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the morphine the better
06-20-2007, 04:43 AM
I came across this article... I have a feeling this is complete bullshit. Tell me if its true.. It came from

http://www.thatspoppycock.com/articles/2006_11_29_otc_ops.htm

heres the article:

Over-the-counter opiates used to stop diarrhea and maybe ease withdrawal
by Chris Strosser
11/29/06

Discussion: http://www.thatspoppycock.com/phpBB2/viewtopic.php?t=20


Did you know that opiates (http://www.thatspoppycock.com/opiates/opiates.htm) can be found over-the-counter at your local drugstore? It's true, and anyone can buy them. In fact, they aren't even restricted to those under 18. Loperamide, meperidine's weird distant cousin, and the active ingredient in Imodium AD, is an opioid. Diphenoxylate, also an opioid, is the active ingredient in Lomotil, which is also used to stop diarrhea. One annoyingly persistent side effect (http://www.thatspoppycock.com/library/opiate_basics.htm#effects) of all opiates is constipation.


The inner workings
Opiates (http://www.thatspoppycock.com/opiates/opiates.htm) cause constipation by binding to opioid receptors (http://www.thatspoppycock.com/library/opiate_basics.htm#receptors) throughout the gastrointestinal tract. This binding causes muscles in the gastrointestinal tract to become tense. The increased muscle tension causes the normal progressive movement of food waste to stop—thus, causing the infamous, unrelenting, opiate-induced constipation. Though a powerful effect is exerted on the gastrointestinal tract, loperamide and diphenoxylate do not affect the brain. Ultimately, this means no euphoric high. The powerful high is avoided because the molecules cannot cross the blood-brain barrier which works sort of like a "drug filter." Typical opiates (http://www.thatspoppycock.com/opiates/opiates.htm) are fat-soluble enough to cross the BBB, and bind to opioid receptors (http://www.thatspoppycock.com/library/opiate_basics.htm#receptors) in the brain.


From controlled substance to over-the-counter wonder
When loperamide was first introduced to the public, it was classified as a Schedule V controlled substance. This was done because opiate withdrawal symptoms (http://www.thatspoppycock.com/articles/library/opiate_basics.htm#withdrawal) were present upon abrupt cessation of long-term therapy with lopermide. It was eventually downgraded to nothing more than an over-the-counter medicine. Recent studies have put forth evidence that it is possible to get the molecules across the BBB. "Drug-containing nanoparticles were coated with polysorbate 80 and injected intravenously into mice." A prolonged, as well as significant analgesic effect occurred upon injection of the coated loperamide.


As withdrawal treatment?
Loperamide may also work as an aid in detoxification. Several medical journals, as well as a countless unofficial accounts report significantly diminished withdrawal symptoms (http://www.thatspoppycock.com/library/opiate_basics.htm#withdrawal) upon dosing loperamide; however, there is a lot of mixed information on this topic. It will, at the least, get rid of the gut-retching diarrhea that comes with most opiate detoxifications. It works for some, and doesn't work for others. As always, you should check with your doctor before starting any sort of withdrawal treatment (http://www.thatspoppycock.com/addiction/otc_comfort_meds.htm).



I dunno seems a little fishy to me.

youwonhundred
06-20-2007, 04:53 AM
No, its not complete bullshit, loperamide IS an opiate, technically speaking, but due to its high molecular weight, it doesn't cross the BBB, so no high. At least, thats my understanding of it, and quite oversimplified I am certain, but it does help ease withdrawal. When coupled with a xanax or two, withdrawal is almost tolerable. Thing is, you need to take like 10-12 mg instead of 2-4mg (the standard dosage listed on the package for diarrhea), but it DOES work.

And if i explained that poorly, someone please fix me cause I'm slightly bent at the moment... Damn I love refill day,:D

Skript
06-20-2007, 05:00 AM
I came across this article... I have a feeling this is complete bullshit. Tell me if its true.. It came from


Poppycock is a legit site with lots of good info... Try using the search engine or doing a little more research yourself before calling bullshit..

the morphine the better
06-20-2007, 05:18 AM
Poppycock is a legit site with lots of good info... Try using the search engine or doing a little more research yourself before calling bullshit..

I really am trying to understand why it is SUCH A BIG DEAL to ask a question that someone once may have already posted? Did I ever call the site bullshit? I asked if it was legit. I asked if the info was bullshit. I never ragged on anything. It's not like asking a question about CWE which is all over the forum.

I am truly sorry I took up so much valuable internet space and bogged down your brain to the point that you got pissy.

It's so weird when people take something like asking a question that may have already been answered or questioning the legitimacy of something as such a huge deal....

Calm down, everything will be fine.

Expecting more flamers.

youwonhundred
06-20-2007, 05:50 AM
I really am trying to understand why it is SUCH A BIG DEAL to ask a question that someone once may have already posted? Did I ever call the site bullshit? I asked if it was legit. I asked if the info was bullshit. I never ragged on anything. It's not like asking a question about CWE which is all over the forum.

I am truly sorry I took up so much valuable internet space and bogged down your brain to the point that you got pissy.

