Favorite opiate potentiator

[SalvationThroughDilaudid]

So what's everyone's favorite opiate potentiator? Mine is phenergen, secondly soma, then benzos coming in third place, with alcohol being never, I had a friend who recently died doing just opies and alcohol, and he wasn't even a regular user, just a pain patient, so he took low dose opies and just had a few beers, but still managed to die.

[Zogledan]

Tonic WAter with white grapefruit juice

Also MST3K seems to make anything stronger

[oxymoron]

Tonic WAter with white grapefruit juice

Also MST3K seems to make anything stronger

I forgot all about MST3K until you just mentioned it, that was some funny shit:D

[Zogledan]

I forgot all about MST3K until you just mentioned it, that was some funny shit:D
A lot of the unreleased episodes
can be downloaded from PTP

I buy DVD qualitiy from this dude
http://www.castleforrester.com/images/web-logo.jpg
http://www.castleforrester.com/

[oxymoron]

A lot of the unreleased episodes
can be downloaded from PTP

I buy DVD qualitiy from this dude
http://www.castleforrester.com/images/web-logo.jpg
http://www.castleforrester.com/

nice link thanks

[SuperJunky]

I put other, it was a close one but my favorite is proglumide, fallowed by antihistamines and enzyme inhibitors, fallowed by benzos and muscle relaxers. More opiates are always good. I usually use a mixture of all of them, you should have made all of the above an option. I usually take proglumide, 2-3 tagmet, 2 cups of red grapefruit juice (not as good as white but it works to some degree), some diazepam or lorazepam, a soma or flexeril or 5 and 75mg of benadryl and occasionally a big swig of codeine/phnergan cough syrup. I use ketamine and DXM on occasion as well. I don't really like alcohol as a potentiator but I drink sometimes, not all that often though. If I do its just 2-5 shots of vodka right in a row. I think it kind of ruins the opiate high.

[Ragdoll]

Definitely not alcohol. Alcohol is it's own thing, to me...but then, I don't like it, no matter what, whether alone or with something else (in addition to the danger of mixing opies and alkiehol, which scares me). I'm always on benzos, so everything else is potentiated by those, whether I like it or not.

[Tres]

Yea, alcohol is a good way to get dead....I have Soma rxed to me, and I use grapefruit juice

[HistoryofMadness]

i put benzos for some reason, even though these days i hardly ever get to partake (lack of resource), probably becuase i've been wanting some benzies all morning. . .

my real favorite potentiators are a list of herbs i talk about all the time... i'm sure listing them again isn't necessary...

[Euphoricgirl]

Good thread Salvation! I am still stuck on grapefruit juice and Damiana.

[ProdigalSon]

Booze, xanax and oxy always gave me the best buzz hands down. But I never really potentiated. Snootin was just fine for me

[SalvationThroughDilaudid]

Yea, alcohol is a good way to get dead....I have Soma rxed to me, and I use grapefruit juice


Couldn't be truer than that. Alcohol and opies is a recipe for death. Actually alcohol and ANY CNS depressant is potentially lethal.

[AWOL]

Couldn't be truer than that. Alcohol and opies is a recipe for death. Actually alcohol and ANY CNS depressant is potentially lethal.
I'll drink to that :drink:

[slugbone]

i like using jacky's suggestion of cocoa, i get a double dip with milk and dark cocoa really helps cause i run out of tagamet sometimes it's kinda expensive

[SalvationThroughDilaudid]

i like using jacky's suggestion of cocoa, i get a double dip with milk and dark cocoa really helps cause i run out of tagamet sometimes it's kinda expensive


I've never heard of that one. Exactly how does this dark cocoa and milk thing work?

[slugbone]

I've never heard of that one. Exactly how does this dark cocoa and milk thing work?

i'll have to try and find that thread. jacky and repeek were discussing milk as a potentiator and jacky mentined that dark cocoa/chocolate is an excellent potentiator in his experience. i tried it with some nestle dark cocoa and sure enough it helps, althouh im not sure on the chemistry involved

[CUBErt]

I wish you could check more than one. Benzos and more opiates are both my favorite potentiators :)

[HistoryofMadness]

hell yeah man that 70% chocolate will knock your socks off after a hit... careful though watch for vomitus

[SalvationThroughDilaudid]

hell yeah man that 70% chocolate will knock your socks off after a hit... careful though watch for vomitus


I just ate some chocolate icecream and had a glass of milk. Does that count?

