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View Full Version : Nucynta tapentadol Pricing?



sourcecod
02-01-2011, 11:23 AM
Swim is curious about the pricing of Nucynta tapentadol 100mg tablets. They are orange, round, scored O-M on one side, and 100 on the other. Swim has been getting them from some old guy for $10 each for the 100s. Sim has asked many friends, but noone seems to know anything about it. Swim reports that snorting half of one burned his nose like hell and so he took the other half orally. He described it as a cross between a typical opiate buzz, slight alcohol buzz, and a slight speedy buzz--but in no way implying speedballing. Not your typical opiate, but what do you think Nucynta tapentadol is worth for a 100?

you can see a picture as I took in my avatar. i placed two on top a bunch of dillies next to a random OP20 I had laying around. heh. thats my avatar. a real pic taken by yours truly :D

In the last two weeks, I bought 20 of these bastards for about 150USD. *sigh*

normus420
02-01-2011, 11:42 AM
dejavu? I feel like ive read this before. what is Nucynta whats the main ingrediant? If its an opiate and its 100mg 10$ seems fair to me.

sourcecod
02-01-2011, 01:19 PM
de ja vu is right because I posted the exact same thread just a day or so before .org went down and the battle began. So i figured I'd ressurrect my thread here to see what people think. Right now an orange round O-M 100 is costing me around $7-$10 each and I get them all day long from this old fucking dude SWIM thats like 75 years old. I wanted to 1) make sure that was fair and 2) see what others thought of this new bullshit miracle drug.

so far it just gets me a feeling as if I railed some adderall mixed with a nice lil shot of say dilly and maybe a small line of OG10 or someshit. it has the typical opiate onset but a bit speedy. but you cant snort these fuckers for the world! I snorted half of one and my nose burned in pain sooooo horrible.... just a heads up on snorting. im gonna assume i wouldnt risk shooting. lol.

Wimpkins
02-01-2011, 03:49 PM
...from what I've heard they are like Ultrams.

borohydride
03-02-2011, 12:55 PM
Interesting that the US has already upgraded the scheduling of tapentalol. The makers must be a bit unhappy.

It was developed by Grunenthal - the tramadol people. A lot of scientists were really impressed that such a simple molecule could be 'morphine potency'... this sounds wrong to me. Joint mu/serotonin activity seems to be the way it works. I suspect that desmethyl tramadol will be stronger than tapentalol - if you can buy pure material (a lot of the RC places cut it).

peel man
03-05-2011, 12:58 PM
my mom was on nucynta when it first came out because she would go through her oxy 5s too quick(thanks mom) i tried them numerous times only oral though and never felt much more than if a took some tramadol. IMO tapentadol is a weak, barely active opiate-ish drug. I did have wicked ass dreams when id take it though. Not sure how well it works for pain but recreational value i give it a .2

doctor diesel
03-05-2011, 04:37 PM
This from Wiki:-

Tapentadol (trade name Nucynta) is a centrally-acting analgesic (http://en.wikipedia.org/wiki/Analgesic) with a dual mode of action as an agonist (http://en.wikipedia.org/wiki/Agonist) at the μ-opioid receptor (http://en.wikipedia.org/wiki/Mu_opioid_receptor) and as a norepinephrine reuptake inhibitor (http://en.wikipedia.org/wiki/Norepinephrine_reuptake_inhibitor).[2] (http://en.wikipedia.org/wiki/Tapentadol#cite_note-1) While its action reflects aspects of tramadol (http://en.wikipedia.org/wiki/Tramadol) and morphine (http://en.wikipedia.org/wiki/Morphine) its ability to kill pain is more on the order of hydrocodone (http://en.wikipedia.org/wiki/Hydrocodone) and oxycodone (http://en.wikipedia.org/wiki/Oxycodone), so not as weak as tramadol but not as strong as morphine.[3] (http://en.wikipedia.org/wiki/Tapentadol#cite_note-drugsofthefuture-2) Tapentadol is a new molecular entity that is structurally similar to tramadol (Ultram). It has opioid and nonopioid acitivity in a single compound.
Tapentadol is FDA approved for the treatment of moderate to severe acute pain. Due to the dual mechanism of action as an opioid agonist and norepinephrine reuptake inhibitor, there is potential for off label use in chronic pain.
Doctors use serotonin and norepinephrine reuptake inhibitors in chronic pain management to increase the effectiveness of opioids and, to a lesser extent, NSAIDs (http://en.wikipedia.org/wiki/NSAID) (along with other analgesics) against neuropathic pain and from certain specific contributing causes such as fibromyalgia (http://en.wikipedia.org/wiki/Fibromyalgia) and diabetic neuropathy. One selective serotonin and norepinephrine reuptake inhibitor (SNRI) often used as an adjunct, atypical & potentiator is duloxetine (http://en.wikipedia.org/wiki/Duloxetine) (Cymbalta). Another opioid with selective norepinephrine reuptake inhibitor effects is levorphanol (http://en.wikipedia.org/wiki/Levorphanol) (Levo-Dromoran).
Its dual mode of action provides analgesia at similar levels of more potent narcotic analgesics such as hydrocodone (http://en.wikipedia.org/wiki/Hydrocodone), oxycodone (http://en.wikipedia.org/wiki/Oxycodone), and meperidine (http://en.wikipedia.org/wiki/Meperidine) with a more tolerable side effect profile.

In tests Tapentadol seemed to be as effective against pain as oxycodone, but I can't recall the comparative dosages. It goes on to say: While Tapentadol is less abused than Oxycodone, the drug will remain in Schedule II since it is considered to have an abuse profile similar to hydromorphone (http://en.wikipedia.org/wiki/Hydromorphone).

I've also read somewhere (forget where) that tapentadol has considerably more activity at the mu receptor than does tramadol.


Doc

sourcecod
03-05-2011, 07:01 PM
well I have to say, since I'm the only one in my circle that can get them, the 100mg ones are like $4 at the pharmacy and seem to fetch $10-12 on the street. People bitch and moan that they snort like bloody hell and some seem to think they are worthless as vicodin 5mg's. But now that I've had a chance to eval them from being opiate-clean to crunching and swallowing 300-400mg, I got wicked fucked up and felt speedy like I would snorting ritalin. When I had a tolerance, I couldn't feel this med at all. anyway, I'm not even gonna say I have the balls to try and IV/IM these fuckers...

as far as my avatar goes, it seems to have been lost, and replaced by a lovely 80 clock.

anyway, this was the avatar I made back in late december:

5858



my timing must be off or something. I kicked in december, went clean for 21 days in january. then chipped every 5-7 days since the end of january. I still have a lot of tapentadols left. All the people that I had sample them, dont want them ever again. However, I can say that just because their recreational value per dollar is low, they do have a very high value in terms of pain relief! I took half of one not to get off or anything, but it got rid of my pain rather quickly! I think to get off on these, you'd have to do 200mg.... which at $20, most people would probalby just buy an OP80 or some roxi's.

correct me if im wrong, anyone out there with tapentadol experience. I'm technically a noob, but I've had them in my possession and ability to obtain since mid november. from what I gather, initially, street prices will hover around ten cents per milligram. eg. Tapentadol 50mg = $5, 75mg = $7, 100mg = $10

Dutch
06-08-2011, 05:05 PM
I would pay like $7-8 for 100s up to $10 if it was the only game in town. I had my first experience with these last week and for my money i'd get these over norco most days out of the week. I pay $2 for 75s and take 2 id have to pay 2.50 for norco and take 7. And these last a good long while. For the price of a happy meal you get a lil buzz and long relief from WD. Fine by me.

sourcecod
06-08-2011, 10:22 PM
I would pay like $7-8 for 100s up to $10 if it was the only game in town. I had my first experience with these last week and for my money i'd get these over norco most days out of the week. I pay $2 for 75s and take 2 id have to pay 2.50 for norco and take 7. And these last a good long while. For the price of a happy meal you get a lil buzz and long relief from WD. Fine by me.


since my last post, my cost has dropped dramatically due to virtually no demand, I got 360x of the OM100s for like $500, comming to wayyyyy less..

anyway, these -- i dont like them too much, but once in while I'll do one they're "okay"....

strikks
06-09-2011, 02:27 AM
i was considering asking my doc to try these but i am afraid to lose my MScontins....so i dunno if he would kick me those instead of my norcos....doesn't sound like they are worth a shit....correct me if i am wrong....would they be better than my norcos for breakthru with MScontins?? or would that be a terrible mistake??....i SURLY don't want him to say "yeah i'll give you those instead of your MS i would prob cry then shit then cry some more (in his office)...my appt is in a couple dayzzzz.....feedback please..

sourcecod
06-09-2011, 01:48 PM
i was considering asking my doc to try these but i am afraid to lose my MScontins....so i dunno if he would kick me those instead of my norcos....doesn't sound like they are worth a shit....correct me if i am wrong....would they be better than my norcos for breakthru with MScontins?? or would that be a terrible mistake??....i SURLY don't want him to say "yeah i'll give you those instead of your MS i would prob cry then shit then cry some more (in his office)...my appt is in a couple dayzzzz.....feedback please..

