levorphanol - Anyone?

[Synack]

Has anyone here taken the oral form of levorphanol tartrate - 2mg is the standard dose. I'm wondering if you feel the same warmth that you do with something like oxycodone?

[Hammilton]

Maybe if your tolerance is nil. If I'm not mistaken it's a partial-agonist, and isn't likely to be any fun at all if you're an addict

[Synack]

well, damn reading this: http://pub.ucsf.edu/newsservices/releases/2003071810/ it sounded pretty good.

edit:

Interactions with Mixed Agonist/Antagonist Opioid Analgesics

Agonist/antagonist analgesics (e.g., pentazocine, nalbuphine, butorphanol, dezocine and buprenorphine) should NOT be administered to a patient who has received or is receiving a course of therapy with a pure agonist opioid analgesic such as Levorphanol. In opioid-dependent patients, mixed agonist/antagonist analgesics may precipitate withdrawal symptoms (http://www.drugs.com/pro/levorphanol.html#).


Found the above while U'ingTFSE :D -- hmm... Anyone else have some input?

[bronyraur]

Maybe if your tolerance is nil. If I'm not mistaken it's a partial-agonist, and isn't likely to be any fun at all if you're an addict

you're probably thinking of BUTORphanol (Stadol). That is nasty stuff.

Can't say I've ever come across Levorphanol (Levo-Dromoran). But it sounds like wild stuff.

[Chemical_Boy]

I have wanted to try this shit forever...

I have never even heard of it in real life though.

Just the name alone is great!!


Le-vor-phan-ol

Lehh-vorrrr-phann-olllll


Just kind of rolls of the tongue in a pleasing way.

[Synack]

I have wanted to try this shit forever...

I have never even heard of it in real life though.

Just the name alone is great!!


Le-vor-phan-ol

Lehh-vorrrr-phann-olllll


Just kind of rolls of the tongue in a pleasing way.

hmm, can't hurt to ask... wish me luck.

[pharmboy]

Swim is currently taking it for break through pain. It does ok on the pain
but the euphoria I just dont know about. I think swims tollerance is to high to get high.
Swim can take 8 - 10 mg and maybe feel a little tierd. Swim would probably prefer Dalaudid.:D

[Synack]

Swim is currently taking it for break through pain. It does ok on the pain
but the euphoria I just dont know about. I think swims tollerance is to high to get high.
Swim can take 8 - 10 mg and maybe feel a little tierd. Swim would probably prefer Dalaudid.:D

Sounds good to me as my tolerance is pretty low I suppose. A long acting med for BT? odd.. IMO.


points for you...

[OxyContinuously]

Swim is currently taking it for break through pain. It does ok on the pain
but the euphoria I just dont know about. I think swims tollerance is to high to get high.
Swim can take 8 - 10 mg and maybe feel a little tierd. Swim would probably prefer Dalaudid.:D


Levorphanol sounds pretty interesting, although I have never had the pleasure. Keep in mind, I am purely recreational here (no chronic pain or anything the requires opiates, besides my animalistic cravings) and levorphanol prob. would NOT be found on the street; I mean of course it could, but it's probably rare.

Oh and by the way, "pharmboy," I don't believe it. "SWIM" is full of shit, in my opinion. 8 to ten mgs?? Come on, dude if you're gonna lie and be fake, go to Yahoo! chat; you'll fit right in.

And think before you write crap. Levorphanol is a very long acting med, so why on Earth would you get that for breakthrough when Roxis, morphine IR, hydromorphone, Actiq, etc. are made for that type of pain, and have the rapid onset and short to medium duration that one would require.

This reeks of bullshit, and this is a perfect example of what I mean by these new members coming here and drastically lowering the quality of conversation/threads/ etc.

enjoy your levorphanol, and be sure to let us know when you get your "Dalaudid" they'll prob give you 50mgs immediate release----you know, SWIMs tolerance and all---

what a joke

[Synack]

Levorphanol sounds pretty interesting, although I have never had the pleasure. Keep in mind, I am purely recreational here (no chronic pain or anything the requires opiates, besides my animalistic cravings) and levorphanol prob. would NOT be found on the street; I mean of course it could, but it's probably rare.

