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View Full Version : Why a sup forum for DXM and Benzos but not Pot?


KiloByte
11-10-2006, 05:22 AM
What do you guys think about adding a marijuana sub forum? I love opiates but my ultimate drug of choice is maijuana(if you want to even refer to it as a drug). I duno where I'd be without it.

flipside
11-10-2006, 06:16 AM
I would assume it's because this is primarily an opitae forum,and benzo's and DXm kinda mix in, if you know what I mean. I could be wrong though.

KiloByte
11-10-2006, 06:17 AM
I would assume it's because this is primarily an opitae forum,and benzo's and DXm kinda mix in, if you know what I mean. I could be wrong though.

Well pot is more of a painkiller than either one of those drugs so whats your point? It mixes in just as well if not better.

flipside
11-10-2006, 06:38 AM
No, no you are taking what I said wrong. I meant that it's pretty common here for a lot of us to use benzos with our opiates or to help with WD's.

By all means feel free to post your experience with pot.

flipside
11-10-2006, 06:39 AM
double post sorry, it's`early

KiloByte
11-10-2006, 06:43 AM
No, no you are taking what I said wrong. I meant that it's pretty common here for a lot of us to use benzos with our opiates or to help with WD's.

By all means feel free to post your experience with pot.

So you guys only use those and don't smoke pot as much? Interesting.

mort
11-10-2006, 06:55 AM
What do you guys think about adding a marijuana sub forum? I love opiates but my ultimate drug of choice is maijuana(if you want to even refer to it as a drug). I duno where I'd be without it.

I would assume it's because there is already a fucking glut of "pot" forums everyfuckingwhereelse.

flipside
11-10-2006, 07:01 AM
So you guys only use those and don't smoke pot as much? Interesting.

I can't speak for anyone else, but I personaly do not use pot. Don't like the way it feels. The only times I have ever resorted to using it where when the nausea from my chemo could not be controlled any other way.

trainwrecker
11-10-2006, 11:49 AM
I love me some pot, it's the tree of life. It's good for potentiation, w/d's, getting hungry, and a million other things. That being said this is an Opiate forum. Oh yeah, DXM actually is an opiate.

AWOL
11-10-2006, 02:01 PM
Well pot is more of a painkiller than either one of those drugs so whats your point? It mixes in just as well if not better.


Pot is more of a painkiller than DXM? DXM is a dissociative, you could chop your arm off on it and not even notice. Hence, dissociative. That’s why you get nitros at the dentist, and the vets are druggin animals with K. And then there’s PCP.


And I think there isn't a pot forum because there isn't a lot to know about pot. You smoke it / eat it, you get high. And it doesn't really tie into the opiate lifestyle the same way DXM, Benzo's, Kratom do. My thoughts.

chemboy7
11-10-2006, 03:09 PM
There isn't a pot forum because it has balls to do with Opaites. I am not adverse to Marijuana, I smoke a bowl occasionally, but alot of addicts are... they have shunned pot. It's no more of a drug than Caffiene or Nicotine (which are both drugs, I know, but they're not DRUGS... you know). There are lots of places on the net for 14 year olds to gather and collaborate about how awesome weed is, I don't attend there; likewise I have little use for a pot sub-forum. Benzos and DXM go together with Opaites like milk and sugar do with coffee, Marijuana has nothing to do with it; if there is a sub-forum for pot why not make one for Barbituates, Qualudes, Amphetamines, Piperazines, Dissociative Anestetics, Alcohol, Phenethylamines, Tryptamines, fuck why not... inhalants. Why not have a sub-forum for all different classes of drugs? Why not? Because this is an Opaite forum.

insanesteveo
11-10-2006, 03:19 PM
its called "other drugs"

i love pot, i used to smoke it all day every day for about 5 years. then i found opiates and when i started doing those all the time i stopped smoking pot so much. i still REALLY enjoy a fat bowl of kb, but i dont like to get really high on opiates. i WILL take a puff or two just to make me feel groovy.

Seedy
11-10-2006, 03:36 PM
There isn't a pot forum because it has balls to do with Opaites. I am not adverse to Marijuana, I smoke a bowl occasionally, but alot of addicts are... they have shunned pot. It's no more of a drug than Caffiene or Nicotine (which are both drugs, I know, but they're not DRUGS... you know). There are lots of places on the net for 14 year olds to gather and collaborate about how awesome weed is, I don't attend there; likewise I have little use for a pot sub-forum. Benzos and DXM go together with Opaites like milk and sugar do with coffee, Marijuana has nothing to do with it; if there is a sub-forum for pot why not make one for Barbituates, Qualudes, Amphetamines, Piperazines, Dissociative Anestetics, Alcohol, Phenethylamines, Tryptamines, fuck why not... inhalants. Why not have a sub-forum for all different classes of drugs? Why not? Because this is an Opaite forum.