It's so weird when people take something like asking a question that may have already been answered or questioning the legitimacy of something as such a huge deal....

Calm down, everything will be fine.

Expecting more flamers.

I don't think either response you got were the least bit "pissy". My personal favorite variation of UTMFSE is http://www.justfuckinggoogleit.com (http://www.justfuckinggoogleit.com/)

the morphine the better
06-20-2007, 05:54 AM
I don't think either response you got were the least bit "pissy". My personal favorite variation of UTMFSE is http://www.justfuckinggoogleit.com (http://www.justfuckinggoogleit.com/)

Only Skript seemed pissy.. hahah at least your response is funny!

youwonhundred
06-20-2007, 06:09 AM
Only Skript seemed pissy.. hahah at least your response is funny!

Yes, yes, humor is vital to survival. But honestly dude, if he was being pissy, he would have been a lot more so. Skript sounded downright POLITE, iff'n ya ask me.:p Thing is, if a question has been discussed repeatedly, the answer is probably (not always, and sometimes its hard to weed out the actual answer from the other assorted bullshit in various threads) going to be easy to find. Neither of us were deliberately trying to be dicks about it (at least I don't think so) but you can check wikipedia or damn near any other source that google pops up, and with just a basic level of reading comprehension (not calling you stupid, I'm just sayin, the answer is there) you could have answered your own question in about 30 seconds. Loperamide IS an opiate, and it may not work for everyone, but it works for me, as I previously stated, at doses from 10-12 mg, about every 8 hours or so. You won't be high, but you will get some relief from it. I keep a bottle handy at all times, and its saved my ass many times.Toss in some xanax and a couple warm blankets and a huge hot water heater (hot showers help a lot too) and its not half bad.

I realize that I am quite rambly tonight, but I can't seem to say everything I need to say in a concise manner. I think, honestly, that its because I've been on the verge of withdrawal for the past week, and now that I have two full bottles, I can actually put forth the effort to post at all, so I am making up for lost time or whatever.

Point is, it can't hurt, it might help, and at the very least, you won't have to combat the trouser chili attacks that drive me utterly fucking nuts during w/d, you dig? Dammit, now I need some fucking weed, and life would be complete for the moment. Unfortunately, the pot man ain't awake at 4am.

Skript
06-20-2007, 06:24 AM
Only Skript seemed pissy.. hahah at least your response is funny!

What kind of answer do you expect?
You asked if the article was true. I told you it was a legit site, matter of fact the entire site is opiate related. Why would you think it was bullshit?

I simply suggested you search the forum as this has been beaten to death over and over again. If you had any bit of interest in the subject you could have simply looked up the word Loperamide rather than post a stupid question when all the info is right in front of your face.

I dont understand why users have to be so defensive when we are just trying to help them out. If I wanted to be PISSY I would have said UTMFSE..

superman
06-20-2007, 07:53 AM
It's not like asking a question about CWE which is all over the forum.

actually, it's EXACTLY like asking about CWE. this shit is common knowledge around here man, it's everywhere.

if you want to fit in here, don't ask to be spoonfed information. this website is a fucking database man, use the search function.

Euphoricgirl
06-20-2007, 07:57 AM
Boys, play nice or you will each have to stand in the corner. ;)

CSiiSEQ
06-20-2007, 10:12 AM
There's really only one piece of info that isn't correct in the section posted. Lomotil is not OTC, it's rx (at least in the US) and also contains atropine to discourage abuse. it's much harder to get an effective dose (to help with w/d) with lomotil than loperamide without having lots of adverse effects from the atropine.

There really is quite a bit of info on lope around here if you're more interested. I would search lope, loperamide and immodium to get to all of it. I used to use it frequently for this reason, haven't in quite a while. It does help when there is nothing else available.

Wrt getting it to cross into the brain, that is getting into a pretty dangerous area. There was just an article published by the place I work at that talked about the dangers of nanoparticles and how we don't know and really won't know (until something happens) what kind of effect they will have on humans. They were comparing it to things like CFC's in aerosols- it wasn't until they had been around for awhile that people started discovering the bad side of them. Kind of getting off the topic now, but I have no desire to make my bbb more permeable to anything, I think I damage it enough on my own!

LegalizeOpiates
06-20-2007, 09:15 PM
Only Skript seemed pissy.. hahah at least your response is funny!


yeah well if you would have taken the extra minute to use the search option before posting you would notice that there is a TON of information about loperamide on here.

stross
06-21-2007, 04:23 PM
This post makes me smile... haha.

renton
06-25-2007, 05:32 PM
I think the feds are pretty careful to make sure there's no drug which is OTC which has recreational value unless they make sure it has some other garbage in it that makes it dangerous to take to get high. That's the problem with DXM, it's one of the few that can get you high so they make sure to add all sorts of nasty stuff that makes you puke your guts out if you try in order to "protect" you ;) Even here in Canada where Codeine is OTC they add caffeine and tylenol to make it hard for anyone to get any sort of buzz off it, sadly allot of people don't realize this and try taking a bunch without doing a cold water extraction and they end up in the ER.