Bad day for Opana lovers

[upstate_007]

http://phx.corporate-ir.net/phoenix.zhtml?c=231492&p=irol-newsArticle&ID=1579508&highlight=

Looks like a reformulation of Opana ER is on it's way. It was originally rejected by the FDA in January, but passed this time.

Of course, it is for a new formula that is less able to be misused.

Assholes.

[borohydride]

It sounds like the only change is improved crush-resistance. I feel certain people will find many, many ingenious ways to get around that issue. I have used a car-jack against appropriately solid surfaces to exert large forces. I imagine it will take 5 or even 10 minutes to overcome.

Just be glad that a drug x2 as potent via IV (oxycodone) has been replaced due to 'abuse worries' for a drug x10 as potent via IV... what a good idea!

[upstate_007]

My fear is that the new formulation will be similar to the new oxycontin formula. It made it incredibly hard to abuse.

[SeVeN]

My fear is that the new formulation will be similar to the new oxycontin formula. It made it incredibly hard to abuse.

Boy thats an understatement. those things suck

[Bartholomew]

Bad day indeed.

Oh well, at least the IRs will still be around!

[borohydride]

My fear is that the new formulation will be similar to the new oxycontin formula. It made it incredibly hard to abuse.

Do you mean Remoxy?

[ryan5892]

lol, seven10 is right about the future.

Take once a day.

Oxycontin, Roxis, now Opana, next hydromorph, o wait, they already got that.

[JUNKYJAY]

I feel bad for you guys in the states (well some states) They gotta take away all the things that make us happy.:cool: I am wondering when canada will pick up on this method of the war on drugs.

[borohydride]

It may not be a:

1-crush
2-snort

any more but if it dissolves in the stomach then it's not going to be that complex. Opana didn't take long to sort out....

[pokergooch]

Im still a little perplexed. I am hoping that they will have 2 types of opana ER. Remember opana ER will go generic soon. From what I have read on the interweb is that there will be the 2 kinds.. I hope so... Also, It will take a while to get these to market. So, if anyone has any info, please share...

[upstate_007]

^^^

I wonder if it will be similar to what happened with Oxycontin. In that when the new formulation was released, Purdue was able to keep all generics off the market. I am not too familiar with how that sort of thing works though. It would be great if great if generics of the current style Opana ER would still be available.

[ryan5892]

It may not be a:

1-crush
2-snort

any more but if it dissolves in the stomach then it's not going to be that complex. Opana didn't take long to sort out....

True, it will be figured out how to abuse, the question is, when is the time taken not worth it?

Many people are finding the OPs a waste of time, and moving onto bigger and better things.

[pokergooch]

ok, after a bit of looking, I saw one post calling the new opana's "opana TRF" For tamper resistant. Here it the meat. Remember, this article was done when they first applied back in September. Im really betting (hoping) that they will leave it up to the doctor on which one you get. In the below article they are talking conventional opana and opana trf.... To me this is semi-good news...
)

Here is the meat of the article :
Seven or eight companies say they are working on crush-resistant painkillers, he says. "Endo never revealed how far along they were," he said. "It was a surprise when they filed with the FDA."

Approval of the abuse deterrent will create extra value for Opana and allow Endo to develop its market beyond its patent expirations.

Generic conventional Opana, in various doses and from several makers, will start to appear on the market in late September 2012 and early 2013.

The abuse-resistant version of Opana, called Opana TRF for tamper-resistant formulation, could be on the market by 2011, Kedra says.

With generics for conventional Opana appearing a few months later, the timing will be perfect, he says. The idea is that doctors will prescribe the abuse-resistant version for both the benefit of patients and to relieve themselves of liability.

"There's a real public health problem around prescription opioids," Rivkind said. The tamper-resistant market has lots of potential, she says.

However, the consensus view of analysts is for a drop in earnings for Endo in 2013, as the patents expire for conventional-Opana.

Having bought Penwest, Endo can now make all the decisions about Opana without consultation. It also won't need to pay Penwest the 22% in royalties that were part of the previous partnership deal.

Edit: Remember that Endo has already worked out a deal to make opana ER generic here in a bit. I can't remember who they are working with, but I remember reading about it. Im sure that the generic ER will be the conventional type...

[PiLL CLiNToN]

As, I've said this is the future ALL narco. pills will have the new OP type of matrix or something like it.

