Meprobamate

[junkyfruit]

Ello,

I did a search on cold water extractions to remove apap from pain killers, and a search to find any info on meprobamate (milltowns, mothers little helper) sold in the retail form of Meprogesic (300mg Acetylsalicyclic Acid BP, 200mg Meprobamate 200 USP).

In what fashion would I seperate the Aspirin from the Meprobamate? I am rather aspirin sensitive (i ate 2 last time and puked for about an hour).



Thanks for any replys.

JunkyFruit-

[red26]

meprobamate... now what exactly is that? sounds good...

[junkyfruit]

Meprobamate is a bitter white powder with a characteristic odor and a bitter taste. It is slightly soluble in water, freely soluble in acetone and alcohol, and sparingly soluble in ether.
C9-H18-N2-O4, used as a tranquilizer, muscle relaxant, and anticonvulsant.


`Miltown'-200 (generic: meprogesic) contains 200 mg meprobamate per tablet. Other ingredients: acacia, carnauba wax, corn starch, gelatin, magnesium carbonate, magnesium stearate, methylcellulose shellac, sugar, talc, titanium dioxide, white wax and other ingredients.


Tranquilizing drug that acts as a depressant of the central nervous system and is commonly used in the treatment of anxiety and sometimes schizophrenia. Although meprobamate is chemically unlike barbiturates and has lower toxicity, it has similar pharmacological effects, especially the ability to induce sleep and alleviate anxiety. The drug possesses some anticonvulsant properties and is used to suppress some forms of . A muscle relaxant, meprobamate is also used to treat abnormal motor activity. It is marketed under the trade names Equanil and Miltown.


Meprobamate's mechanism of action is not known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Meprobamate binds to GABA-A receptors which interrupt neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain.

Related drugs include carisoprodol (a prodrug of meprobamate) and tybamate.

Launched in 1955, it rapidly became a best seller and famous in the popular media as "Happy Pills". This continued throughout the 1960s but by 1970 it was listed as a controlled substance after it was discovered to cause physical and psychological dependence.



JunkyFruit

[red26]

Sorry I ain t got no answer fer ya but that stuff sounds kinda good! YeeeeeHaw! Kiddin. Wow, I'm gunna go ask my old shrink for this stuff. Maybe displace some of my pain issues and get to chill at the same time. Thanx for starting this and again I apologize for not havin any info for you JF.

[SpecialGuy69]

You need to find out if it's water soluble, and if so, how soluble it is. Solubiliy is usually described in terms like mg per ml at x degrees centigrate. The idea of cwe is that tylenol (and I think asprin, too) are barely water soluble at all at low temperatures, so it precipitates out into a solid as the water cools, while the good shit remains in solution.

If vaxn8 comes around, she could tell you for sure if it's soluble. You might be able to find out online if you do enough searching. If it is, just do a normal cwe.

It would be kinda cool if cwe worked the opposite way- like if there was a different liquid you could use where solubilities were reversed- i.e. the apap would remain in solution while the good stuff precipitated out. Then, you could just filter out the solids and you'd have cleaner product.

[Curio]

the question is
where the frig did you get ahold of Miltowns? that's oldschool city...

of course, nearly everyone has soma aka carisprodol around these days and apparently the body breaks it down into the very substance you are trying to extract from amongst those other nasties;)

[Curio]

meprobamate... now what exactly is that? sounds good...

doesn't it sound like a legal term, really though?

MEProb-a-mate....or something naughty, lol...

[junkyfruit]

It is slightly soluble in water, freely soluble in acetone and alcohol, and sparingly soluble in ether.


Well, I am to assume at this point that a cold water extraction would work (although not efficiently at all) Is there a similar extraction process (minus any freaky chemist gear, as i am def, NOT a freaky chemist) that would work with ethanol?

(maybe the same process with chilled ethanol?)


Thanks-

J-F

[junkyfruit]

ComaToes,
its actually rather funny. I read a lot of older Sci-Fi books (mostly robert heinlein and others in the same vein)
and they quite commonly refer to giving the standard wife figure milltowns and a drink to calm her down.

Seeing as I'm 23, def wasnt around in that era, so its interesting to have "old school" drugs :-D


Sorry just ramblin....


J-f

[SpecialGuy69]

Well, I am to assume at this point that a cold water extraction would work (although not efficiently at all) Is there a similar extraction process (minus any freaky chemist gear, as i am def, NOT a freaky chemist) that would work with ethanol?

(maybe the same process with chilled ethanol?)


Thanks-

J-FNo, asprin is also slightly soluble in water. So they will precipitate out at approximately the same temp. You need to find a solvent that it's HIGHLY soluble in- like it says there alcohol - so if asprin isn't soluble in alcohol then it would work.

CWE works because of the difference in the solubility of the 2 active ingredients. If they have the same solubility, you can't separate them. Comprende?

[junkyfruit]

entiendo sí el amo. Creo thats porqué fijé sobre una extracción enfriada del alcohol....


J-f

[OxyContinuously]

As a chemist, i would say your best bet is indeed to do the "freaky chemist" thing. Cold water is not really an option.

[junkyfruit]

Well, its better to learn a new trick than to get continuously sick, i suppose.

Which freaky chemist technique(s) would be used in this?
If possible (i can figure this out on my own if need be) could you mention any husehold items that would perform similar funtions as chemist glassware?


Thanks

J-F

[johnny27]

I was actually going to create a thread on the miltown/carisoprodol thing. Dose'nt seem worth it now, so i really hope you don't mind me asking these couple of Q's in this thread.

First off, i use soma everyday with my PT, its a nice potentator for it. I will be expecting withdrawl from it soon, when i run out. To me, Meprobamate withdrawl sounds bad and dangerous, since it has the same/similar WD's as barbs, meaning possible seizures and so on.

Regarding this, can anyone thru experince tell me, if an everyday use, long term soma kick, is as bad as a meprobamate kick?

Next off, has anyone here used both soma and miltown (seperately) so they can compare their effects, so maybe we can estimate how well the liver can metabolize the carisoprodol in meprobamate?
Thanks

[junkyfruit]

Johnny27:

I don't know from experience but i'm willing to hesitate a guess. In Milltowns the active ingredient (other than aspirin) is meprobamate. In soma the active ingredient metabolizes into meprobamate. So i would think that a meprobamate (milltown) kick would be as bad as a soma kick because basically it is the same thing.


Please someone correct me if I am wrong.


Thanks-

J-f-