How does the time release of Oxycontin work?

[jkis]

I was just wondering how much of the drug is released into the blood stream, and at what intervals throughout the whole process of the time-release. I've searched everywhere and can only find that initially about 33% of the pill is initially put into your system. I know that crushing it and swallowing defeats the whole time-release and is best to do for recreational uses. But I'm just trying to experiment since I dose multiple times per day. By the way, I'm talking about 80mg oxys just so you know what I'm dealing with.

Basically, I want to know exactly how Oxycontin works when taken the way it was intended. If 33% initially is true, my guess would be that 1/3 of the pill is released initially, than 1/3 more after a few hours, and the final 1/3 after another few hours. Or it could just release that 1/3 first and then little by little after that continously until the pill is over with. I could be wrong, which is why I want to know the facts on this. I really have searched everywhere, and would appreciate anyone knowledgable on the subject to help explain it to me.

Second, if my first assumption is true, would taking 3 OC 80s at once swallowed whole, give the same buzz over 8 hours as taking 1 OC80 crushed and swallowed 3 seperate times over 8 hours, without having to dose all those sepearte times? I figure by the 33% rule that those 3 pills would be releasing a total of 80mg initially which would be the same as crushing and swallowing 1 by itself. Seems much more convenient to take them this way if this theory is at all true. So someone please shed some light on the subject.

Thank you in advance for any help and info. I love this site, and while my posts and topics are infrequent, i do read through the forums daily, and have never seen such a group of knowledgable and friendly people all about the same thing.

[AWOL]

Re: How does the time release of Oxycontin work?
Slowly!!







If varies pill to pill, but it is a continuous thing to the best of my knowledge cause it wouldn't really make any sense to release medication on different time intervals. There's really no realistic way of manufacturing a pill to do that anyway, and if you are manufacturing pain killers you want them to be effective at reliving pain as consistently as possible. Not just once every three hours.

The time release is defeated (not entirely, but almost entirely) by smashing the pill because it exposes all of the surface area at one time, instead of allowing the pill to be dissolved and absorbed little by little.

[roxi*stardust]

dv is right, intially the pills releases 33% of the dose as a "loading dose". In theory that dose would last anywhere from 4-6 hours and the remaider of the tablet matrix would dissolve slowly over a period of approx 12 hours give or take. I'll see if I can find the techical deatils for you, I used to have it.

[jkis]

The way I thought the pill was made(the best way i can describe) is in layers. Say one layer of drug, than layer of time release, than drug, than time release, etc. So you get a certain ammount of the drug in your system as the pill disolves, and then it comes to a layer that take a while to get past before the next layer of the drug itself gets disolved into your system. I was on adderrall for a while, and read a chart showing this exactly which is why I'm lead to believe that OC is the same way. Think of it as a bullseye. With each alternate circle being drug, than time coating in the next. Sorry if that was confusing, but does everyone understand what I'm saying? And is this completely incorrect?

Also, would that be a good assumption regardless of how the pill is released, that 3 OCs swallowed whole would be the same effect as 1OC crushed every few hours, over the same overall time period off course? Thanks

[AWOL]

The way I thought the pill was made(the best way i can describe) is in layers. Say one layer of drug, than layer of time release, than drug, than time release, etc. So you get a certain ammount of the drug in your system as the pill disolves, and then it comes to a layer that take a while to get past before the next layer of the drug itself gets disolved into your system. I was on adderrall for a while, and read a chart showing this exactly which is why I'm lead to believe that OC is the same way. Think of it as a bullseye. With each alternate circle being drug, than time coating in the next. Sorry if that was confusing, but does everyone understand what I'm saying? And is this completely incorrect?

Well, like I was saying that wouldn't be a practical way of making pills. It could be done, but not practically. If it were to be done, it would just be that different parts of the time release were set to absorb slower. Like the difference between water paint, and oil paint. It wouldn't work with pills like how OC are manufactured though because it would require the substance to be exposed all at once and breakdown acordingly after that. It would need to be like a gel, or a gel-cap with little time release balls in it.


Also, would that be a good assumption regardless of how the pill is released, that 3 OCs swallowed whole would be the same effect as 1OC crushed every few hours, over the same overall time period off course? Thanks

Well, considering what stardust is saying no, because of the loading dose that she is talking about. You would get that initial loading dose all at once, get really fucked up and probably sick, and then it would fade.

