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View Full Version : methcathinone -> methamphetamine?


Paregoric Kid
04-06-2007, 04:12 PM
is there a fairly simple way to remove the oxygen from methcathione to make it into methamphetamine?

robojunkie
04-07-2007, 03:41 AM
Maybe Wolff-Kishnerr (hydrazine) where you would form the benzyl hydrazine intermediate and proceed to lose nitrogen in situ. Fairly straightforward reaction but aryl ketones are often more resistant to conditions requiring attack at the carbonyl center. I could look up "exhaustive" phenone reductions but I'm away from my search access. It may be possible to perform a classic transition metal catalyzed hydrogenation, as it is an aryl ketone.