thymoquinone/nigella sativa MU/KAPPA opioid

[jacky]

finally found a good report on this plant/compound.
the part used is the oil of the nigella sativa seed
thymoquinone is a component of that oil.

both thymoquinone, and macerated extracts of the seed create an observable analgesic effect. comparable to codeine in its antitussive effect.

the materials are thought to indirectly effect the MU and KAPPA opioid receptors...

I also notice that this plant is a calcium ion channel interruptor, recently VAXN8, a member here at opiophile pulled my attention to the analgesic, opioid tolerance reducing effects of this class of drugs. I started looking for herbs that might have this same effect.

I have taken the nigella sativa oil in amounts up to 4 tablespoons, but only when I have taken kratom or other opiates...I percieve a potentiation of sorts, and what felt like stimulant effects from the combinations, but we all know this type of usage can be hard to deem + or - to ones expectations and the actual results of the experience experiment.

the profile of this plant is at least enticing...analgesic effects, some unproven indirect interaction with the opiate systems?
looking at thymoquinones structure I at least see some superficial resemblence to the menthol compound., menthol I just learned is a possible opioid agonist at the kappa receptor...wouldnt it be interesting if these compounds were similiar, but that thymoquinone isnt a direct agonist, but might indirectly effect the opioidergic system in some way, maybe even through calcium channel blocking effects?

I think this oil is a good health food, and there is little danger in experimenting with it outright that I can see, but if it is comparable to codeine in its anti-tussive effects, maybe it is another minor opioid, a welcome addition, but not applauded.???

I think there are some thymoquinone fortified preperations out there somewhere.

this is a good herb product to use maybe for weening off of opiates/opioids, or maybe for withdrawl effects.

and it is a definite possible additive for an herbal cough preperation.

[Hammilton]

well, the opiates are isoquinolines, and I assume this is. Makes sense.

[Opiyum]

If its easily attainable and reasonably priced I could wait till early WD's begin setting in once the suboxone starts wearing off. I could then take a dose of this stuff, probably on a day that I dont have to work, and see if has the same effect as me taking another dose of Bupe. Would this be a good way of testing it?
If you could direct me to an outlet I'd be willing to try it and share my experience.

Sounds alot safer than Tetrotodoxin...

[Hammilton]

Yeah, that seems reasonable. It probably won't have you nodding, but if it will have any effect, that'd be the way to see. Do it on a day when you can sit around and notice slight changes.

If it works on mu and kappa opioid recepters there's a good chance you'll suffer from cross-tolerance. It sounds like its worth a try.

[Opiyum]

thats what i was thinkin. Im not looking to get high but when the sub starts wearing off you become very sensitive to everything. And i would be able to notice a slight change if it made me better. Normally coming off subs you slowly get worse and worse butif i feel a bit betteer after doseing then ill know it worked.

[imalgen]

No opiates in the last 3 weeks or so. Tolerance assumed at zero-ish?
Thursday night(Male, 165lb) eat 120mg Codeine phosphate with some milk thistle extract and a small amount of magnolia bark extract fortified with 98% Honokiol - for their hepatonic properties.

Approximately 3 hours later no pain relief and not much of anything but some itch - in comes 2mg Thymoquinone sublingual. The potency of Nigella oil alone has been enough to push me over the opi edge into the face of the porcelain pony puking for hours and nauseas for even more, but figuring the codeine was near useless 2mg pure thymoquinone should be enough to just kick it in. Yup.

Worked quite nicely, it felt that with any more thymoquinone i would have been spinning and sick. It kicked up the analgesia and the euphoria a good 4-6 fold the almost nil strength it had before. Enough to keep me awake happily watching a movie, where i normally would have fallen asleep. Some synthetic cannabinoid on top of that and it was actually pleasant and euphoric - which was not expected from any amount of tylenol#3. haha As t3's are normally useless and have nearly no worthy effect even at too large of doses.

Has anyone tried vaping this thymoquinone material? I couldnt believe how strongly the smell of this stuff permeates the body. You could smell me from down the hallway, at just 2mg sublingual! Literally seeping through me. Vaping might be too much to handle? Either way, mailman was nice on Saturday so experimentation will continue with natural opi source instead of codeine phos. blech.

Conclusion: You could most likely cut down your daily opiate consumption a great deal by incorporating with Thymoquinone or Nigella oil.

Next theory: Would also incorporating micro doses of Iboga alkaloids along with(or alternating with) the thymoquinone.

Lego block: What about the addition of Tropane alkaloids along with the prior? 4 square holy grail?

[Paregoric Kid]

thymoquinone is also an antioxidant and can act as an anticonvulsant.

menthol is definitely a kappa agonist. it is kind of weak but it definitely selectively activates the kappa receptors. it is related to thymoquinone as jacky said. check out the paper Menthol: a natural analgesic compound (http://www.ncbi.nlm.nih.gov/pubmed/11897159).

[jacky]

I was taking scopolamine in the form of datura innoxia seed on a daily basis all summer long.

I quit about a month ago.

so now I take it occasionally...about once a week.

I think its possibly and interesting combination idea of using nigella sativa with tropanes...because the nigella sativa can make me feel a bit dizzy and nauseous anyway.
I wouldnt suggest it for anyone else...but doing spiritual plant based research, it might prove interesting.

that smell of thymoquinone is quite strange.
I would be cautious with the pure substance....but I know its quite prevalent in the oil of nigella sativa..

I think you are on to something with the mixing of magnolia and nigella...
that is all this nigella sativa needs...is a few other, legal, fda approved herbs to bolster the effect.
I think this plant has the most potential of any of the opioid active herbs that are already used as dietary supplements.
the problem is that the oil is a bit nasty, and messy.
I think I am going to start trying to obtain the whole seeds...as they are about 50% oil weight.
the ground seeds would mix with other substances better maybe.

although there is something to be said for using oils as carriers. I once saw a patent that described how essential oils can increase bioavailability of certian substances/drugs.
opiates were one consideration.

I know one thing....combining nigella sativa with medications or poppy seeds can lead to some nauseating and dizzying, and quite strong effects.
people should be very careful with this stuff at first..or when combining with other substances. I think its possible that it could cause some problems.
and I know that thymoquinone injected in to animals at a certian dose will KILL KILL KILL.

keep up the good research!

[Papa Verine]

Whole Nigella Sativa seeds are sold in Indian grocery stores around here. I'm not sure what they're commonly used for, but they seem to be sold as a food product/spice.