[roxi*stardust]

You won't achieve a steady plasma state by taking like 20mg of IR medicine every couple hours. You will have rise and falls in the amount of medicine in your bloodstream, hence the long-acting meds like OC. One part of the tablet (the loading dose is released from the outer core then the remainder of the drug dissolves slowly giving only a few mg as each layer dissolves, therefore leading to a steady concetration of the drug in you bloodstream, no rises and falls in the concentration.

[jkis]

well if 1/3 of the pill is the loading dose, that means that 80mg would be the total of the loading dose of swallowing 3 whole pills at once. I wish that would get me sick, but that wouldn't even get me high to be honest. Not bragging either, I wish I had no tolerance and a 10mg perc would get me right.

But anyway, taking the 3 whole therefore, would give me the same initial rush as chewing 1 80, however the remainder of the time would be far less of a high than to chew the other 2 pills every 4 hours, correct? Instead of getting that whole 80 3 times, I would techincally only get it initially with the remainder of the pills being released minimally over the rest of the time. So my hope of getting an 8-12 hour high off of once dose of 3 pills vs. three doses of 3 crushed pills isn't fathomable? I guess I could try it and see myself, but I hate to be wasteful.

And by the way Roxi, if you could find that technical info of how the pills actually work I would greatly appreciate it. Thats really the main thing I was looking for in this post, although I always enjoy all the info I can get.

[AWOL]

Take them and find out, it's one time. If you don't like it, don't do it again. Simple practical results tell you more than theoretical data.

[roxi*stardust]

OxyContin Tablets exhibit a biphasic
absorption pattern with two apparent absorption half-lives of 0.6 and 6.9 hours, which
describes the initial release of oxycodone from the tablet followed by a prolonged release.



Dose proportionality has been established for the 10 mg, 20 mg, 40 mg, and 80 mg tablet
strengths for both peak plasma concentrations (Cmax) and extent of absorption (AUC)
(see Table 1 below). Another study established that the 160 mg tablet is bioequivalent to
2 x 80 mg tablets as well as to 4 x 40 mg for both peak plasma concentrations (Cmax) and
extent of absorption (AUC) (see Table 2 below). Given the short half-life of elimination of
oxycodone from OxyContin®, steady-state plasma concentrations of oxycodone are achieved
within 24-36 hours of initiation of dosing with OxyContin Tablets. In a study comparing
10 mg of OxyContin every 12 hours to 5 mg of immediate-release oxycodone every 6 hours,
the two treatments were found to be equivalent for AUC and Cmax, and similar for Cmin
(trough) concentrations. There was less fluctuation in plasma concentrations for the
OxyContin Tablets than for the immediate-release formulation.


you will only achieve a steady concentration of the drug in your system by mutiple dosings according to the data. So taking 3 tablets at once is not the same as taking 1 3x a day

[jkis]

You won't achieve a steady plasma state by taking like 20mg of IR medicine every couple hours. You will have rise and falls in the amount of medicine in your bloodstream, hence the long-acting meds like OC. One part of the tablet (the loading dose is released from the outer core then the remainder of the drug dissolves slowly giving only a few mg as each layer dissolves, therefore leading to a steady concetration of the drug in you bloodstream, no rises and falls in the concentration.

Are those rises and falls and good thing, or bad thing, in terms of euphoric effects? Trying to basically find the best way to get the most buzz with most convenience and least ammount of pills as possible.

[roxi*stardust]

Are those rises and falls and good thing, or bad thing, in terms of euphoric effects? Trying to basically find the best way to get the most buzz with most convenience and least ammount of pills as possible.
Your want your cake and to eat it too. Most of us do:D . The answer is NO. All the data is for pain relief not euphoria. To get the best euphoria crushing the tablets is the best way to get there, if you want pain relief take them right.

[Hammilton]

adderall is a completely different thing than OC. adderall's little beads. i'm looking at them right now.

unless you mean the IR not the XR. i haven't had IRs

[AWOL]

adderall is a completely different thing than OC. adderall's little beads. i'm looking at them right now.

unless you mean the IR not the XR. i haven't had IRs

Yeah, that's what I was sayin too. The little beads where some are going to break down at different rates than others.


............ can I have some :D

[jkis]

Of course I want my cake and to eat it too, lol...Nah, I really just wanna find the best way to get high, and stay high all day without counting down til my next dose.

And as for the adderrall, they were 30mg ers, the little beads. Didn't even think about them being a completely different structure. Just kind of thought about the oxy as being one really big bead, although I was clearly wrong.

Thanks for such quick helpful answers though, thats why I love this site and the people on it.

