Guinea Pig
12-07-2006, 08:49 PM
Prelude: First of all, let me commend the National Library of Medicine service provided by the National Institute of Health. It is the only thing in terms of drug information that the U.S. is doing to help users.
I did a search on naltrexone and haven't found any real results, so excuse me if this came up before.
Everyone is free to read the actual text of the brief at the link posted below, but here's a summary from a case report on the PubMed site.
The subject was ingesting 200mg codeine 4 times a day (which is quite a dose I might add, I'm not sure why they'd go with codeine of all things) for a total of 800mg daily for the course of several months. With each dose, he was ingesting 0.5mcg of naltrexone (opiate antagonist), from what I understand this is an absolutely minute dose, with the standard dose being 50mg (not mcg). The subject did not experience tolerance, and when he quit cold turkey from this habit, experiencing an "uneventful, asymptomatic" withdrawal. Which I assume means now withdrawal at all.
I'll let the rest of the text speak for itself:
It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome.
Maybe I'm just being too hopeful, but does anyone think it'd be worthwhile to test this out? Better yet, HAVE any members here taken minute doses of an antagonist along with an opiate?
I did a search on naltrexone and haven't found any real results, so excuse me if this came up before.
Everyone is free to read the actual text of the brief at the link posted below, but here's a summary from a case report on the PubMed site.
The subject was ingesting 200mg codeine 4 times a day (which is quite a dose I might add, I'm not sure why they'd go with codeine of all things) for a total of 800mg daily for the course of several months. With each dose, he was ingesting 0.5mcg of naltrexone (opiate antagonist), from what I understand this is an absolutely minute dose, with the standard dose being 50mg (not mcg). The subject did not experience tolerance, and when he quit cold turkey from this habit, experiencing an "uneventful, asymptomatic" withdrawal. Which I assume means now withdrawal at all.
I'll let the rest of the text speak for itself:
It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt ("cold turkey"), asymptomatic and uneventful withdrawal. This points the way to the biochemical substrate of opioid tolerance itself, and shows that this can easily and inexpensively be blocked, even over months of iterative oral administration of substantial doses of opioid analgesics. Finally, it suggests the opioid withdrawal syndrome is directly related to the physiology of opioid tolerance, and can be prevented by blocking tolerance itself. Even when tolerance has been acquired, this can be reduced stepwise over a matter of days, with no symptoms of opioid withdrawal syndrome.
Maybe I'm just being too hopeful, but does anyone think it'd be worthwhile to test this out? Better yet, HAVE any members here taken minute doses of an antagonist along with an opiate?