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Karlin
12-05-2006, 06:59 PM
I am feeling 'rather perplexed' right now... I am hoping one of the medical professionals will answer this, but all replies will be welcome especially people with similiar experiences.

I have been prescribed morphine for about 15 years now, and started using a needle just a few years ago. Back then, three years ago, a 60mg MS Contin or Eslon was sufficient,a good strong rush, and I would take it twice a day [injected]. That amount grew and I was often taking three shots a day.

Eventually I was using larger doses, and got up to 150 or 180 mg sized shots two or three times a day, and the third shot was allways something I 'wanted' but just tried to save some of my stash by not taking it. I know, this is a huge amount...

The problem is that now nothing seems to give me a rush for the first two doses - no tingles, but there is that 'heat-in-the-face'. Within 10 minutes I am feeling about right, but when I don't get that rush it just doesn't seem to be very good - psychologcal or physical, I don't know.

Also, even if I miss that third dose and go about 14 to 16 hrs overnight [I allways delay the morning shot until about 9 AM to let my bowels work] the first dose [150 mg] has no rush, the 2nd one [150mg] at 1pm has very little rush, and then a smaller dose [120mg for eg.] at 6pm gives me a great rush.

Why, when I am at the 14 to 16 hrs without stage, is it not the best shot of the day?
And why is that third one the best one? Does it take that much to get my receptors to kick in now?

Also, I just went thru a four day shortage, taking 200 mg a day, then 100 mg a day and some 'wash', and finally today I took just 80mg until the shrtage [supply] ended and I took a 120mg shot but felt absolutely NOTHING initially, then 15 minutes later I was a little bit relaxed, but not much there at all.

I have NEVER taken more than 500 mg per day, not even once, I am very steady that way. I have NEVER taken more than 180 mg at once either. I guess the trouble is that my consitent useage takes away the tolerance reductions that my friends get when they run out. I just cannot stand to run out, it is a huge fear for me because I get such bad bowel pains, and the other pains being 'unmasked', etc. , and I am perhaps a "chicken" about running out.

I guess it time to face the music and admit my tolerance is to high, I cannot afford to buy more than I am now, and no prescription increases will happen either. But quitting for a day doesn't seem to help, and I WILL do anything I can to not run out because I get so desperate.

Any hints on reducing tolerance at this stage? Or ideas about something wrong with my body/brain that I do not get much effect from huge doses? Or how I can get a better rush again?