[AWOL]

Of course I want my cake and to eat it too, lol...Nah, I really just wanna find the best way to get high, and stay high all day without counting down til my next dose.

And as for the adderrall, they were 30mg ers, the little beads. Didn't even think about them being a completely different structure. Just kind of thought about the oxy as being one really big bead, although I was clearly wrong.

Thanks for such quick helpful answers though, thats why I love this site and the people on it. I want to eat your cake too :p

[robojunkie]

I believe that in terms of pain relief (not euphoria) the most effective dosing regimen is one that allows for a consistent plasma concentration without the ups and downs associated with redosing of IR oxys (or anything else) every few hours. This is why OC and other time release pills have the initial "loading dose" (IR portion) and then the slow continual (hence the name oxycontin) release of the oxycodone.

However, in terms of euphoria I have always found the ups and downs to be the most conducive to a good high. I guess this is an individual thing (whereas many studies have shown that pain is controlled much more efficiently with consistent plasma levels) but most I have talked to prefer quick onset and redosing of whatever their DOC for purposes of euphoria. So, basically if you are looking primarily for euphoria my advice would be to crush up and take one of the 80's, then another after 4 or 6 hours and so on. And yes, I believe taking three 80's "as is" at once would be like eating one crushed up 80 at first (due to the IR one third portion). However after a few hours you would be at a plateau instead of getting to redose two more times do to the remaining two thirds of continual release oxy in your system.

So my advice, in terms of euphoria, is crush 'em up and take one at a time over the day instead of all three "as is" at once.

[AWOL]

taking oxy oraly sucks anyway :rolleyes: I've only ever done it twice. It was crap. Prob good for pain, crap for fun.

[l4l5]

at 60 minutes the drug releases some, and again at 3 and at 6 and then at 9th hours, plasma concentration is preetty steady over the whole 12 hours, after 9 hours it starts going down

[jkis]

at 60 minutes the drug releases some, and again at 3 and at 6 and then at 9th hours, plasma concentration is preetty steady over the whole 12 hours, after 9 hours it starts going down


Thats how I figured it worked, but that goes against what everyone else is saying. I figured it released some every few hours keeping the levels in your system pretty consistent.

It seems there is some confusion over the topic. Roxi provided that information about the pills, but I wonder if the example they used were different, if it would have different results. Say instead of comparing a 10mg OC over 12 hours to 2 5mg IRs every 6, using a 20mg OC over 12 hours to a 5mg IR every 3 hours. I would almost bet that the results would vary greatly, since 6 hours is kind of long for a 5mg IR to last.

[l4l5]

I saw a test on the effectivness of the 12hr release tablets v taking the instant release every 4 hours,it was on google. The plasma levels were all over the place on the patients taking the instant release every 4 hours, whereas the oxy contin patients held plasma levels steady, proving that its better to take the contin stlye,
hell it works for me, when I go to work I take it as directed 1 tablet every 12 hours, keeps the pain at bay no problems, and your colleges dont see u throwing pills in your mouth every 4 hours. Which for me is the most important I dont want my employer thinking im a pill popper. at first i was taking tylenol 3's every 3 hours, and my employer would look at me funny all the time, and something went missing once i was the first person asked to open your breifcase, so it helps in many way the contin

more steady pain releif
less phycological addiction to popping pills
employment prospects
I get less constipation, then dosing every 4 hours

I think the contin should be made in bigger doses even for the people that take oc 80's every 4 hours ect ect.

[OCfenatiq]

The way I thought the pill was made(the best way i can describe) is in layers. Say one layer of drug, than layer of time release, than drug, than time release, etc. So you get a certain ammount of the drug in your system as the pill disolves, and then it comes to a layer that take a while to get past before the next layer of the drug itself gets disolved into your system. I was on adderrall for a while, and read a chart showing this exactly which is why I'm lead to believe that OC is the same way. Think of it as a bullseye. With each alternate circle being drug, than time coating in the next. Sorry if that was confusing, but does everyone understand what I'm saying? And is this completely incorrect?

Also, would that be a good assumption regardless of how the pill is released, that 3 OCs swallowed whole would be the same effect as 1OC crushed every few hours, over the same overall time period off course? Thanks
Like mentioned before the Adderall is a capsule with bead inside instead of powder like other capsules. Each bead is kind of like its own tiny pill with its own coating that delays the release causing them to last longer hence the XR in the name. OC is just a mixture of oxycodone and fillers and crap to dalay its release, not layers. Also like mentioned by dv you can basically do away with the time release if you chew it up before swallowing (doesn't act exactly as taking a few percs but close).

