jacky
11-09-2006, 01:54 AM
looking into the activity of processed aconiti tuber, or more specifically, aconiti kusnezoffii prepared tuber, I find some more recent data relating its activity to kappa opioid stimulation.
the prepared root needs to be taken, and boiled for a period, at least an hour. this apparently destroys some of the more toxic compounds. a common dose tops out at 15 grams of sliced prepared tuber. so if I took 150 grams of aconiti tuber, and boiled it in water, and then take that water and reduce to a dry powder, I should have around 10 full doses.
so I am thinking that I will take 1 full dose, equivalent to 15 grams of prepared tuber, and split that up into 10 units.
I will take the material on a day off, with another day for recoup. if the material makes me sick.
reading about its kappa activity, I notice that the material is supposed to reduce morphine tolerance, which means that if I take this stuff, maybe 4-5 hours after my opiate dosing, I might feel and increase in analgesic effects. and possibly this material might be used for weening off of morphine/other opiates. possibly I could even see the material reducing morphine/opiate withdrawl as well.
I dont think that this stuff is going to create a euphoric effect by itself, but it might be a definite tool of sorts.
the activity of this material seems pretty complex, dopaminergic activity is reported as well, and the stuff can cause heart failure if overdosed on rather than respitory depression. I am sure that taking too much aconiti in conjunction with morphine might lead to respitory depression due to increased effect from the tolerance attentuating powers of the aconiti.
I have been somewhat reluctant to take this material, as some people have reminded me that this is a fairly toxic species, but I think with the preparing, and the smaller doses I will be ok. mesaconitine, one of the active opioids in this plant, is stronger than morphine apparently, so it might be possible that the extract powder I intend to make could be smoked fairly comfortably.
there is a related species of this plant, and the flowers contain a compound some 40x stronger than mesaconitine as a kappa opioid agonist! I would think that a very small amount of those flowers might be smoked as well, but that would be something that I would NEVER suggest to other people.
I have not tolerated dxm very well lately, and think my time with that compound is up, even for use as an opiate potentiator/tolerance augmentator...., but this aconiti material I think has alot of potential, it might have the right stuff, it might be an all around pain reliever, detox aid, tolerance manager.
now I will quit posting about this till I have some experience reports.
the prepared root needs to be taken, and boiled for a period, at least an hour. this apparently destroys some of the more toxic compounds. a common dose tops out at 15 grams of sliced prepared tuber. so if I took 150 grams of aconiti tuber, and boiled it in water, and then take that water and reduce to a dry powder, I should have around 10 full doses.
so I am thinking that I will take 1 full dose, equivalent to 15 grams of prepared tuber, and split that up into 10 units.
I will take the material on a day off, with another day for recoup. if the material makes me sick.
reading about its kappa activity, I notice that the material is supposed to reduce morphine tolerance, which means that if I take this stuff, maybe 4-5 hours after my opiate dosing, I might feel and increase in analgesic effects. and possibly this material might be used for weening off of morphine/other opiates. possibly I could even see the material reducing morphine/opiate withdrawl as well.
I dont think that this stuff is going to create a euphoric effect by itself, but it might be a definite tool of sorts.
the activity of this material seems pretty complex, dopaminergic activity is reported as well, and the stuff can cause heart failure if overdosed on rather than respitory depression. I am sure that taking too much aconiti in conjunction with morphine might lead to respitory depression due to increased effect from the tolerance attentuating powers of the aconiti.
I have been somewhat reluctant to take this material, as some people have reminded me that this is a fairly toxic species, but I think with the preparing, and the smaller doses I will be ok. mesaconitine, one of the active opioids in this plant, is stronger than morphine apparently, so it might be possible that the extract powder I intend to make could be smoked fairly comfortably.
there is a related species of this plant, and the flowers contain a compound some 40x stronger than mesaconitine as a kappa opioid agonist! I would think that a very small amount of those flowers might be smoked as well, but that would be something that I would NEVER suggest to other people.
I have not tolerated dxm very well lately, and think my time with that compound is up, even for use as an opiate potentiator/tolerance augmentator...., but this aconiti material I think has alot of potential, it might have the right stuff, it might be an all around pain reliever, detox aid, tolerance manager.
now I will quit posting about this till I have some experience reports.