Oh and by the way, "pharmboy," I don't believe it. "SWIM" is full of shit, in my opinion. 8 to ten mgs?? Come on, dude if you're gonna lie and be fake, go to Yahoo! chat; you'll fit right in.

And think before you write crap. Levorphanol is a very long acting med, so why on Earth would you get that for breakthrough when Roxis, morphine IR, hydromorphone, Actiq, etc. are made for that type of pain, and have the rapid onset and short to medium duration that one would require.

This reeks of bullshit, and this is a perfect example of what I mean by these new members coming here and drastically lowering the quality of conversation/threads/ etc.

enjoy your levorphanol, and be sure to let us know when you get your "Dalaudid" they'll prob give you 50mgs immediate release----you know, SWIMs tolerance and all---

what a joke

damn my ignorance... and I gave the fucker a whole 8 points...

Good call.

[OxyContinuously]

damn my ignorance... and I gave the fucker a whole 8 points...

Good call.


yeah man, i haer ya....i just dont want s/o who happened to have them or whatever to see that post and think that it's A) good for breakthrough, and B) that ten milligrams is acceptable...someone could get hurt, or even overdose if they're opiate naive, you know?

[Ale]

I have wanted to try this shit forever...

I have never even heard of it in real life though.

Just the name alone is great!!


Le-vor-phan-ol

Lehh-vorrrr-phann-olllll


Just kind of rolls of the tongue in a pleasing way.

LMAO

[wafflehead77]

Levorphanol sounds pretty interesting, although I have never had the pleasure. Keep in mind, I am purely recreational here (no chronic pain or anything the requires opiates, besides my animalistic cravings) and levorphanol prob. would NOT be found on the street; I mean of course it could, but it's probably rare.

Oh and by the way, "pharmboy," I don't believe it. "SWIM" is full of shit, in my opinion. 8 to ten mgs?? Come on, dude if you're gonna lie and be fake, go to Yahoo! chat; you'll fit right in.

And think before you write crap. Levorphanol is a very long acting med, so why on Earth would you get that for breakthrough when Roxis, morphine IR, hydromorphone, Actiq, etc. are made for that type of pain, and have the rapid onset and short to medium duration that one would require.

This reeks of bullshit, and this is a perfect example of what I mean by these new members coming here and drastically lowering the quality of conversation/threads/ etc.

enjoy your levorphanol, and be sure to let us know when you get your "Dalaudid" they'll prob give you 50mgs immediate release----you know, SWIMs tolerance and all---

what a joke

I know this thread has been dead for a while, but I just wanted to correct an inaccuracy about levorphanol.
The recommended starting dose is 2-4 mg q 4-6h. So with a small tolerance, 8-10mg orally is not unheard of. The USP states that 2mg IM, or 4mg oral is equal to 10mg IM morphine sulfate.
Also, levorphanol is not a long-acting drug. Its duration of action is only 4-5 hours, and is said to decrease after prolonged administration.
It has a slow onset when administered orally, between 60-90 minutes, so maybe this is where you were mistaken.

Not just trying to be a dick be disproving your statement, it is just that there is very little information for Levo-Dromoran on this board, and I wanted to make sure that what is here, is correct.

[resorcinol]

I've heard levorphanol is pretty good. Levomethorphan is an opioid too... it's metabolite is levorphanol but I don't think it's technically a prodrug since the levomethorphan is active on its own before conversion.

I'd love to try both. It'd be sweet if the isomer fairy could come and turn DXM into LVM.

Raceorphanol would probably be pretty cool. It'd be a u-opioid agonist and NMDA antagonist at the same time.

[Synack]

I know this thread has been dead for a while, but I just wanted to correct an inaccuracy about levorphanol.
The recommended starting dose is 2-4 mg q 4-6h. So with a small tolerance, 8-10mg orally is not unheard of. The USP states that 2mg IM, or 4mg oral is equal to 10mg IM morphine sulfate.
Also, levorphanol is not a long-acting drug. Its duration of action is only 4-5 hours, and is said to decrease after prolonged administration.
It has a slow onset when administered orally, between 60-90 minutes, so maybe this is where you were mistaken.

