10-Hydroxymorphine

[lister40]

I saw that it was an impurity in morphine sulfate production.. and I was wondering if this could do anything to you? anyone know.. I think I may have made some, but I don't know if I should try it.

[SpecialGuy69]

we told you not to bother fucking up your morphine.

[robojunkie]

Dude, in all seriousness, what the hell are you doing? You said you "remember a little chem from high school" and now you're trying these experimental conversions based on...I don't know what. What makes you think you have this 10-hydroxymorphine? How or why would you suspect that? None of this (and other post last night) makes sense. If you have morphine just be happy with it. Seriously, fuckin around with chemistry with little knowledge of what one is dealing with is what leads to shit like MPTP (not in your case, look it up). If you have to ask basic questions about these things you shouldn't be doing it (for your own good, not trying to be a jerk or condescending, just being honest). If you had a friend who told you he took a wood shop class in high school and now said he's building a 10 story apartment complex, would you rent a unit there?

Oh yeah and the primary MPTP originator was an actual chemist who for the most part knew what he was doing, but unaware of the results/effects of his byproducts. He and his buddies all developed serious Parkinson's symtoms and he died a few years later. Back in the late 70's.

[lister40]

yea, i know about mptp.. causing parkinson's.. that would suck; but I would like to get something stronger than morphine.. but when you get morphine and then 30% hydrogen peroxide and put it at 100F for 24h and it will become a hydroxymorphine.. and I was wonderin' if I could do something with that..

get some morphine and add AA and heat .. that's not complicated.. so why wouldn't it be easy to make a diff. chemical?

[SpecialGuy69]

I think I may have made some, but I don't know if I should try it.

and I was wonderin' if I could do something with that..

first, you are saying you have already done it, now you are saying you might consider making it... Seriously I think we all need to walk away from this one, something isn't right. You know that feeling you get right as you realize someone set you up and your about to get busted?

Something doesn't add up with this guy, we have said 100 times don't bother, morphine is plenty fun and strong, just won't listen, it's like he's determined to make US an accessory to HIS manufacturing. Fuck that.

[lister40]

try it as in use it.. lol wtf I'm wondering if I could synth something else with it.. or should I just use it.. I'm not making you an accessory.. just answer.. should I do it or what?

[cdorr4]

ffffffffffffffffff

[cdorr4]

Oh yeah AND I just got a MRI done yesterday so maybe that will work in my favor

[robojunkie]

Dude, why not just throw a bunch of random crap together, do a fancy dance and pray for etorphine? If you don't know what you're doing don't do it. Just cause one thing is "simple" has no relation whatsoever to another...and as far as you're morphine goes, well if you ain't satifisfied with that I don't know what to tell you...

Or maybe its not "your" morphine? Yeah that's why nothin works, Karma...

[Paregoric Kid]

getting back on topic, is this active or just some inactive byproduct? I couldn't find out that much about it. any idea on the strength compared to morphine if it is active?

[lister40]

getting back on topic, is this active or just some inactive byproduct? I couldn't find out that much about it. any idea on the strength compared to morphine if it is active?
that's what I was wondering, I guess I'll just have to try it out :p

[lister40]

Here is a picture of it: and morphine compared
http://ctd.mdibl.org/cas-images/0/73/131563-73-0.gif http://ctd.mdibl.org/cas-images/2/27/57-27-2.gif

[robojunkie]

It is active on tests with in vitro mu receptors but I not aware of any "dosage" comparison to morphine or other opiates. Just based on the structure and the fact that the the hydroxy is on the alpha face I wouldn't imagine a significantly large difference in activity (to my knowledge at least, I don't have an exact structure of the MOR active site in front of me) as the key binding areas are the aromatic piperidine face (why dxm aint an opiate, as the receptor is obviously stereospecific) and the aliphatic (oily) side chain present in burprenorphine, etorphine, etc. This only regards "activity" though...

Just looking at that para-hydroxy benzyl alcohol system, and the lack of many studies on this compounds metabolism (other than that a very small amount of M is metablolized into this) I would seriously be wary of being the first to f around with it. Few if any common opiates are substituted at that position and if that hydroxy did bind somewhere you'd have a potentially activated (not in a good way) system for other enzymes/bases/etc to bind irreversibily. I ain't gonna draw out the structures to justify this but if that hydroxy is activated in the presence of the wrong enzyme/base/etc this could possibly happen. Don't be a guinea pig, dude.

Basic point: It definitely is active at the MOR. However this compound has been known for well over 60 years...yet its not marketed, no brand name, etc anywhere that I'm aware of. Quite possibly a reason for this...I can't really say for sure and I don't have the time to look up every pharmacokinetic study on it. And, OP, how do you really know you even have this?

[lister40]

I don't know if I have the chemical, but I did the synthesis exactly. I'm not sure if it is 10-hydroxymorphine.. because I have no GC/MS.

morphine/codeine active with the mu.. does oxycodone too?


oh also.. I've been handling it and stuff.. well i took a little lick from my finger and I've been feeling a small sorta high.. I doubt it's a placebo because I really had no intention to get high off of it, but it definetly tastes diff. than before; probably the h2o2 lol

By the way, do you have any lab mice around? :P

[robojunkie]

morphine: active pure MOR agonist
codeine + liver: some morphine, codeine not active as such
oxy + liver: some oxymorphone, same thing oxyC not active as such

So are you now saying you meant to get 10-OH M and it wasn't a byproduct? Why did you settle on this, its pretty obscure and relatively unknown. You only had the peroxide? Bored? Just curious since I know you aren't gonna accept the advice to stick with the M.

[lister40]

I meant to, and I have a bit around.. and I'm also bored..

You would think if it would cause alot of harm they would have something like the mptp .. advise people and stuff..

[nick]

Medicine is poison in the hands of the inexperienced.Be very careful man.

[SpecialGuy69]

this is rediculous. you are trying to convert it just cause you can, and you are eventually going to end up either wasting all of your morphine (if you are lucky) or hurting yourself (if your not). What's not going to happen is you making some really kick-ass opiate from morphine and household chemicals. Quit wasting your time and morphine.

[Duckfeet]

Me, I'd a done either tried it out or got rid of it and quit what you are doing. Reminds me of when I boiled down paregoric and fixed it. I kept trying to find somebody who would give me the "go ahead". Realized finally that anybody who actually *knew* how to do it was long dead, so I shot it up, got sick as a dog. Next day, shot it up again, got sick as a dog. Ate the rest.

Moral of this story...well, you figure it out.

And I *remember* when those fucks were making that bogus fentanyl and came down w/parkinsons. Chemists are like race car drivers: everybody thinks they know how to do it. Cuz of LSD and MDA and beginnings of homemade crank factories, '70s everybody thought they were a chemist.