Good answer man but I have to disagree on one thing: Weed is one powerful motherfucker of a drug. What other common drug can get you as fucked up for the small price of the ammount you can fit in a bowl? It comes on fast and the effects are actually pretty full on. Althouigh I still smoke daily I smoke minute ammounts because if I smoke just a bit too much I become completely useless. AND it is an addiction, no doubt. I still smoke in small ammounts (one small hit a day) is because it enhances creativity and if I don't smoke I can't sleep. I know weed doesn't do me much good but still I smoke it. It's an addiction like any other.

Sitar
11-10-2006, 03:55 PM
Cannabis does not fit into this message board at all, whatsoever, in my view. It's not a painkiller in the sense that opiates are, nor is marijuana a CNS depressant in the way that opiates or benzos are. It just doesn't fit. And DXM is far more a painkiller in every way than pot.

There is an enormous proliferation of cannabis message boards out there; far more than there are opiate message boards. And if you want to discuss marijuana, the "Other Drugs" forum would be the appropriate place for that.

Bottom line is, pot can't be shot up, so it just doesn't fit.

youwonhundred
11-11-2006, 02:37 AM
Bottom line is, pot can't be shot up, so it just doesn't fit.

I just gotta relate this story. It came back to me when i read that post. You would be quite surprised at what people will try to shoot. My uncle (this is according to my mom, a story she told me many years ago) when he was about 15, was told that you could get high on smoking banana peels. Well, my uncle, whose name happens to be "Dick" (so fitting, really) decided that if you could get high smoking them, he was gonna see what happened if you boiled them and shot the resulting liquid. The only question I had about that was, where in the name of god, allah, buddah, whoever did he find a rig big enough to fit banana peel boilings in, or did he cook it down to a half cc..

Like i said, its just a story, so I dunno how accurate it is, but its damn funny regardless. Next thing you know, some dumbass is gonna try to shoot the milk from cornflakes. Which sounds like something a pothead would do.

KiloByte
11-12-2006, 09:37 PM
Pot is more of a painkiller than DXM? DXM is a dissociative, you could chop your arm off on it and not even notice. Hence, dissociative. That’s why you get nitros at the dentist, and the vets are druggin animals with K. And then there’s PCP.


And I think there isn't a pot forum because there isn't a lot to know about pot. You smoke it / eat it, you get high. And it doesn't really tie into the opiate lifestyle the same way DXM, Benzo's, Kratom do. My thoughts.

To a cancer patient pot is a hell of alot more effective at treating their pain and nausea than dxm. And DXM in and of itself is a pretty lame drug to use recreationally espcially compared with pot. I love to smoke a nice fat bowl.

Chemical_Boy
11-12-2006, 09:48 PM
Bottom line is, pot can't be shot up, so it just doesn't fit.

I sniffed a line of resin when I was 15. Does that count?:D

exitwound
11-12-2006, 11:43 PM
To a cancer patient pot is a hell of alot more effective at treating their pain and nausea than dxm. And DXM in and of itself is a pretty lame drug to use recreationally espcially compared with pot. I love to smoke a nice fat bowl.

Yeah.....without marijuana I would be in deep shit taking this much opiates. And it helps nearly as much as the opiates do with many of the painful and uncomfortable symptoms of my conditions. If only I could get it prescribed and have my state medical coverage pay for it!*:mad:

Woods
11-13-2006, 12:11 AM
You can inject THC and related cannabis constituents if you really want, it just requires more chem knowledge then most other drugs to extract into an inject able form due to its chemical nature. Even after extracting it properly, like most benzos you’d need top create some sort of emulsion in order to shoot it without major risk of damaging yourself. I fact, I bet the right strain, extracted properly would have an almost narcotic effect if injected, there just isn’t an economic incentive to create that sort of product.

Now, I’m not saying that this forum has too many sub-forums or anything, but it does have a hell of a lot. It also has a lot of sub-sub-forums. Because of that, I don’t see why at the very least, the other drugs sub-forum couldn’t have a marijuana sub-forum within it. Since that way it would be a sub-forum within a forum it wouldn’t add any clutter to the main forum.