Not just trying to be a dick be disproving your statement, it is just that there is very little information for Levo-Dromoran on this board, and I wanted to make sure that what is here, is correct.

It's not the length of action we're referring to, it's the longer half-life, less than methadone but more than most short acting goodies.

not trying to be a dick or prove you wrong or anything :)

Also, Pharmboy does take this ... despite my comments earlier

[subbie newb]

I dont know how to start a thread so Im reviving this one. Why? I have a bottle of Levorphanal Tartrate 2mg X100 and IM PRETTY EXCITED ABOUT IT!!:D I just snorted 4 of em, why so much? because Im used to 30-60mg of Roxy, and I did 2-3mg of suboxone this morning. I took 8 mg sub tues, 4 wed, and 2.5 this morning. Wiating to see if I will feel the levorphanol or maybe should have waited for tomorrow. Any one insufflated it before? I read you can not take it sublingually.

[Hiram]

I dont know how to start a thread so Im reviving this one. Why? I have a bottle of Levorphanal Tartrate 2mg X100 and IM PRETTY EXCITED ABOUT IT!!:D I just snorted 4 of em, why so much? because Im used to 30-60mg of Roxy, and I did 2-3mg of suboxone this morning. I took 8 mg sub tues, 4 wed, and 2.5 this morning. Wiating to see if I will feel the levorphanol or maybe should have waited for tomorrow. Any one insufflated it before? I read you can not take it sublingually.

I think you have enough to share your experience with and without suboxone. Do keep us informed.

[pharmboy]

First of all OC check my join date, I'm no new comer.

Second What you read and the real world are are two different things.

Levorphanol Tartrate from Roxane is probably only 50% as strong

as the original Levo-Dromaran from years ago.

If you can ever get some you'll see what I mean. I read all the stuff on

Erowid and thought wow this is some shit ! Well it ain't all that. But

it works better than 5mg OxyIR's.:cool:

[robojunkie]

Ignore oxy pharmboy, he has a habit of speaking before he thinks about what he's saying or who he's saying it to. Apparently he would have us believe a 2.5 to 5 times increase due to tolerance is unheard of. Right.

Anyway, I've never tried it, but I do have a particular interest in that this is the only opioid containing the "morphinan" tetracyclic skeleton that is relatively easily synthesized from non-opium derived starting materials. One does not need anything from the poppy to prepare the racemic form, or even to resolve it with common tartaric acid. Not having that epoxy bridge, 6-hydroxy or the 7,8 double bond makes shit a whole fuckload easier, not that I am implying I've done it, but I have read past syntheses and I've had some ideas (though most turned out to have already been done) on this, but the main point is that it has already been reported in papers (and on the underground) as being done in something like 6 steps as I recall, maybe 5 or 7, add one for enantio-pure stuff.

Oh, and sorry to say to all who are having the first idea I had way back in my teenage years, and I imagine every junky has within a few minutes of seeing this structure, that is making DXM into levorphanol, but as I once read on some usenet thing, and I love this quote, "Unless the isomer fairly comes down from the fourth dimension...you're shit outta luck" or something to that effect. DXM, other than the methyl group, is the mirror image of levorphanol, but there is no way whatsoever within reason to equilibrate the two due to the fact that the chirality is due to three sequential chiral centers in the "isoquinoline" moiety. No way to magically just "flip it". Damn, doesn't matter anyway, imagine how fast DXM would disappear to C-V, like p-fed.

[subbie newb]

Wow robo junkie, im very impressed with your knowledge of chemistry. I am just slightly litterate in, able to read but only comprehending a portion of, your discourse on the molecular structure of levorphanol. I read a study that compares the pain killing potential of levorphanol with morphine and oxycodone, and the ratio they came up with is 3mg levo equivelent to 30-45mg oxyco. that is ability to kill pain, not get you high or stop your breathing right?