[HeidiW]

What about Godiva chocolates?

[Nile_dancer]

One of the threads where jacky talks about cocoa... there are more.

http://forum.opiophile.org/showthread.php?p=92310#post92310

[CMonk]

GHB comes in first. A barely threshold dose goes a long way to potentate a nice opiate high.

When drinking pod tea, I find that tagament goes a LONG way to increase the effects.

Finally, benzos are nice in small doses. They tend to make me to sleepy though.

[Nile_dancer]

Cmonk,

Is GHB readily available where you are, or do you make your own?

[Alice Mudgarden]

I voted for muscle relaxers, particularly Soma, with benzos a close second

[charlierm@comcast.net]

HI Oxy...

I JUST read your post about 'my favorite potentiators' and YOU mentioned MST3K, which, I JUST this evening happened to watch, as-in, I JUST got the episode "Teen-agers from Outer-Space', which is absolutely adorable, and, there is a funny comment YOU MUST SEE 'Crow...'Hot Child in the City' ...' reply to my note before the next Ice-Age and I'll mail you a DVD Copy of MST3K...

Charlie

[SalvationThroughDilaudid]

I'm still interested in that milk and chocolate thing. Can anyone elaborate?

[CMonk]

Cmonk,

Is GHB readily available where you are, or do you make your own?


GBL is a short mail order away. You can either take that as in for the same effects as GHB (but a little harder on the stomach) or use NaOH to make GHB.

The first way tastes like nail polish remover, the second like ass sweat. But it works...

[fredw]

Hands down xanax. Couldn't live without it. At night tine through some ambien in there for some real fun.

[Chris_Thantos]

I just ate some chocolate icecream and had a glass of milk. Does that count?


Question for you brother StD - Does milk kill your high? It does for me man - I could drop 4 roxi's and be ready to nod off to never -never land and if I drink milk it fades away - problem is I can not eat chocolate without milk so neither are consumed before during or after I take my med's

KiD

[SalvationThroughDilaudid]

Question for you brother StD - Does milk kill your high? It does for me man - I could drop 4 roxi's and be ready to nod off to never -never land and if I drink milk it fades away - problem is I can not eat chocolate without milk so neither are consumed before during or after I take my med's

KiD


Actually I never noticed any difference when I drink milk. Or ate chocolate for that matter.

[Papa Verine]

I checked "other" because if I have a small dose of opiate and don't think it'll be enough to get me feeling right I use a 30-60mg dose of DXM. DXM potentiates opiates but I no longer use DXM in large disassociative dosages. That's a whole different story...

[OxyContinuously]

I checked "other" because if I have a small dose of opiate and don't think it'll be enough to get me feeling right I use a 30-60mg dose of DXM. DXM potentiates opiates but I no longer use DXM in large disassociative dosages. That's a whole different story...

i agree with you, PapaV---> I do the small dose DXM a lot, too. Don't get me wrong, I have had too many sigma level mindfucks to really have any taste for this chem other than its potentiation abilities.

Oh, that and grapefruit juice work really well. I swear by the shit, and don't you know its bitter taste is growing on me too?

[sweetbaby]

I use many different potentiators, depending on what I have at the moment. Most often i use my scripts for nuerontin and flexaril. I discovered, quite by accident that nuerontin works very well with my opi scripts, that was a happy day :-) even though it gets quite expensive.
Recently I've been using generic tagamet, there's a huge over the counter meds manufactor near by and they have a company store. I can get a bottle of 60 ranitidine for just a $1 !!! obviously i stock up when i go there :-)
Recently i've been researching different herbs and there is another thread here that has some more ideas. Unfortunately I metabolize and build tolerance very quickly, hence the need to change it up frequently.
Thanks for all of the great info and fellowship, I love opiophile!!!!!!!!!!

[halfalien_s4]

i potentiate with klonopin, tagamet, soma, benedryl, other opiates, and restoril....

