Loperamide Hangover?

[Opiophelia]

I'm in the process of getting off of methadone. I'm at 5mgs after 4 and 1/2 years of being at 80+ mgs. Once I did this most recent decrease to 5mgs I started to feel like shit. and I can't be feeling like crap because I work 40 hours a week. So, I decided to give Lope a try.

I did some research and found the perfect recipe for success with lope. here it is:

60 mgs loperamide (30 2 mg pills)
600 mgs Cimetidine taken 30-40 minutes before the lope ( 3 200mg acid reducer pills like Tagamet) (the cimetidine is absolutely necessary because lope doesn't cross the blood brain barrier without a pgp inhibitor)
8 oz Grapefruit juice (this also allows for the lope to cross the BBB easier)
8 oz Tonic water ( tonic water has quinine in it which also acts like cimetidine and the grapefruit juice to help with crossing the bbb)

This little recipe made me feel like I wasn't withdrawaling at all. I even felt energetic and got through work easily. It even kills pain like an opiate because normally my feet are killing me by the time I get off work and this time I didn't feel any pain at all!

BUT I repeated this same thing the next day to get through work and about an hour after taking it I started to feel kinda stoned... and not in a good way. It wasn't like an opiate buzz, more like pot... but not as good. Everything felt all weird and distorted. Then once I got home I was really tired and fell asleep. So then when I woke up today I had a really bad headache but I wasn't in withdrawal. I went to the clinic to get my dose and I don't feel sick but I can't shake this feeling like everything is a little off. I feel kind of lethargic. and this headache won't go away.

Has anybody else experienced this with taking large doses of lope for 2 days in a row?

[Larkin]

cimentidine is not a pgp inhibitor neither is grapefruit juice

the effect the way the lope is metabolizes. and if any grapefruit juice is going to work, its white grapefruit juice

take away everything but the lope and you will fine all those other things dont make much of a difference

[JonnyM]

If I take too much I get a strange feeling, my eyes have issues focusing for a few hours, maybe a little dizziness.

Is this an accurate description?

[Larkin]

i get the same feeling though. lope sticks around a long time. it also dries you the fuck out

[JonnyM]

i get the same feeling though. lope sticks around a long time. it also dries you the fuck out

Yeah it does, and loperamide withdrawals last for fucking ever.

I would switch to a short acting opiate for about 2 weeks and jump off from there. Loperamide can make you miserable for a month +.

[GOLD N DIEMONDS]

NOPE - not at all, and I am doing it now for a week.
JUST USE THE LOPE ONLY
all that other stuff is prolly what is giving you some problems
lot of this 'it will cross the BBB with this' sounds good on paper
but not in pratice

IF LOPE ALONE DIDN'T CROSS THE BBB, I WOULD BE IN THE FETAL POSITION IN MY BATHROOM,
not posting AGAIN about diareha meds,
fuck , i rather be posting about dope, butt .....

[Opiophelia]

Yeah it does, and loperamide withdrawals last for fucking ever.

I would switch to a short acting opiate for about 2 weeks and jump off from there. Loperamide can make you miserable for a month +.


So, you can withdrawal from loperamide? I was curious about that.

and yeah, your description was half-way accurate. I feel all this weird pressure in my head though. its just an odd feeling.

also, I've tried it without the cimetidine and it didnt work. from what Ive read it's imperative to add the cimetidine.

[GOLD N DIEMONDS]

If I take too much I get a strange feeling, my eyes have issues focusing for a few hours, maybe a little dizziness.

Is this an accurate description?


Jonny, I'll get that eye issue thing too. TO ME it feels like the eyes are not focusing in sync, like one eyeball is in focus with an object ,but the other eye is slightly out of focus . Yes it makes one feel a little dizzy, and annoyed

Still beats CT WDs though
so does dope :)

ah crave much GnD?

[JonnyM]

So, you can withdrawal from loperamide? I was curious about that.

and yeah, your description was half-way accurate. I feel all this weird pressure in my head though. its just an odd feeling.

also, I've tried it without the cimetidine and it didnt work. from what Ive read it's imperative to add the cimetidine.

