Dopamine Fresenius

[Majortom]

dopamine HCI do you know or have any idea if it d be helpfull through the process of W/d ? how about tramadol HCI how can you strengthen its effects of opiate ?

[Chipper]

I wouldn't mess with dopamine; it helps Parkinsons' sufferers but I doubt that it would help with w/d's. Mind you, I don't know for sure

[Opilover]

dopamine HCI do you know or have any idea if it d be helpfull through the process of W/d ? how about tramadol HCI how can you strengthen its effects of opiate ?

Never had the tramadol HCI before but I use tramadol 50mg for wd's when I got them,,I take 5 plus a couple of x-tra strength tylenol (sp?) and it seems to add a bit of a buzz feeling..

[mdc420]

Interesting topic regarding dopamine helping wd. I'm currently in day 2 1/2. I had a 6 month or so heroin habit, and kicked a couple weeks ago. My buddy that I tend to use with and score from and I decieded it just wasn't worth it anymore. Well after 1.5 weeks I'm feeling totally normal again...don't even need the subs I had been using to get off anad have the bright idea of one last bang before stopping for good. we only got 5 bags each this lasst time, so I figured I'ld be cool wd wise...not so. I took a bunch of xanax, some precription nasua medication...still fel like shit and couldn't be off the couch. So a little while ago I deceieded to bang some coke. I'm feeling much better, actually able to turn on the computer. I know it won't last, but perhaps floodig the brain with dopamine may help with wd.

what do you guys think...bad idea?

[jacky]

instead of messing with l-dopa, I would rather investigate small doses of epinephrine, or dopamine reuptake inhibitors, cocaine, ritalin etc.
I think its obvious the dopamine agonists might relieve certian aspects of withdrawl, dopamine reuptake inhibitors might be even better than direct agonists...

I know Mr Burroughs, a person whos observation of opiates and addiction I take to be worthy, suggested that his positive treatment with the dopamine agonist apomorphine, in france, deserved further study and support by other scientists/countrys.
its funny, cause I hear people slam him for suggesting this from time to time, but what I dont see is anyone out there trying to substantiate this.
perhaps apomorphine is not tolerated by too large of a percentage of study patients or such, and the pharmaceutical approach was dropped except as an emetic, and then apomorphine to later be found to have erectile dysfunction use. it would be a significantly important treatment even if only 5% of the population was receptive.
its possibly like ibogaine, that apomorphine doesnt fit the bill for everyone.
one thing apomorphine would have as a research target is that it is already approved for some medical uses.
similiar to nitrous oxide, which has shown some significant qualitys as an aid for people who are trying to stop smoking.
reading about the account in the book Junky, I think its obvious that the possibility is there.

some people might think Burroughs was a crank case.....

the guy was one of the first people that I know of that played with the possibilitys of opiates being produced within the body...

" Buddha? a notorious metabolic junky...makes his own you dig. In India, where they got no sense of time, the Man is often a month late.....' Now let me see , is that the second of the third monsoon? I got like a meet in Ketchupore about more or less.'
"And all them junkies sitting around in the lotus posture spitting on the ground and waiting on the man.
"So Buddha says:'I dont have to take this sound. I'll by god metabolize MY OWN JUNK.'

that statement from Naked Lunch was written decades before endogenous opiates/endorphins and the opiate receptors themselves were found by scientists.

it could be that dopamine agonists like pukateine are behind the purported opiate withdrawl relieving effects of the pukatea plant. I have consumed extracts of this plant, and a few others, and all people felt a small amount of relief when withdrawing from opiates.
the plant has mild stimulant effects.
perhaps mild dopamine stimulation from consuming chocolate helps with opiate withdrawl?

