Pure μ1 agonist

[borohydride]

I have had the chance to try a sample of AH-7921, a pure μ1 agonist. This material produces almost no changes in conciousness, even at high doses. There is no euphoria, no relaxation, no freedom from angst. It DOES, however, produce analgesia and stop abstinence syndrome.

I really cannot imagine this material being abused - CODEINE has more abuse potential. It is, however, a long-acting (8 hours+) opioid analgesic which works as well as morphine to reduce pain and it evidently prevents opioid withdrawal.

I am of the opinion that this drug represents a good choice in helping people who wish to give up opioids BUT maybe you can suffer PAWS before the 'acute withdrawal' simply because you can reach the point where you are getting no psychological support BUT you are still physically dependant...

The point is - don't pay money for this stuff... I can foresee the day when, if you ask for help, THIS is what you get.

[Coolwhip]

If it stops WD's, it surely causes them too. What a godawful creation....I would HATE to end up dependent on a drug without ever getting high from it.

[alowishus]

...I would HATE to end up dependent on a drug without ever getting high from it.

Subs...? ;)

[borohydride]

Subs...? ;)


In UK prisons and on the islands north of Scotland where H supplies are poor, unreliable and expensive, temgesic (buprenorphine for pain) and subutex (buprenorphine for dependence) are both widely used to get high.

Trust me when I tell you that at whatever dose, there is NO high from AH-7921, it just stops withdrawal. I think it is potentially a better choice than methadone or subutex because it doesn't do ANYTHING positive, it just reduces a negative.

It's legal most everywhere & if I got a sample, someone must be thinking of selling it.

[alowishus]

Its certainly interesting; quick thought just popped in me head - what if all us junkies (and I mean vast amounts) started to use it, not for getting high but as a way to help WD's.
Think the powers that be would schedule it?
I guess they'd have too, right? Either out of spite or duty.

There is nothing more evil on this dirt ball then sub''s...

[borohydride]

If it gets used that way, they will assuredly control it. This would be a shame because the only 2 reasons for taking it are:

1-For Pain Management
2-To attenuate abstinence syndrome.

I think it could be given twice daily to prevent withdrawal. Not perfect but it could be done with daily pickup (one supervised amd one at home). It's street value would be vastly less than methadone or buprenorphine AND it's vastly cheaper to make than most synthetic opioids.

[Spork]

SWIM had a gram of AH7921 and experienced similar results.

The ROA was also very difficult, as the stuff was caustic as fuck. You couldn't snort it, couldn't smoke it, plug it, etc...

[Larkin]

just saw this... sounds like the the dark future of pain meds

[borohydride]

SWIM had a gram of AH7921 and experienced similar results.

The ROA was also very difficult, as the stuff was caustic as fuck. You couldn't snort it, couldn't smoke it, plug it, etc...

ooohh... sounds nasty. None of those problems with my sample so it's been made at least twice, I guess.

The Chinese can knock up Kgs of this stuff for under $3000. I don't know the bulk price of methadone, but I reckon this stuff is cheaper.

[SuperJunky]

SWIM had a gram of AH7921 and experienced similar results.
The ROA was also very difficult, as the stuff was caustic as fuck. You couldn't snort it, couldn't smoke it, plug it, etc...

I've found this to be the case with more than a 1/2 dozen substance coming from Chinese suppliers. Nothing like having to drop the plunger FAST because the blood clots the second it comes in contact with the solution. Further more, I noticed I could leave a cotton wet or I once even accidentally used some water that had been sitting around a long time, and still didn't get cotton fever. Like it creates an enviorment that is unsuitable for life. I played with some PH adjustments and some substances it helped, others it didn't. Maybe check the PH, I was surprised to find some chems dissolved in distilled water gave ph < 4 at "recreational" doses.

I would be interested to see how this chemical reacts with me, Robo as well as his GF and mine all complained of 0 effect after a massive build of fent tolerance, I never seemed to mind the diminished effect. I was content, the morning hit made me feel a slight mood improvement, but why I probably didn't give two shits, is because on these massive doses of fent my undiagnosed "migraine" disorder cleared up completely during that three year period. No black outs, vision loss, etc.

[Count Zero]

just saw this... sounds like the the dark future of pain meds

+1, if it actually kills pain with no psychoactive effects (ie. fun) I'm surprised the drug companies aren't shoving it down people's throats, that would be their dream analgesic.

[borohydride]

The stuff was discovered by a team at Allen & Hanbury's but after a single patent, they gave up research on it. A US team then spent over 10 years messing with it and developed many κ-receptor agonists and virtually all share the 3,4 dichloro moiety. There is nothing especially special about it except, perhaps, that it doesn't cause the mental detachment of most opioids and I sense that part of the analgesia isn't actually stopping pain signals but rather making one feel separate from the pain. This stuff just doesn't do that. It's toxicity is about the same as M, it's duration is longer - perhaps double.

The best role for this stuff would be a US and UK of the Dutch 'methadone bus' where anyone presenting ID (which the cops do NOT GET) can get hold of methadone for free - the Dutch just think it's cheaper to give everyone access than to suffer the theft & other desperate low-level crime committed by some street junkies. I think they start people on 10mg 3 times a day. Turn up all 3 times for 7 days running and they will a)titrate the dose & b)refer you to a clinic where you possibly can get something other than methadone. I know they were trying out dextromoramide for the refractory cases in which juice just didn't stop the cravings. Anyone who has swallowed a few peach Palfium will know how fast it kicks in and that it kind of does have a rush. Not an IV rush of course, but something to help the psychological dependence.

It's cheap, it's effective, it wouldn't appear on the black-market much... of course it will never get used; too much of a good idea.

[jacky]

Ive been interested in bumping into some of this compound.

I think it prolly has potential for some people.
-might be a good thing to have around for detox, at least short term

some researchers in moderate to severe pain, could benefit from a substance that might be used alongside their standard materials of choice.

[Benz]

This compound must stimulate a sub-mu receptor group if it doesn't produce ANY of the effects you would expect from a pure mu agonist.

How many sub types are there?



Benz

[borohydride]

μ1 anakgesia
μ2 euphoria, addiction, stops breathing
μ3 nothing in the body triggers, only opioid drugd

[borohydride]

It is NO fun.... if your clucking then it works as well a H but does nothing else. Could it be sold as 'incence' in the UK? Nowhere near a controlled drug. $10 for a $20 fix?