Meptazinol- A Legal Opiate- u-agonist

[Hammilton]

You guys might want to take a look at Meptazinol. It seems pretty interesting. Legal is always interesting when it comes to opiates.

I can't find much info about meptazinol abuse, but it obviously can be.

Plus, on a very positive note, unlike my last unscheduled opiate- this one doesn't cause seizures!

[shadowbox]

Is this currently available/being used in the US? I've only seen this referenced in articles out of UK. Also, what do you mean when you say it's "legal"; do you mean it can be purchased w/out a script, etc.? It does look interesting.

[Hammilton]

I mean it's not scheduled. You can do whatever you want with it.

No, I don't believe it's a FDA-approved drug. Even less control .

[mrrice11]

Does this shit like come in a bottle or somthing, in pill form?? how is it sold and where would it be found?

[Hammilton]

You're not experienced with RCs are you? That's essentially what this is, a research chemical. You're not importing it from another country, from their OTC meds; you're purchasing a quantity of powder and dividing it is up to you. Or someone who isn't you. I don't care who does it.

You gotta hobbbadobba dee, gotta hopalong and pee, get back, big Jack, Purple Mountain Majesty!

[jacky]

I found a place that sells a gram for 80,000 US dollars.

pretty damn expensive, even for a reference compound.

[tptptp]

I found a place that sells a gram for 80,000 US dollars.

pretty damn expensive, even for a reference compound.

Jesus H. Christ

Hopefully they make it illegal soon so we can afford it.

[jacky]

there are some posts about this substance over at bluelight.
I cannot find any places that seem to be selling the product as a bulk chem or as a non prescription pain reliever.
I havnt noticed it in any of the canadian pharmacys, or OTC medicine delivery places either.

there are some warnings about it being a partial agonist/antagonist, and that you would want to go into withdrawls before taking it if you are already opiate/opioid dependent.

sounds like a weak partial agonist, that might not cause euphoria in many people. I know picralima nitida is a partial agonist, and that seems to have mainly stimulant effects, and made me somewhat dizzy. picralima is compared to pentazocine, and so is this meptazinol compound.

something I would definitely try, and I am sure that it has its uses, but where and how?
there is one synth report on the internet about how to synthesize the compound that might be of use to someone, but if you have to make something legal that is active I can think of better directions to head in than making this cholinergic, antagonist, weak agonist compound.

I should try to never underestimate any compound though, and would love to spend days trying to research how to change menthol's kappa opioid activity into a mu agonist through augmentation of the structure of that material somehow, so if this compound is sourcable and somewhat cheap I hope that someone out there gets to research it!

[Dolophine]

When I first read your post I was interested that there might be some opiate that is not illegal. But after some research I found out some stuff. I found out it was a pain reliever in the UK or so it says on some sites, for surgeries and stuff. But it's not used often.

So this all sounds good but I found a website that says it's complete crap basically, for anyone who's addicted to opiates. As Jacky said it has agonist/antagonist effects and causes dysphoria according to this one study.

Human pharmacology and abuse potential of meptazinol.


Johnson RE (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Johnson+RE%22%5BAuthor%5D),
Jasinski DR (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Jasinski+DR%22%5BAuthor%5D). Meptazinol was assessed in nine opioid abusers according to a double-blind, randomized, crossover design to determine if it produced typical morphine effects. A comparison of physiologic and subjective effects was made between morphine, 7.5, 15, and 30 mg, meptazinol, 70, 140, and 280 mg, and placebo. Both drugs constricted pupils. Meptazinol, 140 and 280 mg, decreased body temperature. Valid relative potency estimates of morphine to meptazinol were obtained for self-reported liking, opiate symptoms, and pupillary constriction. Meptazinol did not increase euphoria or sedation scale scores but did increase dysphoria scale scores. In the therapeutic dose range, meptazinol produced miosis, morphine-like identification and symptoms, limited liking, and some dysphoria. Dysphoria predominated at the 280 mg dose of meptazinol. From these data, it is concluded that meptazinol is not a typical morphine-like drug and has limited abuse potential.


Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3829579&dopt=Abstract

[Hammilton]

Well, I dunno if that means it's 'complete crap' - i mean, 9 people is a drop in the bucket. Just about all agonist-antagonists are going to play out like this when given like this (orally). I'm most interested in seeing a study like this comparing the drugs when administered IV.

I'm wondering how they got it published when they only gave it to nine users???

[sp33dballin]

here's a link i dug up for ya.. some good reading.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed