br />
<br />
Once I get used to 2 mg does it get even better at 1 mg or is there very little noticeable difference?<br />
<br />
Anyway, I had to share. For those of you who haven't tried it, do some experimentation. The worst thing that can happen is that you won't like it and you can stay at your dose. If you DO like it, you just found a way to save some loot! 8 mg pills are a bit of a pain to try to cut into quarters but I can get close enough with a splitter.</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>limitless_euphoria</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31620</guid>
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			<title><![CDATA[Pharmacist won't fill rest of sub's]]></title>
			<link>http://forum.opiophile.org/showthread.php?t=31606&amp;goto=newpost</link>
			<pubDate>Mon, 30 Aug 2010 15:06:13 GMT</pubDate>
			<description><![CDATA[My friend filled a partial script of sub's and when she went back to get the rest the bitch won't fill the rest of the script. Suboxone is a Shedule 3 so if the bitch doesn't want to fill the rest she should have to transfer to another pharmacy...]]></description>
			<content:encoded><![CDATA[<div>My friend filled a partial script of sub's and when she went back to get the rest the bitch won't fill the rest of the script. Suboxone is a Shedule 3 so if the bitch doesn't want to fill the rest she should have to transfer to another pharmacy right? She can't just make her lose the rest of the script can she? It's not too soon either it is time to get the rest.</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>dyrt57</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31606</guid>
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			<title>Low-dosing sub...Suboxtitute got me thinking?</title>
			<link>http://forum.opiophile.org/showthread.php?t=31565&amp;goto=newpost</link>
			<pubDate>Fri, 27 Aug 2010 21:46:58 GMT</pubDate>
			<description><![CDATA[I'm forever stuck at 16 mg of bupe per day. I try to go down and I get to like 8 or sometimes even 4 mg but then I start not feeling right. I've reduced very gradually too. It's like my body insists on X or else. 
 
She was saying she got down low...]]></description>
			<content:encoded><![CDATA[<div>I'm forever stuck at 16 mg of bupe per day. I try to go down and I get to like 8 or sometimes even 4 mg but then I start not feeling right. I've reduced very gradually too. It's like my body insists on X or else.<br />
<br />
She was saying she got down low and she's happier.<br />
<br />
I figured I'd ask her and all of you other guys who have cut back. How does low-dose feel compared to like 16 mg or 24 mg or even 32 mg. Someone break it down ass illustratively as possible. I'm trying to sell myself on this.<br />
<br />
Do tell.</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>limitless_euphoria</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31565</guid>
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			<title>Sub Dosage Q</title>
			<link>http://forum.opiophile.org/showthread.php?t=31564&amp;goto=newpost</link>
			<pubDate>Fri, 27 Aug 2010 21:38:51 GMT</pubDate>
			<description><![CDATA[Hey guys. I'm on 8mg/day and I was wondering if I will notice anything different if I only take say 6 or 4 mg instead? I got 2mg tablets because the 8s give me a hard time when trying to split them in half as I dose in the morning and at night. So...]]></description>
			<content:encoded><![CDATA[<div>Hey guys. I'm on 8mg/day and I was wondering if I will notice anything different if I only take say 6 or 4 mg instead? I got 2mg tablets because the 8s give me a hard time when trying to split them in half as I dose in the morning and at night. So now I take 2 2mg tablets in the morning and the same at night. Well I'm wondering if tonight I take 2mg instead of 4mg will I notice anything different? I still get a bit of a rush when taking sub and I don't want to lose what little it is :).</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>kevin</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31564</guid>
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			<title>someone gave a spec of sub to thier infant baby</title>
			<link>http://forum.opiophile.org/showthread.php?t=31510&amp;goto=newpost</link>
			<pubDate>Wed, 25 Aug 2010 03:53:45 GMT</pubDate>
			<description><![CDATA[Well it wasnt me and it just happened SWIM's friend gave thier baby a spec of suboxone... it was really small well at least swim thinks it was... swim was not there when it was givien but swims friend showed swim how small it was and said they left...]]></description>
			<content:encoded><![CDATA[<div>Well it wasnt me and it just happened SWIM's friend gave thier baby a spec of suboxone... it was really small well at least swim thinks it was... swim was not there when it was givien but swims friend showed swim how small it was and said they left it in for a like a minute then gave the bottle to the baby... Swim is worried about the infant do you think if what swim's friend is saying is true swim's friends baby will be all right?:(</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>ill_motions</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31510</guid>
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			<title>I suck</title>
			<link>http://forum.opiophile.org/showthread.php?t=31505&amp;goto=newpost</link>
			<pubDate>Tue, 24 Aug 2010 23:49:10 GMT</pubDate>
			<description><![CDATA[Dosed 2mg sub at 11am when I woke up... Didnt really hold me over and I was still feeling kinda achy and I was bored as hell all day just thinking about 80s...  
 