[Alice Mudgarden]

SWIM can't vote again, but wanted to add a recently discovered drug:Chlorpheniramine maleate. It's an antihistamine in the same family as Benadryl. Actually, SWIM used it in the past, but "recently discovered" how good it is with hydrocodone. 3-4 tabs (totaling 12-16 mg) of the CM and a regular dose of hydro has SWIM feeling amazing. It gets even more intense when laying in bed waiting to fall asleep, but feeling so good you don't want to sleep. Great, great stuff. It's basically the same combo of chemicals in the prescription cough syrup Tussionex.

[Narkotikon]

Definately more opiates or benzos. If not those, then I guess I'd say either Phenergan / Benadryl or Clonidine when I have it.

[skeletontea]

Had I seen the "more opiates" option, I probably would have picked that instead of benzos. I always say I'll never combine opiates and benzos again, but I do from time to time.

[i8op8s]

i put benzos for some reason, even though these days i hardly ever get to partake (lack of resource), probably becuase i've been wanting some benzies all morning. . .

my real favorite potentiators are a list of herbs i talk about all the time... i'm sure listing them again isn't necessary...

I wouldnt mind if you listed the herbs again....I tryed searchin through your old posts , but you have so many dang posts i started to nodding after a little....

Thanks...
:eye8:

[Chemical_Boy]

I really don't think that I have ever found anything that I thought really made a noticeable difference as far as increasing my buzz from opiates. I have tried grapefruit juice, tagement, benadryl, hydroxazine, cyclobenzaprine, flexeril, Zanaflex, xanax, booze, and I am sure some other things. Now some of these things would add a buzz of their own- like booze and benzos- but I never felt that my opiate buzz was increased. It would change the nature of the high. I could feel the two distinct intoxications working together side by side, overpowering one another, or creating a new feeling altogether, but nothing really increases the actual opiate high for me other than more opiates. I do not consider added drowsiness from something like phenergen or benadryl to be an increase in the opiate part of the buzz. It just means I am drowsy in addition to an opiate buzz. Some of these things will increase the pain killing capacity, but not the buzz IMO.

[PantyShot9]

I clicked benzos but I also like coke or other stims I'm surprised those weren't listed. Chocolate actually potentiates I remember taking some Tramadol and nodding from it with hot cocoa and my tolerance is not low.

[Diacetyl]

Alcohol, valium and hash + opiate of choice= bliss

[(inaudible screams)]

I really don't think that I have ever found anything that I thought really made a noticeable difference as far as increasing my buzz from opiates. I have tried grapefruit juice, tagement, benadryl, hydroxazine, cyclobenzaprine, flexeril, Zanaflex, xanax, booze, and I am sure some other things. Now some of these things would add a buzz of their own- like booze and benzos- but I never felt that my opiate buzz was increased. It would change the nature of the high. I could feel the two distinct intoxications working together side by side, overpowering one another, or creating a new feeling altogether, but nothing really increases the actual opiate high for me other than more opiates. I do not consider added drowsiness from something like phenergen or benadryl to be an increase in the opiate part of the buzz. It just means I am drowsy in addition to an opiate buzz. Some of these things will increase the pain killing capacity, but not the buzz IMO.


truth. This is why I don't take anything except more opiates.

I don't trust mixing benzos and opiates. SWIM has lost a few friends that way.

[L0VE]

I'll drink to that :drink:

True, I was at the bar last week and had only one beer, and felt really sick and woosy, and I mixed it with methadone 40mg, I suppose not too smart. It would also suck if I died there, since I'm not 21.

[WarmCyanide]

i use caffeine to keep it flyin. strong like bull

[clinton]

i use tagament and grapefruit juice...
i tend not to try and mix other drugs while im using pods...death doesnt really appeal to me right now...
i always thought benzos plus opiates =death...
am i wrong?

[clinton]

new question.....
what are classic opiate buzz killers?
some people have said caffeine,others say food.......

[youwonhundred]

new question.....
what are classic opiate buzz killers?
some people have said caffeine,others say food.......

Cops

[clinton]

ha! i was going to say death ...

[Consumed.]

does anyone know if skelaxin is a good potentiator? its a muscle relaxor that I havent found to do shit on its own....

