Uber painkiller is now available

[hydrosasquatch]

Hi ya'll...excellent forum you have here...

According to published reports, there's a new NON-OPIOID painkiller called Prialt now availale that's 1000 times stronger than morphine! They claim it's non addictive...Yea right! Since I've had chronic leg pain and migraines my entire life anything that can squash that I'd quickly become addicted to, opioid or not.

I don't know if this is the strongest approved pain killer in the world but it's got to be darn close if it isn't...They claim it was originally derived from a toxin from a species of snail...

(How much you want to bet those who really need this stuff will never be approved for it)

By the way...expect Rush Limbaugh to be caught with Prialt at an airport near you in the near future...:)

[WarmCyanide]

isn't it that shit derived from poison dart frogs??

[SirDonkeyPunch]

isnt wildnil or etorphin quite a bit stronger than that...... granted, its made for elephants and not for humans, the dosages are probably so small that they would just equate to some sorm of other high maybe like a tranquilizer like ketamine. Since its non opiate i cant help but to think the euphoria might be crumby and there might be a ceiling effect at a rather low dosage,so even though its more potent it might not do a whole lot.

i plan on doing some research and reporting back here. cuz this seems interesting

[SirDonkeyPunch]

PRIALT®
(ziconotide intrathecal infusion)
For use only in the Medtronic SynchroMed® EL, SynchroMed® II Infusion System,
and the CADD-Micro® ambulatory infusion pump.

Interaction with opioids
Ziconotide does not bind to opioid receptors and its pharmacological effects are not
blocked by opioid antagonists. In animal models, IT ziconotide potentiated opioidinduced
reduction in gastrointestinal (GI) motility, but did not potentiate morphineinduced
respiratory depression.

Dosing with PRIALT was started at 2.4 mcg/day (0.1 mcg/hr) and
the dose could be increased by 2.4 mcg/day (0.1 mcg/hr) two to three times/week
(minimum titration interval 24 hours) to a maximum dose of 19.2 mcg/day
(0.8 mcg/hr). The final mean dose at the end of the trial at 21 days was 6.9 mcg/day
(0.29 mcg/hr).

------------------------------------------------------------------------------------------------

This is just from the product information. apparently its for intrathecal infusion only. Which means it hooks up to a pump that pumps the drug straight into your spinal column. I didnt see anything relating to the euphoric effects however even if it did it might not have the bioavailability to be administered in other ways. if anyone else has stuff to add please do so
------------------------------------------------------------------------------------------------

i like these side effects

The most frequently reported adverse events (=25%) in the 1254 patients (662 patient (javascript:defwindow('patient')) years) in clinical (javascript:defwindow('clinical')) trials were dizziness, nausea, confusion, headache, somnolence, nystagmus, asthenia, and PAIN.

[WarmCyanide]

isnt wildnil or etorphin quite a bit stronger than that...... granted, its made for elephants and not for humans, the dosages are probably so small that they would just equate to some sorm of other high maybe like a tranquilizer like ketamine. Since its non opiate i cant help but to think the euphoria might be crumby and there might be a ceiling effect at a rather low dosage,so even though its more potent it might not do a whole lot.

i plan on doing some research and reporting back here. cuz this seems interesting


although ketamine will put you on your living ass, it is a disassociative. But I guess if you take enough tranqs, you really wont care about the price of pods in china.:D

[devilsdrug]

omfg//////////i just about shit myself

[SirDonkeyPunch]

omfg//////////i just about shit myself

whys that, i knew you were old but not that old....

ok my apologies that was a low blow. But you know we all love to hear your incite on all the various topics. I dont know but to me it just doesnt sound like too much fun.

wait i mean.... w00t for spinal cord injections!!!

[devilsdrug]

its problably too good to be true eh never no though i d be the first one to say let me have hundreth of a mg or whatever shit get it now

[Paregoric Kid]

there are painkillers being developed from venoms and there are ones being developed that work on the nicotine receptors, smokers find them even more useful one thing I read said. there are many opioids out there that are much stronger than any of these, analogues of fentanyls, etorphines, etc.

[bodangly]

If the Prialt didn't even potentiate respiratory depression I doubt it is of any use recreationally.

[vaxn8]

This one is good for pain only. It is VERY sucessful for chronic pain, and lots of docs are hoping it will replace opiates. There is no, zero, none high/euphoric feeling or anything like it. If it doesn't bind to the right receptors, it's not going to do a thing. So if you are truly looking for pain contol look into it. If you're looking for a high, look elsewhere!