An 80 wouldn't get me high normally, let alone after dosing sub during the same day.....]]></description>
			<content:encoded><![CDATA[<div>Dosed 2mg sub at 11am when I woke up... Didnt really hold me over and I was still feeling kinda achy and I was bored as hell all day just thinking about 80s... <br />
<br />
An 80 wouldn't get me high normally, let alone after dosing sub during the same day.. and I knew it would be so stupid to waste $50 bucks on one, but I couldn't stop thinking about the tasty drip...<br />
<br />
So of course, my junkie mind went out and copped an 80...<br />
<br />
and to my surprise, I'm RIPPED! This is so awesome!<br />
<br />
...Nah, just kidding. I dont feel shit and I wasted money. Feeling like an idiot and pissed off at myself because I'm trying to stop using DOC before going to school on the 4th, and doing DOC while on subs is the last thing I need to be doing.<br />
<br />
I suck.</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>maycausedrowsiness</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31505</guid>
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			<title>Needing advice on starting either sub or methadone treatment.....</title>
			<link>http://forum.opiophile.org/showthread.php?t=31494&amp;goto=newpost</link>
			<pubDate>Tue, 24 Aug 2010 05:03:48 GMT</pubDate>
			<description><![CDATA[I need some advice on which treatment is better for getting off norco's 10/325 15 to 22 a day?  I have tried to taper but I can't do that because if I have them I will eat them as most of on her know.  I am getting the pro and con list for either...]]></description>
			<content:encoded><![CDATA[<div>I need some advice on which treatment is better for getting off norco's 10/325 15 to 22 a day?  I have tried to taper but I can't do that because if I have them I will eat them as most of on her know.  I am getting the pro and con list for either suboxone or methadone,  and what better place is there on getting good advice??     Thank you all any input would be MUCH helpful.<font color="Silver"><br />
<br />
<font size="1">---------- Post added at 12:03 AM ---------- Previous post was at 12:02 AM ----------</font><br />
<br />
</font>yeah my spelling isn't the best........the sentence is supposed to read as most of us on here know.</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>tina</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31494</guid>
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			<title>Those on BMT long-term, do you ever wish you could get off of it?</title>
			<link>http://forum.opiophile.org/showthread.php?t=31467&amp;goto=newpost</link>
			<pubDate>Sun, 22 Aug 2010 00:56:48 GMT</pubDate>
			<description><![CDATA[I've been on buprenorphine maintenance treatment (BMT) for over two years now. Since then, I've tried to detox myself from it a couple of times. The longest I went was 3 and 1/2 weeks. It was during a period when I was having severe financial...]]></description>
			<content:encoded><![CDATA[<div>I've been on buprenorphine maintenance treatment (BMT) for over two years now. Since then, I've tried to detox myself from it a couple of times. The longest I went was 3 and 1/2 weeks. It was during a period when I was having severe financial troubles and could not afford to see my doc; I was getting juiced on a shitload of credit card debt as well as two mortgages so I thought I could stop.<br />
<br />
It didn't work. I got sick and tired of feeling sick and tired as well as severely depressed, so, I re-inducted.<br />
<br />
The other time, I couldn't even taper beyond 4 mg. I tried and tried but it was worse than the first time, so, I went back again.<br />
<br />
I swear the longer you're on it, the harder and harder and harder it gets to get off of it.<br />
<br />
I don't know, the thought of being a lifer on this stuff is kind of depressing to me. I know for a fact that it lowers my sex drive (as opiates in general reduce testosterone production) and I feel like I'm not satisfying Mrs. LE as often as I could. Really what I do is go off for like 3 days and then I'm horny again like in my late teens/early 20s. I really miss being able to go #2 without quite the effort. What's more, sometimes I think it does kind of numb me emotionally. I never seem to experience happiness the way I remember it pre-opiate usage overall.<br />
<br />
I miss the times when I would clean up off dope (pre-2006) by using subs to detox over a couple of weeks and feel like a normal human being. Once I went on my nearly two year run after that with doing 1-2g+ of uncut H per day with very, very little clean time (as well as graduating to IV/IM), We're talking five days here, 10 days there. I think I permanently fried the pathways in my brain. Then again, I never stayed on bupe much longer than three months at a clip.<br />
<br />
To you guys who have recently gone on bupe, I really think you should be keenly aware that a lot more users than me have given testimonials that the longer you're on that shit, the harder it will get to even want to end.<br />
<br />
I feel like the only way I'd stand a change is like 90 says in rehab which is JUST NOT FEASIBLE.<br />
<br />
From what my sub doc says, he thinks that people who have abused opiates for many years should just stay on. He says that your body changes permanently and even though some people can go months clean w/o, from what he's seen, sooner or later a stressor will precipitate a relapse.<br />
<br />
I guess I should just be grateful that I've been able to turn my life around, grow up, get gainful employment, be a good Dad to the kids and a better husband and friend to people in general.<br />
<br />
So, how do you guys on bupe for the long-term feel about it? Do you often almost feel ashamed? Do you ever feel like the thought of being a lifer is sort of depressing? I'm curious, as always, to read feedback and thoughts on the matter.</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>limitless_euphoria</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31467</guid>
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			<title>Odd effect when switching from subs to regular opies</title>
			<link>http://forum.opiophile.org/showthread.php?t=31363&amp;goto=newpost</link>
			<pubDate>Sat, 14 Aug 2010 00:53:40 GMT</pubDate>
			<description><![CDATA[This is a bit trivial but hey, I'm bored and high and felt like posting. ;) 
 
When I'm maintaining myself on suboxone I normally take only small doses of 1-2mg per day which holds me just fine. When I want to get high, I don't have to wait long at...]]></description>
			<content:encoded><![CDATA[<div>This is a bit trivial but hey, I'm bored and high and felt like posting. ;)<br />
<br />
When I'm maintaining myself on suboxone I normally take only small doses of 1-2mg per day which holds me just fine. When I want to get high, I don't have to wait long at all before doing my DOC - sometimes I hit it as soon as 6 hrs later. I imagine that the reasons I can do this are the low dose of bupe and my very high metabolism. Sometimes I take a little bit more of my DOC to burn through the blocking effect, but not much.<br />
<br />
Anyway, this is what I have found. When not on subs any time that I shoot morphine, I get the familiar histamine release with associated itching, red skin, and minor &quot;pins and needles&quot;. However, when switching from subs the first couple of shots of morphine have a different type of histamine reaction. There is very little itching and red skin but the &quot;pins and needles&quot; are more like &quot;nails and spikes&quot;. I mean <i>very</i> uncomfortable for about 30-60 sec. Even stranger, instead of the reaction being localized around the injection site, the discomfort is around the upper shoulders and neck area right up to about my ears. Quite odd if you ask me. I'm sure there's a good explanation for it but I know it's not from any increase in the morphine dosage because I don't always use any extra and still get them same reaction. Also, when I do an extra big shot of morph when not currently on subs I get the normal histamine effects at and around the injection site.<br />
<br />
Like I said, it's pretty inconsequential but I've never seen this mentioned before and I'm just curious. Anyone else experience something like this or am I just &quot;special&quot;?  :confused:<br />
<br />
Regards,</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>D-Stabilized</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31363</guid>
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			<title>Naloxone (Narcan) in Suboxone - The Facts</title>
			<link>http://forum.opiophile.org/showthread.php?t=31346&amp;goto=newpost</link>
			<pubDate>Thu, 12 Aug 2010 03:05:22 GMT</pubDate>
			<description><![CDATA[I started to post this as a reply in an earlier thread of mine titled "Low dose bupe = bad headaches" (see: http://forum.opiophile.org/showthread.php?p=521348#post521348 ) but it soon became too long and off-topic, hence I am posting it in a new...]]></description>
			<content:encoded><![CDATA[<div>I started to post this as a reply in an earlier thread of mine titled &quot;Low dose bupe = bad headaches&quot; (see: <a href="http://forum.opiophile.org/showthread.php?p=521348#post521348" target="_blank">http://forum.opiophile.org/showthrea...348#post521348</a> ) but it soon became too long and off-topic, hence I am posting it in a new thread.<br />
<br />
I was doing a little light reading about suboxone in general and naloxone (Narcan) in particular. I was curious as to why the manufacturers continue to produce this formulation despite it being well known that it in fact does NOT generally discourage IV use of the drug. Sure, some people who have only read the product insert or other &quot;official&quot; information on the web may be put off (at least temporarily) but I've not yet come across anyone who said that the naloxone ruined their IV suboxone experience. Apparently, the buprenorphine is not displaced to any significant degree by the naloxone so why continued to put it in there? It's just hype if you ask me. Here's a couple of interesting things that I found out along the way:<br />
<br />
From rxlist.com - <div style="margin:20px; margin-top:5px; ">
	<div class="smallfont" style="margin-bottom:2px">Quote:</div>
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			<hr />
			