[Ganjacake]

i use tagament and grapefruit juice...
i tend not to try and mix other drugs while im using pods...death doesnt really appeal to me right now...
i always thought benzos plus opiates =death...
am i wrong?
yes ! i mix opiates and benzos everyday. Prescribed by dr

[JahRed24]

Benzo's + opiates + smart person = amazing nod/high;)

[bronyraur]

I voted for more opiates.

I like to mix different opiates (provided they're all pure mu agonists).

Benzos are fun too but I like to remember how high I was.

[soulninja]

I personaly like booze with opiates.The only other potentiators i've tried were grapefruit juice and benzo's.I dont really feel alot of difference with grapefruit juice,and benzo's make me forget who the fuck i am(not a big fan).But a few Jack and cokes with my OC is great,plus i sleep great at night.

[Majortom]

Benzo's do just fine for me. On the other hand naltrexone vice versa. There couple of good ideas I can use sometime though.






Grabbing hands , grab all they can
everything counts in large amounts.

[Majortom]

I personaly like booze with opiates.The only other potentiators i've tried were grapefruit juice and benzo's.I dont really feel alot of difference with grapefruit juice,and benzo's make me forget who the fuck i am(not a big fan).But a few Jack and cokes with my OC is great,plus i sleep great at night.

Opiates (strong)w/alcohol very dangerous game. Sorry it is not my thing but couldn't stop myself from saying it.
I voted 4 benzo's but I totally agree w/the not remembering a single thing, most of the times. Best for sleeping though.

[Dan Steely]

i'm with majortom, opiates and alcohol is a dangerous mix and should be discouraged. the forthcoming death toll from college campuses and highschools is soon to make our opiates public enemy #1.

[johnny27]

ya'll probaly sick of hearing it from me, my fav potentatior is cyclizine 100mg with PT. Best drug with opies for me because, does not make me drowsy, and produces very little other effects if any, apart from seriously increasing the euphoria. Funny thing that, how it just increases the euphoria and not adding or combining any other effects. Plus it helps with the itches. Perscription only here in UK, but fairly easily to get prescribed if your doc dose'nt know about your opiate addiction history.

I say it has no side effects for me, bearing in mind i never IV'd 200mg mixed with smack, and start seeing things and trip'n balls.

Here a good combo for you to try, its my all time fav combo, start with 700mg carisoprodol, 100mg or 150mg cyclizine, sallow that shit and wait 25 minutes.
Then take 1 and 1/2 cups pod material mix it with about 500ml white GF, So its not too thick to sallow, and enjoy, 25 minutes give the tablets time to dissolve before sallow heaps of grit, its feels just like the ole times when i just started opiates, and a mixture of tram and codeine had me the best blissful euphoria ever, just lying in bed with a perma grin and laughing about how good life is. Adjust pod amount to tolerance, 1 and 1/2 cups maybe be to much for some.

[BigPoppy]

How much more of a buzz does grapefruit juice give? is it worth it?

[Narkotikon]

I've apparently already voted in this, and I"m sure I voted for more opiates. I'd still stick with that, then say benzos (in small doses), then muscle relaxers, then Clonidine. Why isn't that listed? I know some people say it doesn't potentiate, but I love drinking pod tea on Clonidine. It really brings the nod on. Not that I get Clonidine all that much. After that, I'd say Phenergan.

[BigPoppy]

Swim just tried tagamet, I think it made swims buzz longer and a little better. it's worth the 11 bucks per box

[tasteuvheaven]

i use tagament and grapefruit juice...
i tend not to try and mix other drugs while im using pods...death doesnt really appeal to me right now...
i always thought benzos plus opiates =death...
am i wrong?


I suppose if you take enough of them yes...but i have always been prescribed valium or xanax with percs or fent patches, and have never ever had a problem. I nodd alot more when using both, and feel alot higher.

[tui]

got home after some drinks, had a shot of h,
woke up cold on the toilet floor with a big bump on my head.
but at least i woke up.

be careful,

t

[opiobsessed]

Strange, when I was on suboxone and was prescribed valium 3x daily by my psych doc(your addiction doctor cant do that)I felt the sub was way potentiated and the valium calmed me way down and I wasn't in such a state of rage and nervousness all day like I was.