[Paregoric Kid]

don't be so sure of this one. it must be administered intrathecally, through the spinal cord; it is the most expensive and invasive way to administer a drug. ziconotide is contraindicated in people with psychiatric disorders (psychosis, depression, bipolar, schizophrenia) and it has some very bad side effects, for example seizures are a possible side effect. right now it is being marketed for hard to treat chronic pain, ie for people who aren't responding well to or refuse to take opioids or other analgesics, basically a last resort. afterall this medicine needs to be installed into your back.
these forms of analgesics have no recreational value, they are not opioids (though hallucinations are said to be a possible side effect, hardly recreational I suspect). ziconotide (prialt) is a non-local anaesthetic calcium channel blocker. calcium channel blockers potentiate opiates by the way. I doubt opioids will ever be totally replaced, at least not for a while, and even then I bet it will work through the opioid receptors and nanotech. sure you can shut down nerves and there are other ways to induce analgesia in the body, but there are many different types of pain and not all pain killers work the same for everyone. certain types of pain need to be treated through different mechanisms, this is why there are different classes of analgesics (NSAIDs, opioids, anasthetics, NMDA antagonists/disassociatives, SSRIs).
I'm sure opiates will remain the standard treatment for pain in the terminally ill and hard to treat forms of chronic pain. the "high" has analgesic and antidepressant value, but modern doctors only see this as an unwanted side effect. even if you can get rid of pain without causing euphoria is that going to make a patient feel any better about lying in a hospital bed waiting to die?

[northernstar]

Hi ya'll...excellent forum you have here...

According to published reports, there's a new NON-OPIOID painkiller called Prialt now availale that's 1000 times stronger than morphine! They claim it's non addictive...Yea right! Since I've had chronic leg pain and migraines my entire life anything that can squash that I'd quickly become addicted to, opioid or not.

I don't know if this is the strongest approved pain killer in the world but it's got to be darn close if it isn't...They claim it was originally derived from a toxin from a species of snail...

(How much you want to bet those who really need this stuff will never be approved for it)

By the way...expect Rush Limbaugh to be caught with Prialt at an airport near you in the near future...:)

ya ive been following this stuff for years.....if they ever get it in pill form it will be the end of anything good. its the CONE Snail....there in guam....basicly it touches a fish it dies of paralysis fast...people have died in under 3 seconds from picking them up...some alkaliods have common things with CURARE
( strychnos toxifera) alkloids. i guess the venom paralyzes nerves....one of many venom components does pain receptors...ands thats where they started developing a painkiller....no pain,no anything...no high....FUCK THAT!

[Paregoric Kid]

it is not effective orally, there never will be a pill version. it can only be administered intrathecally.
the curare alkaloid D-tubocurarine is a muscle relaxant used in surgery. curare was studied extensively by Richard Evans Schultes, a famous botanist who travelled south america. he also researched many of the ethnobotanicals of south america. William Burroughs met him during his travels to South America and went in search of yage on one of Schultes expeditions.

[exitwound]

I'd be interested to know how well this works for other pain sufferers, and what the side effects typically are; sometimes I get mighty tired of dealing with opiate nausea/vomiting....

But because of the intrathecal administration route, I probably won't be able to take Prialt because my chronic inflammation would probably attack any intrathecal admin. device :-(

[northernstar]

it is not effective orally, there never will be a pill version. it can only be administered intrathecally.
the curare alkaloid D-tubocurarine is a muscle relaxant used in surgery. curare was studied extensively by Richard Evans Schultes, a famous botanist who travelled south america. he also researched many of the ethnobotanicals of south america. William Burroughs met him during his travels to South America and went in search of yage on one of Schultes expeditions.




my ethnobotanist buddy was quite proud of a letter he had from him, from before he passed on i belive...he was originaly sent to find rubber trees for the us. id love a Urare Tree,lol i thought the tree had up to 40 alkaloids present in the Curare that were related. the cone snail product seems to be a protine, so i guess there simaler only in action. u know a better place to look might be platypus venom....i chemicaly turns on every pain receptor in ther body if a large enough "sting..i guess..its from a hollow foot-claw tube thing..is that count as a stinger?" ..but anyhow ya, u can go into shock from sheer pain..the venom is not toxic at all...a small sting just puts a attacker in agony for hours. But if the venom can stimulate the receptors so much then the secret to building the reverse..a super potent blocker must exist in the stucture of the molecule....of couse iam crazy so....lol

burroughs is awsome ,thought it was ginsberg he looked for yage with also? i never trusted shooting codiene after he wrote of junkys turning blue from trying to refine paragoric,lol...still id kill for some MUGWUMP jizzum or the dark meat of the aquatic sea centapied....

