Rx drugs to counter "tolerance"?

[sebastian869]

Does anyone here take rx meds for opiate tolerance? I remember back in the day like 93 I was given something for tolerance. I cant say I remember it working, but I was wondering if there is possibly something better out there right now.

[moviebuff927]

Proglumide is a good opiate tolerance blocker. But it only works for so long because then your body builds a tolerance to the proglumide. I do think it is over the counter but I don't know anywhere in the USA that you can buy it. You would have to order through an OP.

Tagamet used to be prescription but now it's OTC. It works okay to stunt the metabolism of the opiate.

vaxn8 had a vast knowledge of opiate potentiators and tolerance blockers. Search for his thread and you will be surprised what kind of information he has.

-moviebuff

[HistoryofMadness]

any meds or herbs you use for this should be used in short order. anything that is a potentiator will also help with tolerance because it'll allow you to take less opiates to feel the same.

danshen is good, tagamet, dxm (cough syrup) - that's a start.

there's a thread on potentiators here, and a good approach would be use a few rotating one at a time, find a couple that work, and only use each for a short time to get tolerance down.

[OxyContinuously]

Like others have said, Tagamet works well; and one i didn't see listed yet, but we all know about: grapefruit juice.

later

Oxy

[superman]

tagamet isn't really going to change your tolerance for the better. it will actually slow the metabolism of certain specific(not all) opiods. so your tolerence will rise higher from 100mg morphine daily + tagamet than it would from morphine alone. grapefruit juice is the same deal.

it sounds like what you want to find is a drug that synergises well for you such as valium, pot or something else.

As for a true tolerance blocker/reducer, i know of no such thing, never bothered looking

[Nile_dancer]

Contreversial, but check out this thread.

http://forum.opiophile.org/showthread.php?p=78767

[OxyContinuously]

tagamet isn't really going to change your tolerance for the better. it will actually slow the metabolism of certain specific(not all) opiods. so your tolerence will rise higher from 100mg morphine daily + tagamet than it would from morphine alone. grapefruit juice is the same deal.

it sounds like what you want to find is a drug that synergises well for you such as valium, pot or something else.

As for a true tolerance blocker/reducer, i know of no such thing, never bothered looking

you know what, i was thinking potentiation rather than "tolerance" for some reason. tagamet and GF juice are good potentiators but do little re: tolerance. My fault; I misread the question :-)

later


Oxy

[HistoryofMadness]

you know what, i was thinking potentiation rather than "tolerance" for some reason. tagamet and GF juice are good potentiators but do little re: tolerance. My fault; I misread the question :-)


i disagree, at least in my experience, anything that allows me to take less of an opie allows my tolerance to go down...

i can take less of a dose, potentiate it, maybe use a couple of synergist herbs, and that helps my tolerance.

[sebastian869]

If I can remember right I think it was clonidine, I think it did a little at the start but then I became tolerant to its effect. I have a appointment with my pain management doc in the next couple of week, I gotta ask him what he has to say and I'll report back if its any good.

[insanesteveo]

If I can remember right I think it was clonidine, I think it did a little at the start but then I became tolerant to its effect. I have a appointment with my pain management doc in the next couple of week, I gotta ask him what he has to say and I'll report back if its any good.

i use clonidine. but only to sleep. if i take it during the day to get the potentiation, i end up just nodding out hardcore. im talking never being able to open your eyes. constant yawning. this stuff knocks you out!

[sebastian869]

i use clonidine. but only to sleep. if i take it during the day to get the potentiation, i end up just nodding out hardcore. im talking never being able to open your eyes. constant yawning. this stuff knocks you out!


I do the same as u stated above but I take valium and since I dont take it regularly I get the same effect. I only do it if I need to "reset" my sleep cycle and since its sooo hard core strong for me I take it at like 7pm and wake up at 9am next day, though I hate the hung over feeling I get from that shit. (and I only take 5mg)

[Seedy]

I've been using an indian herb called ashwagandha (withania somnifera) over the last few days and it SEEMS to be lowering my tolerance. Been taking about 2 teaspoons a day. Up until last tuesday I had been taking up to 20 pods per day. my source ran out & it was back to seeds. Had one night of wd's & now I'm back to the seeds dose I was on before pod season. I can't imagine that a drop in tolerance like that would have happened on it's own.

[1cc]

I've used something which is not so much a tolerance blocker as it was something to make opiates more effective. It was called promethazine. I only tried it once. I cannot comment on its effectiveness. I was nodding really good is all I can tell you. But of course I was using H and there is no way for me to confirm if it was just a stronger batch of H or it was the promethazine pill.

http://en.wikipedia.org/wiki/Promethazine

1cc

[El Dave]

Proglumide is a good opiate tolerance blocker. But it only works for so long because then your body builds a tolerance to the proglumide.

Try doing eight days on, eight days off, ad infinitum. Although I have no opiates now to see if it's still doing so, that did a great job with the last of the hydrocodone I was able to get. Since I experienced a reversal in hydro tolerance with the proglumide, I've continued to do the 8 on/8 off cycle just in case I ever run into any more hydro. It doesn't seem to be doing any harm, at least.

[mrnatural]

If I can remember right I think it was clonidine, I think it did a little at the start but then I became tolerant to its effect. I have a appointment with my pain management doc in the next couple of week, I gotta ask him what he has to say and I'll report back if its any good.

I've used clonidine (in a patch) to help with w/ds; never used it as a potentiator. Phenergan (anti-nausea) is sometimes used with opiates in hospitals (particularly with demerol) so you supposedly only have to use half the opiate as you would otherwise. It's also the "fortis" part of mepergan fortis, one of the earliest rx opiates I ever had the priviledge of using. White grapefruit juice and opiates on an empty stomach is what seems to work best for me. I can't abstain long enough to develop a lower tolerance through abstinence; that's the most sure-fire way, I believe.

[tui]

Like others have said, Tagamet works well; and one i didn't see listed yet, but we all know about: grapefruit juice.

later

Oxy

grapefruit juice, huh?
how, why?

t

[Moonrock]

You might as well use naltrexone and stop getting high at all!!!!!

[sidman]

I used GrapeFruit juice (Fresh Squeezed even better) mixed with NoDoz (for better Brain Capillary and Receptor Deliverance) and it worked for me. I used minimal NoDoz ( 1-2 crushed) so I wouldn't get the "Poor-Man's Speed-Ball" Effect.

[ILLWILLMD]

I've used something which is not so much a tolerance blocker as it was something to make opiates more effective. It was called promethazine. I only tried it once. I cannot comment on its effectiveness. I was nodding really good is all I can tell you. But of course I was using H and there is no way for me to confirm if it was just a stronger batch of H or it was the promethazine pill.

http://en.wikipedia.org/wiki/Promethazine

1cc

Promethazine is Phenergan. I take it allot being as how I am on methadone. More often then not I get nauseas in the morn and a heaping dose (180mg) can make it even worse. I take 50mg - 100mg. it does seem to potentiate the done. But the feeling is nothing to write home about. However any little bit of added euphoria is always welcome.