				&quot;NARCAN (naloxone hydrochloride injection, USP), an opioid antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group&quot;.
			
			<hr />
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	</tr>
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</div>Wow. Naloxone, the quintessential &quot;anti-opiate&quot; is actually derived from oxymorphone, possibly the best opie there is! (BTW: If you haven't IV'd oxymorphone, then you only THINK you know what a &quot;rush&quot; is.) In retrospect I guess it makes sense, though. Being structurally very similar to oxymorphone, naloxone can then bind to the same receptors but the replacement of the methyl group with an allyl group somehow changes its effect from that of a strong opioid agonist to an opioid antagonist. Amazing what a big difference a small change in structure can make.<br />
<br />
The dosage of naloxone in suboxone is not small in relation to the dosage of buprenorphine. In fact the starting dose of naloxone in a drug overdose situation is only 0.4mg to 2mg and it can be effective in doses as low as 0.1mg for partially reversing opioid effects after surgery. Considering that a single 8mg tablet of suboxone contains 2mg of naloxone, this is a significant amount. I've seen what a single dose of Narcan can do for a person who has seriously overdosed on opiates and the effects can be dramatic. We're talking about going from barely breathing (or not breathing at all) to seemingly normal in less than a minute. Kinda like throwing a bucket of ice water on a sleeping person. So this tells me that a &quot;normal&quot; dose of naloxone, while extremely effective against the effects of full opioid agonists, is unable to do the same against buprenorphine. So again, why put the shit in there unless it's just a ploy to discourage IV use? After all, what opiophile wants to hear that the drug they are about to inject has Narcan in it?<br />
<br />
Again from rxlist.com: <div style="margin:20px; margin-top:5px; ">
	<div class="smallfont" style="margin-bottom:2px">Quote:</div>
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				&quot;Since the duration of action of some opioids may exceed that of NARCAN, the patient should be kept under continued surveillance. Repeated doses of NARCAN should be administered, as necessary.&quot;
			