I guarantee cimetidine is not required, both cimetidine and grape fruit juice inhibit cytochrome P450 (http://en.wikipedia.org/wiki/Cytochrome_P450) which does not play a role in metabolizing loperamide. You would be much more successful with something that inhibits P-glycoprotein.


and yes you can definitely withdraw from loperamide, not a light withdrawal either.... hell I tell you.

[Spork]

The cimetidine is necessary because it increases the dismal oral bioavailability of loperamide (0.3%)

IF you have a small enough tolerance / take a LARGE amount of lope / have a lower amount of liver enzymes / high gastric pH, you can get relief from just loperamide alone.

I NEVER take lope without cimetidine. It is crucial at least for me, and several people I have introduced lope to as a withdrawal aid.
Not only does the cimetidine inhibit the enzymes that metabolize loperamide so quickly and ruin its oral bioavialiability, because it reduces acid secretion, it raises your gastric pH, which affects p-Glycoprotein efflux.

Also, too much loperamide can give you a strange kind of high, crossed eyes, a weird mild opioid buzzing feeling, but nothing 'euphoric' in my opionion.

The reason it may be working without the cimetidine for some of you is due to your own personal liver enzymes and gastric pH.

Also, Do NOT eat before or after taking lope for a few hours.


I guarantee cimetidine is not required, both cimetidine and grape fruit juice inhibit cytochrome P450 (http://en.wikipedia.org/wiki/Cytochrome_P450) which does not play a role in metabolizing loperamide. You would be much more successful with something that inhibits P-glycoprotein.

Not true, the P450 enzymes, IIRC, 2D6 and 3A4 play a huge role in demethylating loperamide and forming its other metabolites.

[Opiophelia]

ok. Maybe I didn't take enough the first time. the only p-glycoprotein i know of is Quinidine. and you need a prescription for that because it's an antiarrythmic med. Anyway, I dont plan on staying on lope long term. its just to get me through methadone decreases until I'm no longer under my mom's constant supervision.

--- auto merge ---

Thanks spork. Good info.

[JonnyM]

The cimetidine is necessary because it increases the dismal oral bioavailability of loperamide (0.3%)

IF you have a small enough tolerance / take a LARGE amount of lope / have a lower amount of liver enzymes / high gastric pH, you can get relief from just loperamide alone.

I NEVER take lope without cimetidine. It is crucial at least for me, and several people I have introduced lope to as a withdrawal aid.
Not only does the cimetidine inhibit the enzymes that metabolize loperamide so quickly and ruin its oral bioavialiability, because it reduces acid secretion, it raises your gastric pH, which affects p-Glycoprotein efflux.

Also, too much loperamide can give you a strange kind of high, crossed eyes, a weird mild opioid buzzing feeling, but nothing 'euphoric' in my opionion.

The reason it may be working without the cimetidine for some of you is due to your own personal liver enzymes and gastric pH.

Also, Do NOT eat before or after taking lope for a few hours.



Not true, the P450 enzymes, IIRC, 2D6 and 3A4 play a huge role in demethylating loperamide and forming its other metabolites.

Source?

[Spork]

Carvedilol is a pGp inhibitor. I took a huge dose of loperamide with a real pGp inhibitor once, and now I have this permanent high frequency parkinsonian jaw tremor that scares the shit out of me.

I might actually go get some scans done to see if loperamide has caused me any brain damage.

Loperamide DOES form a neurotoxic metabolite, called LPP+ similar to the MPTP metabolite that causes instant parkinsons disease.

There is a study that confirms this, if anyone wants to argue otherwise, I'll find and post the link.

--- auto merge ---


Source?

http://www.springerlink.com/content/ype7xup5lvt8b1ux/

[Disconnect]

I've absolutely had a Loperamide hangover.
shit lasted for DAYS.
vomiting, weakness, headaches.
it was fucking awful.
the best you can do is wait for it to pass.

[JonnyM]

I stand corrected. P450 does indeed have a small effect on loperamide.

