aconiti kusnezoffii prepared infusion

[jacky]

I took the prepared slice roots of aconiti kusnezoffii and weighed out 150 grams. then boiled for a few hours in water, discarded the mark, and took the liquid down to a concentrated few shot glasses worth.

I consider 15 grams a dose according to some sources.

after 6 hours since my last dose of opium containing material, I took 1/4 of one dose to measure any disagreeable effect.
a half an hour later took the other 1/4. a half an hour after that the remaining half of the dose.

I waited a few hours, and though I felt OK without taking more opium containing material I proceeded to take 2/3 my nightly dose.

then I took another full dose of the aconiti liqueur....

I didnt percieve alot of potentiation, or what I might call tolerance reduction, at least not as potent as what I notice from the nigella oil.

still, before I took my nightly dose, I think I felt some mild effects, some sedation, slightly itchyness, and some dizziness.

now that I feel somewhat comfortable taking a measured dose of the material I can take it earlier in the day to see if it can stave of any withdrawl, or help a person skip a dose somewhat comfortably.

at least it isnt overly toxic.

[Dilaudid]

Hello Jacky,http://forum.opiophile.org/images/gnome/editor/separator.gif

Are you sure the Aconiti Kusnezoffii alkaloids are centraly active?
Do they cross the BBB?
Kappa agonist are good for visceral pain, try your extract for pain (spinal or visceral one).
Keep us updated of your experiements.
Best regards.

[jacky]

it contains mesaconitine....
which apperantly releases dynorphin into the spine?
and also is a kappa opioid agonist. some research shows that it may lower morphine tolerance. it is used both topically and internally.

I think it is highly possible that aconite is an ingredient in HEANTOS and OHAH blends.

smells like a sewer when it is first cooking...but the liqueur produced is slightly spicy,and sweet, with a smooth texture, and really no bad taste at all.

the raw prepared root is highly toxic, this material needs to be boiled and the mark thrown away.

I dont feel any worse for wear, and had a good time sleeping last night.
I think higher doses are needed.
I will return to researching this in a few weeks.

[nick]

Jacky,you're in very real danger of growing in to a wise old man.Keep going unknown highs are out there.

[Dilaudid]

Hello Jacky,

Why do not try directly a combo Dermorphin/Dynorphin-A?

May be an opioid peptide FAQ in the future, I have many ideas.

[jacky]

well, someone who did IV some dermorphin said that it had a great rush, but no high really past that. he was able to go without dope for awhile after, as he was opiate dependent.

so me and another member looked around for potent analogs that defy enzyme catabolic destruction, and I remember we found one that might fit the bill....

but the more I think about it, the more I dont really want to risk myself in that way....endorphins are complicated I am sure, and I dont know what type of reactions taking them might cause inevitably.

I also dont know about presenting any findings to the general public. right now most of these if not all of these peptides are not controlled, making research a potentially care free procedure in certian ways, financially, etc. I would hate to see a few hundred peoples misuse of these compounds get in the way of future discoverys, or at least complicate matters for researchers with less means that others.
really this hesitance applies only to these isolated peptides, and some synthetic peptide analogs...I would be far less hesitant if I could somehow produce the peptides myself via some cultured process, or by growing a certian species of plant of course, I just think that these peptide companys might get alarmed at a large number of orders coming in for certian products.

right now I have been somewhat succesful in getting a person in brazil to suggest certian target plant species for aquisition and study to his freinds in the feild, basically natives with botanical knowledge who live in the right areas.....maybe something interesting will come of this new connection , maybe internet herb wrangling of Novel species is possible after all. after my fiasco with lagochilus inebrians I am not paying out as much money for initial aquisition, but if I can get my hands on certian opioid species that exist in other countries I will probably be able to avoid peptide research for awhile.

this aconiti species is interesting....also I just learned that a similiar species, actually more common, contains an opioid in its flowers some 25 times stronger than mesaconitine, that is pretty damn potent i am sure, something I might not try save for vaporization initially of small amounts.

