Magnesium

[katomic]

BACKGROUND: An excess of excitatory pathway activation via N-methyl-d-aspartate (NMDA) receptors has been described in neuropathic pain that responds poorly to morphine. However, in this situation, several published data sets show that coadministration of NMDA receptor antagonists restores the efficacy of opioids. Considering that magnesium behaves like an NMDA receptor antagonist, we investigated the effect of the combination of magnesium and morphine in experimental models of chronic and tonic pain. METHODS: Mechanical hyperalgesia was assessed with the paw-pressure test in mononeuropathic (chronic constrictive injury model) and diabetic rats. Behavioral reactions were scored in a model of inflammation induced by formalin. The animals were assigned to one of three groups according to the intraperitoneal pretreatment: magnesium (30 mg/kg x 3), magnesium (30 mg/kg), and saline. Before testing, morphine was injected intravenously in mononeuropathic (0.3 mg/kg) and diabetic rats (1 mg/kg) and by the subcutaneous route in rats with the formalin test (1.5 mg/kg). RESULTS: Magnesium alone induced a significant antihyperalgesic effect in mononeuropathic and diabetic rats after a cumulative dose of 90 mg/kg. Furthermore, it significantly increased morphine analgesia, regardless of the loading dose used (30 or 90 mg/kg) in the two models of neuropathic pain. In the formalin test, magnesium alone did not have a significant effect. However, in combination with morphine, it revealed the analgesic effect of this opiate. CONCLUSIONS: These data show that magnesium amplifies the analgesic effect of low-dose morphine in conditions of sustained pain. Considering the good tolerability of magnesium, these findings may have clinical applications in neuropathic and persistent pain.


From http://opioids.com/index.html

[Paregoric Kid]

http://forum.opiophile.org/showthread.php?t=651&highlight=magnesium

yeah it's effective but it does not work on the same binding site as DXM which binds to the PCP site, it binds to the magnesium ion site

[kramorph]

Sound interesting.Back in the day when I did loads of speed, epsom salts(MgSO4) was a poular diluent, studies like this suggest it will become a cutting agent for H now too eh! Does it increase the rush and/or euphoria?

[SomniGod]

Are they suggesting to add magnesium to your dope and bang it? What about smokers? Snorting? Also, oral consumption ... like with tea? We all love a good SAFE potentiator!

~S~

[Paregoric Kid]

no it's just saying that magnesium increases the analgesic effects of morphine through NMDA antagonism. it might potentiate opiates like dxm does, it might not.

[ontario_opiophile]

I always found that Magnesium actually blocked the effects of opiates. I have found it to be like Calcium. I will not drink milk before I take my medication and I sure as hell wont take Magnesium. Maybe i'm wrong? It could potentiate something but I took some last night and took my medication 6 hours later and didnt notice anything from it and thats quite unsual. The only thing Magnesium is good for is inducing lucid dreams. I say we should all do a little bit of an experiment. Take 500-800mg of magnesium before bedtime and see if you have alot of dreams. I never dream usually and whenever I take Magnesium I have crazy lucid dreams. It's like being on an acid trip for hours and hours man. It's like I lead a whole other life. It's fucked. Good luck with that.

P.S: Part of the reason Magnesium doesn't help me is because I associate it with Calcium and I know Calcium ruins buzzes. I kind of put them in the same category even though they probably aren't the same thing. So who knows it may work for you guys. I just found it killed my buzz but it could be totally psychological.

[bogumil]

Thats interesting because there are processes for alkaloidextration that call for adition of Magnesiumoxide as a step. That might catch to flies with one swatter.

[Paregoric Kid]

I thought milk was good to take with opiates, it has opioid peptides in it.

[ontario_opiophile]

I thought milk was good to take with opiates, it has opioid peptides in it.


I personally don't take milk with my opiates/opioids but thats only because it has alot of calcium in it. I'm paranoid about taking anything with calcium with my opiates/opioids. I will drink milk an hour or two after taking my methadone but I will not take my medication with it. I usually wake up and make some juice and take my methadone and drink that glass of juice slowly over a period of about 30-40 minutes and then an hour or more after, I will drink milk or take magnesium or calcium. I never knew milk had opioid peptides in it. Even if it does the calcium is enough to scare me away from taking my meds with it. I hate wasting it.

[jacky]

A few months ago I took some magnesium before a dxm dose. I was using the magnesium to see if it interacted with how opioids make me feel for a few weeks, and didnt notice much really. But that night I was caught quite offguard by the strong effect of the DXM. I have taken DXM in moderate doses for up to 6 months on a daily basis to augment opiate addiction, and was used to taking doses up to 350 milligrams for recreational weekend doses, I wasnt using DXM every day at this point, more like once every two weeks. I took around 150 milligrams of DXM, and within two hours all I felt like doing was sitting down, I was quite stimulated, and edged out, and paranoid, which is not my usual DXM state. It seemed to hit harder, whereas I usually feel comfortable out and about on DXM, this time I just wanted to get home and sit down, I was quite nauseous as well.

I dont know if the magensium has an effect or not, but I percieved what I think was an effect of potentiation of DXM with magnesium.