in some areas of the brain the opiate and dopamine receptors are very closely situated, and proof of cross stimulation is supported, that is, that opiates can stimulate dopamine release, and the effect can be terrorizing for the junky...the state is called paradoxical stimulation, and shooting more junk just causes insomnia, chronic sweating, and anxiety. for me heroin and hydrocodone (but not hydromorphone) causes this effect sometimes. Morphine use very rarely gives way to this state, or perhaps I could say, for me, morphine NEVER has cause paradoxical stimulation that was uncomfortable.

so knowing that dopamine and morphine/beta endorphin have interactions would lead me to believe that a dopamine agonist might very well help withdrawl.
or a compound that increases dopamine content in the body...

hopefully after the controversy with Heantos clears up we might learn some more of its ingredients...perhaps some dopamine agonist is at work in that brew.

[jonny-5]

i know that in the past i have used meth to hold off w/d till i could score dope. methamphetamines block the re-uptake of dopamine, therefore slowly flooding the receptors. it does work in the short term, but as for using it for detox, no fucking way. when you crash you feel like complete shit cause now you lack dopamine AND endorphines. um what was my point....oh ya i would think dopamine would help somewhat but the only way to know is to try it.

[HeidiW]

For me, doing speed is the WORST thing to do if I'm in w/d.

[sp33dballin]

i always thought it was pure placebo when i started to feel better from opiate wds after taking a nice fat hit o crack... guess it really isnt all in my head...sure as fuck doesnt help me get to sleep tho.

[Majortom]

For me, doing speed is the WORST thing to do if I'm in w/d.

I agree w/that and any sort of speed wouldn't want them to be around me. make me worst but ı just want ed to put it into thinking as thank to Jacky he has given a thought to the subject cleverly and w/d is not only first 3-7 days. takes months. thats why I opened up the subject when we try to find ways to produce endorphine.

[Nostromos]

i've always found it interesting that a lack of dopamine seems to cause Parkinson's, but an overabundance of dopamine is found in many people with schizophrenia. maybe there's a certain dark quality to the condition "more than happy". all i know 'bout wd treatment is that a former junky told me about a hospital giving him "anti-opiates" or something, and it cleared the withdrawals right up. i'm surprised that's the only time i've heard of this, since withdrawals are pretty fucking horrible. maybe da' man doesn't want us junkies enjoying our lives too much.

[jonny-5]

For me, doing speed is the WORST thing to do if I'm in w/d.


ya ive heard mixed reviews. some people say it makes em way worse, and others (like me) say it makes em feel better for a few hours.

[renton]

People dont realize it's more complex than just one chemical. If your dopamine is down from chronic drug use or w/d than your other feel good chemicals like serotonin and especially Norepinepherinewhich helps to keep you motivated and focused are down as well. I've found a good supplement that helps boost dopamine and norepinepherine is called L-Tyrosine and can be found in any health food store for cheap. It also has been shown to boost the effects of many drugs like opiates and amphetamines plus ravers like to load up on it.

[soulninja]

People dont realize it's more complex than just one chemical. If your dopamine is down from chronic drug use or w/d than your other feel good chemicals like serotonin and especially Norepinepherinewhich helps to keep you motivated and focused are down as well. I've found a good supplement that helps boost dopamine and norepinepherine is called L-Tyrosine and can be found in any health food store for cheap. It also has been shown to boost the effects of many drugs like opiates and amphetamines plus ravers like to load up on it.

That is awesome..thanks for the info.!!

[Majortom]

i've always found it interesting that a lack of dopamine seems to cause Parkinson's, but an overabundance of dopamine is found in many people with schizophrenia. maybe there's a certain dark quality to the condition "more than happy". all i know 'bout wd treatment is that a former junky told me about a hospital giving him "anti-opiates" or something, and it cleared the withdrawals right up. i'm surprised that's the only time i've heard of this, since withdrawals are pretty fucking horrible. maybe da' man doesn't want us junkies enjoying our lives too much.

This is ver interesting Nostromos , it d be nice to know this incident in more details such as how often he was given and in what doses etc? Can you hold on to yhese informations as well?
thnks.