Now I'm on the valium still, but on methadone and it seems like the valium doesn't potentiate the methadone at all, I got a nice buzz of methadone the first month on it, then it just seemed to fade and now all I do is feel like a zombie halfway through the day on methadone, I dont know if its the valium and done combo or I should have stayed on suboxone.

I remember taking vicodin and valium and wow did I feel real good then, that's before the pharm went down they come from.

[Chipper]

Potentiators that I use concurrently include some good ol' pot, a dexedrine or two, a valium and a beer.

[soulninja]

Potentiators that I use concurrently include some good ol' pot, a dexedrine or two, a valium and a beer.


mmmm...beeer

[clinton]

walgreens has their version of tagment buy one get one free....woohoo

[Ickyuck]

DONNATAL

Only problem is if I take more than usual the most worst side effect shows up: dry throat. A dry throat so bad that I get a sore throat, like "I'm getting sick" sore throat.

Anyway, it's a handy little booster.

[antigonemuse]

more fucking opiates

[sidman]

I go for fresh ruby red gapefruit juice,mixed with white grapefruit juice and then I pop 1 xanax and 1 clonopin and 1 Butabital with 5-7 percs that I did a CWE on.
Very enjoyable.

[elegua]

Ok, I was going to start a unique thread on this matter, but so many people brought it up here that I thought I should mention it. So many people here have said that opiates are their favorite opiate potentiators. Well...I think I have a different reaction, though it may relate to pods only.

For example, let's say Mr. T takes 1/2 cup of ground poppies mixed in grapefruit juice. Buzz is nice, but Mr. T thinks he wants to kick it up a notch, so he takes another 1/2 cup about 1.5 to 2 hours later. Result? Almost nothing...so close to nothing that any possible rise in the general buzz could be a matter of placebo. For Mr. T, taking 3/4 of a cup at once is FAR superior to taking 1/2 cup and even a full cup two hours later.

Now, Mr. T has not had a chance to mix pure pharmaceutical opiates with pods (when he has one, he doesn't worry about the other), so he can't speak for that...but does anyone else have a comparable result with pods? Some sort of 'cap' effect where the law of diminishing returns starts really kicking in fast? It so noticable that people with this reaction feel like it's a HUGE waste of pods.

Thoughts? Similar experiences?

[joshua8608]

Ok, I was going to start a unique thread on this matter, but so many people brought it up here that I thought I should mention it. So many people here have said that opiates are their favorite opiate potentiators. Well...I think I have a different reaction, though it may relate to pods only.

For example, let's say Mr. T takes 1/2 cup of ground poppies mixed in grapefruit juice. Buzz is nice, but Mr. T thinks he wants to kick it up a notch, so he takes another 1/2 cup about 1.5 to 2 hours later. Result? Almost nothing...so close to nothing that any possible rise in the general buzz could be a matter of placebo. For Mr. T, taking 3/4 of a cup at once is FAR superior to taking 1/2 cup and even a full cup two hours later.

Now, Mr. T has not had a chance to mix pure pharmaceutical opiates with pods (when he has one, he doesn't worry about the other), so he can't speak for that...but does anyone else have a comparable result with pods? Some sort of 'cap' effect where the law of diminishing returns starts really kicking in fast? It so noticable that people with this reaction feel like it's a HUGE waste of pods.

Thoughts? Similar experiences?

I'm taking a Pharmacology class right now, so maybe I'll sound like I almost know what I'm talking about. Some receptors in the body quickly become desensitized after initial exposure to certain drugs....this tolerance can occur EXTREMELY quickly. It is called tachyphylaxis. It most often occurs in repeated use of nitroglycerin, in which a cofactor, which is required for the drug to act, is depleted. That's why nitroglycerin has to be administered intermittently or in very small doses. The good news is that the tolerance to nitroglycerin can go away almost as quickly as it came, but you still gotta give it time for the cofactor to build back up again.

I don't know exactly why this sort of thing occurs in some opiates, but codeine, for example, is a well-known example of the process. Codeine inhibits the very enzyme responsible for converting it into morphine. So if you take a dose of codeine and don't wait long enough for the next dose, the second dose may be completely wasted.

