Ziconotide...the war is over.

[JahRed24]

http://en.wikipedia.org/wiki/Ziconotide

If they perfect this, opiates will be made OBSOLETE...just giving u guys a heads up b/c within the next ten years there wont be such a thing as "opiates" .. :mad:

[nick]

Wake up man,junk in one form or another will be with us for years to come-probably as long as the human race is around.

Don't worry.

[insanesteveo]

they only approved it for injection straight into the spinal fluid. i dont think many peoples pain is severe enough to do that. and its for chronic pain. that leaves plenty of broken bones and such to precribe opiates for.

plus as nick said, there is always the black market. drugs will be there. as long as they dont find a CURE for happiness(not just a drug to mask depression) we can expect people to do drugs.

[Raz]

Drugs =money= drugs.Blah ,blah Etc etc

[roxi*stardust]

http://en.wikipedia.org/wiki/Ziconotide

If they perfect this, opiates will be made OBSOLETE...just giving u guys a heads up b/c within the next ten years there wont be such a thing as "opiates" .. :mad:
Did you read the whole thing? They don't use IT therapy unless it is a last resort, it's dangerous. There are drugs that are delivered IT now and not very frequently becasue of the risks. Until they get rid of the risks of IT therapy, it will never take the place of systematic analgesics; ie opiates.


Due to the profound side effects or lack of efficacy when delivered through more common routes, such as orally or intravenously, ziconotide must be administered intrathecally (directly into the spine). As this is by far the most expensive and invasive method of drug delivery and involves additional risks of its own,[3] ziconotide therapy is generally considered appropriate (as evidenced by the range of use approved by the FDA in US) only for “management of severe chronic pain in patients for whom intrathecal (IT) therapy is warranted and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies or IT morphine

[Diacetyl]

That shit just won't pass my friend

Well, not in any of our lifetimes, opiates will always be around.

[robojunkie]

Puhhhhhhllllleeeeeeeeeeeeeeessse!!! As long as there are junkies (demand), poppies aren't extinct, and a criminal gang/mafia/whatever willing to organize growing and processing (supply) there will always be junk! Basic economics. Same reason conservative Nobel laureate economist Milton Friedman believes in the full repeal of drug prohibition. These jerk off scientists (and I'm a scientist) oughtta be spending there time developing an adjunct drug to take with opiates that inhibits whatever enzymatic process is responsible for endocytosis and the signalling to initiate this within the brain cell (ie the process of tolerance) so that the development of tolerance would be blocked or drastically inhibited, far more than current potentiator/attenuators. But instead the fuckers try to make an "opioid" with no euphoria but somehow will relieve pain? WTF? Seems to me pain relief, euphoria and the development of tolerance are all part and parcel of the mu-receptor and only fucking with processess inside the cell seem likely or even seem to have any possibility of ever separating these effects, ie pain relief and euphoria with no or minimal tolerance development. That's what I'll work on in a few years...Somehow I doubt any of these wankers'll come up with this before then...

Like, think about it: tolerance develops because the neuron senses "permanent" attachment at the mu-receptor so it either pulls the receptor inside the cell membrane and destroys it or responds by altering its shape/number, depending on which mu-agonist it is (this is why methadone and morphine can be synergistic, different receptor/tolerance responses). But this ain't magic...something (release of hormones/enzymes within cell) is provoked by this "permanent" binding and this response initiates the receptor changes or the endocytosis (dragging receptor in). But enzymes, cofactors and probably other macromolecules inside the neuron need to 1) "hear" the signal that the receptor is "overstimulated" and 2) have to initiate the processess within the cell that we feel as tolerance. Plenty of steps here in which to throw a molecular wrench and delay significantly the tolerance developing cellular processess. And hell, I'm a realist and I know the damn "homeostasis" will eventually figure a way around this too but in my understanding this idea gets around the past problems of developing "non-addictive" mu-agonists. Because one wouldn't be, they'd just be fuckin' up the process of adjustment. Kind of like eating certain foods (analogy: foods equals morphine) that cause heartburn. The heartburn is a physiological response caused by the foods. Take a separate substance like tagamet or prilosec (analogy: endocytosis or tolerance process inhibitor) and you fuck up the body's response to the first thing by attacking it from a different angle, right? No heartburn, no tolerance, that's the analogy. Would be awesome if it works someday...

[doctor diesel]

Still, nice idea eh?

[JahRed24]

i just saw this and thought it was something interesting for you guys to see.. i thought it was pretty good info.. and i know that opiates will be around forever whether it be in illegal black market forum or in a legal prescribed form (like these days). But yeah they probably won't ever perfect something like that within the next 10 - 20yrs....:confused:

[insanesteveo]

http://en.wikipedia.org/wiki/Ziconotide

If they perfect this, opiates will be made OBSOLETE...just giving u guys a heads up b/c within the next ten years there wont be such a thing as "opiates" .. :mad:


i just saw this and thought it was something interesting for you guys to see.. i thought it was pretty good info.. and i know that opiates will be around forever whether it be in illegal black market forum or in a legal prescribed form (like these days). But yeah they probably won't ever perfect something like that within the next 10 - 20yrs....:confused:

uuuuuuuum, what?