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</div>Well, there ya go again. If naloxone has a relatively short duration of action in relation to some (most) opiates, then surely bupe with its very long duration of action (half life=~36 hrs.) will far outlast the effects of naloxone (half life=~60 mins.). Its inclusion just doesn't make sense. In fact, rxlist.com has this to say on the matter: <div style="margin:20px; margin-top:5px; ">
	<div class="smallfont" style="margin-bottom:2px">Quote:</div>
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				&quot;Large doses of naloxone are required to antagonize buprenorphine since the latter has a long duration of action due to its slow rate of binding and subsequent slow dissociation from the opioid receptor.&quot;
			
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</div>How about this excerpt: <div style="margin:20px; margin-top:5px; ">
	<div class="smallfont" style="margin-bottom:2px">Quote:</div>
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			<hr />
			
				&quot;Abrupt reversal of opioid depression with Narcan may result in nausea, vomiting, sweating, tremulousness, tachycardia, increased blood pressure, seizures, ventricular tachycardia and fibrillation, pulmonary edema, and cardiac arrest which may result in death.&quot;
			
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</div>Yeah, that sounds like something that should be in there. This stuff is supposed to protect the user from harm. Hmmm...<br />
<br />
<u><b>Conclusion:</b></u><br />
<br />
The following statement taken directly from <a href="http://www.suboxone.com:" target="_blank">www.suboxone.com:</a> <div style="margin:20px; margin-top:5px; ">
	<div class="smallfont" style="margin-bottom:2px">Quote:</div>
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				&quot;The naloxone in SUBOXONE is there to discourage people from dissolving the tablet and injecting it. When SUBOXONE is placed under the tongue, as directed, very little naloxone reaches the bloodstream, so what the patient feels are the effects of the buprenorphine. However, if naloxone is injected, it can cause a person dependent on a full opioid agonist to quickly go into withdrawal.&quot;
			