Third, while marijuana on its may not be comparable to opiates or the other drugs which are given sub-forums, in combination with opiates, marijuana can be an incredibly powerful drug. Pot on its own may be a close to useless as a painkiller, but used along side opiates, especially powerful opiates, certain strains of good pot can drastically increase and alter the effects of those drugs. Especially when using large quantities powerful opiates for painkilling purposes, marijuana’s ability to drastically increase the power of opiates while lowering the amount used can increase quality life by decreasing some of the negative effects of opiates. These effects may not be as pronounced as with MDMA, but with long term use the latter just isn’t safe or effective, while the former can be used in any quantity for any length of time with virtually no negative side effects.

AWOL
11-13-2006, 02:26 AM
You can inject THC and related cannabis constituents if you really want, it just requires more chem knowledge then most other drugs to extract into an inject able form due to its chemical nature. Even after extracting it properly, like most benzos you’d need top create some sort of emulsion in order to shoot it without major risk of damaging yourself. I fact, I bet the right strain, extracted properly would have an almost narcotic effect if injected, there just isn’t an economic incentive to create that sort of product.

You could bang marinol.

poonwhalla
11-13-2006, 02:52 AM
marinol sucks and there are a lot of THC/pot forums out there. It was my vice but now it is a surface thing to where if its there I know mary very well.

Woods
11-13-2006, 03:09 AM
The difference between THC and marinol is like between a handful of white sugar and a tasty apple.

poonwhalla
11-13-2006, 03:11 AM
is that fructose and thc or simple sugar and marinol?

Woods
11-13-2006, 04:44 AM
What do you mean?

AWOL
11-13-2006, 10:07 AM
The difference between THC and marinol is like between a handful of white sugar and a tasty apple.

Woods, what are you talking about? Marinol IS THC. THC = delta 9 tetrahydocannibol. http://en.wikipedia.org/wiki/Marinol http://en.wikipedia.org/wiki/Tetrahydrocannabinol

remybur12
11-13-2006, 10:10 AM
Marinol is synthetic THC. It's not natural but It has all the effects of marijuana and a little extra. But still I perfer MJ.

greenfox
11-13-2006, 10:13 AM
is that fructose and thc or simple sugar and marinol?

my ex was prescribed marinol (the orange 10mgs) we used to pop `em with pins and eat like 6 or 7 at a time.. at that dose, you get really tired and really hungry.

And how did the dead put it?

"In our group, taking pot was like having a salad....yes, I'll have a salad//"

remybur12
11-13-2006, 10:18 AM
I think marinol has its own effects but some are similar to mj. But be careful you can overdose on marinol.

greenfox
11-13-2006, 10:22 AM
I think marinol has its own effects but some are similar to mj. But be careful you can overdose on marinol.

i've tried; if it's possible, it takes more than 200mg :)

remybur12
11-13-2006, 10:29 AM
I think its like 2mg's for each pound of your weight.

AWOL
11-13-2006, 10:29 AM
I'm not arguing that it's synthetc, obviously it is. And it's not marijuana, that has all sorts of stuff in it including THC. My point to woods is that there is no difference between naturally occuring THC, and synthetic THC, their chemical structure is the same. So whatever analogy he is talking about there with apples and sugar or whatever is null.

remybur12
11-13-2006, 10:31 AM
LOL I feel that. the whole apple and sugar thing is pretty lame

greenfox
11-13-2006, 10:35 AM
LOL I feel that. the whole apple and sugar thing is pretty lame

isn't there sugar in apples? lol j/k had to. No seriously I didn't know that it was 2mg per kg? is that an actual source fact?

AWOL
11-13-2006, 10:38 AM
Yeah and there's shit in a cow. But I'm not going to draw any sort of analogy here about steak =)

greenfox
11-13-2006, 10:45 AM
Yeah and there's shit in a cow. But I'm not going to draw any sort of analogy here about steak =)


LOL! ROTFL!

ok.. ;) I gotta stop... wow...WOW... I don't think I'll ever look at a steak the same way again...

:eek: :vomit:

superman
11-13-2006, 12:11 PM
i am gonna have to say that's a damn good question :)

i am betting that many of us here smoke pot or hash... i know i'd have some nice pics to share from time to time, as well as the odd pictorial showing my hash production (just for myself, i am not a dealer).

especially since this forum serves so many chronic pain patients, not to mention the fact that the worlds foremost marijuana resource is now(edit:sp) GONE(piss me the fuck off, they took some of my awsome pictures with them...)[overgrow.com]

I say hell ya, dope forum would be nice. i'd like to share my easy-as-pie pot processing technique with everyone with hopes that it will encourage more healthy smoking habits. not that it's new.... just simple and effective.

i think i'll go smoke some hash now....

