View Full Version : Taking a Benadryl while on Methadone

03-19-2007, 04:31 PM
I know this should be in a different room, but I needed to get an answer pretty quick. I've got allergies bad today and wanted to take a benadryl, but don't wanna die or anything, or even risk it.

I took my 'daily low dose' of methadone- 40mg instead of 50 or 60 (I have a rotating schedule, so I don't impact my tolerance much), and also around 9am took about 10mg of amphetamine.

any help would be greatly appreciated. I don't want to pass out. I can deal with a little drowsiness, but not stupor.


Papa Verine
03-19-2007, 04:48 PM
Benadryl is interesting for me in that it will make me tired if I lie down and close my eyes... but if I stay active doing something I don't feel drowsy at all. There's no danger of taking Benadryl with methadone and if you're like me you will probably not get drowsy from it until your ready to sleep anyway.

03-19-2007, 04:52 PM
okay, thanks. todays dose of methadone isn't enough to feel, but i just wanted to be safe.

with the adderall, I should be fine, too, i suppose.

03-30-2007, 11:40 PM

03-31-2007, 11:16 AM
You know, Benadryl is such a hardcore narcotic. Nothing to be played with...:rolleyes:

04-02-2007, 05:59 PM
the post was more of the benadryl reacting with the methadone.

theres been so much controversy lately about people dying on methadone.

04-03-2007, 08:38 PM
I have really bad allergies, and took benadryl while on methadone. The worst that happened was some increased drowsiness.

You should be fine if you don't take more than a few of them.

04-07-2007, 12:23 PM
I take 50mg of benedryl w/ my methadone almost every day; Along w/ tagament HB and calcium carbonate washed down w/ grapefruit juice. It's a potentiator and will retard your fascination w/ scratching for a little while. It's not extremely noticeable but I give it 2 and a half stars for it's all around versitility.


04-08-2007, 12:41 AM
u really put all those substances in ur body every day?? thats nasty..so bad for ur body bro.

04-08-2007, 07:23 AM
u really put all those substances in ur body every day?? thats nasty..so bad for ur body bro.

how so? what would you do if you constantly had stomach problems? or constantly had allergy problems. the other substance was grapefruit juice, and methadone.

thats not really harsh on the body at all.

04-08-2007, 08:03 AM
What Matthew is doing is no worse than what you continually ingest JahRed.;)

04-08-2007, 09:40 AM
So by now did you take the benadryl & how did it work out for you? I totally understand your post! I still have some meth tabs I am dying to try but am scared to death b/c I am just not educated enough to know what is safe etc to mix with it so good for you for asking & IMHO the more of these posts the better, especially with methadone & all the publicity lately of OD's with mixing the wrong drugs, long half life etc. knowledge is certainly power IMHO.

anyhow hope your allergies are better & let us know how it worked for you. (if you posted & I missed it sorry I'm a little looped right now):o

Happy Easter too!

04-08-2007, 12:03 PM
search google for Narcotic Dosage Converter, and click the first link.

it'll tell you how much methadone to take going by how much of another opiate you take.

if you are taking any weird prescription drug, maybe post that with your question and someone could tell you if you're in harms way or not. chances are, you're not.

04-08-2007, 01:01 PM
I can see how Benadryl would potentiate done and other opiates, but when I was at the methadone clinic in Lexington, I was told not to take Benadryl because it would make me test positive for benzos. At that clinic, if you tested positive for benzos, they immediately cut your dose in half then brought it back up gradually once you tested negative for them. They were just paranoid about the OD potential. I can't understand how diphenhydramine would make you test positive for benzos, and I didn't really quit taking them because I use it sometimes for sleep (usually 50-75 mg), and I never tested positive for benzos, so maybe they just said that as a scare tactic. They also said not to take pseudoephedrine in cough syrup / cold medicines because that would make you test positive for amphetamines (which I already knew), and also benzos (which I can't understand how that would make you test positive for benzos either).

The funny thing was that they said it was okay to take dextromethorphan in cough syrup because that wouldn't make you test positive for anything, but I know it can make you test positive for PCP, because it happened to me before, and I never have taken PCP. I've never even seen it or heard of it being around here. But that was years ago when I was Robo-tripping a lot.

04-14-2007, 10:07 AM
I'm on 210 done once a day and get weekend take homes, I wish I could take benadryl to potentiate my dose. However I dont know if it would work with me because some years back when I was in the hospital for serious health issues(long story). They gave me a benadryl to sleep that night.

Well it made me sleep but it also made my ulcerative colitis flare up way worse again in the morning so they rushed me down for a colonoscopy at around 4pm. They gave me the usual lovely dose of demerol and the demerol didn't work very well at all. I was like holy shit that damn benadryl did it and I said to them, Hell I'm in pain and I'm wide awake and the pain is awful, why did the benadryl make the demerol not as effective. The doc said "dont worry its all in your head" you're just fine, but I was not, I was hardly buzzed even and could see the horror on this tv screen as I watched them right on the screen seeing how horrible my colon looked.

That damn incident took what little life was left in my colon and I ended up with surgery at another hospital where my colon specialist was. I got a treat in the end when I had that morphine pump all week to myself.

So now I'm scared to take benadryl, if I had that kind of reaction I just described with demerol, what would happen if I took benadryl now on 210mg methadone? the worst I worry is the benadryl could make my done dose not work well at all or worse put me in horrible wd all day long. What do you all think?

04-16-2007, 05:06 PM
ummm no.. benadryl will not make u go into w/d's if u take it with methadone even at 210mgs u should be fine. But if i were u i wouldn't take it, seeing what it did to u last time..

04-16-2007, 05:37 PM
u really put all those substances in ur body every day?? thats nasty..so bad for ur body bro.

how are they nasty? would it be nasty to put opiates in your body everyday? i don't think so.

ummm no.. benadryl will not make u go into w/d's if u take it with methadone even at 210mgs u should be fine. But if i were u i wouldn't take it, seeing what it did to u last time..

he was talking about demerol and benadryl.