I did 8mg intranasally, followed by 4mg more an hour later, followed by one 2mg tab oral 30min later. At this time I calculated I still had 5-6 mg dose strength of buprenorphine in my system due to its long half life so I wasnt expecting much. Let me say I got fairly fucked up. A beer, a glass of wine, I felt moderate euphoria, moderate sedation, loss of interest in sex (I was still able to perform and finish, but unlike cocaine I was finished, no round two).

I woke up feeling hung over but in a pleasant way, no withdrawals, still under the spell due to the long halflife of both drugs. Levo builds up in the sytem, it may only be active for 5-9 hours, but it hangs around for days. Manufacturer urges caution for dosage adjustments, a 3 day period for observation is recommended.

Did it (my 14mg dose) feel like 140 mg of oxy? Not quite, but since the suboxone was in the way, the verdict is still out. I will sample the general population and post my results here. Very curious about the value here, are they too rare? I think it might be 8ea subjective of course or am i crossing the line here...

http://www.drugs.com/pro/levorphanol.html
states that levorphanol is 4-8 times as potent as morphine.
if morphine is equivelent to oxicodone by a factor of 1.5, 30 oxy=45 morph,
than levorphanol @4x oxy is approx 7.5mg = 30mg roxy. Much Weaker than I originally thought, somewhere I saw a ratio that put levorphanol around 3mg= 30-45 of oxicodone, or 10x-15x oxy dose.

The first lower ratio is about half of the second one, maybe its because the tartrate is about half as potent as the base, and these ratios are based on that observation?

Its hard to grasp the potency of this stuff, and this is further complicated by the long half life that causes the drug to accumulate in plasma over a few days time, similar to methadone. I am not even starting to feel the slightest withdrawal today with abstinence, I feel this may have something to due with last nights dosing of 14mg levorphanol, in addition to todays 3.125 residual suboxone carryover from last three days dosing.

I tested positive for oxycodone, negative for opiates (morphine), today. I think this is because i did oxymorphone monday, not because I did levorphanol last night. It appears from reading test literature that levo will show on an opiate test, not an oxy test, but I thought the tests were the same with different cutoffs, the oxy test being 10x more sensitive, so Im confused here. will levo cause a positive immunoassay for oxy?

I read somewhere else that oxymorphone will not show on oxycodone test, that it required its own unique test. Now I dont think thats true, oxycodone urine card tests test for actual drug, or metabolite? (OXMORPHONE IS METABOLITe OF OXYCODONE)

I just snorted two 2mg levos, and am feeling a nice rush with euphoria, rapid pulse, and a desire to do 2 more. within 5 minutes. Wife said she felt like she did a line of coke immediately afterwards. Unique psychoactive effects are noted that may or may not be placebo/psychodrama. I read about unique properties of this drug that are different from other opiates, NMDA antagonist, multiple opiode receptor agonist, possible restless leg treatment potential...

[SynthMorph]

I've always wanted to try some of this stuff iv. Sounds similar to methadone.

[subbie newb]