Sitar
11-13-2006, 05:00 PM
OK, I knew that someone was gonna say that pot could be injected if someone really wanted. But you guys know what I mean... it's not something people really actually do.

I don't see any problem with discussing pot here, that's what the Other Drugs forum is for.

jacky
11-13-2006, 05:19 PM
cannabanoids have a DIRECT effect on kappa receptors in the spine....this means that cannabis can be considered an opioid.

other implications of opioid like involvement of THC have been researched...

just google this...THC kappa opioid cannabis..
you should get search results that list a website called euroanasthesia.org
the article is called "the role of cannabis as an analgesic".

I had some pretty sever withdrawl from cannabis/opium as a kid, apparently the cannabis was thia, and sprayed with opium. A vietnam vet sold it to a few older freinds of mine....the stash lasted 9 months, the weed smelled like chocolate/raisins/flowers, and was golden brown with major crystallization. apparently it was smuggled on fishing boats somehow, this was the mid 80's. when the weed ran out, I didnt sleep or eat for a week, sweated all night, felt like shit all day.
a few years later I ran out of a different type of pot, non opiated, I had been smoking daily for a few years, I still felt some withdrawl effects, no one would believe that I experience withdrawl from cannabis.

and 15-20 years later the subject still comes up, and I tell people that cannabis has some opioid effects.

so basically, cannabis is a welcome topic at opiophile.org , sure, why not, it is after all, one of the best analgesic drugs known to man.

there is alot of research like this being done, probably alot of it outside of the USA. its hard to keep up with all the new opiate/opioid research, and harder still for me to understand some of it.

Woods
11-13-2006, 05:48 PM
Woods, what are you talking about? Marinol IS THC. THC = delta 9 tetrahydocannibol. http://en.wikipedia.org/wiki/Marinol http://en.wikipedia.org/wiki/Tetrahydrocannabinol

My bad, I messed up my analogy. I meant to say something to the effect of "Marijuana is to Marinol as a tasty apple is to white sugar." Sorry for the confusion.

Sitar
11-13-2006, 06:15 PM
cannabanoids have a DIRECT effect on kappa receptors in the spine....this means that cannabis can be considered an opioid.


I hardly think Cannabis can be considered an opioid.

Next time you're in serious opiate withdrawal, see if smoking some pot is gonna make you well. I guarantee it won't. The reason; it's not an opioid whatsoever. It may share some similar effects with opioids, but an opioid it is not.

I'm not trying to start an argument here, so please don't take any of this as such. I just don't believe that Cannabis could be considered an opioid of any kind. It's in its own category and deserves separate attention elsewhere (and there are tons of message boards devoted exclusively to pot).

candyshop
11-13-2006, 06:21 PM
sitar ,no offence meant, but you do realise that you are arguing with the FOUNDER of the board about
the appropriateness of including a subject /topic on a board that HE CREATED

AWOL
11-13-2006, 07:07 PM
http://www.medicalnewstoday.com/medicalnews.php?newsid=21339

http://www.ic.ac.uk/P1931.htm

http://www.annieappleseedproject.org/maraidnerpai.html

http://news.bbc.co.uk/1/hi/in_depth/sci_tech/2001/glasgow_2001/1523461.stm

http://cannabis.net/pain/index.html


I still have to vote for DXM being more of a pain killer than MJ, but here are some links supporting MJ as an effective painkiller apart from, but mainly used in conjunction with opiates.

Sitar
11-13-2006, 07:26 PM
sitar ,no offence meant, but you do realise that you are arguing with the FOUNDER of the board about
the appropriateness of including a subject /topic on a board that HE CREATED

No I'm not. I'm simply questioning the logistics of calling THC an opioid.

