2mg Ativan Vs. 15mg Restoril Vs. 1mg Xanax Vs. 0

[drugsaregood]

Alright...

In my stash there is currently:

2mg ativan
1mg Xanax
15mg restoril


I would think restoril would have the shortest detection times, followed by ativan, then xanax...

Anywho, could anyone fill me in on whats out of the system the fastest and the rough time it would take for your system to be clean? I tried searching for ativan on here, didn't find much about ua's...

Sorry to add yet another how long UA thread...

Anything there gone in under a week?

[Diluted]

ativan has the shortest half life of them all - if you have a week - if you induldge tonight.. do the whole midurine drink some water b12 thingie we all do -- You'll be OK.

[drugsaregood]

ativan has the shortest half life of them all - if you have a week - if you induldge tonight.. do the whole midurine drink some water b12 thingie we all do -- You'll be OK.


Cool thanks man. Anyone want to give their second opinion and verify this? ;p

[Diluted]

Whoops. (http://www.mentalhealth.com/drug/p30-a04.html) After googling for a bit, I found a few reports saying alprazolam is SHORTER than ativan - yet generaly in the same time line. Lord knows I better be dead on accurate for FEAR of a flame.
*jumps behind a bush*

It takes about 11.2 hours for the system to break down 50% (half-life) of the active ingredient (alprazolam)

Although Ativan starts working within the first hour after ingestion, according to the manufacturer, it takes about 2 hours for peak concentration in the blood to be reached. And it takes about 12 hours for the system to break down 50% (half-life) of the active ingredient (lorazepam)

http://halfdoctor.com/medication/

[drugsaregood]

Cool. I managed to find this:

http://www.dr-bob.org/tips/bzd.html

I'm not sure how well half life corelates with detection times though. I mean that shit like stores itself in your brain\blood I remember hearing, thus the long detection times? I mean, pot stores itself in your fat and it can be detected 1-30 days depending on usage...Whats up with these benzos and piss :(

[drugsaregood]

Benzodiazepines
2-7 hours
Infrequent user: 3 days / Chronic user: 4-6 weeks

hm. wonder how accurate that is...3 days? that'd be nice...

[Diluted]

I always rolled the dice, and always came threw pissing clean. lol. at the methadone clinic, I was DEAD AFRAID to loose my takehomes.. and they didn't drug test on the weekends, so I knew the earliest was monday -- on a friday night (when I wasn't serious about recovery) I could smoke some pot, take a benzo - and by monday morning after doing the whole drink a lot of water, catch the urine midstream -- I never failed. It's chronic use that builds up. That's what I love about the internet - is when people post facts - I like to follow it up with a reference.. sorta like a school paper in a cheesy way.

Infact, about six weeks ago I smoked pot for the first time in awhile (makes me all whacked out.. seriously schizophrenic when I smoke pot..) and that was on a tuesday.. friday at the doctor I pee'd clean. Go figure.

[drugsaregood]

I'm really considering putting .5 xanax under my tounge now. Hmmm

[Diluted]

I hate to keep posting and posting.. join me in chat..

[rroberts161]

The drugs in this cluster all seem to have very similar windows of detection using titer based colorimetric detection techniques. Each has fairly smooth and direct fate and excretion.

First, what the literature says: (These are the THEORETICAL TIMES OF DETECTABILITY)

Temazepam, (Restoril) has a terminal half life ranging from 3.5-18.4 hours (mean 8.8 hours). Temazepam should be undetectable after a maximum of 5 times the half life of the longest lived metabolite. The drug is active as ingested, and is excreted in the urine mostly (80% - 90%). The major metabolite (the O-conjugate) has a normal half life of only 10 hours. The theoretical limit for detection in urine should therefore be between 17.5 hours and 92 hours, with an average time to full elimination of 44 hours. This is assuming that the detection test is HIGHLY responsive, and most of them are not.

Lorazepam (Ativan) has a serum half life of about 12 to 15 hours, and the main conjugate has a half-life of about 18 to 20 hours (lorazepam glucuronide). Figure 90 hours for elimination in most cases. Literature states that "95% of lorazepam is excreted in within 120 hours, 88% in the urine and 6.6% in the stools.

Alprazolam (Xanax) has a slightly more complex metabolic path, and the half-life of the drug can vary widely from patient to patient. The literature cites:

"A mean half-life of alprazolam of 16.3 hours has been observed in healthy elderly subjects (range: 9.0-26.9 hours, n = 16) compared to 11.0 hours (range: 6.3-15.8 hours, n = 16) in healthy adult subjects. In patients with alcoholic liver disease (http://www.rxlist.com/script/main/art.asp?articlekey=53394) the half-life of alprazolam ranged between 5.8 and 65.3 hours (mean: 19.7 hours, n = 17) as compared to between 6.3 and 26.9 hours (mean = 11.4 hours, n = 17) in healthy subjects. In an obese (http://www.rxlist.com/script/main/art.asp?articlekey=11760) group of subjects the half-life of alprazolam ranged between 9.9 and 40.4 hours (mean = 21.8 hours, n = 12) as compared to between 6.3 and 15.8 hours (mean = 10.6 hours, n = 12) in healthy subjects."