For me, this poses a big question: Why do things like Codeprex Extended Release Suspension (a polistirex-coated form of codeine) exist? I've also noticed that hydrocodone polistirex (Tussionex) tends to lose its bang after a few hours instead of the claimed 12 hours.

[Jocko]

I'd have to say an excellent way to roll is: 3 Norcos, 1.5 Somas, and a large Bacardi and Coke with a splash of lime. The wireless laptop, looking at the ocean, and the iPod on shuffle ... nice ... VERY nice. I'm sure there are MANY other levels of "nice", but that seems to do the trick.

[OPticrazi]

To tell ya the truth folks there is NOTHING like a 8mg blast of dilliy. If that don't give you that great rush a nice 3 hour buzz..................I really don't know what else to say.
My usual is a 30 z OC, wait 20 minutes and blast a *mg load and FUCKIN A do I feel good!

[Shotalotofdopeamus]

Ok, I was going to start a unique thread on this matter, but so many people brought it up here that I thought I should mention it. So many people here have said that opiates are their favorite opiate potentiators. Well...I think I have a different reaction, though it may relate to pods only.

For example, let's say Mr. T takes 1/2 cup of ground poppies mixed in grapefruit juice. Buzz is nice, but Mr. T thinks he wants to kick it up a notch, so he takes another 1/2 cup about 1.5 to 2 hours later. Result? Almost nothing...so close to nothing that any possible rise in the general buzz could be a matter of placebo. For Mr. T, taking 3/4 of a cup at once is FAR superior to taking 1/2 cup and even a full cup two hours later.

Now, Mr. T has not had a chance to mix pure pharmaceutical opiates with pods (when he has one, he doesn't worry about the other), so he can't speak for that...but does anyone else have a comparable result with pods? Some sort of 'cap' effect where the law of diminishing returns starts really kicking in fast? It so noticable that people with this reaction feel like it's a HUGE waste of pods.

Thoughts? Similar experiences?

I noticed the same effect with myself. If I dose I had better take a large one since adding anything else in later on tends to do fuck all for my high. My DOC is dillys or H, but the effect is the same. Once I dose thats it. I could push 8mg of hydromorphone and shoot 16 4hrs later and not readily feel anything. with H if I wait ill get a really mild rush but I need to wait at least 24hrs to make it work the risk/cost of copping and pushing off again.

[OPticrazi]

I'm taking a Pharmacology class right now, so maybe I'll sound like I almost know what I'm talking about. Some receptors in the body quickly become desensitized after initial exposure to certain drugs....this tolerance can occur EXTREMELY quickly. It is called tachyphylaxis. It most often occurs in repeated use of nitroglycerin, in which a cofactor, which is required for the drug to act, is depleted. That's why nitroglycerin has to be administered intermittently or in very small doses. The good news is that the tolerance to nitroglycerin can go away almost as quickly as it came, but you still gotta give it time for the cofactor to build back up again.

I don't know exactly why this sort of thing occurs in some opiates, but codeine, for example, is a well-known example of the process. Codeine inhibits the very enzyme responsible for converting it into morphine. So if you take a dose of codeine and don't wait long enough for the next dose, the second dose may be completely wasted.

For me, this poses a big question: Why do things like Codeprex Extended Release Suspension (a polistirex-coated form of codeine) exist? I've also noticed that hydrocodone polistirex (Tussionex) tends to lose its bang after a few hours instead of the claimed 12 hours.
Thats the fuckin reason when I was poppin T4's like tick tacks I could never get that same buzz...YOU are one smart motherfucker, HANG around dude we NEED guy a like you! :cool:

[Hammilton]

You really can't consider the desensitization caused by codeine tachyphlaxis, they're way different deals. Tachyphlaxis is an extreme desensitization, codeine doesn't cause this.

There's a lot of reasons codeine doesn't get you high from repeated doses. It really isn't the receptors (though they are part of it) it's more to do with the liver. As you get more codeine in your body, as it needs to be metabolised first, it's also inhibiting your CYP450 (I think I got the number right) enzyme, and it's not able to get as much to your brain as quickly.

