loperamide

[jonny-5]

i came across this on wikipedia, and thought it was really interesting cause i never knew this. Posting it here cause i'm sure someone else will too. oh ya and for those who dont know, loperamide is immodium.

"
When loperamide is taken by itself, it cannot readily cross the blood-brain barrier (http://en.wikipedia.org/wiki/Blood-brain_barrier); however, when loperamide-containing nanoparticles are coated with polysorbate 80 (http://en.wikipedia.org/wiki/Polysorbate_80) and injected, the results were the same as typical opiates and opioids -- long, effective analgesia (http://en.wikipedia.org/wiki/Analgesia). A solution prepared using loperamide coated with polysorbate 80 resulted in a very short duration of action and less effective analgesic effect. The same study concluded that loperamide does not cause any analgesic effects when taken by itself.[2] (http://en.wikipedia.org/wiki/Loperamide#_note-1)
Concurrent administration of P-glycoprotein inhibitors with loperamide has been found to produce respiratory depression, indicative of central opioid action. [3]" (http://en.wikipedia.org/wiki/Loperamide#_note-2)

[JonnyMohawk]

i came across this on wikipedia, and thought it was really interesting cause i never knew this. Posting it here cause i'm sure someone else will too. oh ya and for those who dont know, loperamide is immodium.


We've already had quite a few posts about that. I would say on many occasions I have taken about 48 to 60 along with some hydroxyzine and grapefruit juice and got a slight buzz. Either way it sure fucking helps with wd's.

[(inaudible screams)]

Either way it sure fucking helps with wd's.

Is your main reason for taking the immodium for its intended purpose? I definitely make sure I have a box on hand when supplies are running low. Obviously it stops the liquid hot magma from spewing out of my body, but I personally don't notice any other benefits for w/d. Maybe I need to take more next time......

[Dan Steely]

I remember someone with a 50 mg/day hydro habit saying 12 2mg pills alleviated all physical wd symptoms so most opi addicts are gonna need a lot of them. You better get yer shittin done first cause that stuff will def stop that action.