And anyway, the whole question was raised by someone else as to whether it would be appropriate for a separate forum to be created for pot. And being a member of this forum, I have the privilege to state my opinion on the matter, since the issue was raised. But I will say that I don't think pot should have its own forum since there's already an "Other Drugs" forum, and pot isn't even discussed there enough to warrant a new forum. It just doesn't make sense.

jacky
11-14-2006, 01:50 PM
I have used many things to ease opiate withdrawl, cannabis is one of them, NOT ABOLISH opiate withdrawl, but to help with certian side effects.

no argument really, the medical data states that analgesia due to cannabis consumption is part due to DIRECT opioid agonist activity in the spine. that makes cannabis, an opioid. not particularly strong opioid, but an example nonetheless. there are other studies done on cannabis and THC that hint to indirect opioid activity. check it out.

there are many opioid agonists in nature, in catnip, menthol is another example, opioid activity in picralima nitida, etc etc. I am not saying that they are STELLAR opioids, I am not saying they all abate morphine withdrawl. but they are opioids. menthol kills pain via the kappa opioid receptors. salvinorin a has a wide range of effects on people, much due to the kappa opioid receptors, I have experience profound pain relief on salvinorin a, and also experienced PROFOUND pain from taking salvinorin a.

but hey Sitar, if you dont want to consider cannabis an opioid that is fine, until some more data comes in that debates some of the data that it is such, I geuss we will leave it Ok for THC and cannabis to be considered an opioid, and post such relevance in the opioid in nature forum, or other drugs.

on the international front I would say that this subject is very IMPORTANT for MANY SICK people around the world, here we have data stating finally that cannabis can relieve pain, it is an OPIOID in the spine, maybe not the brain, but the spine is really an extension of the brain, as is the whole body. I have experienced pain relief and withdrawl relief from just using loperamide, and also know a chronic pain patient that uses it for pain relief in combination with their morphine. they CANNOT go off loperamide without experiencing slight withdrawl even when taking morphine, the point, scientists and certian stubborn heroin addicts I know think that it something doesnt effect the brain directly, that it is worthless.
its so fucking obvious that cannabis is a pain reliever, and a panacea....it is INFURIATING that the governement keep this stuff from sick people. I have seen cancer and aids, I have lost freinds and family to those diseases, and I know that cannabis can be very importat to those people.


I know what withdrawl is, and when I quit smoking cannabis, I AM CLIMBING The walls, that is why I have smoked it for the last 5 years with no days missed. whether that withdrawl is due to kappa opioid habituation I dont know.

I just wonder what it is about the data that you dont find true Sitar? do you doubt the validity? or is it more that you just dont think it is WORTH calling it an opioid due to some stigma? around here there is alot of conjecture, and I know personally I have posted opioid information that I find is wrong....like sophora subprostata, it contains a pain reliever, and some data states direct opioid involvment, and other states indirect opioid involvement, I just found the indirect opioid data, and havnt gotten around to posting it yet.
Maybe there is a dispute about this data that I am unaware of? or maybe you just dont think it is a RELEVANT opioid?

personally I have found some pretty cool plants, that have some interesting effects, and the only reason I sought them out was because of data describing opioid effects. I have had a college proffesor FREAKING out, pissed off that I call kratom an opioid, he basically stated I needed more education on the subject to understand him, but he coudlnt put it into words why stating that kratom, or the alkaloids in it arnt not opioids. he stated that most of the data is wrong as well, that they are not direct agonists or some such BS. this guy in a personal message to me stated that I am not going to find any really interesting opioids in nature, that it is basically pointless. then he went on about what a bad ass heroin addict he is. well, I am glad that asshole is gone, cause I hate it when people get all puffed up over stuff like conversations about science.

so I hope that this isnt a sore subject in the future, and if I have offended Sitar or anyone else I apologize, i I am not out for glory.
Billi is the person that has physically put most of the work into opiophile, I am a opiophounder, but I like a good argument, so please dont put me on a pedestal , keep questioning "authority" folks.

exitwound
11-14-2006, 03:51 PM
Great post jacky. I know a lot about how you feel about MJ. I consider it an absolutely essential medicine, especially in high quality pure-indica form. I think that everyone should have their own little, personal garden complete with their own "heirloom" custom-bred strains.

I know that I sure wish I had some local friends with harvests to share.....I'd be able to beef up my own growing thanks to their assistance even while I was disabled, and I'd have much better medicine at a vastly lower (if not zero, just based on trade so that everyone is well supplied between harvests) cost. Ah, well. =/

Sitar
11-14-2006, 05:33 PM
Jacky, thanks for your input and clarifications, however I still take issue with your notion that Cannabis acts on the Opioid receptors.

I've always read that the activity from marijuana is caused by the human body having specific receptors just for pot, which initially mystified the researchers. They were amazed that humans would have receptors in the brain specifically to activate THC. They also discovered endogenous Cannabinoids and called them Anandamides, named after, I think, a Hindu term for pleasure, Ananda.

The research I have done does not indicate that Cannabinoids act upon the Opioid receptors anywhere in the body or brain. It DOES act upon receptors in the spine as you stated, but it is acting upon Cannabinoid receptors, not Opioid receptors.