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	</table>
</div>is patently false. Naloxone compounded at a 1:4 ratio with buprenorphine is physiologically ineffective as a deterrent to injecting suboxone. Therefore its only purpose is to serve as a scare tactic to those unfamiliar with the drug and willing to believe anything they read, especially when it comes from an official source. While of no real benefit to the user, the naloxone in suboxone is itself not a safe drug and should not be given to hundreds of thousands (possibly millions) of people worldwide as a matter of course. All drugs have associated risks and a certain percentage of the population will experience the negative effects of a given drug. Preparations of buprenorphine without the addition of naloxone, such as Subutex are the only proper way to administer this drug.<br />
<br />
Regards,</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>D-Stabilized</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31346</guid>
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			<title>Anyone else now REQUIRED to take a piss test at a third party???</title>
			<link>http://forum.opiophile.org/showthread.php?t=31325&amp;goto=newpost</link>
			<pubDate>Tue, 10 Aug 2010 20:59:24 GMT</pubDate>
			<description><![CDATA[for some reason my doc changed shit from the "random pick a card" piss test he was doing in his office...to basically sending patients to a third party to get a piss test that has to then be confirmed by a lab. on the bottom of this paper is says...]]></description>
			<content:encoded><![CDATA[<div>for some reason my doc changed shit from the &quot;random pick a card&quot; piss test he was doing in his office...to basically sending patients to a third party to get a piss test that has to then be confirmed by a lab. on the bottom of this paper is says something to the effect of this is not a suspicion of you using illegal drugs. these are new rules that have been enacted by the DEA for all suboxone/subutex programs.<br />
<br />
it pissed me off cuz the first place i went to get this stupid piss test done wanted to charge me 300$...for fucks sake yo...anyway i called my doctor and bitched and he gave me this other place that only charged 49.99$...but either way the shit pisses me off..<br />
<br />
now right when he gave me the notice, i told him up front just like when he first gave me the warning he was gonna start doing piss testing..that yes i'm gonna be hot for weed...i still occasionally smoke and i don't see a problem with it so i'm gonna come up hot for weed...are you gonna kick me out or is it gonna be a problem...and he said no again and that he doesn't care about weed..just other hard core drugs..<br />
<br />
the point of this post is...does anyone else have to deal with this shit? does anyone know anything about why i gotta do this shit? is this just cuz the DEA is coming down hard on my doctor personally..or are these new rules...?? i found out my doc went to rehab like 3 years ago so maybe the DEA is doing something to him..i dunno but someone enlighten us cuz this shit is pissing me off...more fucking money i gotta spend on this bullshit that i don't get a TRUE opiate high from...god dammit..</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>kill</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31325</guid>
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			<title>Low dose bupe = bad headaches</title>
			<link>http://forum.opiophile.org/showthread.php?t=31320&amp;goto=newpost</link>
			<pubDate>Tue, 10 Aug 2010 05:32:08 GMT</pubDate>
			<description><![CDATA[As the title implies, I am taking low daily doses of buprenorphine (suboxone), usually 1 to 2 mg. On at least 4 out of 5 days I get intense headaches that don't respond APAP, Advil, Motrin, Aleve, etc. I have a fairly high tolerance for pain and can...]]></description>
			<content:encoded><![CDATA[<div>As the title implies, I am taking low daily doses of buprenorphine (suboxone), usually 1 to 2 mg. On at least 4 out of 5 days I get intense headaches that don't respond APAP, Advil, Motrin, Aleve, etc. I have a fairly high tolerance for pain and can put up with an occasional headache but these things are nearly every day, are severe enough to be disruptive, and usually last until I sleep them off. I'm self-administering the subs so I can't ask my doctor about it. Anyway, I get much better information on here anyway. I didn't see much of anything about this in the forums or on the internet in general other than headaches being listed as a possible side effect.<br />
<br />
How common is this? Any suggestions on preventing and/or dealing with it? I'm gonna try to get my hands on some subutex just to see if the naloxone component in suboxone is the culprit, otherwise I have no idea what to do.<br />
<br />
Thanks in advance...</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>D-Stabilized</dc:creator>
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			<title>End of Taper Slip</title>
			<link>http://forum.opiophile.org/showthread.php?t=31269&amp;goto=newpost</link>
			<pubDate>Sat, 07 Aug 2010 01:35:16 GMT</pubDate>
			<description>OK. So Ive been a reader of these forums since Ive joined, but never really had needs to post because I can usually find what I am looking for through the search. I did find a guide to subs that Duckfeet posted in another thread which helped a lot,...</description>
			<content:encoded><![CDATA[<div>OK. So Ive been a reader of these forums since Ive joined, but never really had needs to post because I can usually find what I am looking for through the search. I did find a guide to subs that Duckfeet posted in another thread which helped a lot, and I think it should be a sticky, but I still have some questions specific to me.<br />
<br />
Ive been using either H, methadone, or Suboxone for the past two years, and Suboxone for the past eight months. For the past two months Ive gone from using subs to taking a week break or so on H to back on subs. Each time was roughly a week to two weeks vacation to my DOC. Now for the past eight days I used a taper with the amount of subs I was able to buy from a friend. I had to do this because I lost my sub script for missed appointments and a dirty UA, and the taper went like this starting with day 1<br />
1. 8mg 2. 4mg 3. 6mg 4. 3mg 5. 2mg 6. 2mg 7. 1mg 8. 1mg day eight being today. The plan was to jump after my second day (day 10) at what I think is .5mg. I am unsure about the mg because i only had 8 mg tablets, and its just hard to be sure that its 0.5mg after its been broken up so many times.<br />
<br />
Here is where I seek advice. Today I sought out some H to aid me in the w/ds that the jump from subs would bring (I was terrified by some of the stories I read and wanted to be ready). Of course being the junky that I am i found myself pushing off as soon as I got home. I know in the guide that Duckfeet posted from a different thread said that using your DOC ,although a slippery slope, is a way to combat Sub w/ds, and that was about all it said. I am wondering if: I totally screwed myself by using today, by using H will I just reset myself to the beginning of w/ds, if anyone has successfully used their DOC to combat the sub w/ds(of course w/o getting hooked back on their DOC), and how I should proceed from here? <br />
<br />
PS I also have a slow metabolism just a FYI, and sorry if this was something that was specifically covered in another thread I searched but maybe my search wasn't good enough. Thank you :)</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>Eacey</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31269</guid>
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			<title>Subs or dope</title>
			<link>http://forum.opiophile.org/showthread.php?t=31267&amp;goto=newpost</link>
			<pubDate>Fri, 06 Aug 2010 20:57:22 GMT</pubDate>
			<description><![CDATA[So I posted a week back in the oxycodone section about getting clean and not knowing what to do.  
It's now been a month and as I mentioned in my previous post I still have the shits. I'm getting kinda worried has anyone ever been this far into it...]]></description>
			<content:encoded><![CDATA[<div>So I posted a week back in the oxycodone section about getting clean and not knowing what to do. <br />
It's now been a month and as I mentioned in my previous post I still have the shits. I'm getting kinda worried has anyone ever been this far into it and still had this problem? Also I do feel so much better but am debating going back on due to the fact that I move back home in two weeks and am worried I'll try and get high. <br />
<br />
I've never in 8 yrs on oxy been completely clean I was either on the ox or on subs. So could this be normal to still have slight symptoms after such a long stint or no?  <br />
<br />
A month is a long time to be clean, at least for me, so part of me says no fucking way back to subs cuz that shit is harder than oc to kick for me and if I happen to use once or twice it's better than dozing everyday an going through sub hell again for a month and counting. <br />
<br />
Opinions? Advice?</div>