The literature makes note that in a healthy adult patients, the elimination half life is 6.3-26.9 hours, with an average of 11.2 hours. Figuring the detection safe rule again of five half lives for conservatively secure testing is 31.5 hours to 134.5 hours with an average of 56 hours.

Note that all of these values are assuming well characterized contexts of use, and the use of the coefficient of 5 for the safe half life multiplier uses the same value as that for the use of nucleotides in radiological imaging, and this is highly conservative. Although I personally do not use temazepam in my practice, I am familiar with all three medications. Asking the opinions of colleagues, it seems that there is general agreement that short of heavy use, the practical window of detection is considered to be five days at best.

This does not mean that these drugs are undetectable after five days. It means that given the technique most typical for drug screenings ( antibody-antigen titer binding with colorimetric indicators) has a practical limit of about this long.


Practical time windows of detection:

On the other hand, if the urine test was to use more sensitive methods of assay such as chromatography, and assuming the technician doing the test knows what long lived metabolite to test for in extremely small amounts, detection might have a considerably wider window. Also, if the person being tested is not healthy and has damage to any of the metabolic pathways of each drug in the body, or other disorders such as kidney problems that limit urine output etc., it is possible that the detection window can be dangerously wider. Finally, elimination testing for medications in humans is very rarely done at doses higher than approved dosages or for periods longer than normal, the possibility of detection certainly tends to be expanded.

DISCLAIMER: I am expressing my opinions only in this post. I am not recommending any person act on the basis of anything said or implied here, and I assume no responsibility for any outcomes connected in any manner to this post. Furthermore, I am not establishing, nor do I intend to establish a doctor-patient relationship with any person reading this message and not in a doctor-patient relationship with me by other means. Lastly, the opinions expressed here are my own, and do not reflect the option of any other person or entity.

rroberts161

[drugsaregood]

The drugs in this cluster all seem to have very similar windows of detection using titer based colorimetric detection techniques. Each has fairly smooth and direct fate and excretion.

First, what the literature says: (These are the THEORETICAL TIMES OF DETECTABILITY)

Temazepam, (Restoril) has a terminal half life ranging from 3.5-18.4 hours (mean 8.8 hours). Temazepam should be undetectable after a maximum of 5 times the half life of the longest lived metabolite. The drug is active as ingested, and is excreted in the urine mostly (80% - 90%). The major metabolite (the O-conjugate) has a normal half life of only 10 hours. The theoretical limit for detection in urine should therefore be between 17.5 hours and 92 hours, with an average time to full elimination of 44 hours. This is assuming that the detection test is HIGHLY responsive, and most of them are not.

Lorazepam (Ativan) has a serum half life of about 12 to 15 hours, and the main conjugate has a half-life of about 18 to 20 hours (lorazepam glucuronide). Figure 90 hours for elimination in most cases. Literature states that "95% of lorazepam is excreted in within 120 hours, 88% in the urine and 6.6% in the stools.

Alprazolam (Xanax) has a slightly more complex metabolic path, and the half-life of the drug can vary widely from patient to patient. The literature cites:

"A mean half-life of alprazolam of 16.3 hours has been observed in healthy elderly subjects (range: 9.0-26.9 hours, n = 16) compared to 11.0 hours (range: 6.3-15.8 hours, n = 16) in healthy adult subjects. In patients with alcoholic liver disease (http://www.rxlist.com/script/main/art.asp?articlekey=53394) the half-life of alprazolam ranged between 5.8 and 65.3 hours (mean: 19.7 hours, n = 17) as compared to between 6.3 and 26.9 hours (mean = 11.4 hours, n = 17) in healthy subjects. In an obese (http://www.rxlist.com/script/main/art.asp?articlekey=11760) group of subjects the half-life of alprazolam ranged between 9.9 and 40.4 hours (mean = 21.8 hours, n = 12) as compared to between 6.3 and 15.8 hours (mean = 10.6 hours, n = 12) in healthy subjects."

The literature makes note that in a healthy adult patients, the elimination half life is 6.3-26.9 hours, with an average of 11.2 hours. Figuring the detection safe rule again of five half lives for conservatively secure testing is 31.5 hours to 134.5 hours with an average of 56 hours.

Note that all of these values are assuming well characterized contexts of use, and the use of the coefficient of 5 for the safe half life multiplier uses the same value as that for the use of nucleotides in radiological imaging, and this is highly conservative. Although I personally do not use temazepam in my practice, I am familiar with all three medications. Asking the opinions of colleagues, it seems that there is general agreement that short of heavy use, the practical window of detection is considered to be five days at best.

This does not mean that these drugs are undetectable after five days. It means that given the technique most typical for drug screenings ( antibody-antigen titer binding with colorimetric indicators) has a practical limit of about this long.