Here's an excellent article that elucidates all of these areas we're discussing:

http://www.iasp-pain.org/TC99Summer.html


Here is another great article with tons of info:

http://www.answers.com/topic/health-issues-and-the-effects-of-cannabis


It states: "It is clear that cannabinoids can affect pain transmission and, specifically, that cannabinoids interact with the brain's natural opioid system acting as a dopamine agonist."

Note that is specifically states that while it interacts with the opioid system, it is not acting as an opioid agonist.

I mean absolutely no disrespect to anyone here; on the contrary, if I didn't care about this website I wouldn't even bother to share my views and information. And that's what this is, afterall, a forum for discussion.

And just to clarify something, I think Cannabis is a wonderful plant, extremely helpful and useful, and the Arts wouldn't be the same without it. I just don't believe it's an opioid, that's all.

jacky
11-15-2006, 12:08 PM
well sure, one study can state that it does not involve opioid receptors, but when another study finds DIRECT agonist activity on a opioid receptor or subtype, then I have to take that as evidence of opioid involvment.

one study reports dynorphin release from thc consumption, dynorphin is a morphine like endogenous opiate, another study relates descriminative drug searching behavior linked with BOTH the mu and the kappa opioid receptor types...perhaps this is influenced by the dynorphine release?

direct or indirect, if it causes opioid agonist activity, analgesia, and if millions of people use it for such or just a few, I am going to give it opioid status at this website.

so all you hippie hating cannabis'aphobes can stop trashing weed and just focus on the hippies.

Sitar
11-15-2006, 12:56 PM
Cannabis doesn't agonize Opioid receptors! I couldn't find one single piece of documentation that said that at all and I looked up every single combination of "cannabis, opioid, analgesia, receptor, cannabinoid", etc. that I could think of.

If you have something that says it does, please post it. I've posted two valid sources that back up my thoughts.

Again, I'm not trying to argue with anyone or make anyone mad, I just need evidence when someone makes a claim that I don't think is right.

Cannabis agonizes Cannabinoid receptors.

jacky
11-20-2006, 02:38 PM
a quote from the website euroanasthesia....

"cannabanoids cause antinociception by direct action on kappa opioid receptors in the spinal cord. Delta 9-THC and a synthetic cannabanoid ( CP55.940) develop cross tolerance with kappa agonists in the tail flick test, suggesting that cannabanoids interact with kappa agonists."

I would print the whole article, but for some reason at this website I cannot paste and post anything...I have only been using a computer for 5 years now and have ALOT to learn.

with the research that suggests cannabanoid stimulated release of dynorphin into the spine, and thus analgesic effects, and the descriminatory behavior noted with the mu and kappa opioid receptors and thc, I would JUMP to state that cannabis has definite indirect effect on the opiate system and possible direct agonist action at the kappa receptors in the spine.

Sitar could be right , maybe the research is shit, maybe cannabis has nothing to do with the opioid systems. but I think there is alot of research that suggests that cannabis effects analgesia somehow through the opiate/opioid receptors, if not directly, then indirectly. I am not personally going to distinguish between indirect and direct agonists in the larger picture if the end effect is increased or additional analgesic effect....but then I might just me miles off base...

if something releases dynorphin, the result could be major analgesia, if thc is known to degrade the effect of opioid degrading enzymes, then the endogenous opioids might build up, so far we have one mention that cannabis can effect the kappa receptors directly in the spine. maybe its a misprint....

so I will apologize to Sitar publicly, I am sorry for beating a dead horse.

if a person wants to post relevant information that cannabis might be involved with the opioid systems go for it, I will wait for more data, or another person with more background in pharmacodynamics to step up the subject.

it seems as time goes on, the interactive nature of our brains becomes more apparent....it seems every neurotransmitter system has interactions with other systems that science once considered independent.

I was once prescribed a medication for depression when getting off of heroin. the drug was effexor.
my dr gave it to me cause he said it seemed to work good for opiate addicts.
well a few years later I realized that tramadol and effexor were VERY similiar, and then later still found that effexor has effects on the opioid and dopamine systems as well as the serotonin. and the same has been found for tramadol.....so my Dr was giving me an opioid active compound, that can cause severe dependence and withdrawl!

maybe I am to inclusive of data that is suggestive? maybe I am off base? I dont know,all I know is the data and my own reactions and experiences are all I have to go by. some compounds that dont exhibit direct agonist activity at certian concentration levels actually can become agonist at higher concentration levels....so much shit to consider.

maybe what we need is a thread that addresses POSSIBLE "opioid interactive" materials? I dont find any data suggesting DIRECT involvment of THC with the opioid receptors, except in one case. and personally I would rather find out that the purported direct kappa opioid interaction of THC is just after all the action of THC releasing dynorphin into the spine, as I think that dynorphin release into the spine would be more of an analgesic than direct kappa activity.

what a mess.