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			<category domain="http://forum.opiophile.org/forumdisplay.php?f=11">Buprenorphine</category>
			<dc:creator>yankee11</dc:creator>
			<guid isPermaLink="true">http://forum.opiophile.org/showthread.php?t=31267</guid>
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			<title>Suboxone is one hell of a drug</title>
			<link>http://forum.opiophile.org/showthread.php?t=31232&amp;goto=newpost</link>
			<pubDate>Wed, 04 Aug 2010 23:14:32 GMT</pubDate>
			<description><![CDATA[Seriously, Suboxone is one hell of a drug.  So check this out. 
  
My girlfriend, who's on suboxone, came to visit me a few weeks ago.  Before she left, I asked her for a suboxone for when the day comes when I can't score.  She told me she didn't...]]></description>
			<content:encoded><![CDATA[<div>Seriously, Suboxone is one hell of a drug.  So check this out.<br />
 <br />
My girlfriend, who's on suboxone, came to visit me a few weeks ago.  Before she left, I asked her for a suboxone for when the day comes when I can't score.  She told me she didn't have any extra, but she gave me about 10 cottons ( she IV's) that she used to filter her suboxone.  So I stashed them away and kept using for another 3 weeks.  Well, 3 days ago the day came when I was out of money and out of dope.  I was pretty sick and remembered those cottons she gave me.  I put one cotton in a spoon, added water, smashed and stirred it around real good.  I really was not expecting this to do ANYTHING, as I had been banging about 2 grams of tar a day for the past 2 months.  Well, I was wrong.  I instantly felt relief from the W/D's.  I actually caught a little buzz, too!  I mean, this is crazy, isn't it?  The rinse of a single suboxone cotton gets me well?  I mean, the shot barely had any orange to it....couldn't have been more than .1 mg.  So I've done this three days in a row now and have felt no W/D's at all....<br />
 <br />
Just thought I'd share this with everyone to show how crazy of a drug suboxone is.</div>

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