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View Full Version : purported opioid active herbs. hot damn.


jacky
05-21-2007, 05:26 PM
so the new journal of ethnopharmacology for may 2007 is out....

I look forward to these journals more than almost any publication out there.

this months publication lists 4 possible opioid active plant materials.

3 of which I have sources for.

2 of which are readily avialable in the international herb trade.

trifolium pratense has mu and delta agonist properties. this is common red clover. ethnobotanical use of this material looks in line with opioid activity in my opinion. this plant is readily avialable in raw and extract form.
it is also a component of the "spice" smoking blend. I am hoping to find some more info on any specific fraction/isolate that might be responsible....if there is an isolated opioid in this plant it might have some significant effect, as the data on this plant suggests a potent binding inhibition.

Ugni molinae is a shrub in chile, the leaf is called murta, the leaf is used as a medicinal product. the berry of this plant tastes like strawberries...so the berry is used in various recipes/preserves and as a flavoring for other fruits. the activity of this plant might not be opioid in nature directly, but might have indirect activity.
it took me a few days but I have found a supplier of the leaf product of this plant. hopefully I will have some ordered in a month.

Casearia sylvestris...this plant is readily available as "guacatonga"...there is some strong ethnobotanical data on this plant that follows the profile of a opioid active material. the herb is relatively cheap, and seems to be a general medicinal herb that doesnt get mentioned as having much toxicity. this plant was tested like the above mentioned with naloxone as a reversal agent of analgesic activity.

Pachyptera hymenaea.....this plant is purported to have opioid activity. the aqueous extract was what was used, I assume of the whole plant. caffeine seemed to reverse some of the analgesic activity associated with the extract. I couldnt find much info about this plant, and have found no sources for the plant material as of yet.

with the addition of these plants to my list of other purported active opioid herbs, I think there must be something like 17-25 herbs with potential as at least minor pain relievers, or other effects though mild that might find beneficial use in the future by adventerous opiophiles, or just plain desperate folks.

looking at all the plant materials that have yet to be looked at, and all the species that are known medicinal in nature that have yet to be analyzed even, I am sure that this list will keep growing.
if only 1 out of 20 of those plants is really interesting to the clandestined opiophile with transgressive motives, then that would be an improvement on the state of the "inebria-nation" as it is now.

I am thinking that a strong ethanol extract of red clover is something to investigate 1st, since it is cheap, and the data regarding that plant looks interesting as a possible strong analgesic.
the Casearia is another that I plant to get within the month, as it is readily avialable.

the trifolium/red clover plant is used for menopasual treatments....that is interesting, another opioid active herb used for womens conditions. looking at the herbs used for period pain/menopasual symptoms might be a good idea in general, perhaps there are others.

well, if anyone has any involvement with any of the above listed herbs, lets hear it!

mrklean
05-21-2007, 05:56 PM
YEEEEHAWW, more opioiods flourishing in nature, always what I love to hear. Thanks for sharing this info, I will also be investigating. Red Clover sounds particularly promising.

jacky
05-21-2007, 06:04 PM
ahhh, the vigilant mrklean is on the trail already.

well alright!

just remember, I think it is red clover that will make your pony founder if too much is eaten...
and also...
red clover contains coumarin and coumarin like compounds, so if you shouldnt be taking blood thinners, I would wait until some possible isolates are available of this plant that are free of the plentiful hay smelling coumarins....

Sitar
05-21-2007, 11:19 PM
What about the Prickly Poppy? It doesn't have opium in it, but it supposedly does contain opioid-like alkaloids which, unlike the Lettuce Opium crap, actually work.

I've smoked Prickly Poppy a few times and it did seem to have some kind of pleasurable effect vaguely similar to opioids I suppose. It's cheap and legal and worth investigating.

To me, the holy grail would be to find a legal plant that can stop dopesickness (without being immensely and prohibitively expensive like Kratom). Kratom would be great if it didn't cost more than actual dope.

HeidiW
05-21-2007, 11:32 PM
Red clover, got plenty of that out on the farm:D

drugsaregood
05-21-2007, 11:53 PM
Where can I signup to receieve these journals? Plants and their effects on humans interests me a great deal.

jacky
05-22-2007, 01:37 PM
argemone species seemed to cause me more pain than they did anything analgesic. I smoked the resin extract a few times...

drugsaregood....you just need to look up journal of ethnopharmacology and then go read the abstracts they present. that gets you a foot in the door...
sometimes it is worth paying for the full pdf report, but most times I think the abstract presented data is enough to base an assumption on as far as if you are going to have further interest in a given species of plant.
I payed 30$ for a report on analgesic herbs 4-5 years ago..it was worth it.

but basically you can look at each issue of the journal of ethnopharmacology and the abstracts presented. if you desire more info, you can buy a subscription to the journal...but that is thousands a year. or you can be lucky and be a researcher/teacher, whos institution has access to many of these journals.

the journal of ethnopharmacology is simply a clearinghouse of info for the ethnobotanist/pharmacognosist/etc in mind....many of the entries are not of any real opiophillic interest, but everyonce in awhile something very interesting comes around.

sp33dballin
05-22-2007, 02:36 PM
I came across this link the other day and have been meaning to post it.. i can't find a better time to do it than now. its a list of free magazines that are very relevant and may help some of you out. peace.

http://physorg.tradepub.com/?pt=cat&page=Biop

sp33dballin
05-22-2007, 02:39 PM
also:

A red clover (Trifolium pratense) phase II
clinical extract possesses opiate activity
by
Nissan HP, Lu J, Booth NL, Yamamura HI, Farnsworth NR, Wang ZJ.
Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA; UIC/NIH Center for Botanical Dietary Supplements Research and Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS), University of Illinois, Chicago, IL 60612, USA.
J Ethnopharmacol. 2007 Feb 11;

ABSTRACT

Trifolium pratense (TP) is one of the most common herbs for the relief of menopausal symptoms. Little is known about its mechanisms of action. In this study, we investigated the affinity of TP at the mu- and delta-opiate receptors. We found that a clinically used TP extract bound to the mu-opiate receptor with a high affinity (K(i)=9.7+/-1.6mug/ml). The same extract was also found to have affinity at the delta-opiate receptor with K(i) of 15.9+/-2.4mug/ml. These results for the first time suggest a potential new mechanism of action of TP at the opiate receptors. Given the essential role of the opioid system in regulating temperature, mood, and hormonal levels and actions, this may explain in part the beneficial effect of TP in alleviating menopausal symptoms.

Rhonda
05-22-2007, 06:53 PM
Is that the same red clover stuff that grows in your backyard? The ones I see growing are more like a pink color, are those the ones?

sp33dballin
05-22-2007, 06:55 PM
i need to do some digging... i wonder what kind of clovers are in those yummy clover cigs you can buy and pretty much any store ;p

Sitar
05-22-2007, 09:43 PM
argemone species seemed to cause me more pain than they did anything analgesic. I smoked the resin extract a few times...

So what does that mean? Elaborate, please.

jacky
05-22-2007, 10:52 PM
well apparently the prickly poppy and related species can have some toxic effects...even causing death in animals that are allowed to over graze...

anyway I smoked some prickly poppy resin a few times, trying to find out if this plant material was going to help cover slight withdrawl, or cause any positive effects.
what I felt was some strange eye pain and lung pain. nothing extreme....but the experiences left me thinking that the last thing I would want to do is consume a larger amount of the extract.

I really havnt heard any positive experiences of anyones elses regarding this plant.

but we have to try them all dont we! try all the purported active plants, and even the ones that dont have scientific data.....