IV levorphanol? I will have two user accounts of this shortly. User one is used to dilaudid, and only shot 1mg to start for safety, said it was very smooth, no burn, but too weak, so then followed with 3mgs. Get back to you with that report. I think IV levorphanol is the way to go after my experience with a slow onset after oral dosing. I got much greater effect from oral dosing versus intranasal. Nasally it gave me a nice mini rush, but no great lasting effect. I settled on oral dosaing as the best route of admin since I do not IV, and I felt inadequete absorbtion nasally. I read that you cannot sublingually do levorphanol, is this related to intranasal absorbtion? Oral dosing however took 60-90 min to set in, after which I was nicely high for 6-8 hours. I ate 2 pills(2mg each), then 3 1 hr later, then 3 more, 1hr after that. 4-5 hours later I felt Higher than ever, strange how the effect is very latent. The next day you dont wake up reaching for your meds, I felt no craving or withdrawel until 2pm the next day, due to the long half life. The effect of Levorphanol is very mellow, smooth, not roxy like at all, more comparable to dilaudid or morphine. The day I had only 1-2mgs of latent buprnorhine equivelent dose/plasma buildup was the day I really felt the Levorphanol, I took a total of 20 mgs that day. Its hard to compare it to oxycodone, since the feeling is quite different. No itchyness, no speedy oxy delerium, but it is definitely there, it whacks you with an opiate dose that can not be denied. The pain killing potential is most remarkable, I was comfortably numb, and the nausea factor was there reminding me I did some powerful shit. I did have energy late into the evening however... I retired at 1 am, and I slept heavily for 11 hours. The next day I stopped taking it and went back to sub, 2mg dose. Had trouble sleeping with dreams about dosing,dosage, needing opiate drugs, I did not wake up but instead dreamt about needing a dose all night. I think its the low dose of sub after using levo for two days that had me craving, after a bender I usually need 4-8mgs of sub to quash my head into opifluf. I am tired and wary of suboxone addiction however, and am using the bare minimum. SUBOXONE ADDICTION IS BRUTAL. THE WITHDRAWALS DONT EVEN really START FOR 3-5 DAYs after you stop taking it. THEY ARE DRAWN OUT LIKE METHADONE, due to the long half life, but not nearly as bad, because sub is a partial agonist. YOU HAVE TO TAPER METHODICALLY TO ALLOW BRAIN/body ADJUSTMENT. I never quit totally after suboxone, with a period of doing nothing, I always went right to oxy from sub the same day or next day, and it took twice as much to get me high. Because I did it this way, the suboxone actually doubled my tolerance to full agonist opiates. If anyone is planning to use suboxone for opiate addiction I recommend using the bare minimum amount to curb withdrawels, 1-2mg daily, and tapering off as soon as possible, and having at least a week clean before using full agonist recreationally again. This is essential to regain sensitivity. Then to avoid addiction I have heard that you need equal time off as on, like the weekend warrior principle. Is this a scientific approach to managing addiction? can you use roxies for 3-4 days, then take 3-4 days off, and have no tolerance or addiction build up? The trick here of course is the discipline required to maintain a pattern of use/abstinance. I have heard of people using oxy for 3-4 months at 60-90mg daily and quiting cold turkey with no withdrawal. If you allow the addiction to take hold, you will pay the price. 60 months and you've got yourself a nice little addiction, a year of straight use and your definitely going to feel intense craving and discomfort if you quit cold turkey. What is the trick to use, not abuse, full agonist opiates and avoid tolerance and withdrawal? I think for some people it is impossible. The nature of the beast is to do what feels good, despite rationality that warns us of the consequence. Hence the Junky's fate.

[subbie newb]

I did 20 mgs levo and 8mg dilaudid friday, 20 mg levorphanol on saturday. 2mgs suboxone sunday, and 2mg suboxone today, monday. I just did a urinalysis imunnoassay for oxycodone and opiates and passed both tests. NEGATIVE!!! Wow...My wife did a dilaudid 8mg on friday and 12mg levorphanol on friday, suboxone 4mg sat and 4mg sunday, she passed both tests today as well. I have a strong guess that if we had done oxycodone we would still be failing these tests. We failed last week, now I think its from the Opana that we failed, not the levorphanol. I had read that Oxymorphone requires its own unique test, but the oxycodone test looks for oxymorphone right? so what I read was wrong, right? opana will show on an oxy test right?

A few weeks ago she did oxys and still tested positive 4 days later, because she had done a lot and slept alot and just layed around, metabolism is a big factor in clearing this stuff out of your system.
I now plan to do 6 mgs of levorphanol and retest to see if I fail later tonight or tommorow. This stuff has to come up as opiates right? Or is it a synthetic like buprenorphine that produces metabolites unlike those from oxycodone or morphine or herione that require its own unique test? If this is true than I have discovered an alternative to suboxone to use for pain that will allow me to continue use and pass these damn random urinalysis, since this fucking agency is relentless and has zero tolerance for drug use, even legally prescribed use :cool:

[SynthMorph]

I did 20 mgs levo and 8mg dilaudid friday, 20 mg levorphanol on saturday. 2mgs suboxone sunday, and 2mg suboxone today, monday. I just did a urinalysis imunnoassay for oxycodone and opiates and passed both tests. NEGATIVE!!! Wow...My wife did a dilaudid 8mg on friday and 12mg levorphanol on friday, suboxone 4mg sat and 4mg sunday, she passed both tests today as well. I have a strong guess that if we had done oxycodone we would still be failing these tests. We failed last week, now I think its from the Opana that we failed, not the levorphanol. I had read that Oxymorphone requires its own unique test, but the oxycodone test looks for oxymorphone right? so what I read was wrong, right? opana will show on an oxy test right?