Still you would be better off using a p-glycoprotein inhibitor like Quinidine which inhibits p-glycoprotein as well as P450.

http://www.ncbi.nlm.nih.gov/pubmed/11014404


I wonder if anyone has ever tried drinking a ton of tonic water with loperamide? I know quinine is present in low doses (like 84mg per litre) but a couple bottles later you have a standard dose of quinine.

[JuStOnEmOrE?]

I was on lope long term for wds... like 2 months to taper myself down.

I was able to taper to the point where I didnt get the lope hangover....

And I've never had to take anything but just lope to get "ok" again. Never taken anything else... and it always worked perfectly for me. Doses may have been a bit high at first (90mg+ in one dose). But it always worked for me and was always effective without any additives.

[GOLD N DIEMONDS]

Carvedilol is a pGp inhibitor. I took a huge dose of loperamide with a real pGp inhibitor once, and now I have this permanent high frequency parkinsonian jaw tremor that scares the shit out of me.

I might actually go get some scans done to see if loperamide has caused me any brain damage.

Loperamide DOES form a neurotoxic metabolite, called LPP+ similar to the MPTP metabolite that causes instant parkinsons disease.

There is a study that confirms this, if anyone wants to argue otherwise, I'll find and post the link.

--- auto merge ---



http://www.springerlink.com/content/ype7xup5lvt8b1ux/


AH
then why don't we all have INSTANT PARKINSON DIEASE?

one study does not make for absolute medical fact,
someone else will do a study to disprove that study

[Larkin]

http://www.imodium.com/images/imodium/pdf/ImodiumLoperimideFacts.pdf

there is some GREAT info on lope. it covers it all really...

there is one thing i can say for sure about lope.... it varies wildly for everyone. based on tolerance and body chemistry. xx mg can make me feel ok one day, the same mg in slight wd 2 days later. and maybe even too much after that. I have found its not consistent, even more so between other people.

everyones BBB pgp is different, metabolism too.

as far eating goes. I found eating to help me feel more from the lope IF im in WD and my stomach is moving fast. if ive been maintaining on lope for a while and im constipated and bloated ill take it on an empty stomach

ive found when your stomach is moving along and you take it with food, the food helps move it along nicely

[GOLD N DIEMONDS]

Larkin-- try a couple cup of strong coffe before first dose of lope in the am ^^^^^^^^^^^^
This keeps me regular
well as regular s a GnD can be

[Count Zero]

I stand corrected. P450 does indeed have a small effect on loperamide.

Still you would be better off using a p-glycoprotein inhibitor like Quinidine which inhibits p-glycoprotein as well as P450.

http://www.ncbi.nlm.nih.gov/pubmed/11014404


I wonder if anyone has ever tried drinking a ton of tonic water with loperamide? I know quinine is present in low doses (like 84mg per litre) but a couple bottles later you have a standard dose of quinine.

Most DC dope is cut with quinine, I wonder if it's for the same reason, supposedly it does increase the rush IV. Never did shit for me snorting but fuck up my nose.

[duck]

Man, lope is a lot like bupe to me, just too many strange attributes to be trustworthy. Im afraid of side effects when you are dosing 30x the normal dose...

[JonnyM]

For science I'll test this with 4 liters of tonic water (336mg's of quinine) and 30mg's of loperamide.


p.s. I'll let everyone know if I get parkinsons. http://webx.simpilot.net:8080/Images/e/eyeroll.gif (Actually if I can find the thread we had on the subject a study was cited where that wasn't the case, I'll look for it and repost it if I do). If it does then I sure feel bad for the lab rats in http://www.ncbi.nlm.nih.gov/pubmed/11014404

[Opiophelia]

I read about a study where they gave rats 60mg doses every day over 3 months with no long term side effects. But the way i feel today is just wrong. I'm gonna limit taking it unless i'm in really bad withdrawal. I'm pretty sure all these symptoms indicate dehydration. But I've been drinking water all day and I still dont feel better. This headache is migraine strength. Wish I had some dope

--- auto merge ---

I may try this too.