Dexter the Meth Orphan
11-21-2006, 10:56 AM
Well pot is more of a painkiller than either one of those drugs so whats your point? It mixes in just as well if not better.

This is deffinitely not the case...Pot gets you stoned...DXM takes you to "another place". And, pot is in no way more of a pain killer than DXM.

superman
11-21-2006, 01:53 PM
i did a search and confirmed the data posted by jacky. the results appear well documented.

and i notice that when my back is hurting and i have no opies, some weed will almost always help a bit.

nice ref jacky, i love reading science journals and regularily buy 3 printed journals and subscribe to one online.

Nothing speaks louder than a well designed study :)

nick
11-21-2006, 02:21 PM
i did a search and confirmed the data posted by jacky. the results appear well documented.

and i notice that when my back is hurting and i have no opies, some weed will almost always help a bit.

nice ref jacky, i love reading science journals and regularily buy 3 printed journals and subscribe to one online.

Nothing speaks louder than a well designed study :)
A well designed study will say what the person doing the study wants.You're more likely to find truth in poetry.

superman
11-21-2006, 03:17 PM
"A well designed study will say what the person doing the study wants.You're more likely to find truth in poetry."

obviously not a man of science... ever heard of the peer review process? basicly it keeps everyone honest by exposing the dishonest and discrediting them. by reading reputable peer review journals one is able get an accurate review of the state of scientific knowledge......

or you can stick you head in the ground, ignore science, and make irrational claims that scientific studies cannot be trusted.

KiloByte
11-24-2006, 01:37 PM
This is deffinitely not the case...Pot gets you stoned...DXM takes you to "another place". And, pot is in no way more of a pain killer than DXM.

If you have nausea (which can be quite painful) dxm does FUCKALL to make that better. Pot has theraputic values and if you guys don't realise that ask a cancer patient that legally gets pot in Cali.

Its pretty sad how even drug users share that same brainwashed view of weed as a stupid drug that only makes you giggle like the rest of the masses.

chemboy7
11-24-2006, 01:46 PM
If you have nausea (which can be quite painful) dxm does FUCKALL to make that better. Pot has theraputic values and if you guys don't realise that ask a cancer patient that legally gets pot in Cali.

Its pretty sad how even drug users share that same brainwashed view of weed as a stupid drug that only makes you giggle like the rest of the masses.

I don't think that anyone has made the claim that Marijuana has no medicinal or recreational value... that's not the point at hand. APAP and Penacillin have medicinal values too but I see little use for a sub forum for them on an Opaite forum. No one is saying that they don't want people talking about pot either, that's what the "other drugs" forum is made for; talk about whatever drug you want in there.

Woods
11-25-2006, 04:12 AM
Its pretty sad how even drug users share that same brainwashed view of weed as a stupid drug that only makes you giggle like the rest of the masses.

How does claiming that DXM has a higher painkilling potential then cannabis equal what you said there in any way? DXM might not be better a fighting nausea, and might even cause it, but its painkilling abilities are well recognized.

Of course there are different types of pain, and different drugs treat different types of pain better. Hell, if your pain is strictly caused by inflammation, aspirin is a better bet then morphine, but it won’t do shit for a broken leg. Pot is great medicine for certain things, but as general painkillers go, a dissociative is going to go a lot farther from disassociating people from their pain.

KiloByte
11-25-2006, 07:54 AM
I don't think that anyone has made the claim that Marijuana has no medicinal or recreational value... that's not the point at hand. APAP and Penacillin have medicinal values too but I see little use for a sub forum for them on an Opaite forum. No one is saying that they don't want people talking about pot either, that's what the "other drugs" forum is made for; talk about whatever drug you want in there.

APAP/Penacillin doesn't have recrational or lifestyle orenting values, marijuna along with most narcotics does. I just feel wierd seeing pot belittled into the general category while dxm is glorified.

chemboy7
11-25-2006, 08:04 AM
APAP/Penacillin doesn't have recrational or lifestyle orenting values, marijuna along with most narcotics does. I just feel wierd seeing pot belittled into the general category while dxm is glorified.