....bet my bottom dollar on that for sure all products opiatewise probally will all be reformed first, then they will go to Adderall,Dextro,Desoxyn,Ritts hell they might even probally do benzos' but i think they just will do CII only..(first) and this is IMO what is the future...i knew it would all go to hell once theem 160's stopped being produced! I can remember back yearrrrs ago everybody on here saying we have nothing ot worry about till 2013 well at the sitaution now folks!

how muuch ya wanna bet cats who took over pablos in the game are sitting around with a enough ogocs to probally fill up an american RV an thats just pr obally theyre persoal stash...funny thing is most off em now are all hardcore iv'ing addicts


snorting anything from the FDA will be a thing of the past soon very soon.....and like boro. said there will be chemists and types alike who will defeat the matrix and i'm sure it will work but only so many will be doing that because friend knows alot of pellheads and they have noooo fuckin' clue what to do with cooking it right down to the proper pow-wow.......

I dunno, hate to rain on pepoles parade = ( ((but lets face it chem's will definetly make this BS go away = ) )))) gotta love you chem types god bless you guys!

[bkiddo]

So one will not be able to crush it. Is anyone really trying to crush these ER's? People I know shave and grate. Wouldn't this still be a possibility? Or is this new formulation going to be just so damn hard that one will end up breaking their colanders?

[pokergooch]

Here is the article about the generic opana:

mpax Laboratories, Inc.(NASDAQ:IPXL) today announced that the U.S. Food and Drug Administration (FDA) has granted final approval of the Company's Abbreviated New Drug Application (ANDA) for the generic version of OPANA® ER (oxymorphone hydrochloride) Extended Release 30mg tablet. In June 2010, the Company was granted final approval for the 5mg, 10mg, 20mg, and 40mg tablets.

As previously announced, in June 2010, the Company reached agreement with Endo Pharmaceuticals and Penwest Pharmaceuticals to grant the Company a license to sell a generic of OPANA® ER on Jan. 1, 2013 or earlier under certain circumstances.

The Company was the first to file a paragraph IV certification on these strengths and will be entitled to 180 days of market exclusivity upon product launch. Global Pharmaceuticals, Impax's generic division will commercialize the product on Jan. 1, 2013 or earlier under certain circumstances.

Endo Pharmaceuticals and Penwest Pharmaceuticals manufacture and market OPANA® ER for the treatment of moderate to severe pain. According to Wolters Kluwer Health, U.S. sales of OPANA® ER tablets were approximately $254 million for the 12 months ended May 31, 2010.

Source Impax Laboratories, Inc.

So, according with everything I've read. Worst case scenario is that we have to wait til the generics come out. I still believe that it will be left up to the doctor on which one to prescribe. Also, I don't think that they will get the reformulated opanas on the market before this January. So, We still have a few months to figure it out. Not going to panic.

[PinkLady]

Fuckers.

[d1ce]

Great. Like someone mentioned earlier in the thread, at least we will still have the IRs. Although I'm concerned for the future state of IR meds as well. They will all have some form of anti-abuse/tamper resist eventually. I think we all knew this was coming...

[Oxyphile]

fucking fantastic. opana has been a godsend for countless CP patients and addicts once they nerfed oxycontin. i can only hope that the current formula generics will still be in production in addition to the new tamper resistant formula once it comes out.

[borohydride]

True, it will be figured out how to abuse, the question is, when is the time taken not worth it?

Many people are finding the OPs a waste of time, and moving onto bigger and better things.

Well, you won't do one at a time!

Just soaking them & crashing out product with acetone will be simple...

[clonaze-whammed]

I was prescribed Jurnista before, (Extended release Hydromorphone)

they were impossible to abuse, no fun at all.

posted a thread about them before:

https://forum.opiophile.org/showthread.php?26209-Jurnista-is-rock-solid-unbreakable

[Milkdud39]

Well I knew this would happen. Once people started switching to Opana because of the new Oxycontin. It really doesn't matter because it only took about a week for the new oxycontin to be defeated. What makes you think this will take any longer?

However I really think the US government is trying to turn everyone into heroin addicts. I mean they keep messing with all these pills and it just causes people to switch to heroin. Way to go government. Turn people onto an unregulated product that is far less safe for addicts. I mean do they seriously think that just because they make pills abuse resistant that it will make addicts say to themselves "Well since these pills are abuse resistant I think that I should just quit taking drugs." I THINK NOT. Like I said all it is doing is changing the epidemic from prescription drugs to street drugs. Which in my honest opinion are far more dangerous.

I really hope that the US government wakes up and just legalizes all drugs. This is a failed drug policy. Didn't work for booze and it will not work for drugs. Why can't the government just learn from their past mistakes.