But there's an even more obvious reason you can't get high again easily within a few hours of getting high initially.

A lot of the high comes from rapidly filling your receptors. If you've already got stuff sitting in them, you're not gonna get nearly the same buzz. Hence the reason you can't get a buzz from buprenorphine a second time within 24 hours, but if you wait more than 24 hours, you can get a good buzz. Well, some people can.

[chemiKalz]

Yea, alcohol is a good way to get dead....I have Soma rxed to me, and I use grapefruit juice


i did use grapefruit, and alcohol, just now found out it can kill ya, good thing im kickin as we speak

[useonceanddestroy]

I think it should be noted that alcohol is a great potentiator, BUT should not be used because in the process of your body eliminating all that booze, it speeds up your metabolism, and thus eliminates all the opiates in your system too... one too many mournings ive woken up in extreme w/d's because of that fuckin alcohol... and if you stay up, you will probably notice that your opiate buzz wears off alot quicker.

on a side note... how many people have come back from the bar loaded, only to 'load' one up for yourself and then, in a state of extreme euphoria, passed out immediately and wasted your hit becuause you were alseep? you wake up and your like, hmmmph ther goes 50 bucks :jerkoff:

hey... i think this deserves a green dot thingy too! alright later gators

[Dr. Oxy]

t.v. is my fav potentiator

[clinton]

are the only non drug potentiators graperuit juice and tagament?
does anyone get added eFFects From booze? i havent tried but my pals claim that it Fenergizes their buzz
aFter a couple oF hours

[tui]

I've asked this before with no conclusive answer. WHY/HOW does grapefruit juice work?

And tagamet... what is that? Is it legal? If yes, where do you buy it?

One more thing, my bf won't eat oranges after a shot- swears citrus will lessen the high. i tease him about it, because i've never noticed a difference. has anyone else heard this, or is it just an old-wives tale?

thanks all

t

[chopstix]

I've asked this before with no conclusive answer. WHY/HOW does grapefruit juice work?

And tagamet... what is that? Is it legal? If yes, where do you buy it?

One more thing, my bf won't eat oranges after a shot- swears citrus will lessen the high. i tease him about it, because i've never noticed a difference. has anyone else heard this, or is it just an old-wives tale?


Tagamet is Cimetidine, it's sold OTC in the states as a anti-acid stomach med. Both it and GF juice and some other things inhibit an enzyme in the liver that metabolizes certain drugs, hydrocodone, oxycodone, morphine, most benzos; it really only has a significant effect on oral medications, it acts on what's called "first pass" metabolism which means that if the enzyme (CYP450) is inhibited, then the chemicals can get from the stomach through the liver and into the bloodstream without as much metabolic interference, if the drug is already initially bypassing the liver (IV, IR, IS), then it's not affected by "first pass" inhibitors.

I've used both tagamet and gf juice extensively on hydro and opium tea. I think I prefer hydro without the inhibitors, with them, I think the hydro rapidly metabolizes into hydromorphone and I've noticed that Norco just doesn't seem to have any legs when I take GF or tagamet. I think I get a better buzz without the "boosters."

Opium tea is a different story, and it's probably true for oral morphine; HUGE difference, it's like a %30 gain in potency and legs. Makes all the difference if you have a tolerance. It works so well, that you'll consider it mandatory in short order.

That's been my experience. I notice the effect with benzos but bfd, they're just benzos. I haven't tried it with oxy but I don't do much oxy. Again, this is for stuff you swallow, doesn't affect IV and friends to any significant degree. And I think your bf is crazy, oranges don't kill a dope buzz, that's silly..

[LorTabitha]

I've discovered that Shasta brand grapefruit soda contains real gf juice (most brands don't, believe it or not!), so I've been adding the soda to my pod tea. Yum!

[edarrin]

inhibiting your CYP450 (I think I got the number right) enzyme, and it's not able to get as much to your brain as quickly.


P450 is a whole system of enzymes in the liver. The one you are thinking of is the 2D6 isozyme which converts codeine to morphine.

Cimitidine isn't OTC in Canada but I was wondering if Ranitidine works(because it is OTC). My pain doc suggested that to me.