[GOLD N DIEMONDS]

For science I'll test this with 4 liters of tonic water (336mg's of quinine) and 30mg's of loperamide.


p.s. I'll let everyone know if I get parkinsons. http://webx.simpilot.net:8080/Images/e/eyeroll.gif (Actually if I can find the thread we had on the subject a study was cited where that wasn't the case, I'll look for it and repost it if I do). If it does then I sure feel bad for the lab rats in http://www.ncbi.nlm.nih.gov/pubmed/11014404

HOT DAMN JM GOOD FOR YOU.
I'll give it a go too, I'll be on lope for another 10+days
tell me JM-
EXACTLY WHAT KIND OF TONIC WATER DO I NEED
I don't think they would list quinine on the bottle , would they?

[JonnyM]

HOT DAMN JM GOOD FOR YOU.
I'll give it a go too, I'll be on lope for another 10+days
tell me JM-
EXACTLY WHAT KIND OF TONIC WATER DO I NEED
I don't think they would list quinine on the bottle , would they?

Actually if you look closely at the photo right on the front it says "contains quinine". As far as I'm aware all tonic waters contain it (for flavoring), I just got diet since I need to drink so much of it.

If you do test it drink the tonic water first, wait 45 minutes and then take the loperamide. I have no idea if anything will even happen but it's worth a shot.

[TheTalkingAsshole]

Actually if you look closely at the photo right on the front it says "contains quinine". As far as I'm aware all tonic waters contain it (for flavoring), I just got diet since I need to drink so much of it.

If you do test it drink the tonic water first, wait 45 minutes and then take the loperamide. I have no idea if anything will even happen but it's worth a shot.

could you boil down the water to get a more concentrated solution? or is quinine too heat sensitive?

[JonnyM]

could you boil down the water to get a more concentrated solution? or is quinine too heat sensitive?
I'm not sure, still I think just drinking it is easier.

It has a relatively long half life (~18 hours) so you have a fairly large window of time to drink all the tonic water.

[Larkin]

could you boil down the water to get a more concentrated solution? or is quinine too heat sensitive?

my thoughts EXACTLY... quinine extraction anyone? I used to steal tonic from work and i drank about 1l when i first started dosing lope. and it MAYBE helped it feel 10% more effective, but thats me

BUT, if its just soda water and quinine, extracting the quinine should be super easy and quinine alone is supposed to give a great rush. let alone scramble

and Gnd. coffee and oatmeal keep me pooping almost daily, but the lope still slows my digestion down a bit, and if i eat a big meal, it takes a good 3-4 hours to not feel full anymore

this past week my lope dose was the lowest its been in a while <40mg, and i felt like SHIT and was shitting 2-3 times a day. big, solid, wooden shits

[JonnyM]

my thoughts EXACTLY... quinine extraction anyone? I used to steal tonic from work and i drank about 1l when i first started dosing lope. and it MAYBE helped it feel 10% more effective, but thats me

BUT, if its just soda water and quinine, extracting the quinine should be super easy and quinine alone is supposed to give a great rush. let alone scramble

and Gnd. coffee and oatmeal keep me pooping almost daily, but the lope still slows my digestion down a bit, and if i eat a big meal, it takes a good 3-4 hours to not feel full anymore

this past week my lope dose was the lowest its been in a while <40mg, and i felt like SHIT and was shitting 2-3 times a day. big, solid, wooden shits

If you are really serious about it then just drop some cash on cinchona bark (https://www.google.com/search?q=Cinchona+bark&hl=en&safe=off&client=firefox-a&hs=B97&rls=org.mozilla:en-US:official&prmd=imvns&source=univ&tbm=shop&tbo=u&sa=X&ei=wJbdTsnvF4myiQKr_42zCA&ved=0CFsQrQQ&biw=1440&bih=721)

[GOLD N DIEMONDS]

Actually if you look closely at the photo right on the front it says "contains quinine". As far as I'm aware all tonic waters contain it (for flavoring), I just got diet since I need to drink so much of it.

If you do test it drink the tonic water first, wait 45 minutes and then take the loperamide. I have no idea if anything will even happen but it's worth a shot.