No one is belittling pot man. Cocaine goes great with Opaites too, but it doesn't have anything to do with Opaites thus no sub forum for it... it is talked about in the "other drugs" forum. It's already been said that DXM and Benzodiazepines go hand in hand with Opaites, it's not like we are playing favorites with drugs here; there just isn't a solid connection with the main theme of the board... Opaites, not recreational drugs in general. I don't understand why your getting so defensive about it; nobody is saying that you can't talk about weed... talk about any drug you want, that's what the "other drugs" forum is all about.

flipside
11-25-2006, 08:10 AM
OK, going to do a comparison and document results on myself.
Not because I am trying to validate any one persons point of view, but because I am in need of alternate drugs to medicate my pain, I know what pot does and does not do for me, it helps my N&V from the chemo but does jack shit for the pain in my bones.

I had already orderd Kratom, will now get dome DXM and just for you MJ loverrs I will partake once more so as to compare all three. No it's not a random, double blind or controlled experiment but should be interesting and hopelfuly helpful ( at least to me if no one else)

Thanks for posting this kiiobyte, it's propmted me to get out there and experiment a little more to see what else may help me with my current situation. Which is currently in Withdrawal and pain. And jacky thanks for the refrences.

AWOL
11-25-2006, 08:19 AM
OK, going to do a comparison and document results on myself.
Not because I am trying to validate any one persons point of view, but because I am in need of alternate drugs to medicate my pain, I know what pot does and does not do for me, it helps my N&V from the chemo but does jack shit for the pain in my bones.

I had already orderd Kratom, will now get dome DXM and just for you MJ loverrs I will partake once more so as to compare all three. No it's not a random, double blind or controlled experiment but should be interesting and hopelfuly helpful ( at least to me if no one else)

Thanks for posting this kiiobyte, it's propmted me to get out there and experiment a little more to see what else may help me with my current situation. Which is currently in Withdrawal and pain. And jacky thanks for the refrences.

If you've not had a lot of experience with DXM before just wanted to warn ya to be cautious with it. Too much and it can turn unpleasant on ya pretty quick. For a female you probably wouldn't need more than say75 - 105mg for potentiation more or less. Just given ya a heads up is all, most people don't care much for DXM once the dose gets bumped up too high.

KiloByte
11-25-2006, 08:39 AM
OK, going to do a comparison and document results on myself.
Not because I am trying to validate any one persons point of view, but because I am in need of alternate drugs to medicate my pain, I know what pot does and does not do for me, it helps my N&V from the chemo but does jack shit for the pain in my bones.

I had already orderd Kratom, will now get dome DXM and just for you MJ loverrs I will partake once more so as to compare all three. No it's not a random, double blind or controlled experiment but should be interesting and hopelfuly helpful ( at least to me if no one else)

Thanks for posting this kiiobyte, it's propmted me to get out there and experiment a little more to see what else may help me with my current situation. Which is currently in Withdrawal and pain. And jacky thanks for the refrences.

I'm glad to hear that, if nothing else at least I inspired 1 person :)

DXM was fun in 10th grade but I could never see myself using it for any form of pain control(I guess it would need to be an extremely desperate situation). I guess I fucked up my view of dxm because I was cosuming it via robo and eventually the gels. Very disgusting stuff which leaves a real mark in your memory, I can barely get down a normal dose(whats prescribed on the box). It was fun to get stoned the next day acompanied by the "afterglow" but overall it felt too manmade and chemicalish for me to want to do it any more. Its too much of a "dark" drug because of the way it disconnectes you from reality unlike other classes of drugs.

Sitar
11-26-2006, 07:48 PM
OK, I've done a lot of looking online and have found NO sources that make even the most remote claim of any kind that Cannabis agonizes OPIOID receptors.

If any of you are finding them, please post them. Otherwise, I'm gonna assume that you guys are hallucinating this "information".

Cannabis DOES agonize receptors in the body and brain, but they are the CANNABINOID receptors. Only Opioids agonize Opioid receptors.

Dexter the Meth Orphan
12-09-2006, 11:46 PM
I'm glad to hear that, if nothing else at least I inspired 1 person :)
Its too much of a "dark" drug because of the way it disconnectes you from reality unlike other classes of drugs.

I have known true hell...

AWOL
12-09-2006, 11:51 PM
I have known true hell...

I enjoyed the stay.

defenestrate
12-13-2006, 12:09 AM
agreed, re: knowing true hell and enjoying the stay. i also managed a hell of a lot of metaprogramming on it back in the day when i had powder.