A few weeks ago she did oxys and still tested positive 4 days later, because she had done a lot and slept alot and just layed around, metabolism is a big factor in clearing this stuff out of your system.
I now plan to do 6 mgs of levorphanol and retest to see if I fail later tonight or tommorow. This stuff has to come up as opiates right? Or is it a synthetic like buprenorphine that produces metabolites unlike those from oxycodone or morphine or herione that require its own unique test? If this is true than I have discovered an alternative to suboxone to use for pain that will allow me to continue use and pass these damn random urinalysis, since this fucking agency is relentless and has zero tolerance for drug use, even legally prescribed use :cool:

Hydromorphone(dilaudid) needs its own special test to be detected same with methadone, fentanyl and I'm almost 90% sure levorphanol needs its own unique test as well.

[jdub]

(snip) Because I did it this way, the suboxone actually doubled my tolerance to full agonist opiates. (snip)

I have been doing a similar routine w/ subs and oc lately and actually seemed to lower my tolerance. I got on bupe about 3 months ago, and take between 1-4mgs daily, usually 2 mgs but I take 4 mgs the first day back from OC's.

Anyway, before I got on the bupe, I would need 400-480 mgs orally to nod. Last week I got that effect from 200 mgs. I don't know if this is just me, because I have heard alot of people have the opposite experien. I guess I should feel lucky.

It's pretty awesome you got these rare levorphanols- Do you know what they were prescribed for?

Also, if you added paragraph breaks to that long post it would be much easier to read. Especially for my (medical)weed-smoking ass, who has to read the same damn paragraph 3x before it penetrates my drug-addled brain.;)

[subbie newb]

tHANKS FOR THE TIP, breaks are good

verdict on levorphanol, basically sucks.
it does however kill the pain, for this it is very powerful. 2mgs is equal to 10-20 mgs of oxy or 10mgs of morphine for pain, and it lasts a long time, up to 8 hours. but the onset is slow 60-90 mins, and the effect is very smooth, dull, fluffy, not at all like the oxy effect which so desired by opiophiles. more effect from oral than from insufflation, takes longer but is much greater absorption IMO.
a sample of the population of testees agreed that it is a strong painkiller, but not a substitute for oxy. Basically they would not choose it over oxycodone ever. There is a reason oxy is the top prescribed painkiller today. it is the most desired. Levo? It will take away withdrawals, but only get you half as high, I had to take 20 mgs a day to feel energized and satisfied. My tolerance level is about 2-4mgs a day suboxone, or 60-180 mgs a day oxy, no more than 60 mgs per dose. this puts me on the verge of nausea. I got a similar nausea from 6 levos at once (12mgs), followed by 3 more at 3 hour intervals. The funny thing is that I felt most high from levo 4 hrs after my last dose of 6mgs, a TOTAL OF 20 mgs that day.

I tested again after doing levo 20 mgs and failed for oxy and opiate. very strange indeed. the next day. my tast last week passed after a one day break.

levorphanol is prescribed for moderate to strong pain, by doctors who are experimental and like to do research on alternative drugs. it has effects beyond the scope of popular opiate painkillers, and may produce desirable result in certain individuals due to its off label effect on the brain and NUERAL PAIN KILLING ABILITY. it is an ndma? antagonist....im no scientist, but upon reading about it the impression i got was that its effects are wide reaching and unique. that said i will not ask for it again, after switching doctors my dr said " I dont think this is a painkiller..." then looked it up and said " well.... maybe its a paikiller" well duh its a strong full agonist opiate painkiller, and the only one of the morphinan group. but if i can trade it in for oxy or dilaudid, it will be done.

one other morphinan drug invented in germany during war time causes hallucinations. interesting