I heard they are planning on adding another ingrediant to OC in the near future, I for get the chemical name, but it is supposed to create a non-euphoric feeling if chewed or crushed but will not be noticed if taken as directed. This is supposed to stop people from snorting or IVing OCs. Hopefully it will be a while since chewing them up is more fun personally...

[roxi*stardust]

OxyContin Tablets exhibit a biphasic
absorption pattern with two apparent absorption half-lives of 0.6 and 6.9 hours, which
describes the initial release of oxycodone from the tablet followed by a prolonged release.


I thought I explained it pretty well. you get an intial "loading dose" from the tablet (approx. 33%) and the remainder orf the tablet dissolves over a period of time to achieve a steady plasma state which takes 24-36 hours of q12 hour dosing. This is how the tablet works.

[alowishus]

FFS jusy eat the damn things and figure out what you like best.

I liked my OC buzz better if I necked 'em whole, when I chewed them they didn't last and the buzz was not as "warm and fuzzy" as when taken whole.

[bronyraur]

I thought I explained it pretty well. you get an intial "loading dose" from the tablet (approx. 33%) and the remainder orf the tablet dissolves over a period of time to achieve a steady plasma state which takes 24-36 hours of q12 hour dosing. This is how the tablet works.



you did explain it well, Roxi. some people just don't like to listen.

this thread reminds of the thread with a kid that was arguing that if you break an OC 80 in half, you'll have 2 pills of 80mg a piece. can't remember his name but what a goon. Complete nonsense!

[alowishus]

you did explain it well, Roxi. some people just don't like to listen.

this thread reminds of the thread with a kid that was arguing that if you break an OC 80 in half, you'll have 2 pills of 80mg a piece. can't remember his name but what a goon. Complete nonsense!

I remember that, I was trying to explain to no avail. Wow good memory. Yeah that was a good one, how he got that idea.....:rolleyes: :rolleyes:

He was sure he had found the holy grail of OC's.
How do you take half of something and are still left w/ a whole? :D

[bronyraur]

Wow good memory.

it's hard to forget a complete moron.:D

[kyuss]

just snort it

[l4l5]

havent seen u around kyuss whats happening man?

[jkis]

Thanks for the info everyone. I never said Roxi didn't give good info, because she did. And I completely understood it. Its just that after that someone else contradicted it, and actually said that they work how I initially assumed they did. I guess I'll have to try swallowing a few whole and see if I like it better or worse. I have never not crushed up or chewed an OC, so it will be interesting to try it for a day or 2, and coupled with the b/t meds see if the high is better or worse. I'm sure its not as much of a rush, but I'm really trying to acheive a long-lasting euphoria over a quick intense rush.

Anyway, thanks again for the responses, and I'm sorry if I sounded ignorant or stupid, but I like to know exact details of everything, and I explained why I questioned roxi's original post already.

[roxi*stardust]

you did explain it well, Roxi. some people just don't like to listen.

this thread reminds of the thread with a kid that was arguing that if you break an OC 80 in half, you'll have 2 pills of 80mg a piece. can't remember his name but what a goon. Complete nonsense!

I remember that, I was trying to explain to no avail. Wow good memory. Yeah that was a good one, how he got that idea.....:rolleyes: :rolleyes:

He was sure he had found the holy grail of OC's.
How do you take half of something and are still left w/ a whole? :D
You have got to be kidding me guys? What was his reasoning behind this? Why would he think he had 2 80's if he broke them in half? God if that was the case.......:D

[Woowoo]

You have got to be kidding me guys? What was his reasoning behind this? Why would he think he had 2 80's if he broke them in half? God if that was the case.......:D
That's fuckin hilarious!! ROFL. Wait let me guess his reasoning. If the pill says "80" on both sides, and you slice it right down the middle, then it still says 80 on both sides!! LOL haha I'm all shits and giggles right now. Maybe it's just the drugs I'm on, but I'm just tickled.

[l4l5]

That's fuckin hilarious!! ROFL. Wait let me guess his reasoning. If the pill says "80" on both sides, and you slice it right down the middle, then it still says 80 on both sides!! LOL haha I'm all shits and giggles right now. Maybe it's just the drugs I'm on, but I'm just tickled.

I repeat is it school holidays somewhere in the world, cause there is so crazy questions and bloaters out there at the moment