DO NOT SWITCH FROM MS-CONTIN TO TAPENTADOL! I Swear you will regret it. However, if say you were switching from vicodin to tapentadol, I'd say rock on.

just sayin from personal experience. I'd rather snort a vicodin and an ms-contin than snort a tapentadol! (and I don't snort any of the three lol)

borohydride
06-09-2011, 02:50 PM
How many mg morphine does 100mg tapentalol equate to? I cannot help but suspect there may be an increased seizure risk of this new(ish) drug. If it's anything like tramadol (or even O-desmethyl tramadol) then it isn't much fun. I hear that shooting O-sesmethyl tramadol can be pretty nice, but these reports were from people with no tolerance (hadn't touched opiates for years) and even then thy were shooting 400mg!

sourcecod
06-09-2011, 04:54 PM
How many mg morphine does 100mg tapentalol equate to? I cannot help but suspect there may be an increased seizure risk of this new(ish) drug. If it's anything like tramadol (or even O-desmethyl tramadol) then it isn't much fun. I hear that shooting O-sesmethyl tramadol can be pretty nice, but these reports were from people with no tolerance (hadn't touched opiates for years) and even then thy were shooting 400mg!

boro, i did your initial idea of incrementing... eventually I was like fuck it and injected the whole 100mg pill after leaving it chill overnight in the saline. Yes I did get a stronger Tapentadol buzz than I would have orally or intranasally.... but it really doesnt compare in sheer awesomeness of banging morphine (in my case Endo E655) or OGs (my case 2x-4x OG40s cleaned white). I would love to know what the actual conversion is. speculation is all over the map. I just gave up on tapentadol, its like the lower end of the opioid food chain, just slightly above vicodin at best. shit. I can't imagine one of my O-M100's even comparing to any of my morphine 60s. but who knows? I suspect noone at this point, at least in this culture--the scientists probably know and probably signed a non-disclosure--but thats me and just speculating based on some personal experience and hypothesis...

borohydride
06-09-2011, 07:55 PM
^Mate, personal experience is where it's at. If it's anything like (desmethyl) tramadol, the serotonin effects really spoil the mu activity. Annoying buzz & nausea is what I got from the two. I cannot even think of any way of making it nice. OK, maybe swapping the -N(CH3)2 for a piperidine (or pyrrolidine ring) might be an interesting move (like methadone to Diconal) but I think it's a dead end.

I've heard that 100mg is supposed to be like 60mg of morphine AS AN ANALGESIC. As you observe, from a euphoria perspective it sucks. The powers that be might like that - non-fun opiates. There is already a method of making things like morphine/hydromorphone/oxymorphone almost as effective orally as they are IV so that pills will need far, far less material in them (imagine, 1,2,3 & 4mg Opana!) but thats a few years off.

We may all have to ditch medical drugs and go entirely with black-market products (don't worry, some really good shit out there just waiting for the market to become favourable... eg BDPC).

Thanks for your reply!

opiophanatic
06-09-2011, 08:11 PM
^Mate, personal experience is where it's at. If it's anything like (desmethyl) tramadol, the serotonin effects really spoil the mu activity. Annoying buzz & nausea is what I got from the two. I cannot even think of any way of making it nice. OK, maybe swapping the -N(CH3)2 for a piperidine (or pyrrolidine ring) might be an interesting move (like methadone to Diconal) but I think it's a dead end.

I've heard that 100mg is supposed to be like 60mg of morphine AS AN ANALGESIC. As you observe, from a euphoria perspective it sucks. The powers that be might like that - non-fun opiates. There is already a method of making things like morphine/hydromorphone/oxymorphone almost as effective orally as they are IV so that pills will need far, far less material in them (imagine, 1,2,3 & 4mg Opana!) but thats a few years off.

We may all have to ditch medical drugs and go entirely with black-market products (don't worry, some really good shit out there just waiting for the market to become favourable... eg BDPC).

Thanks for your reply!

Hey Boro. From what I have read the tapentadol acts like an NRI, rather than having SRI effects(like tramadol). Will this lower the chances of seizure with tapentadol as compared to tramadol?

sourcecod
06-09-2011, 08:17 PM
I'm obliged to agree boro. From a purely pain relief standpoint, I could say I effectively got 60mg of morphine oral sure. From a euphoria standpoint, not so amusing at all, just slightly more than vicodin. Thats my personal find with this damned new drug.

borohydride
06-09-2011, 08:26 PM
^The way of the future, my friend! Not to worry, we can easily make dilaudid from codeine, so it's not all bad ;-)

BTW there is a legal opioid called viminol (Dividol™) that's OTC from pharmacies in Brazil (or over the net). What is interesting is that there are 6 isomers & some are agonists (one is 5.5x morphine) while others are antagonists. The mixture is legal because of the mixed effect. Happily, it's really simple to seperate out the agonist isomers so you end up with a full agonist that is about as potent as diamorphine.

If you want, I can sort out the patent details & write up a simple procedure. It really is as simple as freebase viminol, dissolve in DCM, add d-tartaric acid the good stuff crashes out. I seem to remember that 24x 70mg Dividol tablets cost about $20. That will make about 3/4g of an agonist around 2x morphine... dunno if thats considered cheap where U R...