OK I see it now
EXCELLENT, I'LL GIVE IT A GO
Thanks man, I'm excited,,
Lope ain't dope and I'm bored
I"m going to hide the needle JUST to play it safe, ya know

[Snowpod]

At what dosages of loperamide would somebody typically (user experience) experience a hang-over? I have been considering using immodium for a while to abort my use of poppy pods. I get the worst achey knees, hot flashes, fire-crackker ass and RLS but other than that, everything's pretty cool. Does lope appear to have any efficacy in alleviating any other symptoms apart from the shits (i can't spell the name)?

[JonnyM]

At what dosages of loperamide would somebody typically (user experience) experience a hang-over? I have been considering using immodium for a while to abort my use of poppy pods. I get the worst achey knees, hot flashes, fire-crackker ass and RLS but other than that, everything's pretty cool. Does lope appear to have any efficacy in alleviating any other symptoms apart from the shits (i can't spell the name)?

I don't know what your tolerance is at, I imagine somewhere around 30mg's would be a good place to start.

I find it does ease all withdrawal symptoms (save perhaps hot flashes).

I only felt strange at high doses like 90+ mg's (which I don't take anymore).

[Larkin]

it does eliminate hot flashes and chills for me... IMO, they make WD unbearable, second only to stomach cramps which are new to me with lope. Ive never had stomach issues (except mudbutt) until i started lope.


aint no free lunch!

[Der Alte Krieger]

Personaly I love Schwepps tonic, I guess from all the years of gin 'n tonic but I understand that theres just a trace of quinine in it. I think it would be better, unless your a die hard DIYer, to just buy some Quinine pills
http://www.herbspro.com/shop/productdetail.asp?ptid=15825&utm_source=pricegrabber&utm_medium=Feed

HOWEVER my wife was taking them for leg cramps but stopped because:
"Experts are now cautioning consumers against using quinine to treat leg cramps because of the potentially deadly side effects associated with this off-label use. As the FDA explains, quinine use is justified for the treatment of malaria, because this disease is life-threatening. However, the potential risks of using quinine for the treatment of leg cramps clearly outweigh the possible benefits."
http://www.oshmanlaw.com/pharmaceutical_litigation/quinine.html

So my opinion is, I dunno..................... you pays you money and takes yer choice.

Edit:
A standard quinine pill contains 324 mg of quinine. Studies of quinine for leg cramps have used 200 to 500 mg of quinine per dose. Tonic water, on the other hand, is reported to contain only about 20 mg of quinine per 8-ounce glass.

[OpiatedChronically]

In my experience, enough loperamide COMPLETELY ELIMINATES ALL of my W/D symptoms, and for me those are doses of 80 - 100mgs throughout the day, and once it builds up in my system thanks to it's long half life, I can get by on 40 - 60mgs each day with very little or no W/D symptoms whatsoever......

........however, I've gotten too comfortable with abusing my scripted pain meds and relying on lope far too often to get by until refill day, and lope doesn't help me with pain one tiny bit like some of you report so my days without morphine are spent in agonizing pain, and I'm usually doing a wide range of things to keep my mind occupied, and my already severe depression and anxiety/panic attack issues are seemingly doubled while I'm on the lope train; almost anything remotely sad can make me start crying and feeling so sad, BUT the opposite also occurs with humor cuz I've got all my emotions because my senses back again so funny things seem EXTREMELY FUNNY and I'll laugh harder than I ever do when I'm back on morphine

When I'm on lope I am in severe pain, but because I feel completely sober and all my senses and emotions are back to their full strengths, I actually enjoy things so much more because I can actually FEEL again, ya know? I know Reddragon will know exactly what I mean if he reads this (you da man Red!)

And if I didn't have CP, I would most definitely be making an effort to get clean again, because I feel like my old self when I'm on lope, other than the excruciating pain, I actually feel much happier without opiates, and I want to go back to the days when I only smoked weed to get high and occasionally dabbled with opiates as that special treat, much like psychadelics are for the people who enjoy those experiences, they are cherished yet they are reserved for special occasions or just every now and then (well, I guess those are really the same basic idea..) ......

Lope dehydrates you so much though, and I can really FEEL how dirty of a chemical it is, it makes me feel so sick and filthy on the inside in a way that nothing else ever has, but it sure is better than suffering through full blown W/D.....although I have ceased using lope for a couple of days a few different times after being on doses of 90mg+ each day for a couple of weeks and those 2 or 3 days without lope were FUCKING HORRIBLE!!

