Tetrodotoxin for Wd?

[Paregoric Kid]

I was reading about tetrodotoxin, a chemical found in the pufferfish and suspected to be one of the ingredients in Hatian voodoo's zombie powder. well I come across this sentence on wikipedia, Blocking of fast Na+ channels has potential medical use in treating some cardiac arrhythmias. Tetrodotoxin has proved useful in the treatment of pain (originally used in Japan in the 1930s) from such diverse problems as terminal cancer,[9] (http://en.wikipedia.org/wiki/Tetrodotoxin#cite_note-Hagen_2008-8) migraines, and heroin withdrawal.[10] (http://en.wikipedia.org/wiki/Tetrodotoxin#cite_note-isbn0-7890-0553-0-9)
pretty crazy, check this out:

Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts
Jie Shia (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-4VS4020-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1063694248&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=97a1394b77962cac3e0d7343023010ef#aff1), Ting-Ting Liua (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-4VS4020-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1063694248&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=97a1394b77962cac3e0d7343023010ef#aff1), Xi Wanga (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-4VS4020-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1063694248&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=97a1394b77962cac3e0d7343023010ef#aff1), David H. Epsteinb (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-4VS4020-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1063694248&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=97a1394b77962cac3e0d7343023010ef#aff2), Li-Yan Zhaoa (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-4VS4020-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1063694248&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=97a1394b77962cac3e0d7343023010ef#aff1), Xiao-Li Zhanga (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-4VS4020-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1063694248&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=97a1394b77962cac3e0d7343023010ef#aff1) and Lin Lua (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-4VS4020-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1063694248&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=97a1394b77962cac3e0d7343023010ef#aff1)
aNational Institute on Drug Dependence, Peking University, Beijing 100083, ChinabIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA

Received 18 November 2008;
revised 14 February 2009;
accepted 24 February 2009.
Available online 5 March 2009.

Abstract

Background

Tetrodotoxin (TTX) is a neurotoxin found in puffer fish and other marine animals. New clinical studies suggest that low-dose TTX can safely relieve severe, treatment-resistant cancer pain. The therapeutic potential of TTX in addiction is supported by studies in laboratory animals. The purpose of this double-blind, placebo-controlled study was to assess the effect of a single intramuscular dose of TTX on cue-induced craving and anxiety in abstinent heroin addicts.
Methods

Forty-five abstinent heroin addicts were randomly assigned to three treatment groups: placebo, 5 µg TTX, or 10 µg TTX. Participants were exposed to a neutral video or a heroin-related video. Craving, anxiety, blood pressure, and heart rate were measured pre- and post-exposure.
Results

Heroin-related cues increased both craving and anxiety and had no effect on blood pressure and heart rate. A single dose of TTX dose-dependently attenuated the increases in craving and anxiety while having no effect on blood pressure or heart rate.
Conclusion

The results suggest that low-dose TTX is acutely effective in reducing cue-induced increases in heroin craving and associated anxiety.

[hovadagod]

Looks good but you have to wonder if youd withdraw from the tetrodotoxin.

Also, how can you get the stuff? I think that calcium channels play a big role in WD's.

[More Feen]

I used to use TTX in the 90's (for research, not personally :) )

Some time later, it became VERY difficult to order more because of its potential use as a weapon.

It is very potent at microgram levels, if I remember correctly.

M F

ps-just saw your posted doses of 5ug and 10ug!

[Paregoric Kid]

well I'm not encouraging people to try this for pain or wd unless they do serious research into the dosing and the risks but I will say that you do not need a license to buy or possess less than 100mg (like more feen said it is active in the microgram range, more than an enough to do research) and you can find it online. you could also do an extraction on pufferfish venom but why go through the trouble when you can just order it.

[More Feen]

Just like with BOTOX, TTX will kill you if used improperly (absorb too much through your skin, or inhaling the dust).

Think of the scene in Serpent & The Rainbow where the voodoo guy blows a (gloved) handfull of "zombie" powder into the doctor's face.

When I used it, I would have gloves on, and a mask, and still open the container in a protective hood, at least until it was mixed into a solution. Even in solution, you had to be sure not to get any on you.

If you're a little careless, it wouldn't take much more than a speck the size of a dust mote to knock you down. Actually, lethal dose for 75-kg person is roughly 25 mg, ~30 grains of salt (size wise).

Injected, it would take only ~0.5mg (500ug) worth to KO a 75-kg man. I figure inhalation would be a similar amount.

Just like with Fugu poisoning, you need to put the person on a respirator for a few days until the TTX is broken-down/ and muscles start working again.

Like with Botox, best to leave these diluted poisons in the hands of those with training.
** Botox Info: http://women.emedtv.com/botox/botox-overdose.html
** T T X Info: (more than I can provide): http://en.wikipedia.org/wiki/Tetrodotoxin

M F

PS- P.K. saw the unregulated 100mg amnt--did not know that. I cannot remember, but I guess the amnt we were trying to buy was well over the 100mg!