tebernaemontana pachysiphon

[kingdxm]

I have read that this plant has ibogaine, any body know if it is as good as iboga vine?

[jacky]

I bought more than a couple kilos of tabernaemontana pachysiphon leaf....I sent a few kilos to a generous chemist.
he extracted a small amount of alkaloidal material from the leaf. around maybe 3 grams. he said it was a laborous extraction process , and referred to the alkaloids as being long chained indole alkaloids. it took him something like 5 different extractions to get the largest percentage of alkaloids.

he compared the alkaloid content to that of picralima nitida....but FAR less plentiful.
I know that there is some variation of alkaloid content between the two, but they do contain the active pentazocine like alkaloids.

I havnt tried much of the t.pachysiphon alkaloid, but I have consumed up to 60 grams of the powdered leaf with little effect.

picralima nitida acts like a stimulant. a chemist described his experience as a mild Ibogaine like stimulation.

so it wouldnt suprise me if these apocynacea species would be found to contain traces of ibogaine like compounds, or even ibogaine for that matter.

I just havnt seen the data myself...
have you any sources avialable kingdxm?

I think that picralima nitida has some potential, but the raw seed material is HORRIBLE to consume. this one needs to be extracted. either a complicated, or not so complicated PH manipulation extraction, or even a simple lemon juice/water alkaloid resin extract would work. people in africa use picralima nitida as a painkiller, and it contains alkaloids described as partial agonists, similiar to pentazocine. the seed is also used for treating malaria.

someday I will get around to bioassaying the t.pachysipon.
the suppliers warned me that the stuff can be very potent, and that people use it for recreational use as well as medicinal, but I dont know how much a person would need to consume....if 60 grams wasnt enough, how much is a given oral dose? a POUND?...

maybe some chemist will offer up isolated fractions of the alkaloids of either two at some point in time.

one thing I should mention, is that consuming 30 some grams of picralima nitida seeds gave me this strange, hard, itchy lump on my forehead for a few days...and made me somewhat dizzy. that amount of seeds also kept me up till the early morn.
strange stuff.

[kingdxm]

Erowid claims that there is ibogaine in it as well as in voacanga africana. as to how much either one of them have, who knows:confused:

[Paregoric Kid]

Isolation of opioid-active compounds from Tabernaemontana pachysiphon leaves.

Ingkaninan K (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Ingkaninan%20K%22%5BAuthor%5D), Ijzerman AP (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Ijzerman%20AP%22%5BAuthor%5D), Taesotikult T (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Taesotikult%20T%22%5BAuthor%5D), Verpoorte R (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Verpoorte%20R%22%5BAuthor%5D).
Leiden/Amsterdam Centre for Drug Research, Gorlaeus Laboratories, Leiden University, The Netherlands.
A procedure for prefractionation of crude plant extracts by centrifugal partition chromatography (CPC) has been developed to enable rapid identification of known-positive compounds or false-positive compounds and to increase the chance of identifying minor unknown-active compounds. The study explored the use of CPC as a tool in the prefractionation step before investigation of bioactivity. Fractions obtained by CPC from an ethanolic extract of Tabernaemontana pachysiphon Stapf (Apocynaceae) were screened by means of an opiate-receptor-binding assay and an adenosine A1-receptor-binding assay. Fractions containing fatty acids, which had false-positive effects on the assay, were identified, as were unknown-positive fractions from which two opioid-active compounds, tubotaiwine and apparicine, were subsequently isolated. The affinities (Ki) of tubotaiwine and apparicine at the opiate receptor were 1.65 +/- 0.81 and 2.65 +/- 1.56 micromol, respectively. Both alkaloids had analgesic activity in the abdominal constriction test in mice. CPC prefractionation led to the rapid isolation of two opioid-active compounds, tubotaiwine and apparicine, from the unknown-positive fraction; false-positive fractions were rapidly identified. Both tubotaiwine and apparicine had affinity for adenosine receptors in the micromolar range and also had in-vivo analgesic activity in mice.

[at&t]

Nothing to add, I'm afraid, but just that... Time and time again, I find myself just sittin' here thinking... "wow. Jacky knows Everything..." --

[edit: D'oh!! old thread! sorry... Statement above still holds, but, well... Sorry for irrelevant post to ancient thread... :(

PS. good post as always, PK... ]

[jacky]

ahh, its all show really...
every few months I find out more on a subject that I realize I was quite off base with.

I do have a good capacity for remembering names of plants and their general activities.