Practical time windows of detection:

On the other hand, if the urine test was to use more sensitive methods of assay such as chromatography, and assuming the technician doing the test knows what long lived metabolite to test for in extremely small amounts, detection might have a considerably wider window. Also, if the person being tested is not healthy and has damage to any of the metabolic pathways of each drug in the body, or other disorders such as kidney problems that limit urine output etc., it is possible that the detection window can be dangerously wider. Finally, elimination testing for medications in humans is very rarely done at doses higher than approved dosages or for periods longer than normal, the possibility of detection certainly tends to be expanded.

DISCLAIMER: I am expressing my opinions only in this post. I am not recommending any person act on the basis of anything said or implied here, and I assume no responsibility for any outcomes connected in any manner to this post. Furthermore, I am not establishing, nor do I intend to establish a doctor-patient relationship with any person reading this message and not in a doctor-patient relationship with me by other means. Lastly, the opinions expressed here are my own, and do not reflect the option of any other person or entity.

rroberts161


Holy shit dude! Thanks alot, exactly what I was looking for. I knew lab tests would result in longer detection times, I'm glad I don't get subjected to that...Appreciate it alot...

One more question if you're still around and don't mind. Say someone still has xanax in their system, and would piss dirty if they didn't take steps to insure it wouldn't...If they consumed mass amounts of water, and pissed alot before the test, would that pretty much null all existing metabolites\detectable material? Might be kind of a foolish question, but I've been wondering how useful dillution can be if there's high concentrations of drugs in ones system, or just a little...

Once again, thanks!

[wafflehead77]

From what I have seen, restoril is the shortest, with an average of an 11 hr half-life (3-25), then alprazolam with a 12hr (9-20), then lorazepam with 15hr (9-24)

[chemboy7]

Myself, I would prefer the Restoril the msst, than Xanax, and last (my least favorite Benzodiazepine) Ativan. Really though what would be good is to double up and drop the Restoril ans Alprazolam... I have found that although they are shitty recreational drugs by themselves in the right combinations that you can acually get a nice littel=

[Diacetyl]

Yeah, xanax(Aprazolam) would be the shortest acting. Thats why its so saught after, it kicks in fast and hard and its gone within 6 hours(forme).

Xanax+Alcohol is always fun times for me, but I always proceed with caution.

[rroberts161]

Holy shit dude! Thanks alot, exactly what I was looking for. I knew lab tests would result in longer detection times, I'm glad I don't get subjected to that...Appreciate it alot...

One more question if you're still around and don't mind. Say someone still has xanax in their system, and would piss dirty if they didn't take steps to insure it wouldn't...If they consumed mass amounts of water, and pissed alot before the test, would that pretty much null all existing metabolites\detectable material? Might be kind of a foolish question, but I've been wondering how useful dillution can be if there's high concentrations of drugs in ones system, or just a little...

Once again, thanks!


Excess hydration will make most drugs difficult to detect, but the effect is highly variable. Patients that need to pass a urine test often use the following technique if the sample production is not observed.

Take a small spray bottle like those spray type sinus-decongestant comes in. Dump out the contents and clean carefully. Using a pair of pliers, grip the portion of the bottle that goes up the nose and pull it out. There will be a small tube attached to this. Pull it out and discard it.

Enlarge the hole in the part you removed so that urine will flow easily if desired. Most of these bottles have a hole in the top that is very small. Better it be enlarged so that on spray the urine does not form a sudsy "head" when you use it.

Fill it with urine obtained from a friend known to be clean, or if you can from yourself during a clean period. Replace the cap. This will seal the bottle so it will not leak. Put the bottle under your arm pit and keep it there until it is body temperature.

This will allow you to substitute clean urine for your own, and will defeat the use of temperature to identify urine substitutions. The bottle of choice for this is ideal because its thin walls make for rapid heating of the sample from the heat of the patient's body. Make certain that the temperature does not vary from normal by more than 3 degrees plus or minus.

If you are watched while micturating, the solution of certainty is more difficult.

Obtain urine in a sterile container from a person known to be in good health. Urinate, emptying your bladder as well as possible. Using a Foley catheter, rinse the bladder internally with saline 2 or 3 times. Using the same catheter, instill the clean urine sample into the bladder. Remove the catheter and submit the sample within 30 minutes.

Hope this helps. The later technique may seem drastic, and it is. There are many ways to acquire infections using this approach, even though normal urine is sterile. Furthermore, it is possible to injure oneself in the act of cauterization. Adverse outcomes can include but are not restricted to infection, persistent incontinence, fistula and urethral damage requiring repair. On the other hand, cath procedures are performed all the time and are ordinarily safe. If the test is for a job as, oh say an aircraft pilot or doctor, the trouble might be worth the effort and risk.

Note that if you wait more than a short period of time after instilling the clan urine, your own body will eventually contaminate the sample. Also, some people, especially males, have trouble stopping urination and retaining the urine in the bladder immediately following catheter removal.

DISCLAIMER: I m not suggesting any person act on the basis of the remarks I make above. I am not establishing or intending to establish a doctor-patient relationship by anything written above. I do not accept responsibility for any actions or outcomes by individuals or groups acting upon their understandings of my remarks.

[drugsaregood]

Damn dude, thanks again...Aint no way I'm sticking shit up my wang...