AET and treatment of WD

[Heroine]

Hey I was wondering if anyone else had heard of AET - Alpha-ethyltryptamine? I had read in Dr. Alexander Shulgin's book the 'TIHKAL' (if you haven't heard of him, he is a chemist, created AET and many other research chemicals, DPT, etc..highly intelligent, his 2 books were a great read if you are interested)... that AET made heroin withdrawal "quick and painless." However, I can't seem to find anymore information on those properties of AET, only the obvious tryptamine properties. It mentioned that tolerance goes up quickly to AET and that a gram or so is required to taper down an addiction, however I could not find more specifics.

I was wondernig if anyone else had heard about Alphaethyltryptamine and its relationship with treating opiate addiction and withdrawals.

Can anyone shed any light on whether or not this is really true or to how much of an extent it helps with maintaining through sickness? Thanks

~Heroine

[nick]

Is this Thikal a chemical love storey?I've heard of psychedelics being used to treat addiction.Think it's even been discussed here.Check the search because I'm far too lazy to do it.
You might want to check out the freedom root website,they do a lot of work with ibogaine and have an interest in this area.

[jacky]

yep, I was pretty interested in that too,
maybe well hear some more on it.

shouldnt be extraordinarily hard to synth I would think.

[OxyContinuously]

yep, I was pretty interested in that too,
maybe well hear some more on it.

shouldnt be extraordinarily hard to synth I would think.


Jacky, not hard to make at all. As far as synthesis, it's pretty straight forward, but the problem as with some of the acetic anhydride threads is the availability of the chems needed (too bad we can't go to Home Depot and buy some "tetrahydrofuran"---> imagine that shit?) But if you have an equipped lab, you got it.

Correct me if I am wrong, but i believe it was "alpha ethyl tryptamine" and not diethyl tryptamine that is the substance in question. I know that in the early sixties, AET was marketed as an antidepressant under the name "Monase" made by good old Upjohn Pharmaceuticals. I have read that this does indee show promise in the treatment of withdrawal.

Jacky, you're chem oriented so what do you think about this? With indoles, we all know that putting a methoxyl group on the five position increases the potency of the said original indole (example: 5 methoxy alpha methyl tryptamine is qualitatively and even subjectively more potent than regular alpha methyl tryptamine) How about 5 methoxy alpha ethyl tryptamine? I wonder if that compund too, would show the same promise that AET originally did. Maybe it would even work a little better. I imagine it would be cake to make as well as far as simplicity. Start with a methoxy indole aldehyde as the precursor, reduce it with LiAlH4 in tetrahydrofuran to yield 5 MeO-AeT. What do you think as far as the efficacy of this methoxylated compound versus regular AET?

OxyC

[Heroine]

Is this Thikal a chemical love storey?I've heard of psychedelics being used to treat addiction.Think it's even been discussed here.Check the search because I'm far too lazy to do it.
You might want to check out the freedom root website,they do a lot of work with ibogaine and have an interest in this area.


Yes, exactly; it is the 'Chemical Love Story'. Tryptamines I Have Known and Loved in case anyone cares ;) His other one as PIHKAL (Phenethylamines I Have Known and Loved...the story parts of the book were actually quite enjoyable, so if you are not into chemistry and synthesis, you can still appreciate it)

Thanks for the suggestion on where to look, Nick...I will check out that site, I have not yet been to that one.

[Heroine]

but i believe it was "alpha ethyl tryptamine" and not diethyl tryptamine that is the substance in question. I know that in the early sixties, AET was marketed as an antidepressant under the name "Monase" made by good old Upjohn Pharmaceuticals. I have read that this does indee show promise in the treatment of withdrawal.


OxyC

Yes it is Alpha-ethyl, bro...thanks for reminding me to fix this, that was just a typo I made there, OxyC---Actually, given your name you should be happy to know that I had sniffed 40 mgs of your name-sake (the bullshit Impax G164s) and got to typing this morning before work. Rubber fingers sometimes results in bad typing. When I start typing in all numbers and symbols though, then you should know to dispatch an ambulance to Heroine's house.
Cheers....

[Dilaudid]

Hello opiophiles,

Heroin it's currious we start to talk about AET at the same time (see the topic "the urge")

Hey I was wondering if anyone else had heard of AET - Alpha-ethyltryptamine? I had read in Dr. Alexander Shulgin's book the 'TIHKAL' (if you haven't heard of him, he is a chemist, created AET and many other research chemicals, DPT, etc..highly intelligent, his 2 books were a great read if you are interested)... that AET made heroin withdrawal "quick and painless." However, I can't seem to find anymore information on those properties of AET, only the obvious tryptamine properties. It mentioned that tolerance goes up quickly to AET and that a gram or so is required to taper down an addiction, however I could not find more specifics.

I was wondernig if anyone else had heard about Alphaethyltryptamine and its relationship with treating opiate addiction and withdrawals.

Can anyone shed any light on whether or not this is really true or to how much of an extent it helps with maintaining through sickness? Thanks

~Heroine

AET and AMT (in much lower doses because AMT became quickly hallucinogenic) can help in WD as good antidepressants and empathogenic compounds (help as a weak selective and reversible MAOI-A and these compounds produce 5HT/DA relase), I suppose anxiolytic effects can be expected by action on 5HT1A autoreceptors the same action of some phenethylamine derivatives so it's an extrapolation from SAR studies.
Yes tolerance and cross tolerance occur with these two compounds.
For AET Synth it's pretty easy from gramine, Sacha has writen some synth of this compound you can find them in the litterature or in his seccond book "TIHKAL The continuation"
Have some 1,4-Benzodiazepine handy for night ant stop taking AET at least 6h before sleep time.

DPT is a fully different material and it acts mainly as a 5HT2a agonist, I don't think this compound can help (appart from intrinsec psychedelic properties).

Some "RC" can help especially cyclohexylamines who act on the PCP1 (Selective reuptake DA pump) and by non competitive NMDA antagonist properties: in low doses for reducing NMDA induced hyperalgia and in high doses for psychedelic properties.

[Sitar]

Yes, exactly; it is the 'Chemical Love Story'. Tryptamines I Have Known and Loved in case anyone cares ;) His other one as PIHKAL (Phenethylamines I Have Known and Loved...the story parts of the book were actually quite enjoyable, so if you are not into chemistry and synthesis, you can still appreciate it)

Actually, PiHKAL is "A Chemical Love Story". TiHKAL is "The Continuation".

[SuperJunky]

I found this on erowid, its an experience report about AMT and opiate addiction. I find this extremly interesting. I'd try either AET or AMT just to see how it effects my addiction. http://www.erowid.org/experiences/exp.php?ID=34250

I've smoked DMT when dope sick, not huge doses, just enough to have a 5 minute mind fuck and an hour or two of a weird feeling. I've put just a few mgs on top of weed to smoke when dopesick, either way it seemed to almost completly eliminate the WD. This is when I had less of a habbit, and for some reason I can't seem to bring myself to smoke any when I'm dopesick now, and I think DMT smoked is just two damned short acting to be much help for WD, I think the comedown naseua would only make things worse, unless you could ride that psychadelic metaprograming through to the end. I would assume these chemicals are a little bit similair as far as how it effects the brain but I dont know, mere speculation.