[}<<<*-*>>>{]

Lately I have been cooking up Dramamine along with or before my shot and that's been working nicely. I hate having to swallow pills and wait 45 minutes before I can fix up. I have never heard of anyone else slamming Dramamine but after trying it I know it works like a charm.

[Chicago]

I had a buddy you said the same thing about orange's/juice to only, not grapfruit only orange he allways said it kills your high, maybe ur boyfreind was hanging w/my buddy b/c he moved away years ago,:(
I've asked this before with no conclusive answer. WHY/HOW does grapefruit juice work?

And tagamet... what is that? Is it legal? If yes, where do you buy it?

One more thing, my bf won't eat oranges after a shot- swears citrus will lessen the high. i tease him about it, because i've never noticed a difference. has anyone else heard this, or is it just an old-wives tale?

thanks all

t

[bubbles]

Tagamet, Ruby Grapefruit juice (the only one I can stand) and sometimes I'll start out with a couple of Xanax after the Tag. It really does help because I have a high tolerance for my Vics. Whatever works, right?
Bubbles

[resorcinol]

Besides more opiates (which isn't really a potentiatior, it's just a larger dose), I love Tagamet, Soma, Valium, and the antihistamine called doxylamine.

[SCHTIC]

ill try the juice thing today i never tried but its oonly been like 30 hours since my last sub dose but i got an 80 on my mind and can't shake it so ill grab some juice first? my benzo's prescribed so i don't know how much effect affect they deffinatly don't hurt:cool:

[GA_M'Done120]

I use tagamet 400 mg, phenergan 25mg, klonopin 1mg Elavil 25 mg & white grapefruit juice when I take my daily dose of methadone. Another drug that potentiates opiates that has not been listed is Luvox. It is an SSRI medication (Selective Serotonine Reuptake Inhibitor) used to treat Obsessive Compulsive Disorder. It is not a controlled substance and can be easily obtained from any doctor and it raises the opiate level and slows metabolism for a longer high. It effects the CYP3A4 enzyme in the liver. White grapefruit juice effects the CPY450 enzyme in the liver. Here is the URL that has a list of both potentiators as well as medications that would lower opiate levels as well as substances that would cause acute opiate withdrawal symptoms: http://www.atforum.com/pdf/Drug_Interactions.pdf. Hope this is helpful. Thanks for allowing me to post.

"ALWAYS WALK WITH PRIDE, BUT WATCH WHERE YOU STEP"

[Chicago]

I have taken about 20mg klonopins & 2mg xanax 1hr before my shot of heroin. Never really increases for me, but have a really high benzo tollerence.
But if I take one 2mg CLONODINE PILL about 15-30mins before I fix. I get fucked up. So I got to say clonodine is a strong opiate potenator for me.

[Nemesis1]

Cigarettes are the best if you ask SWIM! Benzos can be worth it during the end of the high to bring back some buzz, but taking them during the peak of the opioidexperience just make your precious time on opioids fly away oh so quick... More opioids is of course something that works, but SWIM is careful because he doesn't want to build up tolerance to opioids...

[Chicago]

:Dyes smoking a NEWPORT,
I have some many holes in my clothes from nodding:(


Cigarettes are the best if you ask SWIM! Benzos can be worth it during the end of the high to bring back some buzz, but taking them during the peak of the opioidexperience just make your precious time on opioids fly away oh so quick... More opioids is of course something that works, but SWIM is careful because he doesn't want to build up tolerance to opioids...

[hydrocronik]

I LOVE me some restoril and soma to go with my Vicodin.......!!!!!!!!

[roxi*stardust]

I have found Adderall to have a great synergy with oxycodone. Ritalin isn't bad either ut not as good as Adderall. I would love to get some Desoxyn.

[gauchoamigo]

MST3K? To me that means 3,000mg of MST Continus, which is enough to kill a bull elephant; and yet nobody has given an alternative reading of that abbreviation. God, man, 200mg MST is way enough for SWIM, who has been opiated since 1976(!), being equivalent to two or three 80mg OC plus grapefruit on top of his normal daily dosage of about a gramme of Afghan skag!
Any explanations forthcoming?

[Somanax]

Mst3k

Mystery science theater 3000

Television show

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