menthol kappa opioid agonist.

[jacky]

looks like it is possible that the menthol compound is partially active or wholely active as an analgesic due to its activation of kappa opioid receptors.

I also noticed something about it being a calcium channel blocker, which according to some opiophiles might be a theraputic agent for opiate tolerance...being that some kappa opioid agonists can also have a positive effect on opiate tolerance side effects maybe menthol is both an agonist, and a calcium channel blocker.

menthol is considered a psychoactive drug, and can be taken in large amounts internally for supposed stimulant effects. this stimulant action would be inline with other kappa opioid active compounds perhaps.

well, I am going to order some pure menthol crystals...and smoke, suck, eat, and sublingual all that I can stand. I love mint, so menthol might be right up my alley. I was just reading a month ago about the psychoactive effect of menthol in the psychoactives encyclopedia...average dose is in the gram range, but doses as high as 10 grams have been taken.

[zombiewoof23]

Interesting. Please let us know how it turns out.

[insaneike]

Well... whats the word?

later

[jacky]

dont know as I still havtn ordered any pure menthol crystals...I am trying to find a supplier of TCM herbs that carries both kappa agonists...aconiti, and menthol.

I would imagine that in higher doses the menthol might be orally active...if not, then maybe a "cool" enema would work, couldnt be too much worse than washing with DR Bronners menthol soap...

well see someday.

[Spell Relief]

Or try Dr. Tichners' (spelled way wrong) Peppermint
oil mouthwash. oOOhh hot stuff! have to de-alcoholize it though.
lol:D :rolleyes:

[dolofina]

dont know as I still havtn ordered any pure menthol crystals...I am trying to find a supplier of TCM herbs that carries both kappa agonists...aconiti, and menthol.


Have you tried East Earth Trade Winds, in California?
They carry a lot of TCM herbs...
http://www.eastearthtrade.com/

[Hammilton]

I'm not positive, but I don't think the calcium channel blocking is the sort that helps with tolerance. I'm pretty sure it's a local only action, which is why it's sort of a cooling aneasthetic


^^I just followed that link, and I see they have a "Cannabis, Semen" Extract. What sort of cannabis semen is that?

[Sunwheel]

Cannabis Semen = Hemp seed

[jacky]

certian calcium channel blockers are known for their ability to lessen some side-effects of morphine tolerance.
that is all I know...
menthol most likely has several actions on the body, at least.
I think it would be a good item to bioassay in larger than normally consumed amounts.

similiar to the psychoactive camphor, menthol is mostly used as a flavoring...most people will take for granted that many substances have a range of action on the body at different doses.

its quite possible I think that menthol might have some positive effects on opiate tolerance, being both calcium channel blocker and an active kappa opioid agonist.

[Hammilton]

No, what I meant was that it's my understanding that menthol blocks calcium channels locally, not the systemic type. A local calcium channel blocker wouldn't have any effect on tolerance. Especially if, internally, it acts as a kappa agonist. that'd only raise it.

[jacky]

ohh, that bit escaped me hamilton, thanks...

menthol has a anti-tussive effect as well.

certian kappa opioid agonist actually though have an effect on morphine tolerance that could be beneficial...though it isnt across the board..ketamine, and other drugs that can effect the kappa opioid receptors are being researched for their possible use in lowering tolerance to other opiates.

and there are other organic kappa opioid agonists out there...
picralima nitida for one
mesaconitine..
chaste tree...
matrine....
and others that I need to look up again to confirm...
some of the above have mild effects on the mu receptor as well.
with picralima nitida it seems one researcher thinks that the mixed agonist activity, primarily the kappa, interferes with the mu agonist activity of the plant from being felt much. but what if we seperate those two? and this drug plant is still used as a pain reliever in africa...

anyway thanks again hammilton for pointing that out. good info.

ill order up a few kilos of menthol when I get back from vaca.

[vaxn8]

No, what I meant was that it's my understanding that menthol blocks calcium channels locally, not the systemic type. A local calcium channel blocker wouldn't have any effect on tolerance. Especially if, internally, it acts as a kappa agonist. that'd only raise it.


True, Hammilton. You need to block the brain's Ca2+ channels to get the effect. In some of the work I did, it was specifically brain stem Ca2+ channels.

[johnny27]

Now, i don't have a clue about all this kappa and mu talk. All i know is that opiates leave me feeling good. But as you mention about calcium in the brain and that, depakote has some sort of effect on calcium in the brain, i think i heard that somewhere. So, does it give you any ideas with your experiments? This is probaly nonsense talk of mine, i don't have a clue and this chemistry.