I also think that thebaine, isothebaine, and oripavine containing poppy species might have certian effects when consumed in large enough amounts....p. fugax, p. bracteaum....p orientale and related species are listed in C Ratsch's encyclopedia of psychoactives as containing these compounds, and now some of them are found in certian smoking blends. thebaine has some data on it that looks promising actually, and is a compound that I know I have consumed to some degree already.

another species of flower is dalea purpurea, I could never get it to grow is sufficient quantity, too bad, cause it contains an opioid compound, and has been used for diarrhea control and as a tonic by native americans. it looks similiar to echinacea....I know a chemist that has 60 some plants growing right now, and I sent most of the root material of the plant that I was able to grow for analysis, but I dont suspect we will know much or have much material until wildcrafting is an option. see, the plants grows over a large amount of the eastern and midwestern united states, and I think that out there somewhere are large enough amounts of harvestable material to provide alot of bioassay material. who knows, maybe the gerynylstillbene or similair spelling compound, that is the active opioid in this case, is a mu opioid?

there are so many directions for research and possibility for people who might be able to use this knowledge to produce stronger compounds from organic sources...sorta like the 7 acetoxy material that has been synthed.

[Paregoric Kid]

yes there are peptides and synthetic peptides and analoges that could be made from them that would work very well. also if you are looking for other poppies to experiment with I suggest trying Papaver setigerum

[jacky]

I think the name of that poppy was changed to p. fugax

[Papa Verine]

Hey Jacky, I have found Dalea Purpurea growing wild in my area. I spend A lot of time searching for and identifying local plants and any reported to contain a natural opioid are particularly interesting to me. Dalea purpurea is actually pretty common here and I've seen A lot of it. Is there anything else you can tell me about it? Do you know what part of the plant would be used?

Too bad it's winter right now but I will definately be doing some research on this plant come Spring/Summer. We don't have much in the way of psychoactive plants and fungi here. I have found and used Calamus, Illinois bundleflower, Phalaris grasses (DMT, 5-meo-DMT) and some weak psilocybian fungi (Gymnopilus, Pluteus spp.) but other than that I haven't had any luck. If anything else comes to mind I might be able to locate in my area please let me know. I'll post all my results and experiences in this forum.

[SuperJunky]

When I was damn near completly opiate niave (only used hydro/codiene a few times) I got a slight buzz from home grown P. Oriental "opium," but when I mixed this with a double the prescribed dose of hydro cough syrup I was obliterated. I didnt experience another opiate high this intense untill I tried oxy or heroin a few years later.

[jacky]

there are some compounds in this p. orientale species that I suspect could metabolize into stronger material....I know of one place that sells the extract of this plant.

interesting.....too bad I missplaced almost a gram of that damn extract.

[SuperJunky]

I dont know where I read it, probably around here some where, or on erowids, that thebaine can be metabolized into hydrocodone, hydromorphone, oxycodone, oxymorphone etc by the liver in the presence of these chemicals. Kind of like taking a bit of one of these drugs to show your liver what could be. I'll have to grow these again this year, they didnt survive last winter.

[jacky]

I just remembered, I have a bunch of papaver orientale that I harvested from my yard last fall.

I remember when billi piss tested after taking poppy seeds. they test came back positive for synthetic opiates, I think hydrocodone...they didnt believe his poppy seed defense, cause they found synthetics.

I have always thought that thebaine is adding to the psychoactive effect of poppy pods/seeds of papaver somniferum...now it seems at least plausible that thebaine and similiar compounds that are contained in other poppies might have effect. oripavines can be highly potent...and I know that in some testing opium consumers took the longest to detox, even compared with the heroin using control group. so perhaps oripavines and more potent compounds than morphine are being created in the liver, and that is why sometimes even poppy seeds can have VERY strong stimulant effects that later turn into intense narcotic/opioid activity.

primates fed thebaine daily metabolized that compound into opiates..first stimulant qualities ensue...thebaine can be toxic in this stage...then the thebaine is metabolized in a few hours to more classic type of opiates and the stronger narcotic action takes place. the primates become dependent on the thebaine.
if this is taking place in primates, then it might be taking place in at least a population of humans that have sufficient enzyme levels.

thebaine is a controlled substance I think.

[SpecialGuy69]

^ jacky- thebaine is almost surely controlled because it's the most common precursor to oxycodone and other opiates.

[dimebagaboy]

jacky contact me i have some interesting artwork and some interesting pics (miami hardcore street scene) lets collaborate and maybe start a little newsletter hit me back if interested:)