Lope w/d, IMHO, can be just as bad and in some cases WORSE than normal opiate W/D....the muscle pain and intense muscle "heat" are enough to make me fucking scream and cry like a pussy ass bitch, and the hot/cold temp flashes aren't fun either. I usually take lope with food and that can actually help get my shit moving towards the exit quicker than usual, although this is not the case every single day on lope...

Also, lope gets to be expensive sometimes, especially when I don't have a debit card, owe my bank money and can't order the super cheap bulk loperamide from Amazon which JM has ever so kindly pointed out for us in the past. I honestly wish I had access to Methadone or Subs, but I don't, so as long as I run out of my Avinza early each month, I'll continue to hop on that dirty fucking lope train till I arrive at Refill Junction and do the damn thing all over again, once more.....once more.....

[JonnyM]

A standard quinine pill contains 324 mg of quinine. Studies of quinine for leg cramps have used 200 to 500 mg of quinine per dose. Tonic water, on the other hand, is reported to contain only about 20 mg of quinine per 8-ounce glass.

I can't find anywhere that states the quinine content of the leg cramp pills, and I trust homeopathic remedies about as much as I do the police.

It would be easier though just to purchase the pills (if that is indeed their content), or to obtain quinidine somehow (which is much more effective).

[JuStOnEmOrE?]

For me lope get rid of everything except a little difficulty sleeping, and the watery eyes and sneezing.

The stomach issues I get from lope usually happened the 5th or 6th day in.

[Princess Kitty]

http://www.imodium.com/images/imodium/pdf/ImodiumLoperimideFacts.pdf

there is some GREAT info on lope. it covers it all really...

there is one thing i can say for sure about lope.... it varies wildly for everyone. based on tolerance and body chemistry. xx mg can make me feel ok one day, the same mg in slight wd 2 days later. and maybe even too much after that. I have found its not consistent, even more so between other people.

everyones BBB pgp is different, metabolism too.

as far eating goes. I found eating to help me feel more from the lope IF im in WD and my stomach is moving fast. if ive been maintaining on lope for a while and im constipated and bloated ill take it on an empty stomach

ive found when your stomach is moving along and you take it with food, the food helps move it along nicely

I take miralax when I'm on lope. Was concerned because after two days of miralax. Nothing. Took a double dose. Now I've been shitting constantly for 3 days. Lovely. I've always had great luck with miralax.

--- auto merge ---

Also with lope when I'm on it for a while usually 2 weeks or less I start out on a moderate dose 50-60 mg split into 2 doses. I take a little less everyday since I have heard that it can mess up your tolly. Don't know if this is fact or not. But I swear it works. I can sleep when I'm on it which is fucking amazing! Obviously the shits go away but the huge ones that go away are stomach issues and the fucking RLS and the hot flashes. I always have a package from Costco of lope and that shit has saved my ass.

[Indy]

If you are really serious about it then just drop some cash on cinchona bark (https://www.google.com/search?q=Cinchona+bark&hl=en&safe=off&client=firefox-a&hs=B97&rls=org.mozilla:en-US:official&prmd=imvns&source=univ&tbm=shop&tbo=u&sa=X&ei=wJbdTsnvF4myiQKr_42zCA&ved=0CFsQrQQ&biw=1440&bih=721)

AKA Jesuit's bark...been meaning to try that.

Lope works great for me. I never got a hangover from it, but there is a very long transition from well to withdrawal, and that can feel a bit like a hangover sometimes. As for lope withdrawals, I have to disagree about them being that bad compared to other opiates, they're just really drawn out. Maybe it's because the only time I've withdrawn from loperamide, I didn't really take enough to ever get me fully well, so it was like i was stepping down with it.

IIRC there isn't enough quinine in tonic water to have an effect. There used to be more, and people used to treat it for restless legs (interesting coincidence, but to my knowledge has no connection to opioids), but then the FDA or some other government agency started regulating it and now there's MUCH less quinine. I'm not exactly sure HOW much less, though, and 4 liters is a lot of servings, so maybe that would do something. I'm sure you know this, but make sure you get some salt and potassium in you when you drink all that water.