[Paregoric Kid]

Ginsberg went down to South America years after Burroughs had. you can read the letters they wrote to each other in the book the Yage Letters.

[vaxn8]

probably attack any intrathecal admin. device :-(

It is administered by an implanted pump. Side fx are overall fairly well tolerated. Of course the list included nausea/vomiting/ and the usual ones. Just because you have n/v from opiates doesn't mean you would have it from this totally unrelated drug.

I have a grad degree in pharmocology & toxicology, and imo listed side effects are really all the same. Obviously there are exceptions, but n/v almost always shows up on a list of adverse events no matter what class.

I seriously looked into this pump just because of convienence and not having to deal with all that comes with opiates. Personally, they won't put one in me because my blood doesn't clot - so that rules out most implanted devices. If they would put one in, I would do it in a minute!

[Paregoric Kid]

"The most common side effects are dizziness, nausea, confusion, and headache. Others may include weakness, hypertonia, ataxia, abnormal vision, anorexia, somnolence, unsteadiness on feet, and memory problems. The most severe, but rare side effects are hallucinations, thoughts of suicide, new or worsening depression, meningitis and seizures. Therefore, it is contradicted in people with a history of psychosis, schizophrenia, clinical depression, and bipolar disorder."

[oxydose]

\FUCK THAT!

Sorry man I love my opiates just as much as the next guy but a real true cure for serious pain? Thats a good thing, no one would be forced to suffer and pay out most of their income seeing doctors once or twice a month and all that junk.

The moneys too good for there never to be anything anywhere.

[Duckfeet]

I'd read something in one of those damn books about cooking down paregoric. Some guy who burglarized drugstores down Louisiana way, had a bunch of bottles of it, and back then I was bold, and I sort of remembered some old book where the guy cooked it down, so I cooked and cooked and cooked...When it got to point I thought looked good, whatever that was, I drew it up and fixed it. All I remember is, getting a weird rush, and then headache, then really crappy cotton fever....lucky I didn't croak...

I think paregoric wasn't codeine, however, but *opium* in alcohol. Gotta taste that u never forget...I'm old enough to have gotten teaspoons of it when I was a kid, from my grandma, and when I tried it many years later, I *knew* that taste.

You could buy paregoric over the counter down in Belize. But I had lurned my lesson by then, so I'd put paragoric on ice, and pour in that rotgut rum they called Guaro they had down there on top of it. Much better, best I can remember...mighta been the rum ;-)






<snip>
i never trusted shooting codiene after he wrote of junkys turning blue from trying to refine paragoric,lol...still id kill for some MUGWUMP jizzum or the dark meat of the aquatic sea centapied....

[mrnatural]

I'd read something in one of those damn books about cooking down paregoric. Some guy who burglarized drugstores down Louisiana way, had a bunch of bottles of it, and back then I was bold, and I sort of remembered some old book where the guy cooked it down, so I cooked and cooked and cooked...When it got to point I thought looked good, whatever that was, I drew it up and fixed it. All I remember is, getting a weird rush, and then headache, then really crappy cotton fever....lucky I didn't croak...

I think paregoric wasn't codeine, however, but *opium* in alcohol. Gotta taste that u never forget...I'm old enough to have gotten teaspoons of it when I was a kid, from my grandma, and when I tried it many years later, I *knew* that taste.

You could buy paregoric over the counter down in Belize. But I had lurned my lesson by then, so I'd put paragoric on ice, and pour in that rotgut rum they called Guaro they had down there on top of it. Much better, best I can remember...mighta been the rum ;-)


Yeah the taste was terrible, but even when I was 10 i would sneak extra tsps from the big bottle my mom had in the cabinet. Label said "tincture of opium in an alcohol base" and I knew it gave me a warm fuzzy feeling. By 15, I would dip one of my mom's Salems in it and smoke it when it was dry. Had some technicolor dreams. By the mid-sixties, you had to sign for a 4 oz bottle, still no scrip necessary. My intro to opiates, although I detoured through alot of other drugs before I came back to opiates as a DOC.