Take a look at this http://www.leap.cc (http://www.leap.cc/)

Law Enforcement against Prohibition. Basically it is our police, judges, and some government people with the right idea. The website shows how much money the government spends on this "War on Drugs." Face it US government, this war is not winnable. Sorry about the rant at the end. It just really bugs me that our government in the US just doesn't get it.

Milkdud39

[Import]

Yeah, like other posters have said, I doubt there is anyone on this board who didn't think this was right around the corner.

However, the only people (abusers) this will affect are the ones who are dopesick and need a hit NOW. Like boro said, all you gotta do is throw the pill in a slightly acidic solution for 12 or 24 hours (however long opana releases over). No biggie. And besides, aren't there a number of somewhat effective techs out there for preparing OPs for sniffing or IV?

I know that this isn't going to be a popular opinion on here, but in some ways I'm kind glad this is happening. I would imagine that these reformulated pills will make quite a few less people try them in the first place, hopefully making it so that the number of suburban teens ODing will drop. Obviously, current addicts are just gonna find a way around the matrix or switch to heroin, but if less people are picking them up for the first time, it's gonna take some of the heat off of opiates. I dunno, that's just one way of looking at it, and not necessarily going to be true. Also, it's easy for me to say, because I stopped taking pharms in favor of heroin a long time ago.

Really the ONLY thing that bothers me about this whole situation is that it could very well make the drugs less effective for the people who actually need them. I couldn't really care less if people have a hard time getting high off of them, but I have a lot of sympathy for the people who need them to maintain a somewhat bearable life.

I guess we could always legalize heroin, separating the CP patients from the abusers. Oh wait, that makes far too much sense for our government.

[upstate_007]

Really the ONLY thing that bothers me about this whole situation is that it could very well make the drugs less effective for the people who actually need them. I couldn't really care less if people have a hard time getting high off of them, but I have a lot of sympathy for the people who need them to maintain a somewhat bearable life.



This is my issue. When oxycontin switched from OC to OP, the new pills were nowhere near as effective. It took twice as much to get almost 75% of the original pain relief. I switched to Opana because of that. I really hope the same does not happen with Opana.

And fuck the suburban teens. They can all OD, choke on their vomit and turn purple/blue and be found by their shitty parents for all I care. If you play with fire you are going to get burned. It is not the fire's fault. Fucking piece of shit lightweights.

[strikks]

god damn right^^import...SPIT THAT SHIT!!....good stuff reeally..these fucks are only fucking up these meds for the chronic pain suffer....man i get pissed..i know so many people that were on oxys and the new ones don't work...and these are older people who swallow them whole...then they all went to opana...(at my doc)...fuckin shame.....

when is my D.O.C. coming?? MSContin?? thats my shit.....WTF??


EDIT---YEAH UPSTATE!! your post was not there b4 i started my slow typing

piece of shit lightweights hahahahah..can't mix and handle your dope...YOU FUCKIN PUKES---OI!!


SHIT LIKE THIS scares me too--- WHY COULDN'T I GET THOSE PILLS??


http://www.tampabay.com/news/courts/civil/pharmaceutical-company-sued-over-largo-womans-morphine-overdose/1107965

[Eddie Dean]

rofl strikks ^^^^ but yeah I am really not surprised anymore and I garuntee like others have said above me this is the future of all opiods.. it fucking sucks cause I miss my OG OC's and now I am going to miss the OG Opanas too! man... :(

[seven10kids]

yeah, im going to stock up my opanas now. lol. the price skyrockets AFTER they stop making them, before you dont have much of a plan to gouge.

[Dr. McKay]

This sucks so bad.
This is all I have been thinking about for the past few days since I found out that the TRF tabs were coming out.
I was happy about 6 months ago when the FDA rejected ENDO's original formula for the TRf tabs, but they were insistant on making them, and now they have achieved it. I just hope that either they will have generic ERs that will not be made this new way or maybe ENDO will offer both formulas ??

[PiLL CLiNToN]

I believe it is fucking pretty hard (being younger) to get the proper meds so yeah doc, to detur abuse go ahead and keep on fucking up my stomach with LOADS OF APAP. and fucking ibprofen and all that funky gunk....Esp so high volumes in the Vics/percs.....

enough is enough, so Codeine Sulfate is an option....WTF! so much for luck with B.T meds.....

Government is going to do what they want and that i'm sure our pain is fuck all to them, I say hey being in real pain, w/e go ahead do what you think will detur abusers but damn why does real pain patients have to be fucked with so bad!!! fucking bullshit

[People Stew]

I guess I've never come across anything crush-proof before, so how does that work exactly? if you stick a crush-proof pill into a pill crusher and try to grind it will it just break in half? It seems like with enough force you could eventually smash a pill regardless of what they do to it.