GABA-A antagonists increases opiate euphoria

[kingdxm]

I found this to be very interesting. When an opiate enters into the brain, besides activating endorphin receptors, the euphoria is mainly caused by activating dopamine in the brain both directly(by releasing dopamine into the synapses) and by blocking the neurotransmitter GABA at the GABA-A receptor site. What this means is that if you use a GABA-A antagonists(and for an extra boost, a dopamine agonist)with your favorite opiate, it will be compareable to adding jet fuel to your car. The most common and easily accessable GABA-A antagonist is alpha-thujone(or just simply thujone), the so-called active ingredient in absinthe. Wormwood has been considered to be a mild narcotic. 3-isothujone, the dominate isomer of wormwood oil, has an antinociceptive(pain-killing) effect, compareable to codeine. Sage(salvia officinalis) actually has a higher concentration of thujone than wormwood, somewhere between 13,000 to 15,000 PPM.
Also anticholinergics, such as scopalamine greatly potentiate narcotics since opiates also gain some of their euphoria-producing effects from blocking acetylcholine.
Wouldn't it be interesting if by taking a combination of thujone(GABA-A blocker), some apomorphine or pukateine(from laurelia novae-zelandiae), and a small amount of scopalamine, that you could produce the opiate euphoria without ever taking a narcotic? This is simply a theory, but it seems plausable. At the very least, you could take this combo with your favorite narcotic and have a blast.

[euphoria2002]

The obvious thing here would be to do some experiments.

Wormwood, and Sage...I'm assuming you're talking about the spice, are easily available. Perhaps a small extraction of the active compounds from both, to be taken in conjunction with your favorite opiate. Then sit back and subjectively evaluate whether or not there is any increase in euphoria.

Scopalamine..... good luck getting ahold of that one, for most people anyways.

Euphoria

ps. I've heard some bad things about overdoing it with that absinthe stuff. Memory problems and the like.

[drugsaregood]

doesn't ambien work on GABA? I've taken that when taking oxy, didn't notice too much but it was there.

[jacky]

thanks for this interesting info kingdxm.....
I have all of the above mentioned ingredients for this experiment, so I will give it a go soon.

I have noticed that when I was using dxm daily, that pukateine was considerably more psychoactive than when taking it without dxm....the activity reminded me of cocaine in a way.

[sweetbaby]

Thanks KING.............Great info!!!
I wrote a whole long reply and then lost it, what a bitch! :-)
anyway I'm not going to rewrite it. What are the sources for finding thujone, pukateine,
scopalamine & sage?? Health food stores, online? I have a chronic pain disease and always looking for ways to make my meds work better (grapefruit juice, vitamin C).
If you don't want to post the info will you please PM me? Thanks so much I'd really appreciate it!!
Posts like yours are one of the reasons i love this site, where I live it's hard to find other opiophiles, but here i feel right at home, ahhhhhhhhhhh :)

[kingdxm]

Ambien is a GABA agonist, as well as the benzodiazepines. It has to be a GABA antagonists. Sage oil and wormwood oil have high quantities of thujone and can be found online pretty easily, you might even find them at your local health food store(especially sage oil). Thujone is actually pretty safe. I have made absinthe many times and have used up to 20 times the recommended amount of wormwood oil with no problems. The convulsant dosage is high enough that you probably wont exceed it. Scopalamine is found in Jimson seeds, mandrake root, henbane, and a dozen or so herbs. You can find them online where they sell other legal psychoactives. For Jimson seeds(datura) I would use 30 to 50 seeds(no more than a 1/4 gram), they are pretty small. I can't personally take anymore than that, the dry mouth and throat that they cause is horrible. It did seem to increase my hydro buzz the last time. Diphenhydramine(Benadryl) has anticholinergic effects, as does the IBS drug Bentyl. Any good anticholinergic drug thoretically would work. Laurelia(pukateine) can be found at one of the herb sites right here at opiophile.

FYI: I found out that chaste tree has a dopamine agonist in it as well, don't know the name of it yet.

[sweetbaby]

Again, Thanks KING!
looks like I have some shopping to do. I'll post when i get some!

[sweetbaby]

Thanks again, KING!!!!!!

Looks like i have some shopping to do :-)
I'll post when I have some results & let you know how they work.......

[halfalien_s4]

ive had scopalamine several times before....last time i had it i wore it as a tiney patch worn behind the ear. my PM doc gave it to me for headaches. its a derivitive of belladona, from niteshade. it can do some weird shit! once i acidently rubbed some of the patch and then my eye, and then my pupil dialated like you've never seen! i meen hardcore! scopolamine is also good for nausea....as well as a potentiator for opiates...

[Paregoric Kid]

hmmmm, I'll try a mix of scopies, high dose caffeine, and wormwood and tell you how it goes

[mrbigsexy]

I have absinthe usually and it doesn't seem to make too much of a difference.

I guess I agree with it, but I don't think you could as far as not taking something that would produce the high. Without anything to incur it, I don't think it could just happen on its own, could it?

[kingdxm]

Absinthe doesn't have a lot of thujone in it so it probably wouldn't work for this experiment.