[josh667]

Most DC dope is cut with quinine, I wonder if it's for the same reason, supposedly it does increase the rush IV. Never did shit for me snorting but fuck up my nose.
not trying to derail, but I thought that the quinine was added to dope to make it taste bitter, so you can't tell the purity with taste.


I also get that strange wobbly eye vision thing with 80+mg of lope...

[dharma bum]

The tonic water is a good idea. Two birds with one stone. You stay hydrated AND get a lil Quinine.

[Der Alte Krieger]

I can't find anywhere that states the quinine content of the leg cramp pills, and I trust homeopathic remedies about as much as I do the police.

Ya gotta have the right connections:
http://dnowgekho.com/products/antibiotics/quinine/order/

They claim these are 300MG. I think they are an Al-Quida front, how much more trustworthy can you get?

[Larkin]

not trying to derail, but I thought that the quinine was added to dope to make it taste bitter, so you can't tell the purity with taste.


I also get that strange wobbly eye vision thing with 80+mg of lope...


i think (know) you can wack good dope down 2-3 times with fucking SUGAR and it still tastes bitter. man that bitter ass dope taste is ROUGH! and it lingers in your mouth, its unmistakable

the quinine is for the rush, one time a junky in philly was telling me he goes to baltimore a lot and brings back scramble, and everyone in philly says the rush is better even if the dope isnt as good (says this guy)

Also, im experiencing a bit of a lope-over myself. I have been cutting my dose down lately but i always taper too steep. so i have been about 60% sick (40% well of course) for the last week or so, and i had shit to do lastnight so i took a healthy dose of about 80mg

I felt fine, went to sleep around 4am. kept waking up with crusty lips and dry mouth, i drank 2 16oz bottles of water over night and just had to brush my teeth to get this oh so funky morning breath gone. Thats honestly my biggest complaint. I do feel a little like when you take too much of a good opiate before bed (oxyc did this to me the most)

EDIT. FUCK, just as i clicked post my most hated side effect came on... HICCUPS!! omfg i hate them!! I get them all the time from opiates but atleast im high enough to not care! FUCK MAN

[Opiophelia]

i tried the tonic water + lope thing last night. I drank 3 liters and took 60mg of lope. Big fucking mistake. I started to feel all dizzy and weird. Sort of like how it feels when you drink a whole bottle of robitussin ( i was into the whole cough syrup thing when i was like 16, but now the thought of it makes me want to puke) So anyway, I finally fell asleep after a few hours of intense stomach pain. When I woke up this morning I had the worst migraine known to man and I threw up 4 times. It's almost 3pm now and I still feel weird, but the headache is now just a dull throb. I thought that maybe it was just over dehydration but ive been chugging water/electrolytes all day to no avail. I don't know if the quinine made any difference with all of this or if maybe I'm just really sensitive to loperamide. I don't know. But i'd rather be in withdrawal than to take any more loperamide.

[JonnyM]

Weird I used tonic water and it seemed to help potentiate it a bit, but other then that no strange side effects from me.


Correlation isn't causation but that being said if anyone decides to try this please note the above experience.

[Opiophelia]

I just may have a sensitivity to lope for some reason. But there is something good that came out of the whole thing. From what I understand Loperamide has a pretty long half life. So this morning when I woke up I didn't feel sick at all. Which is awesome because now that I'm down to 5mgs of methadone I start to feel sick about 12 hours after my dose. And yesterday I threw up about 15 minutes after I took my dose so I may have not even absorbed much of that 5mgs. So, at the very least it's helping me to get through getting off methadone. But I'm not sure if it's worth it for me to go through the horrible side effects. Another weird thing I noticed was i didn't have much of a desire to smoke cigarettes. Anybody else get that from using lope?

[HydroApe]

I don't have much of dsire to smoke unless I'm opiated. In WD, or loping I have no real desire to smoke at all.

[Lopossum]

Drinking a ton of tonic water isn't a bad idea - in addition to potentiating, the vast amounts of water will surely help with the constipation, and you have something to mix with your gin taboot.